DEE fibroblast transdifferentiation RNAseq Transcripts Analysis

Introduction

The following document is a summary of the analysis method of RNASeq data generated from transdifferentiated fibroblasts from individuals with DEE due to variants in CHD2 or SCN2A.
The samples consist of differeing numbers of biological replicates of each genotype (WT = 4, SCN2A =3 and CHD2 =2) extracted from cultured cells as fibroblasts then days 10, 22 and 28. Sample libraries were prepared for sequencing by the service provider (SAGC) using the ribosomal reduction, mRNA enrichment according to the maufacturers protocol (Nugen Universal Plus Total RNA-seq protocol (Part No. 15044223 Rev. B).). Strand-specific sequencing was carried by SAGC in two batches on MGI-T7 and MGI-G400 platforms respectively using a 2 x 150 bp, paired end read strategy. Prior to differential gene expression analysis, RNAseq data were psuedo-mapped to the ENSEMBL v84 set of human transcripts using the Salmon pipeline refer to our protocol document and git repository for details.

Set up the environment

This sets up paths to files, imports metadata associated with the samples and defines sample groups for the QC and statistical tests.

counts_dir = "data/salmon"
ExperimentName = "RNASeq.DEE.iNeuron.10.2024"
pdataFile = "data/metadata/pdata.csv"
sampleList = "data/metadata/sampleOrder.txt"
EpilepsyGenes = "data/reference/EpilepsyGenes_v2024-09.tsv"

Load required libraries

These are loaded up front so you know what the requirements are to run the script.

library(dplyr)
library(reshape2)
library(tximeta)
library(SummarizedExperiment)
library(edgeR)
library(RColorBrewer)
library(ggplot2)
library(pheatmap)
library(VennDiagram)
library(rtracklayer)
library(biomaRt)

Import sample metadata.

An independent file is set up pdata.csv which contains information about the samples; pdata is short for phenotypic data. Generally the more information the better, e.g. cell type, differentiation state, batches, RIN scores, sex, species, etc.

pdata<-read.table(file=pdataFile, header=TRUE, sep=",", as.is = FALSE)
rownames(pdata)<-pdata[,"sampleCode"] # set row names to sample names
pdata.current<-pdata # sometimes you want to throw out a sample or use a subset.  designating pdata.current allows you to temporarily change this without altering your original pdata table
samples<-as.character(pdata.current$sampleCode)
quantFiles <- file.path(counts_dir, pdata.current$folder,"quant.sf")
pdata.current <- data.frame(files = quantFiles, names = samples, pdata.current) # sets the format specifically required by tximeta
kbl(pdata.current) %>%
  kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
  scroll_box(width = "100%", height = "300px")

	files	names	sampleCode	folder	individual	timepoint	diffState	sex	batch	genotype	replicate	RIN
CON_1_FB	data/salmon/8YC-FB-24-05549/quant.sf	CON_1_FB	CON_1_FB	8YC-FB-24-05549	8YC	day_0	fibroblast	F	SAGCQR1262	WT	1	9.9
CON_1_d10	data/salmon/8YC-10-24-05558/quant.sf	CON_1_d10	CON_1_d10	8YC-10-24-05558	8YC	day_10	day_10	F	SAGCQR1262	WT	1	9.9
CON_1_d22	data/salmon/8YC_22/quant.sf	CON_1_d22	CON_1_d22	8YC_22	8YC	day_22	day_22	F	SAGCQR1293	WT	1	9.8
CON_2_FB	data/salmon/FC45-FB-24-05548/quant.sf	CON_2_FB	CON_2_FB	FC45-FB-24-05548	FC45	day_0	fibroblast	F	SAGCQR1262	WT	1	9.6
CON_2_d10	data/salmon/FC45-10-24-05557/quant.sf	CON_2_d10	CON_2_d10	FC45-10-24-05557	FC45	day_10	day_10	F	SAGCQR1262	WT	1	9.9
CON_2_d22	data/salmon/FC45_22/quant.sf	CON_2_d22	CON_2_d22	FC45_22	FC45	day_22	day_22	F	SAGCQR1293	WT	1	10.0
CON_2_d28	data/salmon/FC45_28/quant.sf	CON_2_d28	CON_2_d28	FC45_28	FC45	day_28	day_28	F	SAGCQR1293	WT	1	10.0
CON_3_FB_A	data/salmon/MC2936-FB-24-05546/quant.sf	CON_3_FB_A	CON_3_FB_A	MC2936-FB-24-05546	MC2936	day_0	fibroblast	M	SAGCQR1262	WT	1	8.9
CON_3_FB_B	data/salmon/MC2936_FB/quant.sf	CON_3_FB_B	CON_3_FB_B	MC2936_FB	MC2936	day_0	fibroblast	M	SAGCQR1293	WT	2	10.0
CON_3_d10	data/salmon/MC2936-10-24-05555/quant.sf	CON_3_d10	CON_3_d10	MC2936-10-24-05555	MC2936	day_10	day_10	M	SAGCQR1262	WT	1	9.7
CON_3_d22	data/salmon/MC2936_22/quant.sf	CON_3_d22	CON_3_d22	MC2936_22	MC2936	day_22	day_22	M	SAGCQR1293	WT	1	9.8
CON_3_d28	data/salmon/MC2936_28/quant.sf	CON_3_d28	CON_3_d28	MC2936_28	MC2936	day_28	day_28	M	SAGCQR1293	WT	1	9.7
CON_4_FB_A	data/salmon/MC44-FB-24-05547/quant.sf	CON_4_FB_A	CON_4_FB_A	MC44-FB-24-05547	MC44	day_0	fibroblast	M	SAGCQR1262	WT	1	9.8
CON_4_FB_B	data/salmon/MC44_FB/quant.sf	CON_4_FB_B	CON_4_FB_B	MC44_FB	MC44	day_0	fibroblast	M	SAGCQR1293	WT	2	10.0
CON_4_d10	data/salmon/MC44-10-24-05556/quant.sf	CON_4_d10	CON_4_d10	MC44-10-24-05556	MC44	day_10	day_10	M	SAGCQR1262	WT	1	10.0
CON_4_d22	data/salmon/MC44_22/quant.sf	CON_4_d22	CON_4_d22	MC44_22	MC44	day_22	day_22	M	SAGCQR1293	WT	1	10.0
SCN2A_1_FB	data/salmon/61103MS-FB-24-05542/quant.sf	SCN2A_1_FB	SCN2A_1_FB	61103MS-FB-24-05542	61103	day_0	fibroblast	M	SAGCQR1262	SCN2A	1	9.6
SCN2A_1_d10	data/salmon/61103MS-10-24-05551/quant.sf	SCN2A_1_d10	SCN2A_1_d10	61103MS-10-24-05551	61103	day_10	day_10	M	SAGCQR1262	SCN2A	1	9.9
SCN2A_1_d22	data/salmon/61103MS_22/quant.sf	SCN2A_1_d22	SCN2A_1_d22	61103MS_22	61103	day_22	day_22	M	SAGCQR1293	SCN2A	1	9.9
SCN2A_1_d28	data/salmon/61103MS_28/quant.sf	SCN2A_1_d28	SCN2A_1_d28	61103MS_28	61103	day_28	day_28	M	SAGCQR1293	SCN2A	1	9.8
SCN2A_2_FB	data/salmon/61107AM-FB-24-05541/quant.sf	SCN2A_2_FB	SCN2A_2_FB	61107AM-FB-24-05541	61107	day_0	fibroblast	F	SAGCQR1262	SCN2A	1	10.0
SCN2A_2_d10	data/salmon/61107AM-1-24-05550/quant.sf	SCN2A_2_d10	SCN2A_2_d10	61107AM-1-24-05550	61107	day_10	day_10	F	SAGCQR1262	SCN2A	1	9.9
SCN2A_2_d22	data/salmon/61107AM_22/quant.sf	SCN2A_2_d22	SCN2A_2_d22	61107AM_22	61107	day_22	day_22	F	SAGCQR1293	SCN2A	1	9.9
SCN2A_2_d28	data/salmon/61107AM_28/quant.sf	SCN2A_2_d28	SCN2A_2_d28	61107AM_28	61107	day_28	day_28	F	SAGCQR1293	SCN2A	1	9.8
SCN2A_3_FB	data/salmon/61166AR-FB-24-05543/quant.sf	SCN2A_3_FB	SCN2A_3_FB	61166AR-FB-24-05543	61166	day_0	fibroblast	F	SAGCQR1262	SCN2A	1	9.5
SCN2A_3_d10	data/salmon/61166AR-10-24-05552/quant.sf	SCN2A_3_d10	SCN2A_3_d10	61166AR-10-24-05552	61166	day_10	day_10	F	SAGCQR1262	SCN2A	1	9.9
SCN2A_3_d22	data/salmon/61166AR_22/quant.sf	SCN2A_3_d22	SCN2A_3_d22	61166AR_22	61166	day_22	day_22	F	SAGCQR1293	SCN2A	1	9.8
SCN2A_3_d28	data/salmon/61166AR_28/quant.sf	SCN2A_3_d28	SCN2A_3_d28	61166AR_28	61166	day_28	day_28	F	SAGCQR1293	SCN2A	1	10.0
CHD2_1_FB	data/salmon/61161RG-FB-24-05544/quant.sf	CHD2_1_FB	CHD2_1_FB	61161RG-FB-24-05544	61161	day_0	fibroblast	F	SAGCQR1262	CHD2	1	9.7
CHD2_1_d10	data/salmon/61161RG-10-24-05553/quant.sf	CHD2_1_d10	CHD2_1_d10	61161RG-10-24-05553	61161	day_10	day_10	F	SAGCQR1262	CHD2	1	9.9
CHD2_1_d22	data/salmon/61161RG_22/quant.sf	CHD2_1_d22	CHD2_1_d22	61161RG_22	61161	day_22	day_22	F	SAGCQR1293	CHD2	1	9.9
CHD2_1_d28	data/salmon/61161RG_28/quant.sf	CHD2_1_d28	CHD2_1_d28	61161RG_28	61161	day_28	day_28	F	SAGCQR1293	CHD2	1	9.8
CHD2_2_FB	data/salmon/61171SW-FB-24-05545/quant.sf	CHD2_2_FB	CHD2_2_FB	61171SW-FB-24-05545	61171	day_0	fibroblast	M	SAGCQR1262	CHD2	1	9.6
CHD2_2_d10	data/salmon/61171SW-10-24-05554/quant.sf	CHD2_2_d10	CHD2_2_d10	61171SW-10-24-05554	61171	day_10	day_10	M	SAGCQR1262	CHD2	1	10.0
CHD2_2_d22	data/salmon/61171SW_22/quant.sf	CHD2_2_d22	CHD2_2_d22	61171SW_22	61171	day_22	day_22	M	SAGCQR1293	CHD2	1	9.9

Groups for statistical tests

These are complex data with genotype and differentiation state to be considered. The script below sets up these variables for the series of comparisons to be made with these data. There are four differentiation states (fibroblast, day 10, day 22 and day 28) and three genotypes (SCN2A, CHD2 and WT). There are several hypotheses that can be tested. 1. Transdifferentiation of fibroblasts leads to expression of neuronal marker genes. 2. WT, SCN2A and CHD2 genotypes confer differences in gene expression patterns at each diffrentiation time point.

# Set up vectors of categories

# Grouped categories
diffState = factor(paste(pdata.current$diffState))
genotype = factor(paste(pdata.current$genotype))
diffVsGeno = factor(paste(pdata.current$diffState, pdata.current$genotype, sep="."))
sex = factor(paste(pdata.current$sex))

# Define colour palettes for graphing
# I use the palettes suggested here https://tsitsul.in/blog/coloropt/ but there are many other options
# e.g. https://medialab.github.io/iwanthue/ or https://www.simplifiedsciencepublishing.com/resources/best-color-palettes-for-scientific-figures-and-data-visualizations

xgfs_normal12 = c("#ebac23", "#b80058", "#008cf9", "#006e00", "#00bbad", "#d163e6", "#b24502", "#ff9287", "#5954d6", "#00c6f8", "#878500", "#00a76c", "#bdbdbd")
pal4cellType = xgfs_normal12[c(1:length(levels(diffState)))]
pal4genotype = xgfs_normal12[c(1:length(levels(genotype)))]
pal4diffVsGeno = xgfs_normal12[c(1:length(levels(diffVsGeno)))]
pal4Sex = xgfs_normal12[c(6,9)] # It's sterotyped but it works
blue_col_scale = brewer.pal(4,"Blues")
pal4RIN = colorRampPalette(blue_col_scale)

# Gene and Transcript Lists

diffMarkerGenes = data.frame(ensembl_gene_id = c("ENSG00000111704",
                    "ENSG00000204531",
                    "ENSG00000181449",
                    "ENSG00000007372",
                    "ENSG00000163508",
                    "ENSG00000170558",
                    "ENSG00000132688",
                    "ENSG00000148773",
                    "ENSG00000077279",
                    "ENSG00000258947"))


# Custom sample order
sampleOrder = read.table(sampleList)
sampleOrder = as.vector(sampleOrder[,1])

WTsamples = pdata.current$sampleCode[pdata.current$genotype == "WT"]
SCN2Asamples = pdata.current$sampleCode[pdata.current$genotype == "SCN2A"]
CHD2samples = pdata.current$sampleCode[pdata.current$genotype == "CHD2"]

Epilepsy_gene_list = read.table(EpilepsyGenes, header = TRUE, sep = "\t")
DEE_List = Epilepsy_gene_list$ensembl_gene_id[grep("DEE", Epilepsy_gene_list$Phenotype)] # column names of the original file https://github.com/bahlolab/Genes4Epilepsy/releases/tag/v2024_09 have been edited
DEE_biobank_list = read.table("data/reference/EpilepsyBiobank.list.txt", col.names = "ensembl_gene_id")

SCN2A_gene = "ENSG00000136531"
SCN2A_transcripts = c("ENST00000375437", 
"ENST00000636071",
"ENST00000636985",
"ENST00000631182",
"ENST00000283256",
"ENST00000637266") # GENCODE only

CHD2_gene = "ENSG00000173575"
CHD2_transcripts = c("ENST00000394196",
"ENST00000626874",
"ENST00000628375",
"ENST00000625990",
"ENST00000420239",
"ENST00000626782",
"ENST00000627622",
"ENST00000629346") # GENCODE only

Import counts data

Counts data were generated using the Salmon pipeline. The individual quant.sf files contain counts and TPM data which will be extracted here and combined into transcript or gene counts.

imported.counts <- tximeta(coldata = pdata.current)

## importing quantifications

## reading in files with read_tsv

## 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 
## found matching transcriptome:
## [ Ensembl - Homo sapiens - release 97 ]
## loading existing EnsDb created: 2022-03-29 04:40:14
## loading existing transcript ranges created: 2022-03-29 04:40:25

summarised.genes = summarizeToGene(imported.counts)

## loading existing EnsDb created: 2022-03-29 04:40:14
## obtaining transcript-to-gene mapping from database
## loading existing gene ranges created: 2022-03-29 04:52:57
## gene ranges assigned by total range of isoforms, see `assignRanges`
## summarizing abundance
## summarizing counts
## summarizing length

Export counts for differential expression analysis

The counts.current object is not strictly necessary but it can be helpful if subsetting counts into smaller groups or switching between summarised gene counts or transcript counts.

gene.counts = assays(summarised.genes)[["counts"]]
transcript.counts = assays(imported.counts)[["counts"]]
counts.current<-gene.counts[,samples]

Make a simple table of expression values

These are normalized counts data and give an indication of the level of expression using the TPM units. It’s important to note that edgeR uses CPM to calculate differential expression so if you manually calculate fold changes from these data then you will likely not get the same result however the trend should be the same. This short blog post goes through some of the differences in RNA-seq measures https://haroldpimentel.wordpress.com/2014/05/08/what-the-fpkm-a-review-rna-seq-expression-units/

gene.TPM <- assays(summarised.genes)[["abundance"]]
transcript.TPM <- assays(imported.counts)[["abundance"]]
current.TPM = gene.TPM

Export counts table for unaffected individuals with annotations

selectSamples = WTsamples
expressionMatrix = log(gene.TPM[ , selectSamples ], 2)
ensembl = useMart("ensembl",dataset="hsapiens_gene_ensembl")
Annotations = getBM(attributes = c('hgnc_symbol','ensembl_gene_id','entrezgene_description'),
                     filters = 'ensembl_gene_id',
                     values = gsub("\\..*","",row.names(gene.TPM)),
                     mart = ensembl)

expressionMatrix = cbind(expressionMatrix, data.frame(ensembl_gene_id=gsub("\\..*","",row.names(expressionMatrix))))
expressionMatrix = left_join(expressionMatrix, Annotations, by="ensembl_gene_id")
expressionMatrix = distinct(expressionMatrix, ensembl_gene_id, .keep_all = TRUE)
rownames(expressionMatrix)<-expressionMatrix$ensembl_gene_id
write.table(expressionMatrix, file = "output/misc/WT_FB_to_day_28_iN.log2.TPM.txt", quote = FALSE, row.names=TRUE, col.names=TRUE, sep = "\t")

QC

MDS Plot to file and show in the markdown

The multidimensional scaling (MDS) plot shows the largest distance between samples based on the ranked largest fold changes in gene expression between each sample pair. Only the first two factors are shown in the 2D plot. Each cell fraction has separated into a group in the graph with the nuclear and cytoplasmic samples showing some variation but overall these data look good. All graphs are the same but the colours change to indicate different classes of covariates to help in their interpretation.

## png 
##   2

You can look through the following plots to explore the sources of variation

plotMDS(d, labels=pdata.current$sampleCode, col = pal4diffVsGeno[factor(diffVsGeno)], main = "Colour by Major Groups")

plotMDS(d, labels=pdata.current$sampleCode, col = pal4cellType[factor(diffState)], main = "Colour by Cell Type")

plotMDS(d, labels=pdata.current$sampleCode, col = xgfs_normal12[c(1:length(levels(pdata.current$genotype)))][factor(pdata.current$genotype)], main = "Colour by Genotype")

plotMDS(d, labels=pdata.current$sampleCode, col = xgfs_normal12[c(1:length(levels(pdata.current$batch)))][factor(pdata.current$batch)], main = "Colour by Batch")

plotMDS(d, labels=pdata.current$sampleCode, col = pal4Sex[factor(pdata.current$sex)], main = "Colour by Sex")

plotMDS(d, labels=pdata.current$sampleCode, col = pal4RIN(nrow(pdata.current))[findInterval(pdata$RIN, sort(c(0:10)))], main = "Colour by RIN") #[findInterval(pdata$RIN, sort(pdata.current$RIN))]

Note: CON3 (MC2936) sits apart from all other samples at all timepoints.

Plot library sizes

Library size is taken into account by edgeR during the analysis so that counts are comparable for each gene or transcripts across all samples. Note that edgeR does not perform any normalisation of counts data between genes or transcript (such as TPM or FPKM) because comparisons are only made per transcript or per gene their length is irrelevant.

#par(mar = c(7, 4, 2, 2) + 0.5)
fudge = 7.5 # Hacky way of getting the x-axis labels positioned correctly in this plot you will need to adjust each time. Go down if the labels are longer than the graph and up if the graph is longer than the labels.
barplot(d$samples$lib.size, 
        xlab="Samples", 
        ylab="Library Size", 
        col = pal4genotype[factor(pdata.current$genotype)])
text(seq(1, nrow(pdata.current) + fudge, by = (nrow(pdata.current) + fudge)/nrow(pdata.current)), 
     par("usr")[3] - 0.25, 
     cex=0.6, 
     adj = 1.1, 
     labels=pdata.current$sampleCode, 
     xpd=TRUE, 
     srt=45)

3D PCA plot

Like the MDS plot, the principle components analysis plot is another way of looking at differences between the sample in bulk and exploring the sources of sample variation. Unfortunately this won’t render in the html, but you can see the table containing the PCA output below and some images that have been pasted in looking at each dimension.

pc <- princomp(counts.current, cor=TRUE, scores=TRUE)
summary(pc)

## Importance of components:
##                           Comp.1    Comp.2    Comp.3     Comp.4      Comp.5      Comp.6      Comp.7       Comp.8       Comp.9      Comp.10
## Standard deviation     5.3468110 2.2249377 0.7560462 0.59185112 0.387271098 0.361847092 0.257175861 0.1867847901 0.1811372314 0.1503774026
## Proportion of Variance 0.8168111 0.1414385 0.0163316 0.01000822 0.004285112 0.003740952 0.001889698 0.0009968159 0.0009374485 0.0006460961
## Cumulative Proportion  0.8168111 0.9582496 0.9745812 0.98458939 0.988874502 0.992615454 0.994505152 0.9955019680 0.9964394165 0.9970855126
##                             Comp.11      Comp.12      Comp.13      Comp.14      Comp.15      Comp.16     Comp.17      Comp.18      Comp.19
## Standard deviation     0.1239639395 0.1133897931 0.1062937527 0.0987557313 0.0922427773 0.0830794502 0.081162716 0.0782005508 0.0679125485
## Proportion of Variance 0.0004390588 0.0003673499 0.0003228103 0.0002786484 0.0002431066 0.0001972056 0.000188211 0.0001747236 0.0001317747
## Cumulative Proportion  0.9975245714 0.9978919213 0.9982147316 0.9984933800 0.9987364866 0.9989336922 0.999121903 0.9992966268 0.9994284015
##                             Comp.20      Comp.21     Comp.22      Comp.23      Comp.24      Comp.25      Comp.26      Comp.27      Comp.28
## Standard deviation     0.0618664973 0.0528069028 0.049940264 4.433936e-02 0.0431201468 3.733637e-02 3.216225e-02 0.0301325991 2.874627e-02
## Proportion of Variance 0.0001093561 0.0000796734 0.000071258 5.617082e-05 0.0000531242 3.982871e-05 2.955459e-05 0.0000259421 2.360995e-05
## Cumulative Proportion  0.9995377576 0.9996174310 0.999688689 9.997449e-01 0.9997979840 9.998378e-01 9.998674e-01 0.9998933094 9.999169e-01
##                             Comp.29      Comp.30      Comp.31      Comp.32      Comp.33      Comp.34      Comp.35
## Standard deviation     2.642349e-02 2.347309e-02 2.210091e-02 1.957644e-02 1.786769e-02 1.617995e-02 1.434929e-02
## Proportion of Variance 1.994859e-05 1.574246e-05 1.395572e-05 1.094963e-05 9.121553e-06 7.479735e-06 5.882918e-06
## Cumulative Proportion  9.999369e-01 9.999526e-01 9.999666e-01 9.999775e-01 9.999866e-01 9.999941e-01 1.000000e+00

plot3d(pc$loadings[,1:3], col=xgfs_normal12[c(1:length(levels(pdata.current$genotype)))][factor(pdata.current$genotype)], size=2)
text3d(pc$loadings[,1:3], text=colnames(counts.current), col = xgfs_normal12[c(1:length(levels(pdata.current$genotype)))][factor(pdata.current$genotype)])

Note: The first 6 principle components comprise 99% of the variance. The 3D PCA plot, separates different cell types from each other.

PCA 1 vs 2

PCA plot dim 1 vs dim 2

PCA 1 vs 3

PCA plot dim 1 vs dim 3

PCA 2 vs 3

PCA plot dim 2 vs dim 3

Note: There are no samples to exclude on the basis of the QC analysis above. Here, we filter out anything which isn’t an annotated gene so that we can interpret the analysis. We also reset any groups that might have changed if samples need to be removed from the analysis

Run a preliminary analysis to check data normalisation

This part of the scripts applies normalisation to account for library size and removes genes that have low or no expression spanning over multiple experimental groups (we don’t want to throw out a transcript which is not expressed in just one group as that could be very important). Low abundance transcripts in RNA-seq data are prone to high variation and will often “pollute” the final list of differentially expressed genes due to small variations in read counts per sample that result in apparently high fold changes (e.g. CPM=1 vs CPM=2 is a twofold change but CPM=101 vs CPM=102 is the same change in read count but not a large fold change). edgeR has ways of compressing fold changes when the overall counts are low to help deal with this. We then make some plots to look at the shape of the data to check it fits the typical model expected for RNAseq data.

d = DGEList(counts=counts.current, group=diffVsGeno)
keep = filterByExpr(d)
d = d[keep, , keep.lib.sizes=FALSE]
d = calcNormFactors(d)
f <- factor(diffVsGeno, levels=levels(diffVsGeno))
design = model.matrix(~0+f)
rownames(design) <- colnames(d)
d = estimateDisp(d, design, robust = TRUE)

Mean Variance, BCV and QL plots

The Mean Variance plot shows the pooled variance of the counts from each sample, divided by a scaling factor calculated above (mostly this is library size). The black line indicates a standard Poisson distribution (it is usual for all other data points on the plot to be above this line) and the blue line indicates the prediction for a negative binomial model (we expect our data to lie close to this line). The blue dots are the average gene-level variance (the grey dots are the original values). The red “X” are the common dispersions of transcripts (averaged for transcripts within the bin it represents). Overall these data look good and follow the negative binomial model reasonably closely.

The biological coefficient of variation (BCV) plot shows the differences in variation per gene compared to average gene expression (standard deviation / average expression). You can see that genes with low expression have higher variation.

The Quasi-Likelihood dispersion plot shows the transformation of read count data (black to red) after applying normalisation.

These plots support that these data are of good quality and will be good to perform differential gene expression (or differential export) analyses.

## Warning in plot.window(...): "plot.first" is not a graphical parameter

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plotMeanVar(d, show.tagwise.vars=TRUE, show.raw.vars = TRUE, NBline=TRUE)

## Warning in plot.window(...): "plot.first" is not a graphical parameter

## Warning in plot.xy(xy, type, ...): "plot.first" is not a graphical parameter

## Warning in axis(side = side, at = at, labels = labels, ...): "plot.first" is not a graphical parameter
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plotBCV(d)

plotQLDisp(fit)

Check expression of target genes

Plot out the expression of the target genes in each time point to check their expression levels.

current.gene = SCN2A_gene
gene_data = cbind(pdata.current[ , c("sampleCode", "genotype", "timepoint")], current.TPM[current.gene,])
colnames(gene_data) <- c("sampleCode", "genotype", "timepoint", "SCN2A")
gene_data = mutate(gene_data, genotype.timepoint = paste(genotype, timepoint, sep="."))
gene_data$genotype.timepoint = factor(gene_data$genotype.timepoint)


#png(filename=paste("output/qc/TPM",current.gene,ExperimentName,Test,"png", sep="."), height=980, width=980, bg="white")
ggplot(data = gene_data, aes( x = genotype.timepoint, y = SCN2A, colour = factor(genotype))) +
  geom_boxplot(lwd = 1, outlier.shape = NA) +
  scale_color_manual(values = pal4genotype) + #[factor(pdata.current$genotype)]) +  
  geom_jitter(color = "grey") +
  xlab("Genotype at developmental timepoint") +
  ylab(paste("TPM SCN2A (", current.gene, ")", sep ="")) +
  labs(color="Genotype") +
  theme_bw() +
  theme(axis.text.x = element_text(angle = 45, vjust = 1, hjust = 1))

#dev.off()

current.gene = CHD2_gene
gene_data = cbind(pdata.current[ , c("sampleCode", "genotype", "timepoint")], current.TPM[current.gene,])
colnames(gene_data) <- c("sampleCode", "genotype", "timepoint", "CHD2")
gene_data = mutate(gene_data, genotype.timepoint = paste(genotype, timepoint, sep="."))
gene_data$genotype.diffState = factor(gene_data$genotype.timepoint)


#png(filename=paste("output/qc/TPM",current.gene,ExperimentName,Test,"png", sep="."), height=980, width=980, bg="white")
ggplot(data = gene_data, aes( x = genotype.timepoint, y = CHD2, colour = factor(genotype))) +
  geom_boxplot(lwd = 1, outlier.shape = NA) +
  scale_color_manual(values = pal4genotype) + #[factor(pdata.current$genotype)]) +  
  geom_jitter(color = "grey") +
  xlab("Genotype at developmental timepoint") +
  ylab(paste("TPM CHD2 (", current.gene, ")", sep ="")) +
  labs(color="Genotype") +
  theme_bw() +
  theme(axis.text.x = element_text(angle = 45, vjust = 1, hjust = 1))

#dev.off()

Note: Expression of both genes is variable in different samples and biological replicates. SCN2A expression is very low and moderately increases on average in WT and SCN2A cell lines. CHD2 expression is relatively high and dips at day 10 and 22 compared to fibroblast and day 28 iNeurons.

Data Analysis

Hypotheses to test

In all cases, each cell type will be tested separately except in the final cross comparisons where we will factor in differentiation over time and identify genes that change at different rates.

Hypothesis 1: Transdifferentiation of fibroblasts leads to expression of neuronal marker genes.

We’ll start by looking at the differentiation state of these cell lines relative to some typical marker genes. The first heatmap does not log2 transform the TPMs and also clusters the cell lines. In the second heatmap TPMs are log2 transformed and the ordering is the same as it appears in the pdata table. To avoid any errors during plotting a very small increment (0.0001) is added to all TPMs prior to log2 transformation.

expressionMatrix = gene.TPM[ match(diffMarkerGenes$ensembl_gene_id,row.names(gene.TPM)), ]
ensembl = useMart("ensembl",dataset="hsapiens_gene_ensembl")
Annotations = getBM(attributes = c('hgnc_symbol','ensembl_gene_id'),
                     filters = 'ensembl_gene_id',
                     values = diffMarkerGenes$ensembl_gene_id,
                     mart = ensembl)
Annotations = left_join(diffMarkerGenes, Annotations, by="ensembl_gene_id")
row.names(expressionMatrix) <- Annotations$hgnc_symbol

pheatmap(log2(expressionMatrix + 0.0001), color = colorRampPalette(rev(brewer.pal(n = 7, name ="RdBu"))) (100), 
                   angle_col = 90, cluster_cols = TRUE, cluster_rows = TRUE,
                   main = "Expression (log2 TPM)")

pheatmap(log2(expressionMatrix + 0.0001), color = colorRampPalette(rev(brewer.pal(n = 7, name ="RdBu"))) (100), 
                   angle_col = 90, cluster_cols = FALSE, cluster_rows = FALSE,
                   main = "Expression (log2 TPM)")

write.table(expressionMatrix, file = "output/misc/differentiation.markers.txt", quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

Note: Fibroblast lines cluster together while neurons do not necessarily cluster by differentiation state.

Set up functions for testing differential expression

The following functions save us some typing later on and ensures that the tests we run are consistent between different differentiation time points.

# Define some functions so that code can be reused

# This function tests a subset of genotypes at a particular state of differentiation.  It subsets pdata, fits the statistical generalised linear model to perform differential expression and return the results.
test_a_diff_state = function(diffState, countTable) {
  pdata.current = pdata[pdata$diffState %in% diffState,]
  samples = as.character(pdata.current$sampleCode)
  counts.current = countTable[,samples]
  d = DGEList(counts=counts.current, group=pdata.current$genotype)
  f <- factor(pdata.current$genotype, levels=c("WT","SCN2A","CHD2")) # This sets the levels in the exact order we want
  design = model.matrix(~f)
  rownames(design) <- colnames(d)
  keep = filterByExpr(d, design)
  d = d[keep,]
  d = calcNormFactors(d)
  d = estimateDisp(d, design, robust = TRUE)
  return(glmQLFit(d, design))
}

# This function generates a text table that summarises how many genes are differentially expressed at different levels of differentiation.
sig.gene.summary = function(x) {
  sgs = cbind(summary(decideTests(x, p=0.005)),
              summary(decideTests(x, p=0.01)),
              summary(decideTests(x, p=0.05)),
              summary(decideTests(x, p=0.2)),
              summary(decideTests(x, adjust.method="none", p=0.01)))
  colnames(sgs)<-c("q0.005", "q0.01", "q0.05", "q0.2", "p0.01")
  return(sgs)
}

# ensembl = useMart("ensembl",dataset="hsapiens_gene_ensembl")

# This function adds gene annotations to a table of genes filterd by False Discovery Rate
attach_annotations_by_FDR = function(x, FDR) {
  pValCut = sum(p.adjust(x$table$PValue,method="BH") < FDR)
  tagsToAnnotate = topTags(x, n=pValCut)
  betterAnno = getBM(attributes = c('hgnc_symbol','entrezgene_description', 'chromosome_name', 'start_position', 'end_position', 'gene_biotype','hgnc_id','ensembl_gene_id'),
                     filters = 'ensembl_gene_id',
                     values = gsub("\\..*","",row.names(tagsToAnnotate)),
                     mart = ensembl)

  dexg = cbind(tagsToAnnotate, data.frame(ensembl_gene_id=gsub("\\..*","",row.names(tagsToAnnotate))))
  dexg = left_join(dexg, betterAnno, by="ensembl_gene_id")
  dexg = distinct(dexg, ensembl_gene_id, .keep_all = TRUE)
  rownames(dexg)=rownames(tagsToAnnotate)
  if (is(x, "DGELRT")){
    tpm.dexg = current.TPM[rownames(dexg), rownames(x$samples)]
    tpm.summary = t(aggregate(t(tpm.dexg), list(x$samples$group), mean))
    colnames(tpm.summary) = tpm.summary[1,]
    tpm.summary = apply(tpm.summary[-1,],2,as.numeric)
    rownames(tpm.summary) = rownames(tpm.dexg)
    tpm.dexg = log2(cbind(tpm.dexg + 0.0001, tpm.summary + 0.0001))
    dexg = cbind(dexg, tpm.dexg)
  }
  return(dexg)
}

# As above but filtering by p value
attach_annotations_by_p = function(x, pVal) {
  pValCut = sum(x$table$PValue < pVal)
  tagsToAnnotate = topTags(x, n=pValCut)
  betterAnno = getBM(attributes = c('hgnc_symbol','entrezgene_description', 'chromosome_name', 'start_position', 'end_position', 'gene_biotype','hgnc_id','ensembl_gene_id'),
                     filters = 'ensembl_gene_id',
                     values = gsub("\\..*","",row.names(tagsToAnnotate)),
                     mart = ensembl)

  dexg = cbind(tagsToAnnotate, data.frame(ensembl_gene_id=gsub("\\..*","",row.names(tagsToAnnotate))))
  dexg = left_join(dexg, betterAnno, by="ensembl_gene_id")
  dexg = distinct(dexg, ensembl_gene_id, .keep_all = TRUE)
  rownames(dexg)=rownames(tagsToAnnotate)
  if (is(x, "DGELRT")){
    tpm.dexg = current.TPM[rownames(dexg), rownames(x$samples)]
    tpm.summary = t(aggregate(t(tpm.dexg), list(x$samples$group), mean))
    colnames(tpm.summary) = tpm.summary[1,]
    tpm.summary = apply(tpm.summary[-1,],2,as.numeric)
    rownames(tpm.summary) = rownames(tpm.dexg)
    tpm.dexg = log2(cbind(tpm.dexg + 0.0001, tpm.summary + 0.0001))
    dexg = cbind(dexg, tpm.dexg)
  }
  return(dexg)
}

# This function tests the significance of gene list overlaps.  To use it you need to know the length of the lists you are checking and the background list of genes expressed at the time point/s of interest.
hypergeometric_test_of_lists = function(total_genes, longest_list, shortest_list) {
  n = length(unique(total_genes))
  a = length(longest_list)
  b = length(shortest_list)
  t = length(intersect(longest_list, shortest_list))
  PValue = sum(dhyper(t:b, a, n - a, b))
  df = data.frame("total.genes" = n, "list.1" = a, "list.2" = b, "intersection" = t, "PValue" = PValue)
  return(df)
}

Hypothesis 2: WT, SCN2A and CHD2 genotypes confer differences in gene expression patterns at each diffrentiation time point.

In the following tables: logFC is the log2 transformed fold change between the test groups and the control group. logCPM is the average log2 transformed CPM value for all samples, values less than 0 usually indicate a gene with low expression however it is important to remember that this value is not normalised to gene length so a shorter transcript naturally has less reads mapped than a longer transcript with an equivalent level of expression. PValue is self explanatory, FDR is the adjusted p-value “False Discovery Rate”. In the summary of numbers of differentially expressed genes, FDR is represented by “q” while raw p-values are represented by “p”.

1a. Fibroblasts

Test the differences between WT, SCN2A and CHD2 at the Fibroblast stage.

fit = test_a_diff_state(diffState = "fibroblast", countTable = counts.current)
qlf = glmQLFTest(fit, coef=2:3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## NotSig  12676 12676 12675 12663 12395
## Sig         2     2     3    15   283

FB.genes.expressed = rownames(qlf$table)
attach_annotations_by_p(qlf, 0.01) %>%
  kbl() %>%
  kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
  scroll_box(width = "100%", height = "300px")

	logFC.fSCN2A	logFC.fCHD2	logCPM	F	PValue	FDR	ensembl_gene_id	hgnc_symbol	entrezgene_description	chromosome_name	start_position	end_position	gene_biotype	hgnc_id	CON_1_FB	CON_2_FB	CON_3_FB_A	CON_3_FB_B	CON_4_FB_A	CON_4_FB_B	SCN2A_1_FB	SCN2A_2_FB	SCN2A_3_FB	CHD2_1_FB	CHD2_2_FB	CHD2	SCN2A	WT
ENSG00000164530	9.2672318	7.6556384	7.790190	59.243990	0.0000000	0.0000207	ENSG00000164530	PI16	peptidase inhibitor 16	6	36948263	36964837	protein_coding	HGNC:21245	1.5685901	-13.2877124	1.8602497	-13.2877124	-13.2877124	0.3875004	8.3132082	5.8975554	10.1103921	8.0880708	6.3647256	7.4697370	8.9494521	0.3978533
ENSG00000083099	3.7351734	3.3493742	6.330989	51.016041	0.0000003	0.0019139	ENSG00000083099	LYRM2	LYR motif containing 2	6	89568144	89638749	protein_coding	HGNC:25229	3.1949867	2.6888965	1.0696987	1.5571777	3.2828746	0.7336207	5.0188961	5.9819918	6.5687089	5.6249322	6.2286551	5.9581457	5.9890822	2.4169937
ENSG00000109063	3.6513523	2.3101942	5.155197	32.174940	0.0000041	0.0173265	ENSG00000109063	MYH3	myosin heavy chain 3	17	10628526	10657309	protein_coding	HGNC:7573	0.8480602	2.8387078	0.7874383	2.9153335	0.6148709	1.3582730	5.9686701	4.8309661	7.9754225	5.4247829	6.1832728	5.8533106	6.8361048	1.8952444
ENSG00000254206	2.7146657	3.3129754	2.666425	17.990701	0.0000252	0.0531919	ENSG00000254206	NPIPB11	nuclear pore complex interacting protein family member B11	16	29381310	29406711	protein_coding	HGNC:37453	-2.0763594	-0.1423645	0.1772596	0.1291194	-2.5292809	-1.1611240	1.3445558	1.9404276	2.2891912	2.2318314	2.1845298	2.2083746	1.9088813	-0.5893354
ENSG00000135480	3.7820957	3.1556781	6.342843	24.082386	0.0000261	0.0531919	ENSG00000135480	KRT7	keratin 7	12	52232520	52252186	protein_coding	HGNC:6445	4.4070195	3.9599184	1.7580106	4.6663550	3.9946752	4.3414770	8.3168541	6.0636343	8.3904247	7.1284972	7.6894402	7.4360616	7.9095373	4.0841468
ENSG00000007341	1.3843421	0.6387696	6.747843	23.728919	0.0000275	0.0531919	ENSG00000007341	ST7L	suppression of tumorigenicity 7 like	1	112523514	112620825	protein_coding	HGNC:18441	6.0808947	6.7549955	6.8066110	6.5654689	6.3754893	6.0333273	7.2524579	7.3427444	7.3154031	6.8994755	6.6818092	6.7947434	7.3040282	6.4672648
ENSG00000064989	2.9881644	4.7626175	2.970199	17.894525	0.0000294	0.0531919	ENSG00000064989	CALCRL	calcitonin receptor like receptor	2	187341964	187448460	protein_coding	HGNC:16709	-1.8718280	-13.2877124	-13.2877124	-13.2877124	-0.3365934	-13.2877124	0.8038511	0.0141810	0.5672913	3.0638781	1.7013357	2.5378170	0.4982073	-2.4933834
ENSG00000106069	4.6661987	3.6804938	5.756248	20.065964	0.0000526	0.0832800	ENSG00000106069	CHN2	chimerin 2	7	29146547	29514328	protein_coding	HGNC:1944	2.7170637	1.5844613	0.6769552	1.4557546	1.3148763	2.3939955	3.5830036	4.5846315	7.8068619	6.2585512	5.1201766	5.7988474	6.4368596	1.8519968
ENSG00000213024	2.0169871	1.3515877	7.160798	20.170730	0.0000664	0.0934970	ENSG00000213024	NUP62	nucleoporin 62	19	49906825	49929764	protein_coding	HGNC:8066	4.6465495	4.8917150	4.5804052	4.8299195	5.1333122	5.7102342	6.3392705	6.5076683	7.4661676	6.1983424	6.4140779	6.3102389	6.8612242	5.0190391
ENSG00000241166	4.2399516	-2.8046557	2.251460	16.086412	0.0001149	0.1456085	ENSG00000241166	HLA-L		HSCHR6_MHC_DBB_CTG1	1515484	1518204	transcribed_unprocessed_pseudogene	HGNC:4970	-13.2877124	-0.0779194	-13.2877124	-13.2877124	-13.2877124	0.5075136	2.2400539	1.3334982	0.9362554	-13.2877124	-13.2877124	-13.2877124	1.6100436	-1.3404279
ENSG00000111057	3.4596750	5.1954877	4.526283	14.602141	0.0001314	0.1476177	ENSG00000111057	KRT18	keratin 18	12	52948871	52952906	protein_coding	HGNC:6430	-13.2877124	3.3980105	-13.2877124	-13.2877124	-0.2186185	-13.2877124	4.4183729	3.4877238	5.4113584	2.3557262	7.4736129	6.5145727	4.6469029	0.9261642
ENSG00000244731	-3.3054461	3.5419307	1.812557	14.672658	0.0001433	0.1476177	ENSG00000244731	C4A	complement C4A (Chido/Rodgers blood group)	6	31982057	32002681	protein_coding	HGNC:1323	-13.2877124	-1.7750904	1.0414357	4.2275700	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.3322960	4.9266911	4.0414449	-13.2877124	1.8131503
ENSG00000167393	3.2263936	1.4538977	3.684147	15.238303	0.0001514	0.1476177	ENSG00000167393	PPP2R3B	protein phosphatase 2 regulatory subunit B’’beta	X	333933	386955	protein_coding	HGNC:13417	2.1346238	-13.2877124	2.7162532	-0.9788159	2.9258810	3.8415847	3.8849634	5.9167611	3.3243953	3.5931000	4.1045265	3.8713577	4.8278659	2.4770675
ENSG00000225972	5.6539493	0.1005963	6.369997	16.144869	0.0001743	0.1567709	ENSG00000225972	MTND1P23		1	629062	629433	unprocessed_pseudogene	HGNC:42092	6.5580168	6.2927348	6.0878148	5.6260550	5.0816076	4.1057530	5.6982978	5.9012349	13.0267296	6.4465396	5.4231918	6.0237614	11.4609474	5.8291039
ENSG00000137312	-1.6662508	-9.0869733	4.858307	17.493794	0.0001855	0.1567709	ENSG00000137312	FLOT1	flotillin 1	6	30727709	30742732	protein_coding	HGNC:3757	5.3995838	5.0970812	5.1516244	5.4436381	5.1876357	5.1457875	-13.2877124	4.5483309	3.1860157	-13.2877124	-13.2877124	-13.2877124	3.4373756	5.2438343
ENSG00000139174	1.6513321	2.9834015	2.849188	12.791121	0.0002741	0.2172247	ENSG00000139174	PRICKLE1	prickle planar cell polarity protein 1	12	42456757	42590355	protein_coding	HGNC:17019	4.3087540	1.5602518	-0.5118408	-0.7311991	-13.2877124	-0.5263855	1.2224652	0.9216816	1.2136422	1.7941771	3.6395692	2.9937729	1.1258706	2.0452902
ENSG00000261862	-3.3511838	-2.7839963	3.072612	13.085217	0.0003168	0.2341874	ENSG00000261862	KRTAP1-5	keratin associated protein 1-5	HSCHR17_4_CTG4	175421	176597	protein_coding	HGNC:16777	3.6243936	4.5895933	4.5600874	5.0328549	2.9230889	3.8063444	-0.4183846	1.9719250	-13.2877124	2.0101317	-0.1324340	1.3046512	0.6388533	4.2518627
ENSG00000174564	1.1893128	3.4789206	2.814612	11.973171	0.0003526	0.2341874	ENSG00000174564	IL20RB	interleukin 20 receptor subunit beta	3	136946230	137011085	protein_coding	HGNC:6004	-13.2877124	1.4455731	1.4010395	1.2799936	-13.2877124	-13.2877124	2.3336934	1.9520267	-13.2877124	4.3408204	4.0393879	4.1979625	1.5704984	0.3772737
ENSG00000170421	3.3611238	4.9049124	6.696249	14.245325	0.0003891	0.2341874	ENSG00000170421	KRT8	keratin 8	12	52897187	52949954	protein_coding	HGNC:6446	3.5556359	7.4443834	3.8203234	2.5285513	4.4441016	5.3298751	9.3591420	5.8559226	9.7138019	7.3786731	11.6688783	10.7407942	9.0171633	5.4801413
ENSG00000137507	2.4337810	2.7646691	4.404726	13.734843	0.0004051	0.2341874	ENSG00000137507	LRRC32	leucine rich repeat containing 32	11	76657524	76670747	protein_coding	HGNC:4161	1.2822162	2.4234300	2.0608948	-1.1054950	0.7178306	1.6856114	2.0509965	2.7470243	4.2793657	2.8932826	4.4274869	3.8553828	3.3351316	1.5273406
ENSG00000258388	-7.4761764	-5.4314807	7.081219	12.892434	0.0004053	0.2341874	ENSG00000258388	PPT2-EGFL8		6	32153845	32171978	protein_coding	HGNC:48343	6.7863906	6.7813768	-13.2877124	-13.2877124	6.9716695	7.3040667	2.6620391	-13.2877124	-13.2877124	1.8729276	-13.2877124	0.8729666	1.0771220	6.3921114
ENSG00000109771	1.8243018	1.4869601	7.597406	13.899344	0.0004324	0.2341874	ENSG00000109771	LRP2BP	LRP2 binding protein	4	185363872	185395924	protein_coding	HGNC:25434	5.5799485	4.6951447	5.0904707	4.3628712	5.0476673	4.8264153	5.9053402	6.0345403	7.4217346	6.1640556	6.7532774	6.4885407	6.6290994	4.9836189
ENSG00000145244	1.7095681	1.4297110	4.903230	13.773065	0.0004610	0.2341874	ENSG00000145244	CORIN	corin, serine peptidase	4	47593999	47838106	protein_coding	HGNC:19012	3.8881454	2.5210495	3.5227454	0.7246948	1.9955742	0.9316793	3.2971899	4.3917603	4.3942518	4.2071219	3.8285281	4.0302084	4.1113112	2.7220159
ENSG00000170370	-1.1699209	-1.4972110	5.497926	13.689262	0.0004675	0.2341874	ENSG00000170370	EMX2	empty spiracles homeobox 2	10	117542445	117549546	protein_coding	HGNC:3341	5.2627312	4.9650124	5.1279217	5.3250245	5.3836649	6.3508359	4.5756309	3.7016494	4.2210166	3.7853141	3.6584651	3.7232833	4.2095844	5.4813752
ENSG00000183801	2.0739234	1.6949641	4.211358	13.505064	0.0004716	0.2341874	ENSG00000183801	OLFML1	olfactomedin like 1	11	7485388	7511377	protein_coding	HGNC:24473	3.5795251	1.2701946	1.6466862	1.1391001	2.0718910	3.0124274	3.7943270	4.1178676	4.2831178	3.9026505	3.4484134	3.6933358	4.0791041	2.4138629
ENSG00000109775	2.6414430	2.7825633	7.380301	13.519539	0.0004947	0.2341874	ENSG00000109775	UFSP2	UFM1 specific peptidase 2	4	185399537	185425979	protein_coding	HGNC:25640	4.6329764	4.5927965	5.2386945	4.6289798	5.0782939	5.2711978	5.8384442	5.9567915	8.6188333	6.1323981	8.4653722	7.7265714	7.4163148	4.9373952
ENSG00000197928	-0.3598716	2.0870240	2.152507	11.041593	0.0004987	0.2341874	ENSG00000197928	ZNF677	zinc finger protein 677	19	53235381	53254898	protein_coding	HGNC:28730	2.5104873	-0.3782730	2.2590477	3.4394793	-0.5820843	2.2809501	1.6150240	1.2505372	0.1147348	4.3413044	3.1124528	3.8539428	1.1210691	2.2032604
ENSG00000283787	4.0075943	2.2169104	2.788744	10.795454	0.0005675	0.2567930	ENSG00000283787	PRR33	proline rich 33	11	1888078	1891895	protein_coding	HGNC:35118	0.3881598	-2.0168331	-13.2877124	-13.2877124	-1.6358893	-13.2877124	2.1565021	0.4908935	3.6205071	1.7504269	-1.8832094	0.8622177	2.5979653	-1.6758461
ENSG00000237973	2.2795341	1.6837567	3.439719	12.125130	0.0005874	0.2567930	ENSG00000237973	MTCO1P12		1	631074	632616	unprocessed_pseudogene	HGNC:52014	2.6700134	1.8455968	1.4958179	-13.2877124	1.9637201	2.7614138	4.0161069	4.0888345	4.3518171	4.1265077	2.9817617	3.6648166	4.1595881	1.9671671
ENSG00000151388	1.6567856	2.1044675	4.231495	12.704780	0.0006365	0.2685592	ENSG00000151388	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12	5	33523535	33892019	protein_coding	HGNC:14605	1.1103706	0.9970047	2.2304465	2.0293356	-0.2747073	-0.9759215	1.7384168	1.9184832	3.0381445	1.3631318	3.3361137	2.6634860	2.3534438	1.2494308
ENSG00000105989	3.1447524	1.4389217	2.688951	10.526580	0.0006567	0.2685592	ENSG00000105989	WNT2	Wnt family member 2	7	117275451	117323152	protein_coding	HGNC:12780	-0.3018936	1.6235953	-0.8840639	-13.2877124	-2.0040626	0.6793130	2.9762707	4.2571479	2.6529804	-13.2877124	1.7827214	0.7827633	3.4716629	0.0670012
ENSG00000095110	2.5377699	2.0815106	2.738244	10.557028	0.0007171	0.2686666	ENSG00000095110	NXPE1	neurexophilin and PC-esterase domain family member 1	11	114518934	114559881	protein_coding	HGNC:28527	0.3952350	0.7951926	-0.1847082	-13.2877124	0.6930850	1.2830725	2.8306529	3.4739291	1.3969754	2.0992407	2.7165515	2.4406647	2.7976041	0.4115521
ENSG00000131459	2.3697160	2.4948866	2.833943	10.576042	0.0007326	0.2686666	ENSG00000131459	GFPT2	glutamine-fructose-6-phosphate transaminase 2	5	180300698	180353336	protein_coding	HGNC:4242	-0.2070947	0.9315885	-1.9584542	0.4072603	-0.4944322	-13.2877124	2.9796356	3.0085036	3.8373350	3.6646082	2.3454143	3.1508168	3.3329052	-0.2438122
ENSG00000158747	-1.5538785	-1.2830623	5.731055	12.372970	0.0007458	0.2686666	ENSG00000158747	NBL1	NBL1, DAN family BMP antagonist	1	19596979	19658456	protein_coding	HGNC:7650	5.3242079	5.0450480	6.1115675	6.1714591	5.9813091	6.3262545	4.5635439	4.0779874	3.1691770	4.4739164	4.4115813	4.4430854	4.0452787	5.8977124
ENSG00000233151	6.3188897	6.1884972	6.565700	10.887403	0.0007598	0.2686666	ENSG00000233151	CYP21A2	cytochrome P450 family 21 subfamily A member 2	HSCHR6_MHC_COX_CTG1	3476620	3479992	protein_coding	HGNC:2600	-0.0663579	-13.2877124	1.7676828	2.7230727	0.8047318	0.4950146	0.9898794	-13.2877124	8.8133576	4.2089864	8.2448121	7.3301920	7.2347504	1.2346184
ENSG00000168542	1.5238446	0.9181041	10.663738	12.287733	0.0007660	0.2686666	ENSG00000168542	COL3A1	collagen type III alpha 1 chain	2	188974373	189012746	protein_coding	HGNC:2201	7.4318224	8.7197772	8.0236926	8.6326064	7.6478074	8.3067740	8.9566955	9.0236065	10.2008988	8.7687707	9.2812328	9.0476371	9.5145870	8.2034410
ENSG00000006042	-1.5534270	-0.6431837	4.594949	12.285111	0.0007841	0.2686666	ENSG00000006042	TMEM98	transmembrane protein 98	17	32927910	32945106	protein_coding	HGNC:24529	4.3519042	4.1391589	4.4132342	4.1934590	4.4607339	5.6121446	3.4124339	2.8014869	3.3460825	2.7801062	3.2705472	3.0460677	3.2114200	4.6300914
ENSG00000105974	-1.5785927	-0.9154915	7.806310	12.071749	0.0008302	0.2769953	ENSG00000105974	CAV1	caveolin 1	7	116524994	116561179	protein_coding	HGNC:1527	7.6338804	7.9316748	8.8713139	9.2146877	8.1028748	8.0680446	7.0501544	6.7896952	5.4626861	7.5499288	7.0762120	7.3324272	6.5812752	8.4154073
ENSG00000144355	-5.5321828	-2.5593125	4.837066	10.784164	0.0008753	0.2845505	ENSG00000144355	DLX1	distal-less homeobox 1	2	172084740	172089677	protein_coding	HGNC:2914	3.7035981	5.1025980	6.8673383	7.4976258	2.0782416	1.7683533	-0.2600085	0.2025870	-13.2877124	4.0641814	2.9084321	3.5990727	-0.5951383	5.8764889
ENSG00000260735	1.1424049	0.6689868	6.508036	11.731994	0.0009457	0.2997499	ENSG00000260735		uncharacterized LOC100505915	16	15103135	15103355	transcribed_processed_pseudogene		5.3744619	5.7726942	4.9329342	4.7857540	5.0200759	4.8592029	6.3109521	6.1399053	6.1164620	5.7240661	5.9487093	5.8407558	6.1917444	5.1683035
ENSG00000111907	2.0446962	2.1428290	4.357473	11.504141	0.0009903	0.3020452	ENSG00000111907	TPD52L1	TPD52 like 1	6	125119049	125264407	protein_coding	HGNC:12006	1.9117027	3.6835880	3.2608632	3.6567267	3.6184814	5.1763573	4.3243903	5.6543636	5.5090133	5.0900317	6.2215990	5.7640250	5.2722483	3.8621548
ENSG00000278312	9.5608434	9.1764310	4.771702	15.605808	0.0010223	0.3020452	ENSG00000278312	LENG9	leukocyte receptor cluster member 9	HSCHR19LRC_COX1_CTG3_1	368305	370225	protein_coding	HGNC:16306	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	6.2152859	5.9861432	5.2160039	5.3057507	5.2615752	5.5202978	-13.2877124
ENSG00000198846	-3.5931351	-1.7499020	3.335076	10.549668	0.0010345	0.3020452	ENSG00000198846	TOX	thymocyte selection associated high mobility group box	8	58805412	59119147	protein_coding	HGNC:18988	0.3311124	2.7501423	3.0707197	3.5282032	1.5029604	0.1495846	-2.4843965	-0.4134937	-2.3989996	1.2084542	-0.6186657	0.5666554	-1.4226260	2.4090870
ENSG00000188783	1.8974273	0.2266760	4.392720	11.490059	0.0010483	0.3020452	ENSG00000188783	PRELP	proline and arginine rich end leucine rich repeat protein	1	203475806	203491352	protein_coding	HGNC:9357	1.6073246	2.5241216	1.4398226	0.4104822	-0.9024863	0.9402931	3.3240039	3.5795205	2.6241166	1.6779637	1.6574132	1.6677250	3.2292949	1.3500236
ENSG00000105971	-1.3380731	-0.4558928	5.558588	11.380772	0.0010856	0.3058447	ENSG00000105971	CAV2	caveolin 2	7	116287380	116508541	protein_coding	HGNC:1528	5.0413961	4.4792503	5.4526755	5.5437594	5.8958272	5.4302352	3.5735000	3.8398038	3.6135955	4.2147561	4.7407631	4.5016009	3.6804751	5.3712041
ENSG00000148824	-1.0527820	0.8278007	6.168384	11.004250	0.0012549	0.3434807	ENSG00000148824	MTG1	mitochondrial ribosome associated GTPase 1	10	133394094	133422520	protein_coding	HGNC:32159	4.4527644	4.8395342	5.2199675	5.3781255	5.3354561	5.0858668	4.3179588	3.5257346	3.1931740	6.2490492	5.4134832	5.8909311	3.7587509	5.0855441
ENSG00000103888	-1.1085896	0.8291818	7.999369	10.858855	0.0013265	0.3434807	ENSG00000103888	CEMIP	cell migration inducing hyaluronidase 1	15	80779343	80951776	protein_coding	HGNC:29213	5.9623688	6.3215520	5.6873390	5.8582669	5.1780956	5.7385080	3.9422993	5.8816682	5.1809298	6.8576477	6.2283770	6.5770531	5.2043559	5.8306425
ENSG00000148180	-1.1363838	-0.4491221	7.387349	10.757326	0.0013816	0.3434807	ENSG00000148180	GSN	gelsolin	9	121207794	121332843	protein_coding	HGNC:4620	6.9772067	6.7386078	6.9365661	7.6434110	6.8176347	7.8083136	5.7671008	6.2835602	5.5747461	6.6384431	6.7432739	6.6918104	5.9070577	7.2162022
ENSG00000196569	-0.2901248	1.2513298	6.006351	10.680730	0.0014293	0.3434807	ENSG00000196569	LAMA2	laminin subunit alpha 2	6	128883138	129516566	protein_coding	HGNC:6482	2.7090433	4.4897462	2.9872528	3.3073513	4.4879952	2.4283075	2.0458085	2.4543288	2.8502025	3.3657356	4.6733816	4.1629035	2.4871985	3.6372561
ENSG00000181744	-2.2714461	-2.4062926	3.352766	10.283800	0.0015016	0.3434807	ENSG00000181744	DIPK2A	divergent protein kinase domain 2A	3	143971823	144048719	protein_coding	HGNC:28490	1.4498973	1.8117513	2.4798884	3.0370130	1.9445721	3.2204583	-1.5836012	0.9470549	-1.0514679	2.7289351	-1.3024148	1.8145726	-0.1286515	2.4681086
ENSG00000226065	8.5078315	0.0000000	3.295672	15.495248	0.0015083	0.3434807	ENSG00000226065	ZBTB45P2		2	110383112	110384642	processed_pseudogene	HGNC:49228	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.8361803	2.7622806	6.1702093	-13.2877124	-13.2877124	-13.2877124	4.8402976	-13.2877124
ENSG00000112902	-1.6653262	-0.2606195	6.334418	10.506988	0.0015311	0.3434807	ENSG00000112902	SEMA5A	semaphorin 5A	5	9035033	9546075	protein_coding	HGNC:10736	3.4433596	3.6562657	4.1885450	4.7174597	4.2890476	3.1404417	2.0433001	2.2571956	1.8651979	4.5033130	3.3108363	4.0269262	2.0641544	4.0059354
ENSG00000148677	2.8197176	3.9848936	2.735086	8.837992	0.0015868	0.3434807	ENSG00000148677	ANKRD1	ankyrin repeat domain 1	10	90912096	90921087	protein_coding	HGNC:15819	-1.0978075	-13.2877124	-13.2877124	-13.2877124	1.5217825	0.3057745	2.3694352	1.9093038	2.4552099	1.0988716	4.4662726	3.5997010	2.2637951	-0.3911705
ENSG00000075643	2.8386764	2.0649419	3.382904	9.390120	0.0015933	0.3434807	ENSG00000075643	MOCOS	molybdenum cofactor sulfurase	18	36187497	36272157	protein_coding	HGNC:18234	0.5699829	-1.9721269	-2.0565032	-0.6941789	-13.2877124	0.5138717	1.6870997	0.2735994	2.9192672	1.5735563	1.0674997	1.3426040	1.9992213	-0.5756803
ENSG00000102802	4.1509972	2.7024915	3.142821	8.799562	0.0015972	0.3434807	ENSG00000102802	MEDAG	mesenteric estrogen dependent adipogenesis	13	30906271	30925572	protein_coding	HGNC:25926	0.6577141	-13.2877124	-13.2877124	-0.1399224	-13.2877124	1.6463046	2.8846302	-13.2877124	4.7776542	1.7032615	2.6147249	2.2298074	3.5366631	-0.0954820
ENSG00000182240	1.1043848	1.3453198	4.548622	10.373401	0.0016400	0.3434807	ENSG00000182240	BACE2	beta-secretase 2	21	41167801	41282530	protein_coding	HGNC:934	3.2034854	3.4807324	2.3041115	3.5134911	4.1041556	3.1040424	3.6559463	3.4571002	4.1989644	4.1748481	3.9855702	4.0833112	3.8057537	3.3815173
ENSG00000143315	1.6429707	1.3258019	5.009068	10.342236	0.0016615	0.3434807	ENSG00000143315	PIGM	phosphatidylinositol glycan anchor biosynthesis class M	1	160024953	160031990	protein_coding	HGNC:18858	1.4387245	2.2243602	2.1050518	2.4317280	0.6719038	-0.0964804	2.4658525	3.3109986	3.6886711	3.2528071	2.7980997	3.0432941	3.2399809	1.7085448
ENSG00000164125	1.8856113	2.5727082	4.538921	10.244245	0.0016679	0.3434807	ENSG00000164125	GASK1B	golgi associated kinase 1B	4	158124474	158173318	protein_coding	HGNC:25312	3.4712746	4.0420638	0.6178439	3.1169291	2.1501496	-0.0178070	1.9483474	3.7735701	5.7978903	4.6666281	5.5761416	5.1919011	4.6082002	2.8480131
ENSG00000143369	-0.6745513	-1.1691978	6.443398	10.227770	0.0017156	0.3434807	ENSG00000143369	ECM1	extracellular matrix protein 1	1	150508062	150513789	protein_coding	HGNC:3153	6.0675234	6.3192123	6.3876635	6.4220226	6.7211071	6.4197257	5.9323274	5.4272164	5.1763239	4.9542330	5.4129737	5.2017605	5.5469528	6.4023153
ENSG00000152495	2.2002841	1.4749249	4.540210	10.201133	0.0017269	0.3434807	ENSG00000152495	CAMK4	calcium/calmodulin dependent protein kinase IV	5	111223653	111494886	protein_coding	HGNC:1464	3.0223611	0.5696447	0.5461037	0.7817500	-2.5730290	-13.2877124	2.2205714	1.1802790	2.7783160	1.4995505	1.7025990	1.6046440	2.2003261	1.1106552
ENSG00000181333	-7.0850333	-1.4223913	2.926464	11.063842	0.0017270	0.3434807	ENSG00000181333	HEPHL1	hephaestin like 1	11	94021354	94114208	protein_coding	HGNC:30477	2.1381431	1.2475982	2.4487366	1.3339149	-0.0498213	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.0161368	0.1883313	0.1048009	-13.2877124	1.3898239
ENSG00000142149	-3.2500569	-0.9228285	3.342748	9.565748	0.0017286	0.3434807	ENSG00000142149	HUNK	hormonally up-regulated Neu-associated kinase	21	31873020	32044633	protein_coding	HGNC:13326	2.1065115	-0.1284339	-0.0610654	4.0908117	1.6054128	1.5098073	2.6185786	-3.3725500	-3.3592236	-0.1670177	0.7416025	0.3576725	1.0784841	2.2784767
ENSG00000270554	1.6150678	1.2749664	3.770701	10.062725	0.0017365	0.3434807	ENSG00000270554	EIF3EP4		3	182843521	182844619	processed_pseudogene	HGNC:37921	2.9470098	3.6686841	2.9535133	3.7501095	3.7052760	3.6733895	5.2344128	4.1009549	5.1548118	5.0652920	4.1673375	4.6850779	4.9137712	3.4904058
ENSG00000162545	-2.5091938	-1.4013843	4.505200	10.211287	0.0017482	0.3434807	ENSG00000162545	CAMK2N1	calcium/calmodulin dependent protein kinase II inhibitor 1	1	20482391	20486210	protein_coding	HGNC:24190	3.8049092	3.5510649	5.2475352	5.5650234	4.3016841	2.3605955	1.8620419	2.1737661	1.0732773	3.3180707	2.5920745	3.0002660	1.7727898	4.5012863
ENSG00000235253	1.1142033	0.9294894	4.989509	10.184312	0.0017702	0.3434807	ENSG00000235253	EEF1A1P50		5	132942932	132945050	processed_pseudogene	HGNC:56207	4.6799850	5.2113143	5.1326866	4.1581075	4.7155894	5.0842918	5.9970891	5.9461628	5.6462955	5.5271213	6.0522798	5.8134652	5.8712796	4.8729711
ENSG00000230383	2.1956054	0.8236000	2.318578	8.670107	0.0018105	0.3434807	ENSG00000230383	RPL6P19		7	137721985	137722846	processed_pseudogene	HGNC:36754	1.4336565	1.9315931	1.8570187	3.2474430	0.7332103	1.8663169	3.8954503	3.0687460	4.6145888	2.3003988	3.0792926	2.7417839	3.9930676	2.0556469
ENSG00000225987	0.7885894	2.8181067	2.587593	8.732255	0.0018672	0.3434807	ENSG00000225987	PBX2	PBX homeobox 2	HSCHR6_MHC_APD_CTG1	3517335	3522785	protein_coding	HGNC:8633	0.8835137	-13.2877124	3.3954851	2.5239887	-0.5872293	0.7033532	1.8666145	2.2214775	3.2426202	4.9726695	3.9372839	4.5459330	2.5668624	1.7664998
ENSG00000226618	4.5702972	-4.3744523	3.764198	8.759847	0.0018957	0.3434807	ENSG00000226618	PRRC2A	proline rich coiled-coil 2A	HSCHR6_MHC_MANN_CTG1	2925761	2942812	protein_coding	HGNC:13918	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.9364853	-13.2877124	4.5011603	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.9162104	-1.6481003
ENSG00000176857	1.0429933	1.3569858	4.851922	10.011359	0.0019053	0.3434807	ENSG00000176857	GJA1P1		5	109051315	109052457	processed_pseudogene	HGNC:4275	4.7302310	4.8741871	5.0661363	5.2589574	3.9783605	4.2766440	5.2802763	5.3195163	6.1821968	6.0098546	6.1894272	6.1024331	5.6573533	4.7620527
ENSG00000111669	-0.7661297	-0.7346077	6.870330	9.964837	0.0019133	0.3434807	ENSG00000111669	TPI1	triosephosphate isomerase 1	12	6867119	6870948	protein_coding	HGNC:12009	7.3933289	7.2269048	7.4835902	7.9954247	7.5012874	7.4982438	6.6729676	6.5877332	6.5813319	6.7016991	6.7358727	6.7188871	6.6146196	7.5366494
ENSG00000273993	-1.0241372	0.0000669	5.497535	9.962121	0.0019236	0.3434807	ENSG00000273993	PTPRK	protein tyrosine phosphatase receptor type K	HSCHR6_1_CTG8	313977	870008	protein_coding	HGNC:9674	3.1478549	3.9477183	5.4736642	4.1079463	5.1784318	4.3075709	3.7747625	3.0450973	3.0004466	4.5656233	4.0184311	4.3178159	3.3192212	4.5646636
ENSG00000087302	1.3327870	0.8454574	9.330948	9.893136	0.0019710	0.3457575	ENSG00000087302	RTRAF	RNA transcription, translation and transport factor	14	51989514	52010694	protein_coding	HGNC:23169	6.6834916	6.7949252	7.3100100	7.1441817	7.7099776	7.2737114	7.4446714	8.5053565	8.2180861	6.7332951	8.2201387	7.6603390	8.1213097	7.1932494
ENSG00000176532	3.5167117	2.7660340	3.914092	8.935373	0.0020140	0.3457575	ENSG00000176532	PRR15	proline rich 15	7	29563835	29567293	protein_coding	HGNC:22310	2.9090494	1.1241580	0.0433809	-13.2877124	0.5068172	0.6126111	3.4343995	1.6298448	6.1161563	5.4246668	2.4288033	4.5950520	4.7947895	1.1881407
ENSG00000128266	-3.9827800	-3.4325573	3.117383	8.708387	0.0020181	0.3457575	ENSG00000128266	GNAZ	G protein subunit alpha z	22	23070519	23125032	protein_coding	HGNC:4395	-1.8610335	1.6398744	3.7529539	3.4249202	2.4360336	2.3493356	-13.2877124	-0.0218512	-13.2877124	0.0153677	-13.2877124	-0.9844896	-1.6065210	2.6675509
ENSG00000196782	-1.3891209	-2.3206365	3.824126	9.755028	0.0021028	0.3497212	ENSG00000196782	MAML3	mastermind like transcriptional coactivator 3	4	139716753	140154184	protein_coding	HGNC:16272	4.2586035	3.1958447	3.3913006	2.5443926	2.3670017	1.8200605	-0.2732002	0.9685369	0.3970319	-0.3569510	-0.4074746	-0.3819916	0.4510600	3.1516463
ENSG00000204351	-6.8241320	-1.3828876	2.785575	10.426217	0.0021196	0.3497212	ENSG00000204351	SKIC2	SKI2 subunit of superkiller complex	6	31959116	31969818	protein_coding	HGNC:10898	0.7278447	0.6901033	1.4827007	3.8512223	2.9810487	1.8104707	-13.2877124	-13.2877124	-13.2877124	-0.2796182	1.3460446	0.7510137	-13.2877124	2.4105072
ENSG00000171385	2.3390865	2.5530601	3.934618	9.332379	0.0021240	0.3497212	ENSG00000171385	KCND3	potassium voltage-gated channel subfamily D member 3	1	111770662	111989668	protein_coding	HGNC:6239	-0.8368723	-0.6569470	-1.0045111	0.6189772	1.9249227	-0.7555294	0.4178012	3.1758968	2.7028698	0.8979777	3.9900783	3.1500555	2.4926377	0.3444104
ENSG00000183153	0.6334952	1.0580381	6.397517	9.650359	0.0021892	0.3530419	ENSG00000183153	GJD3	gap junction protein delta 3	17	40360652	40364737	protein_coding	HGNC:19147	6.9784072	7.0465706	6.9980905	6.9982432	7.1373893	7.3978994	7.1288165	7.4642610	7.9752421	8.0270836	8.2104334	8.1216692	7.5652651	7.1005099
ENSG00000230399	2.1256440	2.6571887	2.276203	8.225023	0.0021999	0.3530419	ENSG00000230399	RBBP8P1		X	118632375	118634616	protein_coding	HGNC:39583	0.0208556	0.5214930	-1.1446704	1.2261984	-13.2877124	0.4246502	1.9574986	2.4427203	1.4583789	3.2172755	1.6559553	2.6382599	2.0082158	0.1340316
ENSG00000169203	1.7991046	1.2700007	3.825154	9.462875	0.0022413	0.3551926	ENSG00000169203	NPIPB12	nuclear pore complex interacting protein family member B12	16	29483534	29506408	protein_coding	HGNC:37491	2.7832523	3.3268760	1.4323683	3.7646143	2.8462251	1.5140849	5.1168490	4.2887294	4.5920167	3.3886389	5.3555035	4.6841199	4.7071254	2.8498638
ENSG00000183214	3.8462418	3.9937323	3.717367	8.243845	0.0022761	0.3562542	ENSG00000183214	MICA	MHC class I polypeptide-related sequence A	HSCHR6_MHC_QBL_CTG1	2655411	2671966	protein_coding	HGNC:7090	1.1626116	-13.2877124	1.0436651	1.2301655	-13.2877124	-13.2877124	4.1875986	-13.2877124	4.8628160	5.2284999	-13.2877124	4.2285040	3.9793952	0.1475933
ENSG00000178404	-0.3213847	2.9866594	1.625742	7.871150	0.0023233	0.3576345	ENSG00000178404	CEP295NL	CEP295 N-terminal like	17	78890579	78903217	protein_coding	HGNC:44659	-13.2877124	-0.0834408	0.4200026	0.2060230	-13.2877124	-13.2877124	-0.4215192	-13.2877124	-1.1463237	2.3348125	2.3206842	2.3277657	-1.3237171	-0.8044264
ENSG00000186918	-1.5919006	-1.7991359	4.510161	9.533873	0.0023414	0.3576345	ENSG00000186918	ZNF395	zinc finger protein 395	8	28345590	28402701	protein_coding	HGNC:18737	4.9828514	3.6470477	4.7710204	5.1661523	2.2525041	2.5994982	2.8576144	2.2572852	1.2264086	3.0572900	2.5834791	2.8397488	2.2599157	4.2999408
ENSG00000203811	1.0630182	0.9857453	5.938284	9.394286	0.0024506	0.3698656	ENSG00000203811	H3C14	H3 clustered histone 14	1	149840687	149841208	protein_coding	HGNC:20503	5.5082000	5.7492821	4.9697999	5.1242265	4.8244717	5.5152342	6.3106428	6.2305063	6.1631156	6.7222501	5.6122314	6.2714640	6.2360167	5.3194460
ENSG00000198553	1.6938401	1.1231885	5.122035	9.347118	0.0025251	0.3740648	ENSG00000198553	KCNRG	potassium channel regulator	13	50015254	50020922	protein_coding	HGNC:18893	5.2578954	4.6969700	4.8193643	4.5324686	3.1168456	2.1220157	6.4506033	5.4794390	6.1290362	5.7730714	4.9500407	5.4194674	6.0737174	4.4218447
ENSG00000134901	1.8429187	1.3460793	2.667741	8.370198	0.0025844	0.3740648	ENSG00000134901	POGLUT2	protein O-glucosyltransferase 2	13	102784281	102799040	protein_coding	HGNC:19350	1.4452590	1.0981177	0.6943641	0.0643241	0.7431875	0.2641196	4.2506809	2.1573096	3.0351185	2.6422730	1.7178543	2.2528719	3.4011866	0.7938834
ENSG00000114270	-1.9038619	-0.7568064	5.355342	9.278434	0.0025855	0.3740648	ENSG00000114270	COL7A1	collagen type VII alpha 1 chain	3	48564073	48595329	protein_coding	HGNC:2214	2.3104672	3.2923502	3.8488815	3.8262343	2.8003222	2.5502163	2.7305700	0.8042048	-1.0568123	2.5348562	2.4348633	2.4857259	1.5630043	3.2268664
ENSG00000172349	-0.2708952	0.8275232	7.777414	9.196165	0.0026612	0.3740648	ENSG00000172349	IL16	interleukin 16	15	81159575	81314058	protein_coding	HGNC:5980	4.9293966	4.5153993	4.9590065	4.8722044	5.0005743	4.9613886	4.1964682	4.7831125	4.4631532	5.9895126	5.5896772	5.8034025	4.5008976	4.8818315
ENSG00000138944	-2.6675472	-3.7330705	3.108367	8.502722	0.0026689	0.3740648	ENSG00000138944	SHISAL1	shisa like 1	22	44243665	44312951	protein_coding	HGNC:29335	1.5992202	-2.1271602	1.6946248	2.6736564	1.4225737	-1.6409377	-0.9531402	-2.2027712	-1.6046125	-1.5810696	-13.2877124	-2.5806380	-1.4974303	1.4039360
ENSG00000027075	3.6061638	3.6567498	2.562007	8.071848	0.0026980	0.3740648	ENSG00000027075	PRKCH	protein kinase C eta	14	61187559	61550980	protein_coding	HGNC:9403	-13.2877124	-1.7160450	-13.2877124	-13.2877124	2.1125290	0.7708595	3.4201706	3.8593743	6.5515330	4.1069991	5.4343826	4.9182528	5.3100953	0.0784855
ENSG00000196139	-1.2286393	2.4942865	2.252457	7.684288	0.0027061	0.3740648	ENSG00000196139	AKR1C3	aldo-keto reductase family 1 member C3	10	5035354	5107686	protein_coding	HGNC:386	2.3877477	1.0672057	-13.2877124	2.4102982	1.1014968	3.2071057	-13.2877124	0.0175386	1.6216712	4.8272340	2.2378075	4.0489895	0.4470131	2.0015284
ENSG00000133059	-1.8212050	-1.1722761	4.083164	9.137660	0.0027852	0.3740648	ENSG00000133059	DSTYK	dual serine/threonine and tyrosine protein kinase	1	205142505	205211702	protein_coding	HGNC:29043	2.7954945	1.1495384	1.7634558	1.8743957	2.1330897	2.5172918	0.0021106	0.0740820	0.0360137	0.4589195	1.0937461	0.8109720	0.0377013	2.1339100
ENSG00000234338	1.3444044	0.6880803	4.406182	9.120544	0.0027870	0.3740648	ENSG00000234338			7	64835280	64836882	processed_pseudogene		3.9045970	3.2636459	3.7393544	3.2760724	3.6463705	4.2496572	4.2364180	5.2260309	5.0901856	4.1788962	4.5589341	4.3813927	4.9123442	3.7218724
ENSG00000148737	1.1913416	1.0711400	5.597446	9.095833	0.0028013	0.3740648	ENSG00000148737	TCF7L2	transcription factor 7 like 2	10	112950247	113167678	protein_coding	HGNC:11641	4.6903072	5.2093584	4.0480518	4.7330388	3.7055343	6.5920196	5.6612414	4.9936838	6.2270402	4.9612560	6.6394567	6.0317434	5.7130906	5.1663700
ENSG00000182389	3.9095497	6.4905594	1.626634	9.907858	0.0028212	0.3740648	ENSG00000182389	CACNB4	calcium voltage-gated channel auxiliary subunit beta 4	2	151832771	152099167	protein_coding	HGNC:1404	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-2.5030285	-1.5282403	0.8355902	3.3770190	2.6057117	-2.5195115	-13.2877124
ENSG00000248905	-1.1552121	-0.4314471	8.738746	9.028201	0.0028658	0.3740648	ENSG00000248905	FMN1	formin 1	15	32765544	33194714	protein_coding	HGNC:3768	7.0423226	5.4786355	6.7616918	6.6843926	6.8654091	7.2878039	4.9005166	4.7142861	5.4209539	6.4085150	5.4516907	6.0080135	5.0438182	6.7827123
ENSG00000187800	2.4836795	3.0404997	4.122015	8.671321	0.0028781	0.3740648	ENSG00000187800	PEAR1	platelet endothelial aggregation receptor 1	1	156893698	156916429	protein_coding	HGNC:33631	-2.3953745	2.1167380	0.0216872	-1.1991527	-0.5135595	-13.2877124	3.1556225	3.4521920	3.2983326	1.2679953	5.5035510	4.5781727	3.3071338	0.1545534
ENSG00000179564	0.9704118	0.3542652	6.987003	8.964784	0.0029497	0.3740648	ENSG00000179564	LSMEM2	leucine rich single-pass membrane protein 2	3	50279087	50288114	protein_coding	HGNC:26781	6.9564092	6.9864450	6.9428061	6.3393825	6.8529220	6.5044959	7.8624675	7.4105646	7.5890488	7.3010587	6.9498105	7.1360981	7.6327662	6.7843692
ENSG00000156535	-1.2243937	-0.5302166	6.224155	8.958453	0.0029600	0.3740648	ENSG00000156535	CD109	CD109 molecule	6	73695785	73828316	protein_coding	HGNC:21685	3.3477650	3.7942957	4.1480996	4.4165842	3.1207182	3.8299759	2.7158027	2.6998756	1.7009191	3.2020998	3.3141061	3.2591896	2.4434409	3.8423077
ENSG00000169136	2.0030478	1.2252246	4.856737	8.893795	0.0030794	0.3740648	ENSG00000169136	ATF5	activating transcription factor 5	19	49928702	49933935	protein_coding	HGNC:790	4.4045693	3.3831676	1.3810181	2.6675048	3.6918318	4.0415856	4.6345724	4.9246565	6.0827988	4.7543768	4.8464596	4.8011530	5.3574566	3.5435182
ENSG00000125414	3.1138209	0.1484581	4.724751	8.781524	0.0031324	0.3740648	ENSG00000125414	MYH2	myosin heavy chain 2	17	10521148	10549700	protein_coding	HGNC:7572	-1.8549408	-13.2877124	-2.0224197	-13.2877124	2.6897983	4.9303165	4.1680736	2.5091883	4.2752478	1.6665012	-0.4832445	0.9596975	3.8424138	2.6425523
ENSG00000165152	-2.7977979	-1.2624622	2.755629	8.154241	0.0031699	0.3740648	ENSG00000165152	PGAP4	post-GPI attachment to proteins GalNAc transferase 4	9	101473170	101533537	protein_coding	HGNC:28180	2.0133050	1.3084855	1.3307982	2.0582784	0.3108136	1.9021431	-13.2877124	-1.4678965	-0.4549430	0.1539000	0.3265316	0.2427964	-1.4591157	1.5987039
ENSG00000069943	1.1553661	1.1560524	6.321832	8.794801	0.0031891	0.3740648	ENSG00000069943	PIGB	phosphatidylinositol glycan anchor biosynthesis class B	15	55318960	55355648	protein_coding	HGNC:8959	6.1134852	7.0372985	6.9187816	6.3238582	6.6319656	6.7655261	6.8872141	7.6359346	8.2982353	7.3063598	8.2648521	7.8637836	7.7189712	6.6669199
ENSG00000227715	-6.2400119	-4.9438020	5.031909	7.930225	0.0031993	0.3740648	ENSG00000227715	HLA-A	major histocompatibility complex, class I, A	HSCHR6_MHC_MCF_CTG1	1286636	1289979	protein_coding	HGNC:4931	1.1447845	-0.4907704	7.4368742	7.7647597	0.5907352	-13.2877124	0.1601341	-0.4957518	-13.2877124	-13.2877124	1.7452167	0.7452597	-0.7157363	6.0414093
ENSG00000082397	1.7721109	0.7684464	4.258648	8.762204	0.0032345	0.3740648	ENSG00000082397	EPB41L3	erythrocyte membrane protein band 4.1 like 3	18	5392381	5630700	protein_coding	HGNC:3380	2.6860561	2.6672089	0.7888744	1.6494453	1.5960554	1.5320785	3.4754477	2.7848455	4.8588413	2.3122885	3.0555178	2.7312441	3.9705999	1.9737670
ENSG00000149294	0.3906273	2.9733003	2.369297	7.534296	0.0032454	0.3740648	ENSG00000149294	NCAM1	neural cell adhesion molecule 1	11	112961275	113278436	protein_coding	HGNC:7656	-0.0941716	1.1457831	-13.2877124	-13.2877124	2.7769847	-13.2877124	2.5459207	2.4420334	-13.2877124	0.6678485	3.3465369	2.5559069	1.9099624	0.7375362
ENSG00000206460	3.0936817	-5.1533805	3.310273	8.218502	0.0032619	0.3740648	ENSG00000206460	CDSN	corneodesmosin	HSCHR6_MHC_QBL_CTG1	2373089	2378448	protein_coding	HGNC:1802	-13.2877124	-13.2877124	2.2164260	2.6874030	-13.2877124	-13.2877124	3.8117024	-13.2877124	4.6870256	-13.2877124	-13.2877124	-13.2877124	3.7297966	0.8861381
ENSG00000175229	-2.7291268	-0.9365568	3.048932	8.290517	0.0032948	0.3740648	ENSG00000175229	GAL3ST3	galactose-3-O-sulfotransferase 3	11	66040765	66049161	protein_coding	HGNC:24144	2.9326682	1.4506121	3.1167625	3.1802473	1.7599164	1.0631930	-0.5717440	1.1401831	-1.0711029	2.6374447	1.7633627	2.2656124	0.1604246	2.4847313
ENSG00000152953	1.4733193	1.7543486	4.488598	8.720222	0.0033109	0.3740648	ENSG00000152953	STK32B	serine/threonine kinase 32B	4	5051480	5500994	protein_coding	HGNC:14217	2.0104547	3.4810460	-0.0632132	2.3023773	1.9653096	1.8289975	3.5938519	3.4466466	3.6365750	4.0691225	3.9243554	3.9985540	3.5612931	2.2500939
ENSG00000176435	1.2347353	3.4979254	2.550614	7.478689	0.0033760	0.3740648	ENSG00000176435	CLEC14A	C-type lectin domain containing 14A	14	38254000	38256093	protein_coding	HGNC:19832	-13.2877124	2.0525223	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.0295320	-0.4845903	0.1153196	3.0120820	3.7272137	3.4135121	0.9710104	-0.5322662
ENSG00000152234	-0.3844144	-1.1059029	5.730173	8.658595	0.0033918	0.3740648	ENSG00000152234	ATP5F1A	ATP synthase F1 subunit alpha	18	46080248	46104334	protein_coding	HGNC:823	5.3195284	5.5987609	5.5612405	6.7471044	5.6574733	5.7985987	5.2086626	4.8767839	5.0063681	5.1553524	4.3734475	4.8167359	5.0371147	5.8628077
ENSG00000111325	0.8410817	-0.1488178	7.375281	8.651855	0.0033948	0.3740648	ENSG00000111325	OGFOD2	2-oxoglutarate and iron dependent oxygenase domain containing 2	12	122974580	122980043	protein_coding	HGNC:25823	7.1526406	7.2861520	6.6663968	7.0390593	7.5218723	6.9842689	8.0114418	8.2127661	7.5300935	6.7834097	7.2052411	7.0096887	7.9455486	7.1324576
ENSG00000204977	1.2623174	0.8481954	8.077950	8.586807	0.0034965	0.3740648	ENSG00000204977	TRIM13	tripartite motif containing 13	13	49995888	50020481	protein_coding	HGNC:9976	6.2680629	5.3484128	5.2572103	5.0824798	4.8715573	4.7855727	6.4028731	6.0262255	6.5182465	6.2185886	5.8478968	6.0451159	6.3306333	5.3621890
ENSG00000262102	-8.7942701	-8.7942701	4.377038	9.639960	0.0035495	0.3740648	ENSG00000262102	DSEL	dermatan sulfate epimerase like	HSCHR18_2_CTG2	152309	162707	protein_coding	HGNC:18144	-13.2877124	-13.2877124	3.5429333	3.0489204	2.8044233	2.5099253	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.4424250
ENSG00000101255	1.3507506	1.4974590	4.947749	8.577765	0.0035563	0.3740648	ENSG00000101255	TRIB3	tribbles pseudokinase 3	20	362835	397559	protein_coding	HGNC:16228	2.9769996	4.8417756	3.2736725	3.9562689	2.8053816	3.7957623	4.3816950	4.8346677	5.3531886	4.7046984	5.4571779	5.1294516	4.9110089	3.7834787
ENSG00000087510	-3.2349948	0.6158484	2.978051	7.812619	0.0035588	0.3740648	ENSG00000087510	TFAP2C	transcription factor AP-2 gamma	20	56629306	56639283	protein_coding	HGNC:11744	0.6225443	2.5387984	2.1338587	2.9598771	1.9201134	0.7041655	0.0687795	-13.2877124	-13.2877124	3.5320304	1.9356766	2.9442285	-1.5159081	2.0550707
ENSG00000134668	-2.0840120	-1.5503623	3.940140	8.556906	0.0035792	0.3740648	ENSG00000134668	SPOCD1	SPOC domain containing 1	1	31790422	31816022	protein_coding	HGNC:26338	5.0137405	4.1357687	3.9389675	4.3683324	4.2477317	3.7683957	2.7937107	5.1681167	-1.7070487	4.3362448	1.5132396	3.5269427	3.8478396	4.3037866
ENSG00000054983	0.4407641	2.2847739	2.303416	7.517518	0.0035823	0.3740648	ENSG00000054983	GALC	galactosylceramidase	14	87837820	87993665	protein_coding	HGNC:4115	0.8399459	2.3686047	-0.3097796	-13.2877124	2.4501946	1.1529226	1.3453521	-0.4178583	1.8141017	4.6169137	2.6286637	3.9411995	1.1818156	1.3645539
ENSG00000093072	-0.7769501	1.5990353	2.116245	7.448115	0.0035897	0.3740648	ENSG00000093072	ADA2	adenosine deaminase 2	22	17178790	17258235	protein_coding	HGNC:1839	1.8573178	0.1954270	0.1409775	-0.5210510	-0.3943236	1.1374740	-0.9526068	-1.0340658	-0.6813095	1.1889275	2.0843398	1.7050140	-0.8813046	0.6673190
ENSG00000146197	1.4003744	0.7299753	7.604679	8.529617	0.0035898	0.3740648	ENSG00000146197	SCUBE3	signal peptide, CUB domain and EGF like domain containing 3	6	35213956	35253079	protein_coding	HGNC:13655	5.0151247	4.4755781	4.1598919	4.0181589	4.1424532	4.7001726	5.8468435	4.5707014	6.2652511	4.6640087	5.5693613	5.1865679	5.7209715	4.4629076
ENSG00000204469	-9.2402572	-6.1239037	4.775132	8.604227	0.0035929	0.3740648	ENSG00000204469	PRRC2A	proline rich coiled-coil 2A	6	31620715	31637771	protein_coding	HGNC:13918	4.3989246	4.9125458	-13.2877124	-0.7840059	-13.2877124	3.2126588	-13.2877124	-13.2877124	-13.2877124	0.9370377	-13.2877124	-0.0628869	-13.2877124	3.3473290
ENSG00000241644	3.0017075	6.4881744	1.543857	9.032215	0.0036240	0.3740648	ENSG00000241644	INMT	indolethylamine N-methyltransferase	7	30697985	30757602	protein_coding	HGNC:6069	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.4585479	1.9410815	2.2306264	2.0931055	-0.1263096	-13.2877124
ENSG00000122641	1.3558382	2.2179706	5.665736	8.518394	0.0036415	0.3740648	ENSG00000122641	INHBA	inhibin subunit beta A	7	41667168	41705834	protein_coding	HGNC:6066	3.8255523	3.6228992	3.1791135	1.9242611	1.6893211	1.4941007	3.3167886	4.2127491	4.1465930	3.6205037	5.8764565	5.1506984	3.9454200	2.9194133
ENSG00000020633	3.4267046	3.9808310	2.084078	8.129240	0.0036586	0.3740648	ENSG00000020633	RUNX3	RUNX family transcription factor 3	1	24899511	24965121	protein_coding	HGNC:10473	-2.3500222	1.2960950	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.4061023	1.4897227	-1.3155403	2.0069026	3.4037457	2.8681623	0.5962119	-1.1777861
ENSG00000204389	-7.6709701	-7.6709701	3.341186	9.559661	0.0036997	0.3752345	ENSG00000204389	HSPA1A	heat shock protein family A (Hsp70) member 1A	6	31815543	31817946	protein_coding	HGNC:5232	4.0006976	2.9585515	-13.2877124	-13.2877124	4.1983427	4.2733044	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.3570030
ENSG00000169519	-0.9835489	-1.5698236	4.359521	8.377839	0.0039133	0.3892005	ENSG00000169519	METTL15	methyltransferase 15, mitochondrial 12S rRNA N4-cytidine	11	28108248	28527041	protein_coding	HGNC:26606	3.1909523	2.7480915	3.8163380	3.3081213	2.9227402	3.3224315	2.4625364	1.0620070	2.3446322	1.9422281	1.1751605	1.6090855	2.0794058	3.2587438
ENSG00000156928	-1.4115251	-2.4719219	8.385059	8.337160	0.0039218	0.3892005	ENSG00000156928	MALSU1	mitochondrial assembly of ribosomal large subunit 1	7	23298739	23311729	protein_coding	HGNC:21721	7.4071351	7.7336585	8.4397181	8.2299016	7.8062128	7.7093783	4.5910600	7.5596557	5.2061124	5.9861212	4.4024635	5.4014851	6.3789594	7.9298924
ENSG00000237165	-4.6130727	3.2730631	2.554476	7.673606	0.0039295	0.3892005	ENSG00000237165	CDSN	corneodesmosin	HSCHR6_MHC_MCF_CTG1	2459207	2464559	protein_coding	HGNC:1802	-13.2877124	-13.2877124	2.3294549	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	4.4617959	-13.2877124	3.4618024	-13.2877124	-0.2553641
ENSG00000227761	1.0484001	-1.9501320	5.266557	8.269113	0.0040854	0.4015122	ENSG00000227761	BAG6	BAG cochaperone 6	HSCHR6_MHC_DBB_CTG1	2886791	2900476	protein_coding	HGNC:13919	4.6597329	6.2837376	5.5447692	5.2517521	4.6276463	4.7911792	5.6108278	6.0932572	5.7323637	4.9134204	3.0258543	4.2585468	5.8270185	5.3241939
ENSG00000115317	2.2091250	1.0931918	7.125961	8.172255	0.0042409	0.4015789	ENSG00000115317	HTRA2	HtrA serine peptidase 2	2	74529596	74533350	protein_coding	HGNC:14348	6.7375498	7.1653017	4.8660038	4.5614595	3.8090615	4.3299912	7.7650367	6.4936457	8.8347082	6.9965894	6.9806311	6.9886323	7.9928663	5.8122916
ENSG00000204851	2.0511298	0.9048684	4.754988	8.184744	0.0042529	0.4015789	ENSG00000204851	PNMA8B	PNMA family member 8B	19	46486906	46495879	protein_coding	HGNC:29206	2.4288049	1.4280727	-1.2408237	0.5371937	2.0981281	2.7446853	3.7397760	3.0648166	4.0159782	3.1964834	1.6393845	2.6185373	3.6593590	1.8027855
ENSG00000171790	1.3588117	0.9189487	6.432399	8.144955	0.0042983	0.4015789	ENSG00000171790	SLFNL1	schlafen like 1	1	41015589	41023237	protein_coding	HGNC:26313	4.5425707	3.8985188	3.7780876	4.3041844	4.3496660	4.4598878	5.4003068	4.8926554	5.7236478	3.8228409	5.7379410	5.0772537	5.3783028	4.2490387
ENSG00000142910	2.8915301	2.7605651	2.915787	7.134872	0.0043353	0.4015789	ENSG00000142910	TINAGL1	tubulointerstitial nephritis antigen like 1	1	31576485	31587686	protein_coding	HGNC:19168	-0.9069402	0.9392574	-13.2877124	3.8885102	-13.2877124	-13.2877124	3.6082837	1.6019684	3.5165389	1.6376450	4.1212064	3.3585283	3.1524692	1.5245035
ENSG00000176020	3.2133267	-5.1796057	3.380992	7.680206	0.0043373	0.4015789	ENSG00000176020	AMIGO3	adhesion molecule with Ig like domain 3	3	49716829	49719684	protein_coding	HGNC:24075	-13.2877124	2.8374409	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.3435862	4.8406131	-13.2877124	-13.2877124	-13.2877124	3.6931833	0.2525792
ENSG00000278119	2.3629452	0.2587623	2.044481	6.974848	0.0043837	0.4015789	ENSG00000278119	GOLGA8J	golgin A8 family member J	HSCHR15_4_CTG8	2368159	2381905	protein_coding	HGNC:38650	-1.5459673	-1.6510515	-2.6333001	-13.2877124	-0.1634424	-13.2877124	0.6465212	0.7183095	0.7681149	-1.7290477	-0.9917713	-1.3138159	0.7118429	-1.8066355
ENSG00000167306	0.9194999	1.1064990	6.178865	8.083225	0.0044268	0.4015789	ENSG00000167306	MYO5B	myosin VB	18	49822789	50195164	protein_coding	HGNC:7603	2.7945864	3.4697610	2.8415207	2.1079580	2.6826881	2.6128750	3.1191168	3.9828644	3.6315110	4.1724789	3.6237351	3.9240412	3.6203180	2.8085103
ENSG00000134986	1.0749670	0.8533131	6.408012	8.072726	0.0044456	0.4015789	ENSG00000134986	NREP	neuronal regeneration related protein	5	111662621	111997464	protein_coding	HGNC:16834	6.9310914	6.8634223	4.9939551	6.0960006	6.1694769	6.4066406	7.2820769	6.9593931	7.4229840	6.3830815	7.4997324	7.0468496	7.2342511	6.3679356
ENSG00000156030	-1.3367422	-0.6209897	5.053553	8.077037	0.0044607	0.4015789	ENSG00000156030	MIDEAS	mitotic deacetylase associated SANT domain protein	14	73715122	73790285	protein_coding	HGNC:19853	2.3548578	3.6524058	3.3938876	3.8110618	3.2287437	3.9071842	1.9256391	1.3729354	2.4324739	3.9125894	3.6427009	3.7839471	1.9741871	3.4728073
ENSG00000143387	-1.3866084	-0.8865103	5.393091	8.066585	0.0044705	0.4015789	ENSG00000143387	CTSK	cathepsin K	1	150794880	150809577	protein_coding	HGNC:2536	4.7246887	5.5058572	5.9623493	6.2984657	5.7404299	6.1603343	3.8064959	4.9516162	3.5445043	5.0839841	4.5685033	4.8491451	4.2378803	5.8155967
ENSG00000149932	-0.6476158	-1.3794176	4.421013	8.078856	0.0044899	0.4015789	ENSG00000149932	TMEM219	transmembrane protein 219	16	29940885	29973050	protein_coding	HGNC:25201	5.3140843	5.6682740	5.6529967	6.2269900	5.7612729	5.6053531	5.3313879	4.6006279	4.8684297	4.8029983	4.0166178	4.4627375	4.9655682	5.7314643
ENSG00000111640	-0.8761762	-0.6709205	10.140524	8.047964	0.0044902	0.4015789	ENSG00000111640	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	12	6534512	6538374	protein_coding	HGNC:4141	10.6426246	10.7133591	11.2048414	11.5811585	10.8842274	11.1613433	10.2902577	10.1173236	9.6014559	10.1454828	10.5147990	10.3419269	10.0314905	11.0681475
ENSG00000184557	-2.0198969	-2.3073967	4.020141	8.048287	0.0045196	0.4015789	ENSG00000184557	SOCS3	suppressor of cytokine signaling 3	17	78356778	78360077	protein_coding	HGNC:19391	2.0741046	3.3343137	4.3968457	5.0975439	2.9192318	1.7772493	1.9490384	1.3826363	1.0346651	1.0573823	3.8242137	3.0219869	1.5054255	3.7476314
ENSG00000197915	1.8234717	1.4323877	8.392650	8.029865	0.0045296	0.4015789	ENSG00000197915	HRNR	hornerin	1	152212076	152224193	protein_coding	HGNC:20846	3.9711771	4.9344679	2.8945293	3.0676539	5.3260221	5.4433140	6.2506005	6.3431774	6.2464456	5.2240108	6.5255801	6.0168531	6.2807704	4.6019680
ENSG00000160298	1.3666167	0.5611312	3.563387	7.938783	0.0045775	0.4030135	ENSG00000160298	C21orf58	chromosome 21 open reading frame 58	21	46300181	46323875	protein_coding	HGNC:1300	2.5775680	2.8211353	2.3445246	2.6374554	3.5669499	0.8432394	3.2451266	3.6396735	3.6277219	2.3264804	2.9769677	2.6880794	3.5154421	2.6623176
ENSG00000281216	-7.4104334	-7.4104334	3.067836	8.961803	0.0046361	0.4049923	ENSG00000281216	KIF26B	kinesin family member 26B	HSCHR1_1_CTG32_1	47982	407457	protein_coding	HGNC:25484	1.7672705	-13.2877124	0.6875472	2.0777267	1.1668292	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.9362674
ENSG00000133110	4.2710413	3.2531658	9.940895	7.967789	0.0046654	0.4049923	ENSG00000133110	POSTN	periostin	13	37562583	37598844	protein_coding	HGNC:16953	4.6914338	7.7538893	3.9304450	4.1318557	5.8703544	6.1785337	4.7653462	8.2155474	11.5463387	5.5122214	10.1460075	9.2029797	10.1099600	6.0782307
ENSG00000158246	-1.7017771	-1.0907073	5.139862	7.950746	0.0047361	0.4049923	ENSG00000158246	TENT5B	terminal nucleotidyltransferase 5B	1	27005020	27012850	protein_coding	HGNC:28273	5.3510663	4.1847187	4.8727768	5.6806621	4.8481314	4.0872978	2.3638672	4.0195801	2.1499737	4.1158633	3.4537255	3.8224523	3.1045777	4.9494829
ENSG00000248449	2.8388668	2.3761428	3.152582	7.133017	0.0047572	0.4049923	ENSG00000248449	PCDHGB8P		5	141426286	141429158	transcribed_unitary_pseudogene	HGNC:8715	-0.7053563	1.7957404	-13.2877124	-13.2877124	-13.2877124	1.2829836	1.3845201	2.2211176	3.8485579	2.0778224	2.8681445	2.5264382	2.8532635	0.1196762
ENSG00000188451	1.0374416	1.2356963	4.197515	7.939437	0.0047597	0.4049923	ENSG00000188451	SRP72P2		6	158237336	158242797	processed_pseudogene	HGNC:31096	2.9893650	3.4026987	3.1283160	3.4281365	2.1998356	3.4755961	4.5018640	3.4397935	3.9246783	4.1692013	4.5066965	4.3477954	4.0207107	3.1630525
ENSG00000133121	-1.5056348	-0.7397357	4.181172	7.937553	0.0048182	0.4053860	ENSG00000133121	STARD13	StAR related lipid transfer domain containing 13	13	33103137	33350630	protein_coding	HGNC:19164	1.6705055	2.9268845	3.3806139	5.2064480	2.0594581	3.0898185	3.3331824	2.5339592	0.8391445	2.1183730	1.8122370	1.9734100	2.5573603	3.5608837
ENSG00000046604	-6.3197284	-6.3197284	2.235506	8.618000	0.0048643	0.4053860	ENSG00000046604	DSG2	desmoglein 2	18	31497624	31551351	protein_coding	HGNC:3049	-2.7650426	-0.2640706	1.4588513	2.4294727	-0.4684953	0.2223990	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.8751368
ENSG00000171453	0.7341627	0.6048101	6.006258	7.869210	0.0049002	0.4053860	ENSG00000171453	POLR1C	RNA polymerase I and III subunit C	6	43509702	43562419	protein_coding	HGNC:20194	5.2369379	5.4802873	5.2501813	5.7470952	5.5982934	5.6237591	6.2576008	6.1427143	5.7052885	6.3037688	5.8992479	6.1156403	6.0541328	5.5018359
ENSG00000148943	1.1102153	0.5603432	4.704034	7.862810	0.0049634	0.4053860	ENSG00000148943	LIN7C	lin-7 homolog C, crumbs cell polarity complex component	11	27494418	27506769	protein_coding	HGNC:17789	2.0663834	2.4856048	2.5619774	1.9995747	2.2382262	2.7916686	3.3796716	2.7815030	3.7281054	2.8185602	3.0233592	2.9245908	3.3474647	2.3847635
ENSG00000066468	-3.9014374	0.2090931	3.160214	7.242877	0.0050218	0.4053860	ENSG00000066468	FGFR2	fibroblast growth factor receptor 2	10	121478332	121598458	protein_coding	HGNC:3689	1.8089628	-13.2877124	2.5117451	2.9278547	2.0763248	4.5202530	1.0902701	-0.9362900	-13.2877124	0.9444402	2.9927556	2.3051493	-0.1779829	2.8738624
ENSG00000285162	3.5749985	2.5190618	3.183466	6.878830	0.0050333	0.4053860	ENSG00000285162	NA	NA	NA	NA	NA	NA	NA	-2.0449610	-13.2877124	-2.1788809	-13.2877124	0.8697782	-13.2877124	1.3212320	-2.2124472	3.5162415	1.7803979	0.5330250	1.2875222	2.2384157	-1.3890743
ENSG00000244556	0.5281789	1.3171170	3.885991	7.804008	0.0050530	0.4053860	ENSG00000244556	ODCP		7	129028889	129030527	processed_pseudogene	HGNC:8110	3.0296137	3.5300559	2.5163755	3.7517133	3.2208320	3.4335436	3.5735441	3.5820004	3.7183609	4.4884747	4.5944383	4.5424291	3.6261774	3.2985891
ENSG00000172803	0.1381156	-1.1911167	6.301032	7.792913	0.0050760	0.4053860	ENSG00000172803	SNX32	sorting nexin 32	11	65833834	65856896	protein_coding	HGNC:26423	5.7340247	5.6097293	6.2734328	5.6296531	5.6475740	6.0357583	5.8147750	6.1347121	5.3867177	4.9968451	4.0974151	4.6161159	5.8106999	5.8440537
ENSG00000115474	0.8342308	0.0108739	5.358141	7.794137	0.0050962	0.4053860	ENSG00000115474	KCNJ13	potassium inwardly rectifying channel subfamily J member 13	2	232765802	232776565	protein_coding	HGNC:6259	4.1592250	4.1228850	4.0397848	4.7184386	3.6374069	5.8820147	5.0243884	4.7640688	5.1189823	4.7196583	4.4276514	4.5810300	4.9768054	4.6388645
ENSG00000185112	1.5173281	2.0956535	3.520375	7.548225	0.0050988	0.4053860	ENSG00000185112	FAM43A	family with sequence similarity 43 member A	3	194685883	194689037	protein_coding	HGNC:26888	1.1066043	2.0227406	1.5251077	2.3078805	-0.1805427	1.5102125	0.6113849	3.2671224	3.5042962	3.0414494	4.0311897	3.6195803	2.9070454	1.5670143
ENSG00000221883	1.2498346	0.8641513	4.734216	7.784729	0.0051517	0.4053860	ENSG00000221883	ARIH2OS		3	48917765	48918829	lncRNA	HGNC:34425	4.5481034	5.0628793	3.6245004	3.9336344	4.5882521	3.8174244	4.4586417	5.3710860	5.8174764	4.8403458	5.0168736	4.9313082	5.3191439	4.3527006
ENSG00000183682	1.2292969	0.8731036	5.790813	7.724302	0.0052640	0.4053860	ENSG00000183682	BMP8A	bone morphogenetic protein 8a	1	39491636	39529869	protein_coding	HGNC:21650	2.9227364	4.1557932	3.2121008	2.9052554	2.6351078	2.1130924	4.0418250	4.4835633	4.2545725	4.2367871	3.7922472	4.0315720	4.2712624	3.1348851
ENSG00000153130	-1.2469286	-2.3789218	3.299478	7.599784	0.0053585	0.4053860	ENSG00000153130	SCOC	short coiled-coil protein	4	140257286	140385728	protein_coding	HGNC:20335	3.0977259	2.8454704	2.6650114	2.1785754	3.3175120	5.0648524	-1.2521160	2.1615272	2.5701372	0.8772362	1.1166921	1.0019262	1.8523149	3.5455196
ENSG00000284790	3.8287999	2.8860497	2.106904	7.201823	0.0053611	0.4053860	ENSG00000284790	NA	NA	NA	NA	NA	NA	NA	0.3424273	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.2369432	1.9473860	2.5667231	1.6098022	0.4730845	1.1506162	2.0165391	-2.2419664
ENSG00000175895	-3.3484611	0.3048205	2.314421	7.146823	0.0053876	0.4053860	ENSG00000175895	PLEKHF2	pleckstrin homology and FYVE domain containing 2	8	95115642	95156698	protein_coding	HGNC:20757	2.1925496	0.7803479	3.0479004	2.6723298	0.8985853	2.4898925	-1.9523276	-13.2877124	-1.8667942	2.1555155	0.3292315	1.5139005	-2.4936190	2.2436143
ENSG00000262096	-3.5329542	-3.8460395	2.082405	7.145995	0.0053893	0.4053860	ENSG00000262096	PCDHB19P		5	141239923	141242293	transcribed_unprocessed_pseudogene	HGNC:14549	2.4230946	0.5102196	1.6073497	1.4716380	-13.2877124	3.0073864	-1.6281891	-1.5574503	-13.2877124	-13.2877124	-1.3457368	-2.3453702	-2.1771312	1.7830316
ENSG00000178358	1.3780505	2.4759988	2.419397	6.795007	0.0054375	0.4053860	ENSG00000178358	OR2D3	olfactory receptor family 2 subfamily D member 3	11	6921002	6921994	protein_coding	HGNC:15146	2.5834483	1.4976956	1.8352559	1.2176489	-13.2877124	-13.2877124	3.3470672	2.6374853	2.1705039	4.1164414	3.9557888	4.0383501	2.8004717	1.2939431
ENSG00000144401	1.0193728	0.3944910	6.947270	7.640398	0.0054618	0.4053860	ENSG00000144401	METTL21A	methyltransferase 21A, HSPA lysine	2	207580631	207625928	protein_coding	HGNC:30476	5.8212295	6.2424737	5.1690782	5.8371750	5.2175892	4.4259263	6.4844877	5.9500667	5.7980140	5.7061886	5.6647681	5.6856271	6.1085458	5.5653282
ENSG00000101265	-2.2423424	-0.2094679	3.047122	7.387035	0.0054808	0.4053860	ENSG00000101265	RASSF2	Ras association domain family member 2	20	4780023	4823608	protein_coding	HGNC:9883	0.6400360	1.7891625	1.1506260	0.5446832	1.4535392	1.9220951	-2.8810715	-0.2559802	-1.1879569	1.4981150	0.5924135	1.1152001	-1.0871377	1.3431077
ENSG00000118600	1.5413812	1.1049002	4.880654	7.651656	0.0054911	0.4053860	ENSG00000118600	RXYLT1	ribitol xylosyltransferase 1	12	63779833	63809792	protein_coding	HGNC:13530	2.7227462	2.9973753	2.5959321	1.1592242	3.2339112	3.4762314	4.0592911	4.0352886	4.2218257	4.0805074	3.4319664	3.7923768	4.1078771	2.8547571
ENSG00000218732	3.0609213	1.7533739	2.510475	6.671324	0.0055211	0.4053860	ENSG00000218732			6	72316599	72317436	processed_pseudogene		-13.2877124	-13.2877124	1.3321895	-13.2877124	2.3780746	3.8982239	4.8981977	3.6425435	4.5114000	3.9446667	1.5440694	3.1948838	4.4399630	1.9149938
ENSG00000185630	-1.4743726	-1.5160940	6.331266	7.585531	0.0056121	0.4053860	ENSG00000185630	PBX1	PBX homeobox 1	1	164555584	164899296	protein_coding	HGNC:8632	5.6124866	3.5386335	3.9284695	5.3620426	6.2720125	6.6520641	4.9590238	5.2191026	4.4343215	4.7881001	3.6928674	4.3420114	4.9064515	5.6183814
ENSG00000111452	2.1403109	2.4657657	3.511958	7.173266	0.0056485	0.4053860	ENSG00000111452	ADGRD1	adhesion G protein-coupled receptor D1	12	130953907	131141469	protein_coding	HGNC:19893	0.7478961	0.9411011	-13.2877124	-13.2877124	0.2004466	3.3792259	2.4759448	3.6525346	4.2978747	3.5233069	3.9829850	3.7713771	3.6556589	1.3366393
ENSG00000184985	1.7165377	0.7121859	3.804090	7.514345	0.0056486	0.4053860	ENSG00000184985	SORCS2	sortilin related VPS10 domain containing receptor 2	4	7192538	7742827	protein_coding	HGNC:16698	3.6084307	1.3516736	0.6824582	1.1203699	-0.2627978	3.2931572	1.8412735	2.5251215	3.1423309	1.7110794	3.0846960	2.5555426	2.5984426	2.2811442
ENSG00000175426	1.7899393	1.4210820	5.596958	7.564787	0.0057093	0.4053860	ENSG00000175426	PCSK1	proprotein convertase subtilisin/kexin type 1	5	96390333	96434143	protein_coding	HGNC:8743	3.5812825	3.4980450	1.4720120	1.5874274	1.9367691	2.3797923	4.7604208	3.2766345	4.6888407	4.6529761	3.2995392	4.1294704	4.3828167	2.6660037
ENSG00000120942	0.9935636	2.2290858	2.624019	6.886586	0.0057153	0.4053860	ENSG00000120942	UBIAD1	UbiA prenyltransferase domain containing 1	1	11273198	11296049	protein_coding	HGNC:30791	-2.0803197	0.6430601	-1.2476385	0.7020520	0.2166883	0.3226423	-1.3119862	1.6659926	0.7732225	1.7962572	2.4927851	2.1861544	0.8169871	0.0609093
ENSG00000182957	-2.9185364	-0.7419427	2.472324	6.897666	0.0057332	0.4053860	ENSG00000182957	SPATA13	spermatogenesis associated 13	13	23979805	24307074	protein_coding	HGNC:23222	-0.3586260	1.3195168	1.8829893	1.9691475	-2.3678807	2.0991299	-2.0192172	-3.5156453	-2.0877395	2.9936026	-0.0662204	2.1570020	-2.3975089	1.3559302
ENSG00000111912	1.6510839	1.2162259	3.584439	7.391568	0.0058023	0.4053860	ENSG00000111912	NCOA7	nuclear receptor coactivator 7	6	125781161	125932034	protein_coding	HGNC:21081	1.0341262	3.9883405	1.1650720	3.9729572	0.8463056	1.2152592	3.2262169	2.8612930	5.3571864	1.8797908	3.2413027	2.7155301	4.2633946	2.7363929
ENSG00000111331	-2.5530446	-1.2325531	2.162257	6.764061	0.0058116	0.4053860	ENSG00000111331	OAS3	2’-5’-oligoadenylate synthetase 3	12	112938051	112976460	protein_coding	HGNC:8088	2.8414563	0.4765714	0.4295645	1.0144131	-1.1053429	2.5507369	-0.1020580	-3.1454266	0.6821804	-1.1094179	-1.3524884	-1.2258400	-0.1793622	1.6048542
ENSG00000125740	-1.0783412	-1.4515129	5.841742	7.499084	0.0058594	0.4053860	ENSG00000125740	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit	19	45467995	45475179	protein_coding	HGNC:3797	3.6373032	5.6375586	5.7361346	6.3196658	4.9314770	4.6254243	3.6159749	4.8608635	4.2092212	3.5329859	4.1012042	3.8448908	4.3174915	5.3842864
ENSG00000105849	-1.9961020	-1.2009931	3.038318	7.330479	0.0058991	0.4053860	ENSG00000105849	POLR1F	RNA polymerase I subunit F	7	19695461	19709037	protein_coding	HGNC:18027	0.6246044	2.4342127	1.7375289	2.8220163	1.2846024	2.2206206	0.1709365	-1.3423161	-0.0066198	0.5019079	3.2826954	2.4786883	-0.2540610	2.0267826
ENSG00000186522	-0.4928755	-1.4157275	4.569571	7.500510	0.0059105	0.4053860	ENSG00000186522	SEPTIN10	septin 10	2	109542799	109614143	protein_coding	HGNC:14349	5.2428521	5.1330743	4.0708786	4.1897053	3.4130363	4.4904329	4.7823637	2.5075039	3.3199830	2.5480926	3.5586826	3.1401237	3.8477306	4.5560470
ENSG00000140548	-1.3548484	-1.1645055	7.634300	7.467086	0.0059417	0.4053860	ENSG00000140548	ZNF710	zinc finger protein 710	15	90001324	90082206	protein_coding	HGNC:25352	6.8297883	6.8849360	7.6807861	7.1107775	8.1427520	7.0786178	6.0515697	5.9617759	4.0756262	6.7089333	5.3576378	6.1860302	5.6000791	7.3708897
ENSG00000170430	-1.7420875	-1.3090112	3.236447	7.413108	0.0059430	0.4053860	ENSG00000170430	MGMT	O-6-methylguanine-DNA methyltransferase	10	129467190	129770983	protein_coding	HGNC:7059	4.0755393	3.1830084	4.0425580	4.2187946	3.6822075	4.7878952	1.7590548	2.8389469	1.5343684	1.0671782	3.0015331	2.3368315	2.1631074	4.0804140
ENSG00000162877	3.5799509	2.6258635	2.973638	6.555912	0.0059843	0.4053860	ENSG00000162877	PM20D1	peptidase M20 domain containing 1	1	205828025	205850132	protein_coding	HGNC:26518	2.8119496	0.3033295	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.8915506	0.2252009	4.9886434	3.4849669	-13.2877124	2.4849798	3.7491305	0.4606063
ENSG00000139193	0.8635472	2.3096145	2.351533	6.646382	0.0060067	0.4053860	ENSG00000139193	CD27	CD27 molecule	12	6444955	6451718	protein_coding	HGNC:11922	2.0443913	1.9585153	1.0014492	-13.2877124	0.3434374	2.5700633	2.1535612	1.4153552	2.2396935	4.3298638	3.1251622	3.8497671	1.9805697	1.5211221
ENSG00000205918	0.8538122	-0.1216283	8.279062	7.442097	0.0060147	0.4053860	ENSG00000205918	PDPK2P		16	2616453	2642432	transcribed_unprocessed_pseudogene	HGNC:49897	6.4611520	7.9056287	7.4486803	7.7688789	7.2827880	7.0745527	8.1777132	7.9198381	8.1394210	7.2635792	7.2022532	7.2332419	8.0833852	7.3968890
ENSG00000167244	4.1875356	4.2963522	4.285453	6.672381	0.0060191	0.4053860	ENSG00000167244	IGF2	insulin like growth factor 2	11	2129112	2158391	protein_coding	HGNC:5466	1.0439128	-13.2877124	-13.2877124	-1.2186722	-2.1175620	-0.0120549	-2.6457781	4.9589107	-13.2877124	-0.9527464	4.5887205	3.6193687	3.3813459	-0.6920644
ENSG00000228960	2.5947589	1.9886413	8.049919	7.439802	0.0060244	0.4053860	ENSG00000228960	OR2A9P		7	144299373	144300305	transcribed_unprocessed_pseudogene	HGNC:8236	7.3272730	7.7973193	3.0538502	2.2668024	7.7929754	6.2264390	8.9190344	9.4555410	8.7636811	8.1164535	8.9350698	8.5830617	9.0775304	6.8513593
ENSG00000140105	0.8557682	0.5385314	6.670873	7.434002	0.0060434	0.4053860	ENSG00000140105	WARS1	tryptophanyl-tRNA synthetase 1	14	100333790	100376805	protein_coding	HGNC:12729	5.2853687	6.5380137	6.2606059	6.4467690	5.3980516	5.9299526	6.0216374	6.8806470	7.0492464	5.6030795	7.1507430	6.5751960	6.7153840	6.0551423
ENSG00000274829	-3.5048227	-1.0164238	2.873842	6.855036	0.0061033	0.4072484	ENSG00000274829	PARN	poly(A)-specific ribonuclease	HSCHR16_1_CTG1	8558	205584	protein_coding	HGNC:8609	2.7800875	3.9153130	4.9033657	6.3298136	4.6652523	-13.2877124	0.6102200	-13.2877124	-13.2877124	3.2350372	2.1336243	2.7869812	-0.9745536	4.7160365
ENSG00000197381	0.7182869	1.3480279	4.708062	7.403760	0.0061995	0.4115011	ENSG00000197381	ADARB1	adenosine deaminase RNA specific B1	21	45073853	45226560	protein_coding	HGNC:226	2.4104857	3.9353023	2.8425006	2.3077540	2.4229439	2.8255952	2.6824791	2.5416308	3.0049538	3.8099237	4.3528586	4.1067824	2.7562808	2.9129790
ENSG00000162599	1.6206337	1.0139578	3.987170	7.295361	0.0063925	0.4221070	ENSG00000162599	NFIA	nuclear factor I A	1	60865259	61462788	protein_coding	HGNC:7784	-0.0856819	3.8526025	0.7375172	3.7441795	2.7552818	1.9533543	3.2053866	2.2859928	2.9241837	3.1595376	3.5149063	3.3481364	2.8540886	2.7754172
ENSG00000188152	1.0358234	1.1018461	5.334618	7.309841	0.0064658	0.4245143	ENSG00000188152	NUTM2G	NUT family member 2G	9	96928310	96940253	protein_coding	HGNC:23449	4.5190872	4.2710766	3.3673293	3.5421245	3.1892670	3.0791224	4.4795409	4.8754454	4.8501382	4.9678897	4.8386605	4.9047216	4.7460397	3.7686639
ENSG00000176928	-3.7084098	1.3637872	2.307811	6.971119	0.0064960	0.4245143	ENSG00000176928	GCNT4	glucosaminyl (N-acetyl) transferase 4	5	75025346	75052558	protein_coding	HGNC:17973	-13.2877124	-2.8096709	1.5291968	0.0531934	-0.1080676	0.9754446	-2.9572212	-13.2877124	-13.2877124	0.4724888	1.7149690	1.2235452	-4.5399447	0.2142523
ENSG00000162585	0.8028578	0.5415466	7.379363	7.267964	0.0065576	0.4256915	ENSG00000162585	FAAP20	FA core complex associated protein 20	1	2184461	2212720	protein_coding	HGNC:26428	6.2563806	6.9619166	6.8800312	7.5149372	7.0369899	7.1231445	7.0072898	7.1770548	7.4949569	7.3640358	7.2276417	7.2974501	7.2407894	7.0084880
ENSG00000171720	-1.3628714	-2.1669777	3.227832	7.195552	0.0065811	0.4256915	ENSG00000171720	HDAC3	histone deacetylase 3	5	141620876	141636849	protein_coding	HGNC:4854	3.5262597	3.7667446	4.6682561	3.6053975	3.9412570	3.1524478	2.5874639	1.6259867	2.6014555	1.6235579	-0.0083485	1.0270018	2.3377996	3.8577117
ENSG00000133026	0.7400233	0.2797858	7.558331	7.239989	0.0066493	0.4265028	ENSG00000133026	MYH10	myosin heavy chain 10	17	8474207	8631376	protein_coding	HGNC:7568	5.5827110	4.9833371	5.4264651	5.2539714	6.5520555	4.7887412	5.1295964	5.9738931	6.2091596	5.0370949	6.1608898	5.7057562	5.8400001	5.5556082
ENSG00000168298	-1.0179432	-1.3551826	5.573701	7.235733	0.0066799	0.4265028	ENSG00000168298	H1-4	H1.4 linker histone, cluster member	6	26156329	26157115	protein_coding	HGNC:4718	7.5191698	6.6812810	7.5073302	7.7694579	7.1948763	7.8847182	7.1135230	5.5937803	5.4785707	6.0483337	6.0609441	6.0546527	6.2690384	7.4771572
ENSG00000184640	-1.0835158	-0.5495722	7.431360	7.207340	0.0067584	0.4265028	ENSG00000184640	SEPTIN9	septin 9	17	77280569	77500596	protein_coding	HGNC:7323	5.8616887	6.7274947	6.8498020	7.3088644	6.1799707	7.1201540	5.8215316	6.6204704	5.0851365	5.9620075	5.8676343	5.9155924	5.9764425	6.7585340
ENSG00000226430	2.9359569	2.4459895	2.842761	6.397416	0.0067862	0.4265028	ENSG00000226430	USP17L7	ubiquitin specific peptidase 17 like family member 7	8	12132417	12134099	protein_coding	HGNC:37180	-13.2877124	0.9706534	-13.2877124	1.3919772	1.4795617	-13.2877124	4.0925996	2.1390991	1.8888851	3.5438335	-0.0836334	2.6560854	3.0686132	0.2972983
ENSG00000145242	6.0688495	8.7438088	3.254913	8.872320	0.0068144	0.4265028	ENSG00000145242	EPHA5	EPH receptor A5	4	65319563	65670495	protein_coding	HGNC:3389	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-2.8502620	-1.1615435	1.5718918	-13.2877124	4.1410524	3.1410606	0.2463667	-13.2877124
ENSG00000183715	2.2878345	-5.0190078	2.703412	6.728700	0.0069242	0.4265028	ENSG00000183715	OPCML	opioid binding protein/cell adhesion molecule like	11	132414977	133532501	protein_coding	HGNC:8143	-3.0319048	3.1808391	-13.2877124	-13.2877124	2.7313066	0.4130492	1.3140607	-1.4795687	4.6681413	-13.2877124	-13.2877124	-13.2877124	3.2362063	1.5162568
ENSG00000122257	-1.0899131	-0.8651591	4.215899	7.178444	0.0069655	0.4265028	ENSG00000122257	RBBP6	RB binding protein 6, ubiquitin ligase	16	24537693	24572863	protein_coding	HGNC:9889	1.9986512	3.5626047	3.5464109	2.7905615	3.1484656	3.5305808	0.7236442	2.2043508	3.3240920	0.7394187	3.4657498	2.6687752	2.4396258	3.1921287
ENSG00000170558	1.3457711	0.7246324	6.729755	7.148093	0.0069681	0.4265028	ENSG00000170558	CDH2	cadherin 2	18	27932879	28177946	protein_coding	HGNC:1759	4.9587987	4.8754114	3.8112640	4.2881904	4.6055832	4.8728380	5.4383900	5.1327771	6.4996771	4.4918282	5.8653733	5.3362398	5.8153807	4.6212994
ENSG00000165028	-1.8601622	1.3067816	2.420700	6.449505	0.0069993	0.4265028	ENSG00000165028	NIPSNAP3B	nipsnap homolog 3B	9	104764129	104777764	protein_coding	HGNC:23641	-0.4034522	-0.0012716	-1.3077299	-0.5297828	-0.1061548	1.4851733	-1.9558717	-1.2993330	-13.2877124	1.6759749	0.4945487	1.2029605	-2.1753185	0.1332018
ENSG00000159261	5.1354703	5.0366918	2.265323	8.044178	0.0071117	0.4265028	ENSG00000159261	CLDN14	claudin 14	21	36460621	36576569	protein_coding	HGNC:2035	-13.2877124	-13.2877124	-13.2877124	0.2829403	-13.2877124	-13.2877124	0.4982723	1.7210366	3.7367515	2.4107302	3.1157536	2.8058870	2.5882136	-2.3014294
ENSG00000106366	1.5094843	0.4822335	8.712346	7.100275	0.0071309	0.4265028	ENSG00000106366	SERPINE1	serpin family E member 1	7	101127104	101139247	protein_coding	HGNC:8583	7.7849475	7.0049538	6.4210866	6.5848604	6.6257565	6.6715816	9.0001549	6.6263152	8.4243027	7.3694570	7.4501266	7.4103555	8.3134558	6.9294892
ENSG00000125991	-0.8501681	-0.4164521	6.015605	7.101270	0.0071356	0.4265028	ENSG00000125991	ERGIC3	ERGIC and golgi 3	20	35542038	35557634	protein_coding	HGNC:15927	6.2273937	6.9763335	6.6375751	6.9739478	6.6493815	6.4804873	5.3255096	6.1340790	5.6219913	6.1147063	6.1266689	6.1206999	5.7331775	6.6813454
ENSG00000095303	1.8251682	0.2835348	4.427071	7.107149	0.0071617	0.4265028	ENSG00000095303	PTGS1	prostaglandin-endoperoxide synthase 1	9	122370530	122395703	protein_coding	HGNC:9604	2.5962148	2.5982732	2.5656661	2.9553666	1.3233637	2.6313732	4.3835571	3.0392404	4.7538653	2.4739996	2.0033932	2.2578009	4.2243060	2.5226338
ENSG00000178752	1.5354165	1.2211331	5.041416	7.107543	0.0071763	0.4265028	ENSG00000178752	ERFE	erythroferrone	2	238158970	238168900	protein_coding	HGNC:26727	3.0442093	4.1643251	3.7754775	4.9554533	3.6390153	6.0965999	5.0360144	4.8139351	6.4485176	4.2059633	5.9097725	5.2960036	5.6271562	4.6609748
ENSG00000006016	1.4510812	0.0839045	6.861955	7.086823	0.0071847	0.4265028	ENSG00000006016	CRLF1	cytokine receptor like factor 1	19	18572220	18607741	protein_coding	HGNC:2364	8.5199620	6.9315489	7.1976716	7.3908015	7.1088812	6.3543411	8.4551970	7.2990018	10.5453616	7.2845551	7.6901307	7.5015482	9.3828812	7.4145068
ENSG00000204381	-1.4500560	-1.1331944	5.733347	7.084033	0.0072055	0.4265028	ENSG00000204381	LAYN	layilin	11	111540280	111561745	protein_coding	HGNC:29471	5.6336318	5.8676210	5.5926061	5.9625848	6.5216382	6.6817549	4.0212806	5.4345579	2.9656022	4.9394198	4.5565586	4.7606526	4.4875114	6.1057041
ENSG00000006015	2.5210300	-0.3117054	6.270047	7.087173	0.0072117	0.4265028	ENSG00000006015	REX1BD	required for excision 1-B domain containing	19	18588685	18592337	protein_coding	HGNC:26098	6.2889878	5.3832104	6.2670900	6.2790915	3.9463241	4.0092842	5.6507698	5.6538646	8.3417895	4.1910150	5.9917706	5.3558099	7.1464384	5.6730122
ENSG00000102226	-1.1473185	-0.5315773	4.647717	7.092162	0.0072313	0.4265028	ENSG00000102226	USP11	ubiquitin specific peptidase 11	X	47232866	47248328	protein_coding	HGNC:12609	3.7576051	3.6476059	4.7943506	5.1981090	3.2737195	4.2865618	2.3491756	4.2797031	2.0781733	3.8140913	2.8336999	3.4056197	3.2600845	4.3183647
ENSG00000134283	0.8999047	1.9309307	5.845172	7.067166	0.0072850	0.4265028	ENSG00000134283	PPHLN1	periphilin 1	12	42238447	42459715	protein_coding	HGNC:19369	5.7916098	5.6664856	4.8011242	3.5669292	6.2813763	4.2583186	5.2871388	5.3899414	6.7133206	6.1328104	7.6849287	7.1082476	5.9535025	5.3388576
ENSG00000152661	-0.3688700	1.2704411	6.312498	7.038561	0.0073658	0.4265028	ENSG00000152661	GJA1	gap junction protein alpha 1	6	121435595	121449727	protein_coding	HGNC:4274	4.1366146	6.1380310	4.8982412	4.6295797	4.7279230	4.7558616	3.5052888	4.9166989	4.6509448	5.6738252	6.6504089	6.2432191	4.4742855	5.0305400
ENSG00000120594	3.1160202	3.8634548	3.245209	6.237388	0.0073783	0.4265028	ENSG00000120594	PLXDC2	plexin domain containing 2	10	19816239	20289856	protein_coding	HGNC:21013	1.5506485	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-3.1406856	-0.8376224	3.4601989	2.3699656	2.9101557	2.6651973	1.9608580	-1.0340678
ENSG00000165323	1.3129057	-5.4525261	2.487055	6.827026	0.0073869	0.4265028	ENSG00000165323	FAT3	FAT atypical cadherin 3	11	92224818	92896473	protein_coding	HGNC:23112	2.3382960	-0.7058080	-13.2877124	-1.0619326	-4.2558596	-3.1256106	-1.0594799	-1.3656595	0.8554763	-13.2877124	-13.2877124	-13.2877124	-0.1642279	0.0740848
ENSG00000232070	2.5598275	3.1393825	2.169020	6.255677	0.0073892	0.4265028	ENSG00000232070	TMEM253	transmembrane protein 253	14	21098811	21103724	protein_coding	HGNC:32545	0.7260421	0.6407903	-13.2877124	2.8667618	-13.2877124	-13.2877124	1.4882240	3.4633121	2.1619289	3.8376479	3.1032621	3.5166878	2.6096122	0.8084312
ENSG00000138650	-3.7846014	-2.8550648	2.660374	6.404536	0.0074078	0.4265028	ENSG00000138650	PCDH10	protocadherin 10	4	133149294	133208606	protein_coding	HGNC:13404	1.3880611	-13.2877124	2.0219945	1.9350508	-0.2638905	0.9720235	-13.2877124	-13.2877124	-1.9283417	-13.2877124	-0.3811412	-1.3809533	-3.5122063	1.1480839
ENSG00000112139	1.5300900	0.3999563	3.433052	6.915832	0.0074347	0.4265028	ENSG00000112139	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	6	37630679	37699306	protein_coding	HGNC:19267	0.5625497	-0.3222365	0.1813545	1.9242732	-0.1054003	1.5060885	1.6905369	5.2288702	1.1560898	0.7534437	-0.8412002	0.1660662	3.8398801	0.8713240
ENSG00000137337	-6.9230830	-0.2968394	2.952523	7.435849	0.0075426	0.4296542	ENSG00000137337	MDC1	mediator of DNA damage checkpoint 1	6	30699807	30717447	protein_coding	HGNC:21163	1.5742299	2.0171843	0.9326886	-13.2877124	-13.2877124	0.9363918	-13.2877124	-13.2877124	-13.2877124	0.7706143	0.5717448	0.6746035	-13.2877124	0.8544561
ENSG00000274587	-3.0189163	0.5678190	2.786919	6.439688	0.0075574	0.4296542	ENSG00000274587	LILRB3	leukocyte immunoglobulin like receptor B3	HSCHR19_4_CTG3_1	191638	198073	protein_coding	HGNC:6607	3.3065449	4.4163330	-0.2613031	1.8615259	4.6858800	3.7896256	2.2391304	-13.2877124	2.4942986	3.7618001	4.4420218	4.1416351	1.7873999	3.6492825
ENSG00000026025	-1.1297256	-1.3756436	12.516238	6.961379	0.0076501	0.4297146	ENSG00000026025	VIM	vimentin	10	17228241	17237593	protein_coding	HGNC:12692	12.2291330	12.2287952	13.2074809	13.7995626	12.2720874	12.5744841	11.9997199	11.6833494	10.4596181	11.7011385	11.0830564	11.4249473	11.5170454	12.8521550
ENSG00000280787	-5.7172955	1.3036283	2.506583	7.031979	0.0077324	0.4297146	ENSG00000280787	HERC2P2		HSCHR15_3_CTG3	139181	224046	transcribed_unprocessed_pseudogene	HGNC:4870	1.1318397	-13.2877124	-0.5080566	1.1368699	-13.2877124	1.4542654	-13.2877124	-13.2877124	-13.2877124	1.6900076	2.5266911	2.1681719	-13.2877124	0.3847782
ENSG00000102743	1.5253721	1.0159650	3.446000	6.818759	0.0077356	0.4297146	ENSG00000102743	SLC25A15	solute carrier family 25 member 15	13	40789412	40812460	protein_coding	HGNC:10985	0.6535746	2.0139746	0.8490225	0.0438764	2.9759458	1.8345709	3.1571644	4.0631357	3.5593007	2.8184293	2.5576895	2.6939419	3.6409651	1.7281765
ENSG00000088538	1.1576220	0.0741137	4.214153	6.956118	0.0077524	0.4297146	ENSG00000088538	DOCK3	dedicator of cytokinesis 3	3	50674927	51384198	protein_coding	HGNC:2989	1.3946722	0.7016378	1.2269000	0.5380057	0.7408352	0.7473324	2.3285668	1.6636680	1.9460919	1.4595874	0.3941695	1.0230715	2.0053479	0.9257549
ENSG00000204176	1.5370010	2.1312308	5.779967	6.940318	0.0077850	0.4297146	ENSG00000204176	SYT15	synaptotagmin 15	10	46578217	46594173	protein_coding	HGNC:17167	4.4213444	2.9687497	1.5387264	4.4117573	3.2310233	1.7038834	1.3300736	4.6438890	5.8073863	3.9808410	6.6747113	5.8820399	4.7990173	3.4614578
ENSG00000232804	1.8094490	-6.9208076	4.038745	7.111525	0.0078276	0.4297146	ENSG00000232804	HSPA1B	heat shock protein family A (Hsp70) member 1B	HSCHR6_MHC_APD_CTG1	3160360	3162874	protein_coding	HGNC:5233	-13.2877124	-13.2877124	4.0643262	3.9876457	-13.2877124	3.1088101	3.7988398	5.1229264	4.2061499	-13.2877124	-13.2877124	-13.2877124	4.4858867	2.7803145
ENSG00000184349	-5.8376322	-5.8376322	1.903462	7.280288	0.0078355	0.4297146	ENSG00000184349	EFNA5	ephrin A5	5	107376894	107670937	protein_coding	HGNC:3225	-13.2877124	1.7727974	3.4191136	1.2340978	1.4278502	0.8563898	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.8051137
ENSG00000168077	1.2153284	-0.0786396	6.645360	6.908020	0.0078681	0.4297146	ENSG00000168077	SCARA3	scavenger receptor class A member 3	8	27633868	27676776	protein_coding	HGNC:19000	4.6229395	4.3765041	5.0751678	5.5006291	4.5837596	4.6210150	6.3497622	4.5580906	6.2131651	5.2089651	4.0186700	4.7332426	5.9013190	4.8495370
ENSG00000276068	1.0994517	0.7453094	6.894284	6.888715	0.0079442	0.4297146	ENSG00000276068	NAIP	NLR family apoptosis inhibitory protein	HSCHR5_1_CTG1_1	516878	573494	protein_coding	HGNC:7634	4.4581066	4.6942930	4.6359366	4.2502647	3.3339197	3.9676921	4.4675501	5.8417520	5.1507333	4.9632512	5.0863200	5.0260976	5.2605229	4.2914606
ENSG00000248769	-2.6133438	-6.4230709	2.337213	6.539563	0.0079845	0.4297146	ENSG00000248769			5	69653248	69654334	unprocessed_pseudogene		4.2113713	4.0095048	3.1960178	1.7113460	3.6150424	-13.2877124	-13.2877124	2.2831860	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.6982825	3.3055379
ENSG00000278839	-3.6659388	-0.3425032	2.148773	6.555619	0.0080072	0.4297146	ENSG00000278839	SERF1B	small EDRK-rich factor 1A	HSCHR5_2_CTG1_1	492256	510143	protein_coding	HGNC:10756	4.1278113	4.3821706	3.0488315	2.5677365	3.6457702	4.2909249	-13.2877124	-13.2877124	-0.5820908	3.0700765	3.7466132	3.4476436	-2.1666212	3.8181443
ENSG00000196843	-1.7075895	-1.7696459	2.997252	6.747973	0.0080483	0.4297146	ENSG00000196843	ARID5A	AT-rich interaction domain 5A	2	96536743	96552638	protein_coding	HGNC:17361	3.0625148	2.2890341	3.2133255	3.2999056	1.7201138	2.8416093	1.4122244	-0.4212390	0.1787771	0.9380253	1.1127622	1.0280379	0.5977867	2.8355116
ENSG00000196611	-4.2092645	-1.2505617	3.073717	6.402907	0.0080950	0.4297146	ENSG00000196611	MMP1	matrix metallopeptidase 1	11	102789401	102798160	protein_coding	HGNC:7155	4.6635526	3.8688952	2.0647311	1.6980384	1.2066463	-13.2877124	-1.3239096	-0.2537354	-13.2877124	-0.2162014	2.8657880	2.0268298	-1.2766330	3.0499219
ENSG00000100890	-1.2852944	-1.5760294	3.535559	6.867049	0.0080994	0.4297146	ENSG00000100890	PRORP	protein only RNase P catalytic subunit	14	35121846	35277622	protein_coding	HGNC:19958	4.2765649	3.4232419	3.9731890	3.3428173	4.7637235	4.8451790	3.1797333	3.0368170	1.2722090	2.1186322	2.2439597	2.1826564	2.7139518	4.2207084
ENSG00000141448	2.2595272	1.9728584	3.345818	6.493790	0.0081182	0.4297146	ENSG00000141448	GATA6	GATA binding protein 6	18	22169589	22202528	protein_coding	HGNC:4174	1.7530615	1.7533829	-0.7357807	-13.2877124	-0.8561390	-13.2877124	1.7847561	1.7737462	3.4019077	1.8933447	2.7036268	2.3546397	2.5389553	0.3960378
ENSG00000004059	-1.0613968	-0.3278007	5.112347	6.836693	0.0081945	0.4297146	ENSG00000004059	ARF5	ADP ribosylation factor 5	7	127588386	127591700	protein_coding	HGNC:658	5.9995508	6.3404334	5.7271510	6.8018590	6.1751679	6.1188511	4.8567331	5.4545045	4.5036015	5.9060071	5.6738497	5.7945931	4.9926008	6.2330333
ENSG00000134697	-1.0897969	-1.2488784	3.783674	6.845893	0.0082577	0.4297146	ENSG00000134697	GNL2	G protein nucleolar 2	1	37566816	37595937	protein_coding	HGNC:29925	3.7475118	4.4633435	4.3171119	3.8202301	3.1639271	3.6068515	1.8389421	4.6788015	2.1719856	1.6639575	5.2242487	4.3416385	3.4895802	3.9180026
ENSG00000118596	-1.4865194	-0.7578093	4.384714	6.835321	0.0082660	0.4297146	ENSG00000118596	SLC16A7	solute carrier family 16 member 7	12	59596029	59789855	protein_coding	HGNC:10928	3.6042107	2.2946846	2.0901488	1.8022768	2.9654605	4.0031194	2.1713148	1.8912177	-0.4104282	2.6962431	3.0701257	2.8952623	1.5795374	3.0196617
ENSG00000075945	-0.2953874	-2.2605063	2.822423	6.605228	0.0082838	0.4297146	ENSG00000075945	KIFAP3	kinesin associated protein 3	1	169921326	170085208	protein_coding	HGNC:17060	1.7050078	1.8266534	2.1709195	2.2914155	2.6384826	1.7866566	1.6105158	1.4114723	1.4259029	-0.8729875	0.0183023	-0.3595808	1.4855165	2.1089600
ENSG00000137571	2.7218199	1.3123445	4.370948	6.728323	0.0083510	0.4297146	ENSG00000137571	SLCO5A1	solute carrier organic anion transporter family member 5A1	8	69667046	69834978	protein_coding	HGNC:19046	0.6370398	0.3734689	-13.2877124	-13.2877124	0.6541541	0.9528151	3.3077125	2.3452842	2.0482006	2.3349009	-13.2877124	1.3349292	2.6720068	0.0840956
ENSG00000166979	-3.0865057	-0.6921047	2.597265	6.277644	0.0083555	0.4297146	ENSG00000166979	EVA1C	eva-1 homolog C	21	32412006	32515397	protein_coding	HGNC:13239	3.8107568	0.0241452	5.0346228	3.4722298	3.3141818	3.8594475	0.9873784	-0.6382631	-13.2877124	1.8348443	2.9737082	2.5138515	-0.1925544	3.7967775
ENSG00000080298	-4.0495830	0.3214288	2.244722	6.636071	0.0083570	0.4297146	ENSG00000080298	RFX3	regulatory factor X3	9	3218297	3526004	protein_coding	HGNC:9984	-0.3231206	2.4631453	-0.4908879	-1.2990064	-1.4609415	2.3243628	-13.2877124	-13.2877124	-3.6365889	-1.2924222	3.7503192	2.7934367	-5.2179673	1.0934709
ENSG00000183770	-4.0509378	-1.2202556	2.613313	6.454229	0.0083939	0.4297146	ENSG00000183770	FOXL2	forkhead box L2	3	138944224	138947137	protein_coding	HGNC:1092	1.9723250	1.8886692	0.1052570	-13.2877124	2.3768449	3.5822974	-1.9594302	-1.8883490	-13.2877124	-0.2664825	1.3220585	0.7362022	-2.5081407	2.1085004
ENSG00000124785	-2.1437235	-2.0273713	5.637982	6.786870	0.0084011	0.4297146	ENSG00000124785	NRN1	neuritin 1	6	5997999	6007605	protein_coding	HGNC:17972	3.1905736	6.6449925	7.2378266	7.2981275	5.0737074	5.5945300	3.1177482	4.9645718	2.7923577	3.9122379	4.4783131	4.2228633	3.9644504	6.3794560
ENSG00000159200	1.3916113	1.1483917	4.753124	6.796569	0.0084058	0.4297146	ENSG00000159200	RCAN1	regulator of calcineurin 1	21	34513142	34615113	protein_coding	HGNC:3040	2.7484567	3.3762252	3.7428261	4.1731254	2.6836340	3.6166260	5.2350902	2.8986758	4.5755076	4.0982412	4.6779384	4.4170126	4.5228090	3.4859008
ENSG00000232859	-1.0219039	2.0298841	2.121655	5.914388	0.0085147	0.4311871	ENSG00000232859	LYRM9	LYR motif containing 9	17	27878314	27894752	protein_coding	HGNC:27314	-0.8252357	1.6750585	-13.2877124	2.7034644	0.0272447	3.4049067	0.5260227	2.5931185	-13.2877124	4.2384652	3.8049179	4.0379164	1.3169318	1.8667462
ENSG00000173992	-1.1717090	-1.2815638	3.940267	6.783377	0.0085256	0.4311871	ENSG00000173992	CCS	copper chaperone for superoxide dismutase	11	66593153	66606019	protein_coding	HGNC:1613	4.5006228	4.2123988	5.4826471	5.6172938	4.8895913	5.3879755	3.6762055	3.7016969	3.7626643	4.1943359	3.6895621	3.9639133	3.7139795	5.1049853
ENSG00000228299	7.9673835	6.4707930	3.093787	8.260000	0.0085367	0.4311871	ENSG00000228299	HLA-C	major histocompatibility complex, class I, C	HSCHR6_MHC_DBB_CTG1	2526549	2529920	protein_coding	HGNC:4933	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.3659187	3.9110389	5.5684673	4.7066754	-13.2877124	3.7066808	4.4390672	-13.2877124
ENSG00000274744	2.7418128	2.5370733	2.131324	6.011494	0.0085721	0.4312593	ENSG00000274744	NA	NA	NA	NA	NA	NA	NA	-13.2877124	-0.0794780	-13.2877124	0.8708949	-1.2641347	1.9257917	1.9440038	2.4002218	2.5883229	1.1891800	2.8955254	2.2811611	2.3353838	0.2205776
ENSG00000223620	-1.6952726	-5.5516343	3.572557	6.681333	0.0086387	0.4328896	ENSG00000223620	RBM48P1		4	126563509	126564776	processed_pseudogene	HGNC:44054	0.9418448	4.3796761	6.1706506	5.0667125	3.9410547	4.6681579	2.7056705	4.0957716	-13.2877124	-13.2877124	-0.0076724	-1.0075274	2.9770905	4.8165366
ENSG00000179886	0.8200205	-0.5188313	4.652804	6.730484	0.0087002	0.4329466	ENSG00000179886	TIGD5	tigger transposable element derived 5	8	143597831	143603224	protein_coding	HGNC:18336	1.7774892	3.0161796	2.7051722	2.8356731	1.8633256	2.0433235	3.2769647	3.3086460	2.7872346	2.1028358	1.6900827	1.9111704	3.1432060	2.4567633
ENSG00000197429	1.8946705	1.7744062	2.786084	6.203762	0.0087091	0.4329466	ENSG00000197429	IPP	intracisternal A particle-promoted polypeptide	1	45694324	45750653	protein_coding	HGNC:6108	0.4891277	0.0836396	1.2727190	2.0477998	1.2720859	-13.2877124	3.7188070	1.5916067	2.3428884	3.4335540	1.6062939	2.7917243	2.8246717	0.9297153
ENSG00000214279	4.3109479	4.6220837	1.810990	7.455389	0.0087643	0.4329466	ENSG00000214279	SCART1	scavenger receptor family member expressed on T cells 1	10	133453928	133523558	protein_coding	HGNC:32411	-13.2877124	-2.0779483	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.9314660	-0.5805733	-0.6214218	0.3200075	1.0409724	0.7250653	0.1047576	-4.6598685
ENSG00000157456	1.1506576	1.2409512	6.519573	6.693693	0.0087901	0.4329466	ENSG00000157456	CCNB2	cyclin B2	15	59105126	59125045	protein_coding	HGNC:1580	4.8952731	4.9065017	4.4982895	5.2181243	5.6589538	5.7773506	4.9290461	6.4831820	6.5087305	6.3474777	6.4176689	6.3830001	6.1360273	5.2284874
ENSG00000127329	2.8656975	0.1416554	2.731353	5.998134	0.0088373	0.4329466	ENSG00000127329	PTPRB	protein tyrosine phosphatase receptor type B	12	70515870	70637440	protein_coding	HGNC:9665	0.9041288	-13.2877124	-13.2877124	-13.2877124	-2.0157534	-13.2877124	1.7732541	-2.0741160	1.6971853	-1.9247330	-0.0999923	-0.7412676	1.2012991	-1.5015114
ENSG00000285154	2.4495613	0.7894529	3.383309	6.386980	0.0088902	0.4329466	ENSG00000285154		olfactory receptor 2A1/2A42	HSCHR7_3_CTG4_4	369356	370276	protein_coding		4.3055199	3.1005683	-13.2877124	-13.2877124	1.2870591	4.0417712	4.8985301	5.8542872	4.9175237	4.6181635	0.2650948	3.6870851	5.2964607	2.9776439
ENSG00000276886	-1.0882100	-0.7206627	9.733247	6.656731	0.0089482	0.4329466	ENSG00000276886	GREM1	gremlin 1, DAN family BMP antagonist	HSCHR15_4_CTG8	4932598	4949251	protein_coding	HGNC:2001	8.3535434	7.5572568	8.4493017	8.8000496	8.7423221	9.1366310	7.7905205	7.0875386	7.0271949	7.4665295	8.1268415	7.8341379	7.3453139	8.5836003
ENSG00000204348	2.5944632	0.5781839	3.879435	6.514783	0.0089597	0.4329466	ENSG00000204348	DXO	decapping exoribonuclease	6	31969810	31972290	protein_coding	HGNC:2992	-13.2877124	1.7974978	1.1851923	-13.2877124	3.7066805	4.1682134	5.5595614	5.4598965	2.8097980	3.4409932	1.8276134	2.8489788	5.0325170	2.6160958
ENSG00000220884	1.4185573	1.8155706	3.694329	6.562666	0.0089750	0.4329466	ENSG00000220884	MESTP1		6	128928995	128929988	processed_pseudogene	HGNC:29660	1.7277571	4.1441358	4.0675018	2.9497854	3.2492232	3.1323921	4.6061557	5.3655521	4.0797717	4.0118320	6.0005754	5.3247620	4.7812333	3.4096937
ENSG00000120875	-4.2879240	-0.7022859	2.256824	6.544114	0.0089813	0.4329466	ENSG00000120875	DUSP4	dual specificity phosphatase 4	8	29333064	29350684	protein_coding	HGNC:3070	1.2556790	-0.0029114	-2.8936142	0.7903767	1.6765274	1.2611493	-13.2877124	-1.9126458	-13.2877124	0.4893343	-0.3550067	0.1280710	-3.4965223	0.8537712
ENSG00000180340	0.4463139	1.6530780	5.224977	6.649921	0.0090446	0.4343440	ENSG00000180340	FZD2	frizzled class receptor 2	17	44557484	44561262	protein_coding	HGNC:4040	3.5485681	4.5425058	4.7975281	4.3893683	3.8464234	2.5193492	3.5151803	5.0744422	4.4280710	4.8784330	6.3752554	5.8128378	4.4736752	4.1139455
ENSG00000142794	0.4609106	-5.7259693	2.363369	6.540052	0.0091294	0.4350072	ENSG00000142794	NBPF3	NBPF member 3	1	21440128	21485005	protein_coding	HGNC:25076	0.7502206	1.2000077	1.4432496	2.1355533	-0.0746629	-13.2877124	2.8674913	1.8055814	-0.2030086	-13.2877124	-13.2877124	-13.2877124	1.9588286	1.0051010
ENSG00000270728	-1.8661523	-2.0992212	2.447685	6.215864	0.0091624	0.4350072	ENSG00000270728			1	19297080	19297903	transcribed_processed_pseudogene		5.9686025	4.8779778	3.8173691	3.9216520	4.9512447	5.8583326	2.3982168	3.4571552	3.0737233	3.0848878	2.7000006	2.9052415	3.0399339	5.1308590
ENSG00000165617	2.1225213	1.5324289	4.910288	6.623001	0.0091756	0.4350072	ENSG00000165617	DACT1	dishevelled binding antagonist of beta catenin 1	14	58633967	58648321	protein_coding	HGNC:17748	3.8161296	3.5651274	1.1743431	0.0798307	2.5717533	1.2854371	4.4726891	3.3944207	4.8653166	2.1506357	4.6599804	3.8934210	4.3661182	2.6483973
ENSG00000235176	-0.0743097	-7.0578021	3.293692	6.800589	0.0092081	0.4350072	ENSG00000235176	POLR1H	RNA polymerase I subunit H	HSCHR6_MHC_MANN_CTG1	1319656	1325658	protein_coding	HGNC:13182	2.8634875	2.2008919	1.4096462	2.1620611	1.9039958	1.0268985	2.3424617	2.6150393	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.9002288	2.0465923
ENSG00000100439	1.5065226	1.6118923	4.954499	6.615113	0.0092299	0.4350072	ENSG00000100439	ABHD4	abhydrolase domain containing 4, N-acyl phospholipase B	14	22598290	22612963	protein_coding	HGNC:20154	2.7445023	2.6609797	2.1250556	3.6533416	2.7339120	3.7694652	4.2211065	3.5250380	5.0375517	3.3575368	5.0010708	4.4016868	4.3924472	3.0663917
ENSG00000077380	-0.5075927	-1.7084999	4.878919	6.603404	0.0092650	0.4350446	ENSG00000077380	DYNC1I2	dynein cytoplasmic 1 intermediate chain 2	2	171687409	171750158	protein_coding	HGNC:2964	4.7098365	4.0831105	4.4452131	4.0544206	3.7626745	5.2583633	4.0956684	3.3051019	4.6650798	2.6067397	4.6946058	3.9993840	4.1251965	4.4742946
ENSG00000107731	2.0552159	2.3300445	6.015326	6.580191	0.0093728	0.4384054	ENSG00000107731	UNC5B	unc-5 netrin receptor B	10	71212570	71302864	protein_coding	HGNC:12568	2.4174081	4.0347209	0.7904067	1.4746909	0.1510223	0.4496575	3.1196173	3.7878912	5.1089029	3.4943912	5.3123192	4.6725464	4.2482570	2.2588566
ENSG00000184254	1.0587094	0.0549403	5.714488	6.567032	0.0094058	0.4384054	ENSG00000184254	ALDH1A3	aldehyde dehydrogenase 1 family member A3	15	100861924	100916626	protein_coding	HGNC:409	4.3615055	4.3804640	4.3447037	4.3243831	3.9611124	3.5752044	4.9953968	5.2220407	5.3026993	4.6940087	3.7946072	4.3132894	5.1791487	4.1862668
ENSG00000105664	3.7548329	-0.0893030	9.108648	6.544556	0.0094904	0.4404622	ENSG00000105664	COMP	cartilage oligomeric matrix protein	19	18782773	18791305	protein_coding	HGNC:2227	8.3310115	5.4621615	2.0974608	2.5579847	4.5747586	5.0820215	8.3376355	5.0838820	11.2511981	4.4322155	7.0330404	6.2531773	9.8636383	6.1765079
ENSG00000270890	1.2663808	0.5741130	3.604248	6.500097	0.0095205	0.4404622	ENSG00000270890			6	143858062	143858689	processed_pseudogene		4.7459005	4.2410782	5.0913668	5.2214209	4.2696355	5.1512496	5.3087861	6.1085017	6.1340795	5.1070197	5.5338753	5.3361773	5.8977995	4.8410316
ENSG00000151881	0.1016252	1.8183292	2.368624	5.994369	0.0095770	0.4404622	ENSG00000151881	TMEM267	transmembrane protein 267	5	43444252	43483893	protein_coding	HGNC:26139	-1.3730544	0.1277521	2.6550383	1.4136520	1.2463302	3.1846748	1.6093725	0.0500182	1.4799072	4.6783222	2.5836714	3.9818104	1.1965605	1.8683087
ENSG00000164430	1.6838870	1.9064305	2.521153	5.935403	0.0096233	0.4404622	ENSG00000164430	CGAS	cyclic GMP-AMP synthase	6	73413515	73452297	protein_coding	HGNC:21367	-0.2917668	0.4560975	1.1114260	1.1601089	-0.7465601	1.3591000	1.4697927	0.5477469	2.5488913	1.4150896	3.9737124	3.1998972	1.7489571	0.6997497
ENSG00000161939	1.8815562	1.4797328	3.362836	6.312090	0.0096236	0.4404622	ENSG00000161939	RNASEK-C17orf49		17	7012635	7017520	protein_coding	HGNC:44419	2.6434450	4.1542855	2.6399323	2.2352764	-13.2877124	1.0364583	5.0235664	4.3345953	3.7621801	4.0669045	4.1872840	4.1283495	4.4653608	2.6263216
ENSG00000100568	0.7681081	0.5119051	6.511402	6.499674	0.0097227	0.4433952	ENSG00000100568	VTI1B	vesicle transport through interaction with t-SNAREs 1B	14	67647085	67674820	protein_coding	HGNC:17793	4.6934637	4.7718484	4.2596535	4.1401925	4.5199214	4.6498552	5.0884348	4.7313740	5.0706671	4.8488303	5.1819919	5.0250071	4.9725838	4.5238542
ENSG00000172830	-1.2220678	-0.0194071	3.848018	6.500748	0.0098490	0.4438855	ENSG00000172830	SSH3	slingshot protein phosphatase 3	11	67303478	67312607	protein_coding	HGNC:30581	2.9313990	4.7945852	3.1459396	3.9933349	4.6588532	3.4556509	2.7513116	1.2402862	2.4531072	2.6150787	3.7255803	3.2746411	2.2801335	4.0058799
ENSG00000253485	1.2261646	2.8620085	2.515819	5.822519	0.0098549	0.4438855	ENSG00000253485	PCDHGA5	protocadherin gamma subfamily A, 5	5	141364162	141512975	protein_coding	HGNC:8703	-13.2877124	-0.0827623	-0.8536550	-13.2877124	0.1487897	-13.2877124	-13.2877124	1.7997824	-0.2697905	2.4282290	1.7104430	2.1135232	0.5231323	-1.2028110
ENSG00000118849	2.0322881	1.9929030	2.930983	6.012887	0.0098745	0.4438855	ENSG00000118849	RARRES1	retinoic acid receptor responder 1	3	158696892	158732489	protein_coding	HGNC:9867	-13.2877124	0.0619227	3.0374428	-13.2877124	2.8540381	1.8957071	2.9127501	3.6047749	3.6055982	4.7097562	3.1544205	4.1322577	3.4091343	1.7517251
ENSG00000113916	-1.2271612	-1.0450295	4.470514	6.488708	0.0098795	0.4438855	ENSG00000113916	BCL6	BCL6 transcription repressor	3	187721377	187745725	protein_coding	HGNC:1001	3.6224312	3.5908294	4.3426859	5.3493021	3.1247344	3.5191833	2.7420849	2.7699860	1.5633300	2.9870860	2.8063022	2.8995241	2.4565197	4.1376170
ENSG00000196739	0.3134777	1.4409239	3.948477	6.471226	0.0099085	0.4438855	ENSG00000196739	COL27A1	collagen type XXVII alpha 1 chain	9	114155537	114312511	protein_coding	HGNC:22986	2.1147681	1.2011433	1.0748267	1.5420391	0.9764282	0.7472043	2.1431357	1.8482658	2.3130113	2.9243802	2.2756463	2.6361745	2.1140421	1.3500327

We can also make each comparison individually

outPath = "output/fibroblast/DEG"
Test = "FB.SCN2A.vs.WT"
qlf = glmQLFTest(fit, coef=2)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0    19   159
## NotSig  12675 12675 12671 12614 12276
## Up          3     3     7    45   243

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("SCN2A", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

SCN2AUp = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
SCN2ADown = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "FB.CHD2.vs.WT"
qlf = glmQLFTest(fit, coef=3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0     1    53
## NotSig  12677 12676 12674 12668 12483
## Up          1     2     4     9   142

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("CHD2", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

CHD2Up = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
CHD2Down = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "FB"
venn.diagram(list(CHD2 = CHD2Up, SCN2A = SCN2AUp), filename = paste(outPath,ExperimentName,Test,"up.png", sep="."), imagetype = "png", main = paste(Test, "up regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

venn.diagram(list(CHD2 = CHD2Down, SCN2A = SCN2ADown), filename = paste(outPath,ExperimentName,Test,"down.png", sep="."), imagetype = "png", main = paste(Test, "down regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

SCN2AUp.FB = SCN2AUp
SCN2ADown.FB = SCN2ADown
CHD2Up.FB = CHD2Up
CHD2Down.FB = CHD2Down

Venn diagram up regulated

Venn diagram down regulated

Note:

1b. Day 10

Test the differences between WT, SCN2A and CHD2 at day 10 of transdifferentiation

fit = test_a_diff_state(diffState = "day_10", countTable = counts.current)
qlf = glmQLFTest(fit, coef=2:3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## NotSig  13417 13416 13416 13406 13190
## Sig         0     1     1    11   227

d10.genes.expressed = rownames(qlf$table)
attach_annotations_by_p(qlf, 0.01) %>%
  kbl() %>%
  kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
  scroll_box(width = "100%", height = "300px")

	logFC.fSCN2A	logFC.fCHD2	logCPM	F	PValue	FDR	ensembl_gene_id	hgnc_symbol	entrezgene_description	chromosome_name	start_position	end_position	gene_biotype	hgnc_id	CON_1_d10	CON_2_d10	CON_3_d10	CON_4_d10	SCN2A_1_d10	SCN2A_2_d10	SCN2A_3_d10	CHD2_1_d10	CHD2_2_d10	CHD2	SCN2A	WT
ENSG00000205670	1.1109690	-2.8670979	5.111151	56.216825	0.0000007	0.0096303	ENSG00000205670	SMIM11	small integral membrane protein 11	21	34375480	34416961	protein_coding	HGNC:1293	1.7279004	1.8757907	2.3472333	2.6248601	3.4989420	3.2143996	3.1711564	-0.2125826	-0.9589814	-0.5380409	3.3023126	2.1889706
ENSG00000145423	1.6377410	-3.9650408	4.829294	30.689430	0.0000113	0.0744249	ENSG00000145423	SFRP2	secreted frizzled related protein 2	4	153780591	153789083	protein_coding	HGNC:10777	2.8385954	1.9235029	3.3462642	3.5103637	4.8870347	3.7472545	5.2329475	-0.3310041	-2.5659723	-1.0531075	4.7482138	3.0229027
ENSG00000167654	-1.8586439	-4.4124957	3.351054	27.201655	0.0000166	0.0744249	ENSG00000167654	ATCAY	ATCAY kinesin light chain interacting caytaxin	19	3879864	3928082	protein_coding	HGNC:779	1.2929837	1.5053285	1.7844562	1.0400269	-0.2760868	-0.2171520	0.0090848	-2.6193858	-2.4218631	-2.5172467	-0.1560660	1.4316748
ENSG00000274803	-4.7279520	-8.5497244	3.297805	22.596314	0.0000329	0.1102878	ENSG00000274803	BDP1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	HSCHR5_1_CTG1_1	985599	1097795	protein_coding	HGNC:13652	0.8649211	-0.2879325	1.9532470	-0.1561801	-13.2877124	-0.7935493	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-2.3780120	0.8895055
ENSG00000168280	-1.6429411	-3.1411079	4.864263	24.751557	0.0000532	0.1427689	ENSG00000168280	KIF5C	kinesin family member 5C	2	148875227	149026759	protein_coding	HGNC:6325	2.5084451	2.4759292	2.9638224	2.1493872	1.6612128	-0.0883897	0.7404112	0.0756805	1.6581863	1.0738381	0.9446201	2.5540728
ENSG00000228299	9.2721868	7.0535966	5.991991	21.269655	0.0000892	0.1824389	ENSG00000228299	HLA-C	major histocompatibility complex, class I, C	HSCHR6_MHC_DBB_CTG1	2526549	2529920	protein_coding	HGNC:4933	-13.2877124	-13.2877124	-0.7530836	-13.2877124	5.2226331	7.0679616	7.6151456	6.1786337	-13.2877124	5.1786357	6.9369237	-2.7523544
ENSG00000254245	-0.8293449	1.8080382	4.565303	21.912353	0.0000969	0.1824389	ENSG00000254245	PCDHGA3	protocadherin gamma subfamily A, 3	5	141343829	141512975	protein_coding	HGNC:8701	2.0890106	2.2563788	2.0353779	0.6936560	2.0619932	0.5106885	1.1658566	3.6409081	2.6946877	3.2440209	1.3866311	1.8825597
ENSG00000242265	1.0532422	-2.0926882	5.210991	21.284756	0.0001088	0.1824389	ENSG00000242265	PEG10	paternally expressed 10	7	94656325	94669695	protein_coding	HGNC:14005	4.0088744	2.0018033	2.2697546	3.5097194	4.5132524	3.6865599	4.3025930	0.3319734	-0.6381957	-0.0730518	4.2080361	3.1825463
ENSG00000104332	-1.0134353	-3.1659616	5.700179	20.487815	0.0001296	0.1932381	ENSG00000104332	SFRP1	secreted frizzled related protein 1	8	41261962	41309473	protein_coding	HGNC:10776	3.9264478	3.4237250	3.4913146	4.3097311	2.3617981	2.7371009	3.4832480	1.2789363	-0.3836743	0.6749505	2.9380032	3.8332253
ENSG00000169432	-1.9965164	-4.1318240	2.730590	17.197044	0.0001503	0.1953724	ENSG00000169432	SCN9A	sodium voltage-gated channel alpha subunit 9	2	166195185	166376001	protein_coding	HGNC:10597	0.8072428	0.9149257	0.8664364	-0.4965332	-0.9351668	-1.0184629	0.2491565	-2.8731434	-0.1636670	-0.9584178	-0.4440949	0.6246386
ENSG00000165507	0.9894895	2.1080638	6.627775	19.536910	0.0001602	0.1953724	ENSG00000165507	DEPP1	DEPP autophagy regulator 1	10	44970981	44978809	protein_coding	HGNC:23355	5.3448830	4.6217167	4.3611750	5.1185411	6.3556513	5.9077408	6.6080715	7.6372956	6.5798852	7.2033740	6.3187839	4.9135204
ENSG00000115648	0.6637055	2.8296577	4.787978	19.148913	0.0001816	0.2030415	ENSG00000115648	MLPH	melanophilin	2	237485428	237555322	protein_coding	HGNC:29643	2.7780062	1.7881357	0.1319937	3.8152768	3.2319968	3.4589770	2.2336810	5.6774482	4.7123012	5.2741222	3.0643962	2.6716111
ENSG00000283589	4.2431217	1.1638787	2.686979	13.899336	0.0002423	0.2500604	ENSG00000283589	GOLGA8N	golgin A8 family member N	HSCHR15_6_CTG8	2111786	2125658	protein_coding	HGNC:44405	-1.7461172	-13.2877124	-13.2877124	-2.7816429	1.5893800	-0.4985191	1.8194708	-1.3659793	-1.4289970	-1.3971441	1.2723318	-3.1722486
ENSG00000204469	-8.1719015	-10.3683092	4.991044	18.617891	0.0003142	0.3011576	ENSG00000204469	PRRC2A	proline rich coiled-coil 2A	6	31620715	31637771	protein_coding	HGNC:13918	4.1279226	3.4733313	-2.1966473	2.8831107	-1.0479587	-13.2877124	-3.0299121	-13.2877124	-13.2877124	-13.2877124	-2.3071279	3.1773411
ENSG00000137801	0.0262683	-2.5596675	7.996566	16.415296	0.0003523	0.3150825	ENSG00000137801	THBS1	thrombospondin 1	15	39581079	39599466	protein_coding	HGNC:11785	5.6404140	4.9126265	5.6298109	5.8846672	6.1183209	5.6366534	5.5489828	4.2539723	3.5298584	3.9368772	5.7904144	5.5591767
ENSG00000115596	0.8455571	4.1873444	1.683187	11.552663	0.0004815	0.4037877	ENSG00000115596	WNT6	Wnt family member 6	2	218859805	218874233	protein_coding	HGNC:12785	-13.2877124	-1.6824875	-1.0461373	-13.2877124	-13.2877124	-0.1101169	-1.8813426	2.5981708	1.3846074	2.1153985	-1.3242816	-2.3291452
ENSG00000165973	0.8718048	4.7395410	2.035979	11.162162	0.0005796	0.4314633	ENSG00000165973	NELL1	neural EGFL like 1	11	20669551	21575686	protein_coding	HGNC:7750	-13.2877124	-1.2367924	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-0.5197742	1.4369406	2.1892252	1.8615715	-2.1043233	-3.2357721
ENSG00000205213	-0.6779152	-3.0626138	3.798560	14.422854	0.0005923	0.4314633	ENSG00000205213	LGR4	leucine rich repeat containing G protein-coupled receptor 4	11	27365961	27472790	protein_coding	HGNC:13299	4.5831596	2.9476684	1.4511721	1.1961544	1.2998448	-0.0778052	1.3663502	-1.3449047	-1.7428300	-1.5301911	0.9970387	3.1981256
ENSG00000017483	0.8104196	3.0098249	4.234887	14.561185	0.0006110	0.4314633	ENSG00000017483	SLC38A5	solute carrier family 38 member 5	X	48458537	48470260	protein_coding	HGNC:18070	3.5926969	1.1643023	0.0294656	2.7056367	3.8544549	4.5717265	2.2958934	5.1962599	5.8797335	5.5780980	3.8465268	2.4495511
ENSG00000118971	0.1210536	-1.9403977	6.479976	14.218537	0.0006583	0.4416314	ENSG00000118971	CCND2	cyclin D2	12	4269771	4305353	protein_coding	HGNC:1583	3.4159502	3.1812467	3.1329181	4.3220903	3.8280078	3.6640953	4.0309842	1.4934665	1.8364025	1.6751001	3.8488581	3.6004674
ENSG00000160111	0.3052606	3.0614858	2.354876	11.832118	0.0007427	0.4425982	ENSG00000160111	CPAMD8	C3 and PZP like alpha-2-macroglobulin domain containing 8	19	16892951	17026815	protein_coding	HGNC:23228	0.4516052	-1.8298698	-2.1918605	-13.2877124	-0.3429875	0.5032999	-2.0285046	2.2223038	1.8132374	2.0322208	-0.2916109	-1.0986446
ENSG00000197467	-0.9520930	1.5497010	3.663131	13.800174	0.0007505	0.4425982	ENSG00000197467	COL13A1	collagen type XIII alpha 1 chain	10	69801880	69964275	protein_coding	HGNC:2190	1.8695990	1.3102214	-0.0271442	2.1972864	2.1202998	0.3796786	0.9394523	3.5343155	3.1617760	3.3600374	1.3347010	1.5486374
ENSG00000105825	1.3037831	-1.6871851	6.079915	13.357398	0.0008589	0.4425982	ENSG00000105825	TFPI2	tissue factor pathway inhibitor 2	7	93885396	93890753	protein_coding	HGNC:11761	5.1378723	4.1513688	3.2912051	5.3712959	6.2995564	5.5501518	6.5037886	2.6405834	3.4846938	3.1235131	6.1724099	4.7026674
ENSG00000168237	0.3335141	-3.7780785	6.694987	13.137480	0.0009231	0.4425982	ENSG00000168237	GLYCTK	glycerate kinase	3	52287089	52295257	protein_coding	HGNC:24247	5.1591939	3.3703807	6.8853731	5.5198300	5.2560339	6.2449395	6.6139252	2.4300960	2.0284599	2.2432096	6.1429824	5.7154777
ENSG00000154258	-0.0559019	-7.6200980	3.139800	13.885999	0.0009744	0.4425982	ENSG00000154258	ABCA9	ATP binding cassette subfamily A member 9	17	68974488	69060949	protein_coding	HGNC:39	2.4871804	-0.0475367	1.0178934	1.4121230	0.2108464	0.3432964	0.7537688	-13.2877124	-13.2877124	-13.2877124	0.4549518	1.4932174
ENSG00000008394	0.6284339	-5.4315692	3.442209	12.893930	0.0009859	0.4425982	ENSG00000008394	MGST1	microsomal glutathione S-transferase 1	12	16347142	16609259	protein_coding	HGNC:7061	3.7723263	1.4563178	4.5962984	3.7300340	5.1762131	3.6014976	4.2881949	-1.2645887	-13.2877124	-2.2642422	4.4989605	3.7513296
ENSG00000234046	0.0000000	8.4968005	2.379406	21.237015	0.0009883	0.4425982	ENSG00000234046	TRIM26	tripartite motif containing 26	HSCHR6_MHC_SSTO_CTG1	1483342	1512318	protein_coding	HGNC:12962	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.9744884	2.4452105	2.7339864	-13.2877124	-13.2877124
ENSG00000007384	0.2192033	1.8962821	5.188225	12.871332	0.0010067	0.4425982	ENSG00000007384	RHBDF1	rhomboid 5 homolog 1	16	58059	76355	protein_coding	HGNC:20561	4.9570674	3.7113923	2.5766701	2.4842116	4.2122701	3.2420682	3.4755852	4.7677630	4.9206257	4.8462180	3.7049273	3.8001679
ENSG00000160200	1.9484898	-0.9846753	3.615289	12.758616	0.0010308	0.4425982	ENSG00000160200	CBS	cystathionine beta-synthase	21	43053191	43076943	protein_coding	HGNC:1550	3.9703794	2.3958385	0.0652359	2.2395700	2.9207704	3.2374290	3.7355614	2.4681800	2.0895490	2.2912505	3.3374250	2.7391188
ENSG00000188833	0.6340263	2.4783781	3.419000	12.679238	0.0010528	0.4425982	ENSG00000188833	ENTPD8	ectonucleoside triphosphate diphosphohydrolase 8	9	137434364	137441816	protein_coding	HGNC:24860	0.2863785	1.4036086	0.7689346	-0.3079800	1.9039938	1.6627073	0.8143765	2.6349011	3.9332913	3.4254825	1.5305897	0.6728743
ENSG00000132821	-2.3442558	-1.5482852	2.992106	12.153052	0.0010832	0.4425982	ENSG00000132821	VSTM2L	V-set and transmembrane domain containing 2 like	20	37903111	37945350	protein_coding	HGNC:16096	2.7550230	2.8443157	3.6772428	2.2900186	1.7292386	0.0115772	1.5976041	2.0208172	1.2625089	1.6909226	1.2927794	2.9825627
ENSG00000183311	-3.6059940	-3.9556202	2.433442	10.300078	0.0011152	0.4425982	ENSG00000183311	TUBB	tubulin beta class I	HSCHR6_MHC_QBL_CTG1	1975313	1980539	protein_coding	HGNC:20778	2.1071793	1.7161279	0.7357301	1.0468032	-13.2877124	-0.6001464	-13.2877124	-1.5406313	-13.2877124	-2.5402117	-2.1846718	1.5014649
ENSG00000232653	-2.5575513	-0.0982507	3.450142	11.940580	0.0011666	0.4425982	ENSG00000232653	GOLGA8N	golgin A8 family member N	15	32593456	32607310	protein_coding	HGNC:44405	1.7567492	0.7788982	1.9097074	3.4515226	1.4031597	-0.1496838	0.3535480	2.6452172	2.6542463	2.6497389	0.6852522	2.3068723
ENSG00000158270	-0.6127930	-1.7261682	5.876244	12.374673	0.0011751	0.4425982	ENSG00000158270	COLEC12	collectin subfamily member 12	18	316737	500722	protein_coding	HGNC:16016	3.0665532	3.1031770	4.0745003	3.8280717	3.5029646	2.5243757	3.3274172	2.0994544	1.7926309	1.9541840	3.1767667	3.5855999
ENSG00000233564	-1.6094214	-4.8442323	4.305777	11.791539	0.0011838	0.4425982	ENSG00000233564	PRR3	proline rich 3	HSCHR6_MHC_MCF_CTG1	1900932	1907769	protein_coding	HGNC:21149	3.0561978	4.1797210	3.8454717	3.6660564	-13.2877124	3.6966496	2.4390385	2.5500651	2.6242862	2.5876530	2.6157925	3.7417115
ENSG00000206406	-2.2030896	3.3228046	2.682846	10.606853	0.0012292	0.4425982	ENSG00000206406	CSNK2B	casein kinase 2 beta	HSCHR6_MHC_QBL_CTG1	2921060	2929370	protein_coding	HGNC:2460	-13.2877124	-13.2877124	3.2513866	-13.2877124	-0.1222212	-0.4761530	-13.2877124	3.6229141	4.9455371	4.4307654	-0.8732351	1.2514321
ENSG00000179431	-0.7258902	-2.0518807	4.075301	12.209142	0.0012620	0.4425982	ENSG00000179431	FJX1	four-jointed box kinase 1	11	35618460	35620865	protein_coding	HGNC:17166	2.6575611	3.0514170	2.6887616	3.2933334	2.4390912	2.4732648	2.7955542	0.9181702	0.9052746	0.9117368	2.5784531	2.9472575
ENSG00000225164	0.0000000	9.5098889	3.256448	19.124772	0.0013538	0.4425982	ENSG00000225164	PRRC2A	proline rich coiled-coil 2A	HSCHR6_MHC_COX_CTG1	3098008	3115058	protein_coding	HGNC:13918	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-0.9577843	3.0201178	2.1088897	-13.2877124	-13.2877124
ENSG00000131969	3.4620508	2.9384847	2.212305	9.908798	0.0013759	0.4425982	ENSG00000131969	ABHD12B	abhydrolase domain containing 12B	14	50872053	50904970	protein_coding	HGNC:19837	-13.2877124	-0.5487546	-1.6944146	-0.3734338	-0.0329332	2.1736900	3.3812698	1.4594122	0.9845456	1.2414293	2.4068171	-1.1806320
ENSG00000111203	2.0252827	1.0617995	3.849232	11.889978	0.0014008	0.4425982	ENSG00000111203	ITFG2	integrin alpha FG-GAP repeat containing 2	12	2812622	2859791	protein_coding	HGNC:30879	2.7923000	1.6070239	2.6607938	1.0588665	3.0775479	4.2321180	4.5872816	3.0355227	2.5246913	2.8025994	4.0951740	2.2001170
ENSG00000138080	-0.3085759	0.9234370	6.803911	11.835285	0.0014050	0.4425982	ENSG00000138080	EMILIN1	elastin microfibril interfacer 1	2	27078615	27086403	protein_coding	HGNC:19880	4.3117245	4.5669276	4.2886445	3.9048330	4.2237666	4.0446854	4.3756133	5.3180839	5.2273308	5.2734208	4.2210016	4.2869440
ENSG00000104903	-3.3250628	-1.1489643	2.511549	10.305493	0.0014055	0.4425982	ENSG00000104903	LYL1	LYL1 basic helix-loop-helix family member	19	13099033	13103161	protein_coding	HGNC:6734	2.9827813	0.8206773	2.3196176	2.3912148	-0.5989048	-0.9288442	-1.6342716	1.6997897	0.2398159	1.1471041	-0.9926446	2.3153713
ENSG00000137959	-3.7493182	0.2584196	3.807364	10.692692	0.0014185	0.4425982	ENSG00000137959	IFI44L	interferon induced protein 44 like	1	78619902	78646145	protein_coding	HGNC:17817	1.7298025	2.2748130	2.9152723	2.6758629	-2.5287147	-3.8546069	-1.4952840	-1.1490630	2.9017418	1.9862651	-2.3288429	2.4653268
ENSG00000284254	-7.4811554	-0.5334848	2.701008	13.242396	0.0015294	0.4458292	ENSG00000284254	HNRNPH1	heterogeneous nuclear ribonucleoprotein H1	HG30_PATCH	380457	401011	protein_coding	HGNC:5041	3.0319109	1.1206134	3.3655159	2.0891293	-13.2877124	-13.2877124	-13.2877124	2.2586082	1.8542909	2.0705672	-13.2877124	2.6389408
ENSG00000176788	0.1613143	-1.3599672	7.307437	11.566388	0.0015398	0.4458292	ENSG00000176788	BASP1	brain abundant membrane attached signal protein 1	5	17065598	17276843	protein_coding	HGNC:957	5.8035074	6.0800619	6.7326703	6.8156881	6.7469077	6.4201068	6.9583196	4.9973049	5.1343036	5.0674296	6.7251635	6.4199656
ENSG00000092969	-0.2834416	-1.4033315	6.371103	11.542649	0.0015533	0.4458292	ENSG00000092969	TGFB2	transforming growth factor beta 2	1	218345336	218444619	protein_coding	HGNC:11768	3.7968237	3.6734049	3.5328547	3.9740996	3.4259394	3.5007973	3.8386479	2.6646917	2.0077222	2.3732843	3.5998940	3.7534566
ENSG00000179862	2.2349505	3.7131524	2.067125	9.538592	0.0015626	0.4458292	ENSG00000179862	CITED4	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4	1	40861054	40862363	protein_coding	HGNC:18696	-1.8995767	-1.2143842	-13.2877124	0.2570867	0.2725548	1.5266017	1.5862527	1.7661346	3.1952569	2.6508608	1.2411676	-1.0784555
ENSG00000138744	0.7233345	2.3220666	2.700407	10.969078	0.0016308	0.4458292	ENSG00000138744	NAAA	N-acylethanolamine acid amidase	4	75910655	75941013	protein_coding	HGNC:736	0.9577222	0.9774074	-0.5936549	0.2790754	1.6219862	3.3412615	2.3761467	3.2666170	2.9703849	3.1260909	2.6170147	0.5328765
ENSG00000112246	1.1429846	1.6317212	5.093223	11.403473	0.0016422	0.4458292	ENSG00000112246	SIM1	SIM bHLH transcription factor 1	6	100385009	100464921	protein_coding	HGNC:10882	0.6727892	1.4008822	1.3227911	2.3554956	2.6243665	2.2124710	2.9492342	2.9156320	3.1835241	3.0557872	2.6263775	1.5672991
ENSG00000168497	-0.3204066	3.0347842	2.927116	10.483066	0.0016614	0.4458292	ENSG00000168497	CAVIN2	caveolae associated protein 2	2	191834310	191847088	protein_coding	HGNC:10690	-13.2877124	-0.3005248	0.4745991	-0.7300237	-0.3982655	-2.0476903	-0.2362366	3.3873086	0.3313819	2.5511255	-0.6977507	-0.5122651
ENSG00000101445	1.5181257	2.0209976	5.213237	11.244765	0.0017377	0.4537567	ENSG00000101445	PPP1R16B	protein phosphatase 1 regulatory subunit 16B	20	38805697	38923024	protein_coding	HGNC:15850	1.0125823	1.7832249	0.0368943	-0.1315835	2.3051992	2.6870761	2.7892600	3.0319066	2.9835163	3.0079143	2.6084289	0.8871735
ENSG00000147488	-1.8282392	-3.6916631	4.236861	11.114090	0.0017586	0.4537567	ENSG00000147488	ST18	ST18 C2H2C-type zinc finger transcription factor	8	52110838	52460959	protein_coding	HGNC:18695	2.3873545	2.1949229	3.8728472	2.6590788	2.3814310	-0.2480205	2.1797910	0.2758748	-0.6232540	-0.1047493	1.8187774	2.9437857
ENSG00000172803	1.0927335	-0.3294587	5.663963	11.068735	0.0018360	0.4571760	ENSG00000172803	SNX32	sorting nexin 32	11	65833834	65856896	protein_coding	HGNC:26423	3.1856533	4.0130983	4.0857160	3.9391584	4.9308100	5.0048908	5.1543785	3.8681000	2.9787991	3.4909141	5.0330463	3.8470769
ENSG00000224552	-5.2752805	-7.8924466	2.709324	11.232758	0.0018602	0.4571760	ENSG00000224552	ABHD16A	abhydrolase domain containing 16A, phospholipase	HSCHR6_MHC_MANN_CTG1	2991996	3008464	protein_coding	HGNC:13921	3.2971644	3.6871195	-13.2877124	3.2751315	-13.2877124	-0.1601113	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-1.7447516	3.0175334
ENSG00000109610	2.4180852	-1.6293247	2.353499	9.677085	0.0018741	0.4571760	ENSG00000109610	SOD3	superoxide dismutase 3	4	24789912	24800842	protein_coding	HGNC:11181	0.5536200	-0.0237610	0.2901519	0.1267681	2.7263129	0.8109744	3.7405501	0.4679044	-13.2877124	-0.5319913	2.8572193	0.2527919
ENSG00000127533	-0.8207226	2.4328472	2.812399	10.019559	0.0020695	0.4746968	ENSG00000127533	F2RL3	F2R like thrombin or trypsin receptor 3	19	16888999	16892606	protein_coding	HGNC:3540	-1.9260537	0.9304126	-1.6012863	-2.9306333	-1.9217509	-0.4424184	-1.4379085	1.6670819	2.4273203	2.0967088	-1.1319075	-0.6050967
ENSG00000196497	-0.8173209	-3.9896520	3.696830	10.251188	0.0021108	0.4746968	ENSG00000196497	IPO4	importin 4	14	24180219	24188869	protein_coding	HGNC:19426	3.3215385	2.5277064	1.8369700	3.6895111	3.2471125	4.2075146	4.0326916	0.6515665	1.8076958	1.3424694	3.8854603	3.0107050
ENSG00000100156	0.1492725	2.2287968	2.448703	10.007818	0.0021143	0.4746968	ENSG00000100156	SLC16A8	solute carrier family 16 member 8	22	38078134	38084184	protein_coding	HGNC:16270	0.0662049	0.2544223	0.7898511	1.0572832	1.1994299	0.3254371	1.5524051	2.7696482	2.7009164	2.7356916	1.1116076	0.5968693
ENSG00000085365	1.1029400	0.6018600	5.719130	10.672264	0.0021160	0.4746968	ENSG00000085365	SCAMP1	secretory carrier membrane protein 1	5	78360611	78480739	protein_coding	HGNC:10563	2.9002686	2.5603853	2.1300429	2.0289061	3.5616442	3.1990570	3.2831090	2.8789803	2.7692362	2.8251516	3.3564115	2.4477487
ENSG00000134864	0.1187021	1.2949094	6.972478	10.649097	0.0021302	0.4746968	ENSG00000134864	GGACT	gamma-glutamylamine cyclotransferase	13	100530164	100589528	protein_coding	HGNC:25100	4.7324255	4.5462905	5.2670380	5.0913667	5.1820154	4.9741292	5.0385688	6.7495348	5.4892656	6.2528490	5.0675424	4.9371904
ENSG00000156299	2.0587175	-0.4450971	2.695254	10.202559	0.0021582	0.4746968	ENSG00000156299	TIAM1	TIAM Rac1 associated GEF 1	21	31118416	31559977	protein_coding	HGNC:11805	-0.2541311	-2.1038723	-1.0897033	-1.4186623	0.1355716	2.1644899	2.3621495	-1.4454799	-1.7387460	-1.5846740	1.8376695	-1.0626240
ENSG00000144355	-4.0365073	-4.9222596	3.267762	9.033314	0.0021966	0.4753542	ENSG00000144355	DLX1	distal-less homeobox 1	2	172084740	172089677	protein_coding	HGNC:2914	3.0216403	-0.5274207	5.1540587	2.0795672	-13.2877124	2.2421506	-13.2877124	0.7277436	-13.2877124	-0.2721693	0.6572492	3.6043013
ENSG00000157087	-0.5043753	-2.2337715	4.715261	10.509342	0.0022629	0.4819212	ENSG00000157087	ATP2B2	ATPase plasma membrane Ca2+ transporting 2	3	10324023	10708007	protein_coding	HGNC:815	1.0712272	2.5572912	2.4194588	2.5081817	1.4092302	1.9020002	2.4501922	-0.5940512	1.3197069	0.6593008	1.9828450	2.2498976
ENSG00000185567	-0.7401934	0.4010970	7.041804	10.314589	0.0024082	0.4847097	ENSG00000185567	AHNAK2	AHNAK nucleoprotein 2	14	104937244	104978374	protein_coding	HGNC:20125	4.8392513	4.3175386	4.4160214	3.3841410	3.6880512	3.3047937	3.8281415	4.9904458	4.5429871	4.7839951	3.6234748	4.3282929
ENSG00000156535	-0.3727370	-1.4097313	4.924772	10.306773	0.0024282	0.4847097	ENSG00000156535	CD109	CD109 molecule	6	73695785	73828316	protein_coding	HGNC:21685	1.8103933	1.3090621	1.8251954	1.5185986	1.6410040	1.1888313	1.2870768	0.4033528	0.0647711	0.2439725	1.3856773	1.6315537
ENSG00000106070	-0.0556769	-2.0774939	3.930836	10.311762	0.0024344	0.4847097	ENSG00000106070	GRB10	growth factor receptor bound protein 10	7	50590063	50793462	protein_coding	HGNC:4564	2.0080691	2.9010731	1.1806348	2.4004267	1.0886023	2.5079593	1.5374238	0.1787758	0.4167241	0.3026501	1.8369453	2.2508564
ENSG00000070182	1.0047520	0.4675623	7.701029	10.272457	0.0024458	0.4847097	ENSG00000070182	SPTB	spectrin beta, erythrocytic	14	64746283	64879907	protein_coding	HGNC:11274	3.4098104	3.8632184	4.0110886	3.9612146	5.1080568	4.7535721	5.0061456	4.4226294	4.2329124	4.3308875	4.9634866	3.8298465
ENSG00000185008	-4.0504021	-2.3216673	3.194014	9.115677	0.0024566	0.4847097	ENSG00000185008	ROBO2	roundabout guidance receptor 2	3	75906695	77649964	protein_coding	HGNC:10250	-0.0104468	0.2729488	3.7566430	-0.3918645	-13.2877124	-1.2811444	-1.5631090	-0.6933388	-1.1282100	-0.8944506	-2.0000190	2.0426129
ENSG00000187244	-1.3307511	0.9282443	4.471305	10.218380	0.0025337	0.4876006	ENSG00000187244	BCAM	basal cell adhesion molecule (Lutheran blood group)	19	44809071	44821421	protein_coding	HGNC:6722	2.8482223	3.2440472	3.1977398	1.2039453	1.5366706	1.7608120	2.5502304	4.3361799	4.5188857	4.4304231	2.0176141	2.8152934
ENSG00000095303	-1.3151250	1.2854696	3.827693	10.171468	0.0025439	0.4876006	ENSG00000095303	PTGS1	prostaglandin-endoperoxide synthase 1	9	122370530	122395703	protein_coding	HGNC:9604	1.6795526	2.7398511	0.8898504	-0.9132923	1.2919477	-0.5378890	1.1850997	3.0977101	3.1968844	3.1481493	0.8509738	1.6167407
ENSG00000225972	5.3153463	0.4829493	7.173928	10.037479	0.0027120	0.4920083	ENSG00000225972	MTND1P23		1	629062	629433	unprocessed_pseudogene	HGNC:42092	6.5295148	3.8804919	5.7801248	6.4314709	6.5267854	4.8917045	12.9285377	6.6509177	6.1047169	6.4035132	11.3659572	5.9563604
ENSG00000161981	0.3981785	1.3846059	4.422801	10.012696	0.0027327	0.4920083	ENSG00000161981	SNRNP25	small nuclear ribonucleoprotein U11/U12 subunit 25	16	53828	57669	protein_coding	HGNC:14161	3.4204968	3.3191257	2.8046236	2.8251779	3.5071650	3.5444692	4.5905626	4.7168409	4.3163367	4.5304423	3.9736495	3.1194174
ENSG00000276561	-4.2075758	-1.7310106	2.543450	8.998290	0.0027345	0.4920083	ENSG00000276561	IRF7	interferon regulatory factor 7	HSCHR11_1_CTG8	142446	145898	protein_coding	HGNC:6122	3.4605077	0.8661404	3.4017038	3.4440725	-13.2877124	-0.8070004	-0.1140852	1.7661198	-0.0409703	1.1287487	-1.0042023	3.0994231
ENSG00000250492	-0.7464510	2.0473500	2.895811	9.575361	0.0027882	0.4920083	ENSG00000250492	INTS6P1		5	39718984	39721513	processed_pseudogene	HGNC:43921	0.6914413	0.5845825	0.1224806	0.1542643	-2.4193914	0.9520346	-1.5207736	1.8663027	2.9768147	2.5258723	-0.2804322	0.4103302
ENSG00000171532	-0.9919058	-2.3233557	3.913187	9.953453	0.0027930	0.4920083	ENSG00000171532	NEUROD2	neuronal differentiation 2	17	39603536	39609777	protein_coding	HGNC:7763	1.7029966	2.9472135	2.6185474	1.7324203	1.5400615	1.8806409	1.3806203	0.4962547	-1.5444810	-0.1898728	1.6157708	2.3527944
ENSG00000067798	0.4207731	-2.7030185	3.642499	9.718523	0.0028685	0.4920083	ENSG00000067798	NAV3	neuron navigator 3	12	77324641	78213010	protein_coding	HGNC:15998	2.3957053	-0.2215929	3.4456540	0.4742024	2.6657614	1.3733943	3.0778210	0.0151807	-2.2821299	-0.7176527	2.5343769	2.2019914
ENSG00000133110	0.5475309	-2.2669504	9.136463	9.843072	0.0028748	0.4920083	ENSG00000133110	POSTN	periostin	13	37562583	37598844	protein_coding	HGNC:16953	8.2441975	6.0771403	7.1872100	6.1845473	7.1009990	7.7770051	8.4469458	4.8067055	5.0540050	4.9356479	7.8777151	7.2026121
ENSG00000118600	2.3848362	1.7562353	4.223217	9.856881	0.0028887	0.4920083	ENSG00000118600	RXYLT1	ribitol xylosyltransferase 1	12	63779833	63809792	protein_coding	HGNC:13530	-1.6005904	0.1208111	1.0284539	2.2227072	3.4675183	2.7594405	3.0567474	2.1847208	1.9152880	2.0562849	3.1240033	1.0222982
ENSG00000229698	-6.3792969	-8.0533180	2.827400	11.114953	0.0029021	0.4920083	ENSG00000229698	HLA-F	major histocompatibility complex, class I, F	HSCHR6_MHC_SSTO_CTG1	1029074	1044770	protein_coding	HGNC:4963	4.7204271	2.8689165	4.8083125	2.9912127	-13.2877124	-13.2877124	-0.8301263	-13.2877124	-13.2877124	-13.2877124	-2.4145759	4.1218004
ENSG00000117632	-1.1964385	-1.1382124	5.132757	9.770912	0.0029693	0.4920083	ENSG00000117632	STMN1	stathmin 1	1	25884181	25906991	protein_coding	HGNC:6510	4.5398392	5.2389894	5.8830056	4.5151527	4.3844593	4.5556683	4.5047247	4.5870400	4.1475646	4.3839724	4.4833895	5.1589372
ENSG00000188959	1.8122832	-1.3958757	2.588106	9.216033	0.0029703	0.4920083	ENSG00000188959	C9orf152	chromosome 9 open reading frame 152	9	110190048	110208159	protein_coding	HGNC:31455	0.7833577	-0.6292688	-0.7990789	-0.5447399	2.5528821	1.8921730	0.3644985	-1.5695863	-1.4828271	-1.5255546	1.8569760	-0.1408785
ENSG00000205238	0.5352818	1.6226752	6.963199	9.677022	0.0030648	0.5014728	ENSG00000205238	SPDYE2	speedy/RINGO cell cycle regulator family member E2	7	102551226	102563538	protein_coding	HGNC:33841	4.5433748	5.7064702	5.7419624	6.3931621	5.9596885	6.4205380	6.5347108	7.4670022	7.1053811	7.2974924	6.3255872	5.7354101
ENSG00000239264	0.9125045	1.3682418	8.548598	9.577159	0.0031846	0.5139604	ENSG00000239264	TXNDC5	thioredoxin domain containing 5	6	7881517	7910788	protein_coding	HGNC:21073	5.9344914	6.0599583	6.2432239	5.7586038	7.3654176	6.9762465	6.9499431	8.0296820	6.5409019	7.4693729	7.1100616	6.0099222
ENSG00000163082	1.0538527	-0.4800094	5.263301	9.539274	0.0032431	0.5139604	ENSG00000163082	SGPP2	sphingosine-1-phosphate phosphatase 2	2	222424543	222562621	protein_coding	HGNC:19953	1.9541025	2.6413516	1.5051587	2.2676437	3.6607836	3.2920929	3.1068232	1.7343025	1.7166938	1.7255248	3.3719159	2.1511954
ENSG00000131669	-0.6279472	0.9560262	4.975060	9.535509	0.0032585	0.5139604	ENSG00000131669	NINJ1	ninjurin 1	9	93121496	93134251	protein_coding	HGNC:7824	4.1197016	4.9307277	3.9037187	4.4123536	3.8445953	4.1690807	3.6271190	5.5107593	5.3032582	5.4107363	3.8976073	4.3948002
ENSG00000157181	-1.7276614	1.3939180	3.115654	9.071319	0.0033459	0.5139604	ENSG00000157181	ODR4	odr-4 GPCR localization factor homolog	1	186375838	186421378	protein_coding	HGNC:24299	1.3718220	2.4911173	2.5189513	0.3998022	-2.0698637	-0.3977978	-1.5589968	0.3366307	2.6634612	1.9256797	-1.1664110	1.9317855
ENSG00000178078	1.9959017	3.1771130	2.062120	8.077858	0.0034094	0.5139604	ENSG00000178078	STAP2	signal transducing adaptor family member 2	19	4324043	4342786	protein_coding	HGNC:30430	-13.2877124	1.5077840	-2.3354735	0.1143617	3.1331803	2.4951479	1.6544264	3.9628433	3.2312223	3.6429217	2.5492182	0.0442038
ENSG00000164941	1.2777231	0.9082054	4.213074	9.428562	0.0034259	0.5139604	ENSG00000164941	INTS8	integrator complex subunit 8	8	94813311	94881746	protein_coding	HGNC:26048	2.4322659	2.0592085	2.5969809	2.4523456	2.9897955	2.1278640	3.4292551	2.2234578	3.7387651	3.1715342	2.9440224	2.3983657
ENSG00000196361	-1.1827544	-4.4950525	2.731290	8.858203	0.0034266	0.5139604	ENSG00000196361	ELAVL3	ELAV like RNA binding protein 3	19	11451326	11481046	protein_coding	HGNC:3314	0.0075113	-0.7201983	4.0337526	0.2888168	-0.3100210	-0.1452479	-0.0444789	-1.8004451	-3.9334850	-2.5041616	-0.1624636	2.2639819
ENSG00000106546	-0.0852735	-1.6795714	4.435365	9.372289	0.0034849	0.5139604	ENSG00000106546	AHR	aryl hydrocarbon receptor	7	16916359	17346152	protein_coding	HGNC:348	3.3209769	2.0095697	2.9142922	0.9266341	2.1928068	3.2355523	1.7949286	0.0550665	2.2525228	1.5370629	2.5410838	2.5520969
ENSG00000167194	-1.5974696	-3.4642337	6.339565	9.329618	0.0035201	0.5139604	ENSG00000167194	C16orf92	chromosome 16 open reading frame 92	16	30023198	30027736	protein_coding	HGNC:26346	5.8508152	7.8474885	8.4419269	4.6135044	5.8516024	5.9741456	5.8158357	4.0873582	3.6926846	3.9034760	5.8821341	7.3669032
ENSG00000223532	-0.8669204	1.7295439	8.392943	9.318357	0.0035242	0.5139604	ENSG00000223532	HLA-B	major histocompatibility complex, class I, B	HSCHR6_MHC_COX_CTG1	2750417	2837604	protein_coding	HGNC:4932	8.1749199	7.5773357	7.0150189	8.0032282	7.1484330	7.5031525	6.5889410	7.6806503	9.5634826	8.9096180	7.1277406	7.7580559
ENSG00000105127	0.9292669	1.1317474	6.491037	9.275269	0.0035866	0.5174381	ENSG00000105127	AKAP8	A-kinase anchoring protein 8	19	15353385	15379815	protein_coding	HGNC:378	2.9437126	3.9320767	3.9891495	3.9219189	4.6838653	5.0911419	4.6154873	4.9364418	4.9269037	4.9316807	4.8125501	3.7547603
ENSG00000171867	-0.5475833	-1.3226216	6.679954	9.212241	0.0036763	0.5226530	ENSG00000171867	PRNP	prion protein (Kanno blood group)	20	4686350	4701590	protein_coding	HGNC:9449	5.8844539	4.8228052	5.6393247	5.1918105	5.1107890	5.1538890	4.7019150	4.7520858	3.8085427	4.3561135	5.0027453	5.4410273
ENSG00000206353	3.9476144	3.0255689	3.573192	8.425603	0.0037212	0.5226530	ENSG00000206353	SKIC2	SKI2 subunit of superkiller complex	HSCHR6_MHC_QBL_CTG1	3215050	3225721	protein_coding	HGNC:10898	-13.2877124	-0.8090843	-1.6356338	-13.2877124	1.9583958	2.7039625	2.3438288	2.3493791	-13.2877124	1.3494075	2.3672469	-2.1636344
ENSG00000159307	0.0128445	2.5996387	4.378316	9.215278	0.0037531	0.5226530	ENSG00000159307	SCUBE1	signal peptide, CUB domain and EGF like domain containing 1	22	43197280	43343372	protein_coding	HGNC:13441	2.5770640	0.5589680	-1.4344067	-2.9144883	-2.4922409	2.0911088	-1.4236075	3.2945824	2.9665023	3.1398483	0.6814529	0.9897000
ENSG00000105894	-3.4351865	-2.5099604	3.313532	8.552458	0.0037962	0.5226530	ENSG00000105894	PTN	pleiotrophin	7	137227341	137343774	protein_coding	HGNC:9630	0.7393375	2.8175162	4.7339339	2.3139290	0.9285591	-0.4011718	-1.7732843	-0.2936931	1.3769566	0.7710446	-0.0227035	3.3327769
ENSG00000282725	-2.9035895	-2.3105444	3.216272	8.734605	0.0038175	0.5226530	ENSG00000282725	CORO7	coronin 7	HSCHR16_3_CTG1	56867	128028	protein_coding	HGNC:26161	3.4578020	3.5934337	3.3461760	4.2193872	2.8012899	-13.2877124	3.2201310	2.0972963	2.8013795	2.4918703	2.4409033	3.6964270
ENSG00000120093	1.2162365	1.0671698	6.786901	9.037559	0.0039425	0.5306809	ENSG00000120093	HOXB3	homeobox B3	17	48548870	48604912	protein_coding	HGNC:5114	3.5191350	3.9816905	3.2680882	4.6094607	5.3652871	5.3842117	5.6260476	5.0830301	5.1895936	5.1372957	5.4634884	3.9379959
ENSG00000110092	-0.4897887	-1.1322686	6.476408	8.977775	0.0040387	0.5306809	ENSG00000110092	CCND1	cyclin D1	11	69641156	69654474	protein_coding	HGNC:1582	4.8734788	3.8532995	5.2740465	5.5658455	3.7777528	4.4691258	4.7999711	4.0897546	3.6104205	3.8699040	4.4087356	5.0204644
ENSG00000172156	2.7782768	0.2211919	2.484032	8.216983	0.0040806	0.5306809	ENSG00000172156	CCL11	C-C motif chemokine ligand 11	17	34285742	34288334	protein_coding	HGNC:10610	1.0542414	1.4758859	-13.2877124	-13.2877124	2.9629844	3.9333188	3.3470059	1.2409340	0.1030007	0.7813681	3.4703204	0.2804718
ENSG00000230456	3.4002493	-3.9792615	2.014752	7.917826	0.0041111	0.5306809	ENSG00000230456	DDR1	discoidin domain receptor tyrosine kinase 1	HSCHR6_MHC_DBB_CTG1	2137270	2156466	protein_coding	HGNC:2730	-1.7213586	-13.2877124	1.3351373	-13.2877124	2.7205608	-1.7121590	1.7968286	-13.2877124	-13.2877124	-13.2877124	1.7895274	-0.5010047
ENSG00000060982	0.2159561	-2.8459952	4.016417	8.835321	0.0041804	0.5306809	ENSG00000060982	BCAT1	branched chain amino acid transaminase 1	12	24810024	24949101	protein_coding	HGNC:976	3.3452773	1.7144816	3.7687979	3.4843186	2.2373551	1.5969866	1.1532839	-1.4525620	-1.9075598	-1.6621976	1.7318526	3.2580343
ENSG00000183160	-0.4430935	-2.2207671	4.459441	8.889406	0.0042236	0.5306809	ENSG00000183160	TMEM119	transmembrane protein 119	12	108589851	108598320	protein_coding	HGNC:27884	3.5530032	2.2963490	3.7451696	3.1315603	2.9899931	1.8704062	4.2838387	0.3372692	2.2913018	1.6225415	3.3729490	3.2788180
ENSG00000135925	-0.6605472	2.1370536	3.419350	8.788075	0.0042563	0.5306809	ENSG00000135925	WNT10A	Wnt family member 10A	2	218880852	218899581	protein_coding	HGNC:13829	-13.2877124	1.8751525	1.9020767	1.2295818	-0.4954732	1.0499653	1.1402741	3.4874674	3.6137604	3.5519954	0.7323526	1.2855508
ENSG00000185274	1.4382495	1.5112903	5.438174	8.841252	0.0042841	0.5306809	ENSG00000185274	GALNT17	polypeptide N-acetylgalactosaminyltransferase 17	7	71132144	71713600	protein_coding	HGNC:16347	2.8058659	2.5606352	1.6740403	1.5852621	4.1792699	3.9062340	2.5208605	3.8130108	3.4903143	3.6606663	3.6948576	2.2543026
ENSG00000133636	2.4028535	-2.3503023	2.498466	8.064124	0.0043091	0.5306809	ENSG00000133636	NTS	neurotensin	12	85874295	85882992	protein_coding	HGNC:8038	-13.2877124	1.7380808	1.8523109	-1.2186151	2.1191875	2.4660327	4.2505179	-13.2877124	0.1168531	-0.8830138	3.2682278	0.8829339
ENSG00000167244	1.9601216	-2.1441333	5.321336	8.828556	0.0043145	0.5306809	ENSG00000167244	IGF2	insulin like growth factor 2	11	2129112	2158391	protein_coding	HGNC:5466	0.4004341	3.1863083	-0.0111517	1.3030665	4.3198594	4.5680590	1.6589326	1.0153256	-0.0300756	0.5853126	3.9650028	1.7951976
ENSG00000067715	-1.4425793	-1.5782033	3.501353	8.845578	0.0043147	0.5306809	ENSG00000067715	SYT1	synaptotagmin 1	12	78863993	79452008	protein_coding	HGNC:11509	2.8693521	1.4987048	1.2027901	1.7701808	2.2100709	0.3188710	1.6409332	0.3109915	-0.7535627	-0.1252447	1.5838414	1.9860531
ENSG00000139514	0.8592398	1.1491500	6.788696	8.794239	0.0043508	0.5306809	ENSG00000139514	SLC7A1	solute carrier family 7 member 1	13	29509414	29595688	protein_coding	HGNC:11057	2.9830047	2.9763361	2.8522050	2.7226813	4.1259027	4.1753085	3.1206076	4.2441922	3.8675083	4.0681094	3.8817912	2.8874364
ENSG00000136840	-0.5032231	0.8636157	4.901376	8.763910	0.0044305	0.5333368	ENSG00000136840	ST6GALNAC4	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	9	127907886	127917041	protein_coding	HGNC:17846	3.9854092	4.7184420	4.2579444	3.8600890	3.1431411	3.8543598	3.9298137	5.1790448	4.7297382	4.9718125	3.6832597	4.2444883
ENSG00000278823	6.3119476	7.6548383	2.217223	10.248976	0.0044924	0.5333368	ENSG00000278823	BMERB1	bMERB domain containing 1	HSCHR16_1_CTG1	1092272	1283041	protein_coding	HGNC:19213	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.6617756	-13.2877124	1.2586950	2.2111546	1.4784153	1.8908128	0.8893302	-13.2877124
ENSG00000186532	0.4962295	2.0078896	3.464643	8.739211	0.0045052	0.5333368	ENSG00000186532	SMYD4	SET and MYND domain containing 4	17	1779485	1830634	protein_coding	HGNC:21067	2.2614869	0.0658756	-0.8470612	3.0647672	1.8739718	2.8439163	1.5278891	3.0188569	1.8074600	2.5367375	2.1941608	1.8840919
ENSG00000115232	0.7133425	-0.8096671	4.644826	8.685092	0.0045805	0.5333368	ENSG00000115232	ITGA4	integrin subunit alpha 4	2	181457202	181538940	protein_coding	HGNC:6140	2.8743791	2.1704068	1.9110776	1.9611051	2.4696886	2.2772707	3.6404407	1.9850843	-0.0171645	1.3065632	2.9296196	2.2845793
ENSG00000065911	-0.2577847	0.8799845	5.500479	8.661309	0.0046033	0.5333368	ENSG00000065911	MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	2	74186172	74217565	protein_coding	HGNC:7434	2.6908884	3.4455534	3.2926177	3.3834642	2.9481603	3.1178863	3.0898652	3.4742428	3.9750269	3.7462555	3.0538620	3.2321407
ENSG00000255220	1.1915160	-3.8220766	2.303039	8.479620	0.0046624	0.5333368	ENSG00000255220	DDX18P5		11	130295641	130296946	processed_pseudogene	HGNC:33968	-0.3011628	0.7991536	2.2419966	1.4931139	3.0232097	2.5403219	2.0594574	-1.9200355	-13.2877124	-2.9194897	2.5941685	1.3358765
ENSG00000182484	-0.4192397	-3.1405345	2.658094	8.178289	0.0046996	0.5333368	ENSG00000182484	WASH6P		X	156020826	156025710	protein_coding	HGNC:31685	2.4356838	3.0032048	3.4875002	1.8661104	1.6614030	1.6455094	1.4731032	-0.7158792	-3.7637780	-1.5511984	1.5958230	2.8221994
ENSG00000142227	-1.3424309	-0.9787249	4.772638	8.615105	0.0047164	0.5333368	ENSG00000142227	EMP3	epithelial membrane protein 3 (MAM blood group)	19	48321310	48330559	protein_coding	HGNC:3335	6.5167830	5.6241548	6.5969985	5.5842303	4.9795830	4.3549652	5.2744397	5.4726872	4.8015878	5.1758128	4.9183605	6.1582082
ENSG00000244257	-8.0873902	0.5215113	3.573284	9.529296	0.0047365	0.5333368	ENSG00000244257	PKD1P1		16	16310341	16334190	transcribed_unprocessed_pseudogene	HGNC:30065	-13.2877124	1.1539609	1.0153791	1.1512737	-13.2877124	-13.2877124	-13.2877124	1.0240891	1.4181597	1.2345375	-13.2877124	0.6932911
ENSG00000143340	3.7717958	3.3416632	1.755619	7.863298	0.0047701	0.5333368	ENSG00000143340	FAM163A	family with sequence similarity 163 member A	1	179743291	179816198	protein_coding	HGNC:28274	-2.2317725	-3.5439214	-13.2877124	-13.2877124	-0.3212538	0.4881715	1.1625987	-0.2634834	0.2827660	0.0353417	0.5661309	-3.7425790
ENSG00000187713	-0.1135844	2.6068505	3.655239	8.530467	0.0048489	0.5372711	ENSG00000187713	TMEM203	transmembrane protein 203	9	137204082	137205648	protein_coding	HGNC:28217	2.4343589	1.9999340	0.4345999	-0.0500856	0.9635829	2.2185654	1.4473433	2.0051772	5.1190728	4.2767778	1.6371474	1.5512049
ENSG00000163528	2.3521660	-0.9450375	1.787416	7.332708	0.0049167	0.5372711	ENSG00000163528	CHCHD4	coiled-coil-helix-coiled-coil-helix domain containing 4	3	14112077	14124870	protein_coding	HGNC:26467	0.5324387	-13.2877124	-0.1459501	-0.4791564	1.9946843	1.2049051	2.6819435	-2.0857355	-1.0005887	-1.4434538	2.0826695	-0.3828646
ENSG00000273645	-0.6002739	-8.0828702	3.360492	8.920710	0.0049497	0.5372711	ENSG00000273645	KBTBD11	kelch repeat and BTB domain containing 11	HSCHR8_8_CTG1	157254	190312	protein_coding	HGNC:29104	1.0362156	0.3390017	1.0169106	0.3113148	1.2807408	0.2038927	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.2556167	0.7181183
ENSG00000198121	-0.7168839	-2.4670976	4.023425	8.485271	0.0049761	0.5372711	ENSG00000198121	LPAR1	lysophosphatidic acid receptor 1	9	110873263	111038470	protein_coding	HGNC:3166	3.8959840	0.9615759	3.2173736	3.3384340	2.2770680	2.6102122	2.1111021	-0.4297877	1.3106467	0.6883585	2.3479553	3.1799271
ENSG00000107105	-3.3898338	-2.0166357	2.223070	7.476537	0.0050623	0.5372711	ENSG00000107105	ELAVL2	ELAV like RNA binding protein 2	9	23690104	23826337	protein_coding	HGNC:3313	-0.2843561	1.5128514	1.3358531	1.1809842	-13.2877124	-3.3432492	-1.6506710	-0.7396949	-0.5498735	-0.6416645	-2.8464105	1.0817493
ENSG00000126709	-3.0532196	0.4621675	6.546245	8.429517	0.0050875	0.5372711	ENSG00000126709	IFI6	interferon alpha inducible protein 6	1	27666064	27672212	protein_coding	HGNC:4054	6.7649216	6.8999619	7.2060505	7.9885737	3.9509188	4.2481603	4.7646217	3.9354840	8.6913204	7.7437539	4.3610826	7.2987742
ENSG00000225201	-9.6771120	-7.1202959	4.311897	8.939886	0.0051094	0.5372711	ENSG00000225201	HLA-E	major histocompatibility complex, class I, E	HSCHR6_MHC_MCF_CTG1	1833523	1838261	protein_coding	HGNC:4962	3.0165662	5.3436799	0.6557530	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-0.2239651	-1.2237966	-13.2877124	3.6517861
ENSG00000286169	-1.6536411	-1.4970655	3.871740	8.431268	0.0051275	0.5372711	ENSG00000286169	NA	NA	NA	NA	NA	NA	NA	1.6491303	2.9869213	1.8410142	2.2223662	0.6716122	0.2897979	0.4060294	0.6515050	0.2500375	0.4646913	0.4647916	2.2715338
ENSG00000198857	2.1576446	0.9991505	3.328997	8.307867	0.0052152	0.5372711	ENSG00000198857	HSD3BP5		1	119601340	119609250	transcribed_unprocessed_pseudogene	HGNC:5223	0.3781365	1.7633946	2.2827559	1.9477570	2.9651068	3.6332528	4.8179247	2.7350696	2.7492848	2.7421947	4.0126637	1.7461442
ENSG00000148773	4.1411956	2.8717052	1.864692	7.629740	0.0052863	0.5372711	ENSG00000148773	MKI67	marker of proliferation Ki-67	10	128096659	128126423	protein_coding	HGNC:7107	-13.2877124	-13.2877124	-3.9811494	-4.7233342	-2.1342110	-0.7242086	-0.9135015	-1.7538863	-4.2488757	-2.5182919	-1.1371019	-5.3021835
ENSG00000130707	-0.3311669	1.1549902	6.153462	8.291608	0.0053647	0.5372711	ENSG00000130707	ASS1	argininosuccinate synthase 1	9	130444961	130501274	protein_coding	HGNC:758	4.2200809	5.5895701	5.2451732	5.1509275	5.1928725	5.2957688	4.9156257	6.0974921	6.9932696	6.6138161	5.1435110	5.1318253
ENSG00000276886	-2.6899556	-2.5870446	4.290872	8.294713	0.0053714	0.5372711	ENSG00000276886	GREM1	gremlin 1, DAN family BMP antagonist	HSCHR15_4_CTG8	4932598	4949251	protein_coding	HGNC:2001	3.0661596	0.9912140	2.0376939	3.6722940	1.0539315	-13.2877124	0.5124535	0.7583586	-0.9191868	0.1508014	0.2235276	2.7664887
ENSG00000115271	-2.9701193	-7.6220459	2.572808	7.919253	0.0053820	0.5372711	ENSG00000115271	GCA	grancalcin	2	162318840	162371595	protein_coding	HGNC:15990	-13.2877124	2.0720965	4.1108016	3.6581202	1.2981574	-13.2877124	1.5997529	-13.2877124	-13.2877124	-13.2877124	0.8718854	3.0919758
ENSG00000185885	-3.2153979	-1.2902141	2.620727	7.471327	0.0054806	0.5372711	ENSG00000185885	IFITM1	interferon induced transmembrane protein 1	11	310041	315272	protein_coding	HGNC:5412	4.7452723	3.4459628	3.8770148	3.9463917	2.2042497	-0.7872613	-13.2877124	2.8010442	2.3317127	2.5853801	0.7901857	4.0837958
ENSG00000124194	-0.7197857	1.0659331	3.399741	8.240237	0.0055321	0.5372711	ENSG00000124194	GDAP1L1	ganglioside induced differentiation associated protein 1 like 1	20	44247099	44280947	protein_coding	HGNC:4213	1.6167012	1.2494775	2.6281276	1.9437417	0.7152371	0.5389880	1.2516197	2.7336450	2.4341908	2.5916737	0.8681051	1.9517310
ENSG00000115461	-0.3440946	-2.2802282	9.502659	8.198192	0.0055765	0.5372711	ENSG00000115461	IGFBP5	insulin like growth factor binding protein 5	2	216672105	216695549	protein_coding	HGNC:5474	6.9579387	5.8913154	8.0459362	5.5989031	6.3705350	6.7711289	6.8488277	4.9294871	4.2850987	4.6429753	6.6782142	6.9554354
ENSG00000224299	3.3112178	3.0643511	2.810768	7.322954	0.0055898	0.5372711	ENSG00000224299	MTATP6P16		2	201550524	201551049	unprocessed_pseudogene	HGNC:52061	2.4318572	-13.2877124	-13.2877124	2.9712443	5.7786154	5.2040057	3.1741801	4.1495422	5.0932975	4.6972528	5.0701403	1.7266351
ENSG00000157227	-0.3499503	-1.4960093	8.501829	8.177798	0.0056252	0.5372711	ENSG00000157227	MMP14	matrix metallopeptidase 14	14	22836560	22849041	protein_coding	HGNC:7160	8.7053744	7.2502256	8.2216321	7.6390031	8.2898170	7.6362851	7.6695244	6.9158467	6.1210504	6.5725029	7.8978446	8.0600275
ENSG00000166428	-0.1576446	0.7080543	7.265780	8.168691	0.0056476	0.5372711	ENSG00000166428	PLD4	phospholipase D family member 4	14	104924713	104937761	protein_coding	HGNC:23792	5.4874368	5.3792278	5.6161975	5.2143918	5.5328461	4.9082426	5.3011944	6.0656408	6.1470666	6.1069280	5.2699600	5.4317944
ENSG00000168874	0.5826446	2.6004981	3.887231	8.200696	0.0056535	0.5372711	ENSG00000168874	ATOH8	atonal bHLH transcription factor 8	2	85751344	85791383	protein_coding	HGNC:24126	-3.2598893	0.3330561	-1.9350840	0.8615799	0.4157003	-0.9984398	1.4134560	2.4142863	2.8833764	2.6678135	0.5843956	-0.2164989
ENSG00000111325	0.7150853	-0.4538740	6.732948	8.139272	0.0057198	0.5372711	ENSG00000111325	OGFOD2	2-oxoglutarate and iron dependent oxygenase domain containing 2	12	122974580	122980043	protein_coding	HGNC:25823	6.0191137	4.9373515	5.8474802	5.9192992	6.5929843	6.2837616	6.6718406	5.6030428	4.9581748	5.3163438	6.5256790	5.7387095
ENSG00000115325	1.9038516	1.8435781	2.731614	7.854917	0.0057296	0.5372711	ENSG00000115325	DOK1	docking protein 1	2	74549026	74557551	protein_coding	HGNC:2990	1.0880059	-0.5306766	0.1066632	0.5253473	1.9598744	2.6416306	2.4500948	2.2614273	2.5954669	2.4380935	2.3780646	0.4152297
ENSG00000116127	-1.5533523	-0.3369005	3.597220	8.147531	0.0057311	0.5372711	ENSG00000116127	ALMS1	ALMS1 centrosome and basal body associated protein	2	73385758	73625166	protein_coding	HGNC:428	4.2684268	0.7660311	0.0418051	1.0185188	0.6615772	-1.6057976	-0.3094256	-0.5770738	-0.0020703	-0.2611129	-0.1427738	2.5866281
ENSG00000183426	0.9995875	1.8865266	4.187808	8.155409	0.0057663	0.5372711	ENSG00000183426	NPIPA1	nuclear pore complex interacting protein family member A1	16	14922802	14952060	protein_coding	HGNC:7909	0.7604432	1.0847011	0.8036139	2.9398987	2.6861520	2.1317037	3.3285952	2.2888083	4.3073312	3.6255737	2.7980238	1.7261760
ENSG00000153132	-0.9154202	-7.8468824	3.051841	8.484347	0.0058523	0.5386197	ENSG00000153132	CLGN	calmegin	4	140388453	140427661	protein_coding	HGNC:2060	2.9160938	-0.8563245	2.1502045	1.2577776	0.0457980	1.4545349	1.2666384	-13.2877124	-13.2877124	-13.2877124	1.0423964	1.9001937
ENSG00000174989	1.0338996	0.6027263	5.141332	8.089743	0.0058611	0.5386197	ENSG00000174989	FBXW8	F-box and WD repeat domain containing 8	12	116910950	117032498	protein_coding	HGNC:13597	1.7929220	2.1681908	2.0913312	1.8283200	2.8563127	3.3794470	3.3043901	2.7490678	2.7447805	2.7469256	3.1978412	1.9793299
ENSG00000162981	-2.2723692	-2.1291087	2.598383	7.650263	0.0059172	0.5400730	ENSG00000162981	LRATD1	LRAT domain containing 1	2	14632700	14650814	protein_coding	HGNC:20743	-0.4671804	0.0142839	1.3068210	0.6321630	-2.0473802	-0.9297756	-2.1482825	-1.6503992	-1.5804482	-1.6149998	-1.5959048	0.5253603
ENSG00000213995	1.0323194	1.0440025	4.495407	8.031560	0.0060439	0.5469301	ENSG00000213995	NAXD	NAD(P)HX dehydratase	13	110615545	110639996	protein_coding	HGNC:25576	2.0919601	2.0151536	2.7094726	2.2390127	3.4966269	3.6249922	3.1173526	3.2710726	3.4160448	3.3453789	3.4286270	2.2903557
ENSG00000272670	1.8272329	3.6870417	2.850757	7.327093	0.0060738	0.5469301	ENSG00000272670	DOC2B	double C2 domain beta	HSCHR17_1_CTG1	82789	120568	protein_coding	HGNC:2986	-13.2877124	-0.5757250	-1.0360229	-2.7795512	-13.2877124	-3.0981596	0.9847446	2.5152414	0.5533929	1.8448809	-0.5174332	-1.6166623
ENSG00000120129	-0.4606345	0.6218394	5.853472	7.980226	0.0061299	0.5483027	ENSG00000120129	DUSP1	dual specificity phosphatase 1	5	172768096	172771195	protein_coding	HGNC:3064	4.7913006	4.2313018	4.5085005	4.6282234	4.3111723	4.3389016	3.9610596	5.0470521	5.3139277	5.1866519	4.2136599	4.5540387
ENSG00000122783	-0.3216866	1.7337195	6.397365	7.927586	0.0062697	0.5570907	ENSG00000122783	CYREN	cell cycle regulator of NHEJ	7	135092363	135170795	protein_coding	HGNC:22432	5.8935846	4.6357275	4.1962949	6.5871268	5.1863497	4.6546591	6.0358283	7.6912957	7.2691254	7.4955980	5.4060989	5.6350639
ENSG00000281900	0.2852229	-8.3000437	3.902583	8.267255	0.0063424	0.5593817	ENSG00000281900	KLHL5P1		HSCHR22_1_CTG7	163262	165936	processed_pseudogene	HGNC:56977	2.7578735	3.3825789	-13.2877124	3.8913937	3.7909802	3.4615448	2.9820360	-13.2877124	-13.2877124	-13.2877124	3.4488624	3.0014953
ENSG00000103888	-0.1287963	1.2392526	4.229058	7.872498	0.0065015	0.5593817	ENSG00000103888	CEMIP	cell migration inducing hyaluronidase 1	15	80779343	80951776	protein_coding	HGNC:29213	2.9108894	2.9589445	3.7822173	3.2826603	2.5088751	1.7801887	3.7416322	3.2015006	2.6469483	2.9507073	2.9070831	3.2774651
ENSG00000064205	-2.8685572	-4.3726243	3.710801	7.497684	0.0065068	0.5593817	ENSG00000064205	CCN5	cellular communication network factor 5	20	44714844	44728509	protein_coding	HGNC:12770	5.3744710	-2.3287247	3.5286054	1.8792086	0.3142870	-0.3020803	0.9658678	-1.1872012	-0.7763204	-0.9671826	0.4178185	3.8304003
ENSG00000152049	-0.4907763	-3.5285367	4.588616	7.786008	0.0065747	0.5593817	ENSG00000152049	KCNE4	potassium voltage-gated channel subfamily E regulatory subunit 4	2	223052190	223198399	protein_coding	HGNC:6244	4.4882856	0.9602225	1.6524374	3.4377591	2.4473872	2.4489311	2.9917424	-0.1361218	-1.0489703	-0.5215200	2.6529628	3.2618946
ENSG00000168140	0.4957420	1.3128497	6.340351	7.808569	0.0066015	0.5593817	ENSG00000168140	VASN	vasorin	16	4371848	4383538	protein_coding	HGNC:18517	4.0384187	3.9736650	3.8440748	4.0563182	4.0665144	4.9871198	4.6110800	5.8158716	4.5959001	5.3311713	4.6030613	3.9804878
ENSG00000163840	-1.6317844	0.0871460	4.180782	7.799149	0.0066920	0.5593817	ENSG00000163840	DTX3L	deltex E3 ubiquitin ligase 3L	3	122564338	122575203	protein_coding	HGNC:30323	1.6165200	1.7892806	1.5588603	1.0983980	-0.0002308	-1.2201503	1.6459091	1.3233274	1.9368249	1.6624443	0.6036052	1.5373145
ENSG00000138161	0.1048698	2.3166313	3.478085	7.773815	0.0067270	0.5593817	ENSG00000138161	CUZD1	CUB and zona pellucida like domains 1	10	122832158	122846175	protein_coding	HGNC:17937	1.4895881	2.4687175	1.0563671	-1.3968553	-0.3819982	2.4255901	1.0686302	3.4214639	3.7306883	3.5843451	1.4572092	1.4333665
ENSG00000198108	0.2281801	-2.3076672	4.104989	7.762610	0.0067477	0.5593817	ENSG00000198108	CHSY3	chondroitin sulfate synthase 3	5	129904465	130186634	protein_coding	HGNC:24293	2.7003063	0.7128678	2.2049420	1.5493769	2.4064749	2.0465560	2.4283844	0.3821393	-2.0327133	-0.3699040	2.3041083	1.9704786
ENSG00000136960	-0.1887162	-2.6366862	6.907648	7.754885	0.0067590	0.5593817	ENSG00000136960	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	8	119557086	119673453	protein_coding	HGNC:3357	6.4658854	3.6619388	6.0863053	5.2411649	5.6054766	5.9783241	4.7249055	3.6217326	1.9339446	3.0117427	5.5254184	5.6922316
ENSG00000138771	1.4678320	-0.1744853	4.104861	7.779515	0.0067780	0.5593817	ENSG00000138771	SHROOM3	shroom family member 3	4	76435229	76783253	protein_coding	HGNC:30422	3.2855031	0.1454688	0.8938623	0.3201473	2.3324785	2.7770205	0.5931692	0.5478249	0.2087208	0.3882127	2.1591564	1.8035755
ENSG00000184058	-5.0189108	-1.1756132	2.866165	7.434795	0.0067887	0.5593817	ENSG00000184058	TBX1	T-box transcription factor 1	22	19756703	19783593	protein_coding	HGNC:11592	2.6998763	3.1837880	-0.7697355	1.1900724	-1.5033638	-1.8335211	-13.2877124	1.7855413	0.0124700	1.1558007	-2.2437535	2.2057466
ENSG00000111358	-1.4253807	-6.3784012	1.718656	7.526601	0.0067958	0.5593817	ENSG00000111358	GTF2H3	general transcription factor IIH subunit 3	12	123633739	123662604	protein_coding	HGNC:4657	3.1168255	1.3015736	1.9421470	1.0753019	2.0157480	-1.5617242	1.4401331	-13.2877124	-13.2877124	-13.2877124	1.2420653	2.0950535
ENSG00000088930	-0.4650165	-1.2297874	4.855927	7.717612	0.0068952	0.5632039	ENSG00000088930	XRN2	5’-3’ exoribonuclease 2	20	21303331	21389825	protein_coding	HGNC:12836	3.0878577	3.0251770	2.9721208	3.2270306	2.4291858	2.7337463	3.0062833	1.8446885	1.8961118	1.8706295	2.7421945	3.0812305
ENSG00000181333	-7.4737324	-1.4482006	2.536125	8.443966	0.0069546	0.5632039	ENSG00000181333	HEPHL1	hephaestin like 1	11	94021354	94114208	protein_coding	HGNC:30477	-0.8528027	-0.7870024	1.9319806	-0.2716789	-13.2877124	-13.2877124	-13.2877124	-0.6200553	-1.5324576	-1.0052986	-13.2877124	0.5304194
ENSG00000085117	-0.2662758	1.3667669	5.215825	7.673936	0.0070270	0.5632039	ENSG00000085117	CD82	CD82 molecule	11	44564427	44620363	protein_coding	HGNC:6210	4.2258897	4.5837379	3.6867431	4.0516440	4.0630159	4.7317019	4.3473892	5.7061602	5.6353995	5.6712135	4.4068999	4.1729651
ENSG00000145819	-0.0118569	1.5655213	4.261982	7.691794	0.0070410	0.5632039	ENSG00000145819	ARHGAP26	Rho GTPase activating protein 26	5	142770377	143229011	protein_coding	HGNC:17073	1.7146623	2.9278113	0.4501001	1.9413452	2.4672028	1.7574317	0.8702653	4.1726519	4.5046871	4.3482007	1.8397798	2.0088562
ENSG00000113083	-0.2856976	-1.2573430	5.530297	7.660545	0.0070521	0.5632039	ENSG00000113083	LOX	lysyl oxidase	5	122063195	122078413	protein_coding	HGNC:6664	3.9319778	2.8331888	3.4763376	4.1512684	3.5757846	2.8712286	3.5829729	2.5180977	1.8351221	2.2166535	3.3796321	3.6805494
ENSG00000169071	0.3176487	-1.9344958	3.742487	7.648259	0.0071141	0.5635069	ENSG00000169071	ROR2	receptor tyrosine kinase like orphan receptor 2	9	91563091	91950228	protein_coding	HGNC:10257	1.6988337	1.4198641	0.5877596	1.6867358	1.6565312	2.1715777	1.5555978	0.0855593	-1.2215021	-0.4247506	1.8206608	1.4119919
ENSG00000186994	0.8607001	-0.9450879	3.513874	7.664364	0.0071399	0.5635069	ENSG00000186994	KANK3	KN motif and ankyrin repeat domains 3	19	8322584	8343262	protein_coding	HGNC:24796	2.0711150	1.1719677	1.2557044	1.8264138	2.1279092	2.6282447	2.4278244	0.8131101	0.0837498	0.4940387	2.4091088	1.6310670
ENSG00000148341	0.5797894	1.3760901	4.522438	7.634612	0.0071856	0.5637960	ENSG00000148341	SH3GLB2	SH3 domain containing GRB2 like, endophilin B2	9	129007036	129028331	protein_coding	HGNC:10834	2.0881820	3.1133111	2.2803577	2.5744673	4.0683938	3.3462966	3.1754815	4.2468183	4.6832958	4.4815011	3.5842351	2.5680489
ENSG00000236353	2.3896927	-5.1446425	2.251736	7.393004	0.0073659	0.5666778	ENSG00000236353	PBX2	PBX homeobox 2	HSCHR6_MHC_MCF_CTG1	3526760	3532202	protein_coding	HGNC:8633	1.0070239	1.2627735	-13.2877124	1.0144196	-13.2877124	2.2347941	2.8372417	-13.2877124	-13.2877124	-13.2877124	1.9822883	0.6847101
ENSG00000284626	5.6627008	7.0272404	1.718214	8.467498	0.0074065	0.5666778	ENSG00000284626			15	90234200	90265462	protein_coding		-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.6772160	-1.5404341	-2.7559313	0.3177255	0.9860381	0.6902392	-0.5208564	-13.2877124
ENSG00000168477	1.2421822	3.0253597	4.338109	7.569967	0.0074162	0.5666778	ENSG00000168477	TNXB	tenascin XB	6	32041153	32115334	protein_coding	HGNC:11976	-0.9290969	-13.2877124	-2.0955120	1.0927757	1.0459454	-0.6638309	1.5035167	2.5003771	1.6540725	2.1384118	0.8826430	-0.4678766
ENSG00000120885	1.2729240	2.9034457	8.477550	7.542020	0.0074227	0.5666778	ENSG00000120885	CLU	clusterin	8	27596917	27614700	protein_coding	HGNC:2095	5.2806434	7.6297861	7.3328299	6.2688756	9.1745225	7.4243549	6.0269502	10.6997899	8.1442305	9.9264196	8.0853710	6.8925598
ENSG00000116132	-0.2354759	-1.1758957	6.891664	7.524387	0.0074819	0.5666778	ENSG00000116132	PRRX1	paired related homeobox 1	1	170662728	170739421	protein_coding	HGNC:9142	6.0077724	5.1924534	5.9695439	5.5491122	5.5268206	5.4325861	5.9436542	4.0842232	4.8706118	4.5303480	5.6519265	5.7169725
ENSG00000099994	-0.9475672	1.1018035	3.564876	7.539386	0.0074875	0.5666778	ENSG00000099994	SUSD2	sushi domain containing 2	22	24181487	24189106	protein_coding	HGNC:30667	1.8786249	1.7099496	0.1253919	0.7951394	0.3898718	0.5925408	0.5783871	2.6440503	2.3013450	2.4828498	0.5231795	1.2890654
ENSG00000182463	-0.0395205	-1.7342619	4.053687	7.536275	0.0075180	0.5666778	ENSG00000182463	TSHZ2	teashirt zinc finger homeobox 2	20	52972358	53495330	protein_coding	HGNC:13010	1.9170116	0.1087038	0.3067942	-0.3697101	0.6876457	1.6286840	1.8567603	0.4563825	-1.5460432	-0.2221742	1.4724696	0.7793760
ENSG00000148600	-3.4847304	-3.7704684	1.893208	6.646002	0.0076842	0.5730870	ENSG00000148600	CDHR1	cadherin related family member 1	10	84194537	84219621	protein_coding	HGNC:14550	-1.6335552	0.4013334	1.4929945	0.4876006	-13.2877124	-13.2877124	-1.5602343	-13.2877124	-2.5767166	-3.5758562	-3.1443457	0.5508657
ENSG00000174804	0.8467582	-0.3748851	6.296850	7.449599	0.0077390	0.5730870	ENSG00000174804	FZD4	frizzled class receptor 4	11	86945679	86955395	protein_coding	HGNC:4042	3.0447957	1.9197188	3.3144048	2.3787707	3.3534083	3.8903389	3.8149436	2.4973186	2.2530498	2.3803479	3.7049948	2.7647236
ENSG00000149600	-0.0296234	-1.7710309	3.543483	7.464984	0.0077541	0.5730870	ENSG00000149600	COMMD7	COMM domain containing 7	20	32702699	32743467	protein_coding	HGNC:16223	2.7834889	2.8468258	3.2423424	2.2077064	2.9828662	3.0428042	2.1968720	0.7511166	0.8372998	0.7948517	2.7887767	2.8156783
ENSG00000241738	0.3466591	1.6514403	3.417989	7.471086	0.0077739	0.5730870	ENSG00000241738	ZNF90P1		3	101357292	101359242	processed_pseudogene	HGNC:12888	0.7391966	0.8040056	1.9103013	2.0811115	2.1756661	1.9986050	1.4896257	3.0287161	3.1990210	3.1163801	1.9161246	1.5116446
ENSG00000176595	5.7089764	7.8073620	2.152631	8.336455	0.0078233	0.5735833	ENSG00000176595	KBTBD11	kelch repeat and BTB domain containing 11	8	1973677	2006936	protein_coding	HGNC:29104	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.0136438	0.2653361	0.5392690	0.4087945	-1.5710331	-13.2877124
ENSG00000117133	1.2562230	0.5743687	4.212904	7.433114	0.0078807	0.5746490	ENSG00000117133	RPF1	ribosome production factor 1 homolog	1	84479259	84498352	protein_coding	HGNC:30350	1.6677264	2.2760070	2.4433695	2.6966358	3.9390250	3.6099536	3.4921558	3.0878652	2.6831238	2.8996418	3.6930185	2.3177729
ENSG00000233615	3.9108124	0.7378548	1.168468	6.895699	0.0081355	0.5884943	ENSG00000233615	HNRNPA1P42		1	240919653	240920609	processed_pseudogene	HGNC:48771	-1.2957619	-1.6115702	-13.2877124	-13.2877124	2.4600296	0.5419905	2.7737362	-1.3326110	-1.2488722	-1.2901342	2.2013230	-2.4446495
ENSG00000276358	-0.6713265	2.2822227	2.918111	7.079487	0.0081838	0.5884943	ENSG00000276358	PLEKHM1	pleckstrin homology and RUN domain containing M1	HSCHR17_2_CTG5	126405	180904	protein_coding	HGNC:29017	3.7249306	2.0068456	1.5016694	0.7211705	3.9579764	-13.2877124	-1.9910886	3.5393239	0.7244075	2.7310259	2.3961883	2.4410728
ENSG00000242110	0.6443532	-2.7466661	2.307401	6.882848	0.0082439	0.5884943	ENSG00000242110	AMACR	alpha-methylacyl-CoA racemase	5	33986165	34008104	protein_coding	HGNC:451	0.3332806	1.6593739	1.5986834	1.7905010	2.0398799	2.1899118	0.9400547	-1.9337937	-1.3860422	-1.6340768	1.8201435	1.4471410
ENSG00000135473	0.7413400	-0.4665344	4.619879	7.306240	0.0082992	0.5884943	ENSG00000135473	PAN2	poly(A) specific ribonuclease subunit PAN2	12	56316223	56334053	protein_coding	HGNC:20074	2.8658778	1.5308698	4.4103383	3.0131340	4.3655344	3.7795463	3.6575666	1.4343341	1.1426970	1.2958723	3.9685770	3.3043839
ENSG00000100814	-1.2922471	-2.3866970	2.555359	7.070550	0.0083603	0.5884943	ENSG00000100814	CCNB1IP1	cyclin B1 interacting protein 1	14	20311368	20333312	protein_coding	HGNC:19437	2.9730855	2.4917433	2.2965059	1.6458746	1.2876720	1.1600502	1.4087863	0.4451164	1.3543173	0.9701851	1.2890725	2.4275222
ENSG00000230341	0.5829501	-8.3045222	4.042281	7.577137	0.0084180	0.5884943	ENSG00000230341	PPP1R18	protein phosphatase 1 regulatory subunit 18	HSCHR6_MHC_APD_CTG1	2005896	2017402	protein_coding	HGNC:29413	1.3503434	2.2350058	1.0821371	1.9633513	2.8501209	2.7480073	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.2150153	1.7305543
ENSG00000150991	0.2108766	1.4590739	12.489862	7.247929	0.0084747	0.5884943	ENSG00000150991	UBC	ubiquitin C	12	124911604	124917368	protein_coding	HGNC:12468	10.2352385	10.5555261	9.2145549	9.9623885	10.0631843	10.3107676	10.8312878	10.9278933	11.9616603	11.5354548	10.4380829	10.0708174
ENSG00000071575	-1.3347322	-1.4383612	4.442150	7.246612	0.0085573	0.5884943	ENSG00000071575	TRIB2	tribbles pseudokinase 2	2	12716910	12742734	protein_coding	HGNC:30809	4.3849395	2.1699724	3.3051929	1.5638932	0.6216304	2.7329182	2.4490508	1.6183223	0.8214270	1.2742116	2.1855675	3.2567921
ENSG00000169075	0.0156712	1.0692688	5.011863	7.225551	0.0085944	0.5884943	ENSG00000169075	BRD7P3		6	118501430	118502906	processed_pseudogene	HGNC:24171	3.4175281	3.9547172	3.9436232	4.3004905	4.0668448	4.2601860	3.8725285	4.8376744	5.1843618	5.0214069	4.0751860	3.9374037
ENSG00000275079	-5.4223671	-1.1823953	3.663118	6.675194	0.0086267	0.5884943	ENSG00000275079	LPCAT1	lysophosphatidylcholine acyltransferase 1	HSCHR5_3_CTG1	8170	53293	protein_coding	HGNC:25718	2.9993959	0.9075898	3.3968385	2.6994897	-13.2877124	-13.2877124	-1.6225719	-13.2877124	1.7716131	0.7716553	-3.2066458	2.7496006
ENSG00000137124	0.5728062	-2.0592410	3.276617	7.145527	0.0086958	0.5884943	ENSG00000137124	ALDH1B1	aldehyde dehydrogenase 1 family member B1	9	38392702	38398661	protein_coding	HGNC:407	1.7484338	0.0914561	1.4880471	1.3707345	2.2000501	1.8721381	1.7771461	-2.3264002	1.3571652	0.4652923	1.9613981	1.2952076
ENSG00000069702	-0.6224464	-1.6063350	4.444606	7.197499	0.0087390	0.5884943	ENSG00000069702	TGFBR3	transforming growth factor beta receptor 3	1	91680343	91906335	protein_coding	HGNC:11774	3.3014627	2.3152662	2.0014445	3.4725891	1.6486587	1.6790765	2.0320857	-0.0033900	1.8292517	1.1862406	1.7973737	2.9040455
ENSG00000186153	2.9629213	2.2039184	2.982529	6.776429	0.0087950	0.5884943	ENSG00000186153	WWOX	WW domain containing oxidoreductase	16	78099400	79212667	protein_coding	HGNC:12799	-1.2388339	1.8820964	-13.2877124	1.0896358	4.3575246	4.4632187	2.6559114	1.9427202	2.9009054	2.4999413	4.0256159	0.6411113
ENSG00000184640	-0.1610854	-0.8881888	7.193330	7.159427	0.0088257	0.5884943	ENSG00000184640	SEPTIN9	septin 9	17	77280569	77500596	protein_coding	HGNC:7323	6.0925383	5.9049617	5.6021455	5.6680377	5.8864682	5.8416447	5.8115393	4.6962536	4.5974220	4.6476841	5.8468796	5.8302282
ENSG00000233076	0.6882284	2.9667323	1.496304	6.060016	0.0088316	0.5884943	ENSG00000233076	DDAH2	DDAH family member 2, ADMA-independent	HSCHR6_MHC_MANN_CTG1	3032085	3035664	protein_coding	HGNC:2716	-1.3011770	-1.5798960	-0.3858367	-13.2877124	-13.2877124	-0.2374930	1.3759925	2.2945549	1.6051956	1.9906638	0.1990309	-1.4095312
ENSG00000140937	-0.2942599	-1.5852983	6.566138	7.139637	0.0089084	0.5884943	ENSG00000140937	CDH11	cadherin 11	16	64943753	65126112	protein_coding	HGNC:1750	7.4490000	4.8816712	6.2176202	6.2180805	6.2038309	6.0041133	5.4640444	4.0959707	4.0540981	4.0751860	5.9231159	6.4638351
ENSG00000172548	1.9521692	0.3151388	2.666956	6.979942	0.0089115	0.5884943	ENSG00000172548	NIPAL4	NIPA like domain containing 4	5	157460213	157474722	protein_coding	HGNC:28018	-0.0970404	-0.7319226	0.2827600	-1.6706628	2.2397768	1.2346914	2.0357625	-0.2355197	0.3374748	0.0792395	1.8974914	-0.3828524
ENSG00000116095	-1.1580188	0.3743697	4.251520	7.155983	0.0089329	0.5884943	ENSG00000116095	PLEKHA3	pleckstrin homology domain containing A3	2	178480457	178516463	protein_coding	HGNC:14338	-0.0751415	0.4811780	0.3125525	-0.2610938	2.4691194	-0.5278928	0.6183561	0.3940257	0.7073304	0.5591658	1.3721626	0.1445320
ENSG00000038427	-0.2370914	-1.8523390	9.410725	7.126759	0.0089584	0.5884943	ENSG00000038427	VCAN	versican	5	83471618	83582303	protein_coding	HGNC:2464	7.1721094	6.1334552	7.1373699	6.0701876	6.6494630	6.3694099	6.7097658	5.3919531	3.9689731	4.8492227	6.5836626	6.7224608
ENSG00000143624	-5.4634770	2.9857313	2.646556	7.375555	0.0090489	0.5884943	ENSG00000143624	INTS3	integrator complex subunit 3	1	153728050	153774808	protein_coding	HGNC:26153	-13.2877124	-13.2877124	-13.2877124	0.7808174	-13.2877124	-13.2877124	-13.2877124	1.2986953	1.6157713	1.4659269	-13.2877124	-1.2189307
ENSG00000018510	0.2853358	-1.6173226	3.830401	7.112462	0.0091092	0.5884943	ENSG00000018510	AGPS	alkylglycerone phosphate synthase	2	177392746	177567024	protein_coding	HGNC:327	2.3371031	2.3585701	0.6529747	1.0982754	3.1736732	2.1516143	2.8896363	1.6676238	1.6832383	1.6754524	2.7989142	1.7964815
ENSG00000203685	0.7817217	-1.1749436	3.612009	7.114037	0.0091249	0.5884943	ENSG00000203685	STUM	stum, mechanosensory transduction mediator homolog	1	226548764	226609230	protein_coding	HGNC:30491	0.2186547	-0.2931397	0.1139911	0.0163779	0.2465017	0.7368179	1.5081233	-0.7653344	-1.6775272	-1.1505051	0.9252959	0.0262359
ENSG00000146221	-2.0009615	-3.2222598	4.860779	7.080989	0.0092278	0.5884943	ENSG00000146221	TCTE1	t-complex-associated-testis-expressed 1	6	44278734	44297698	protein_coding	HGNC:11693	1.9219732	4.7184688	3.8441204	2.9257612	-13.2877124	2.5791558	2.2496689	0.6430194	0.4304159	0.5406304	1.8388489	3.7025597
ENSG00000163975	2.1719731	2.8203988	2.323652	6.402199	0.0093310	0.5884943	ENSG00000163975	MELTF	melanotransferrin	3	196980590	197029835	protein_coding	HGNC:7037	-3.7152206	-0.8061299	-3.3904871	-1.5514119	0.4220230	-2.4544269	1.3839730	1.0166967	1.2272359	1.1258032	0.4619183	-1.8828529
ENSG00000278032	-1.5466896	0.4910113	6.181801	7.036996	0.0093507	0.5884943	ENSG00000278032	LY6E	lymphocyte antigen 6 family member E	HSCHR8_4_CTG7	8270	14120	protein_coding	HGNC:6727	6.6983016	5.8733357	5.5375429	5.9878701	2.4663666	5.3435701	4.7701582	6.2402354	6.8696453	6.5889960	4.6131067	6.0894700
ENSG00000039560	-0.3610194	-2.2090734	4.007515	7.044207	0.0093708	0.5884943	ENSG00000039560	RAI14	retinoic acid induced 14	5	34656328	34832612	protein_coding	HGNC:14873	2.9466141	3.3937657	1.3121389	2.3410362	1.8786355	4.0377046	3.0563831	0.3040799	-0.5525435	-0.0615651	3.2438613	2.6876027
ENSG00000139352	-0.1694198	1.2864210	10.647784	7.028755	0.0093732	0.5884943	ENSG00000139352	ASCL1	achaete-scute family bHLH transcription factor 1	12	102957674	102960513	protein_coding	HGNC:738	8.3856973	9.3874892	8.6193121	7.9063225	8.3007718	8.9638218	8.6369101	9.4493564	10.3951113	9.9983831	8.6590929	8.6771685
ENSG00000124875	0.1124585	-3.7757284	4.013267	6.857677	0.0093809	0.5884943	ENSG00000124875	CXCL6	C-X-C motif chemokine ligand 6	4	73836640	73849064	protein_coding	HGNC:10643	3.3477265	2.4641868	5.1264853	2.3051791	3.8384480	1.2521322	5.1094313	2.2496377	-2.1228997	1.3176572	4.0933523	3.7963143
ENSG00000137819	1.1056821	-1.0642149	3.995521	7.046593	0.0094079	0.5884943	ENSG00000137819	PAQR5	progestin and adipoQ receptor family member 5	15	69298912	69407780	protein_coding	HGNC:29645	1.4122992	0.0996803	0.0598841	1.2799389	2.7567161	1.9612447	1.0164478	-0.2028010	-0.1914782	-0.1971285	2.0790050	0.8487613
ENSG00000166233	-0.6105329	-0.9550025	5.037369	7.005639	0.0095005	0.5884943	ENSG00000166233	ARIH1	ariadne RBR E3 ubiquitin protein ligase 1	15	72474330	72602987	protein_coding	HGNC:689	5.2740137	2.9183103	4.3056341	1.5711054	3.3150561	3.2228344	3.9165395	2.5574915	3.0651845	2.8335562	3.5189266	4.1085174
ENSG00000254827	-0.5537890	-2.3475117	3.716772	6.998194	0.0095349	0.5884943	ENSG00000254827	SLC22A18AS	SLC22A18 antisense RNA	11	2887344	2903814	lncRNA	HGNC:10965	3.0137995	2.7354149	4.0366282	2.6591306	2.6723961	2.9045866	2.7024838	1.6589043	-1.2549193	0.8386622	2.7635616	3.2274460
ENSG00000130649	-5.3370105	-6.0485205	4.979058	6.433218	0.0095581	0.5884943	ENSG00000130649	CYP2E1	cytochrome P450 family 2 subfamily E member 1	10	133520406	133561220	protein_coding	HGNC:2631	-13.2877124	2.3469915	-13.2877124	4.8516050	-0.2063671	-13.2877124	0.2873080	-0.8308010	1.9601365	1.1548444	-0.5234089	3.0857620
ENSG00000120328	-0.5963445	-2.9680738	2.610206	6.709387	0.0096138	0.5884943	ENSG00000120328	PCDHB12	protocadherin beta 12	5	141208697	141212571	protein_coding	HGNC:8683	1.6580433	0.7689203	1.5095347	-0.0927694	-1.4984274	0.9107004	0.1373146	-1.1464035	-2.6157822	-1.7015904	0.1521847	1.1118292
ENSG00000165169	-1.5310891	-1.0589031	3.281950	6.975379	0.0096189	0.5884943	ENSG00000165169	DYNLT3	dynein light chain Tctex-type 3	X	37836757	37847571	protein_coding	HGNC:11694	2.2553361	2.5565003	2.7081510	1.8325368	1.0139939	0.5153421	1.3279506	2.1501697	1.0102363	1.6899790	0.9901765	2.3752972
ENSG00000262246	1.5092221	2.9608211	4.186458	6.978850	0.0096524	0.5884943	ENSG00000262246	CORO7	coronin 7	16	4354542	4425705	protein_coding	HGNC:26161	0.3661381	-13.2877124	2.0574811	-13.2877124	2.4194957	1.8943948	1.5320371	3.4846736	3.1732309	3.3373402	1.9951154	0.4467030
ENSG00000092820	0.8887046	1.6025700	4.623000	6.973511	0.0096921	0.5884943	ENSG00000092820	EZR	ezrin	6	158765741	158819368	protein_coding	HGNC:12691	1.7295336	2.5706640	1.2489786	1.8557709	2.4729114	3.0942626	3.0755167	3.0784375	3.8358304	3.5062759	2.9082809	1.9310415
ENSG00000204033	-3.7450467	-4.0269528	2.061701	6.229095	0.0097542	0.5884943	ENSG00000204033	LRIT2	leucine rich repeat, Ig-like and transmembrane domains 2	10	84220571	84225544	protein_coding	HGNC:23443	-13.2877124	1.0073986	2.0886742	0.2559913	-13.2877124	-1.4768034	-13.2877124	-2.3537783	-13.2877124	-3.3530411	-3.0609630	0.8988099
ENSG00000079785	-0.8602744	-0.9242179	4.538177	6.937061	0.0098418	0.5884943	ENSG00000079785	DDX1	DEAD-box helicase 1	2	15591178	15634346	protein_coding	HGNC:2734	3.1982323	3.9969556	4.6980634	4.0612157	2.3312592	3.8733252	2.3067572	2.3420153	2.5751470	2.4632850	3.0376858	4.0831140
ENSG00000146242	0.4051478	-1.6302624	3.846496	6.943328	0.0098433	0.5884943	ENSG00000146242	TPBG	trophoblast glycoprotein	6	82363206	82367420	protein_coding	HGNC:12004	2.3375358	0.4546265	2.1617029	2.2199045	1.7737521	2.0338268	2.8819312	0.1096080	0.0410705	0.0757462	2.3108906	1.9595725
ENSG00000257150	2.0862882	-2.9184351	2.061882	6.527021	0.0099590	0.5884943	ENSG00000257150	PGAM1P5		12	95672305	95673068	transcribed_processed_pseudogene	HGNC:42452	-13.2877124	-1.4705768	1.2816383	-2.1645674	1.6536948	1.8395021	1.6521629	-2.7734224	-13.2877124	-3.7724363	1.7178382	-0.4077769
ENSG00000102109	-1.7204383	-3.0597223	3.650040	6.861503	0.0099715	0.5884943	ENSG00000102109	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	X	48831096	48835610	protein_coding	HGNC:17301	2.4753648	5.4427523	4.6349366	2.5956476	2.6145410	2.9923773	2.5130998	1.7022657	0.6165214	1.2592092	2.7217793	4.3209508
ENSG00000172819	-0.7150388	-2.0528443	3.700240	6.913255	0.0099847	0.5884943	ENSG00000172819	RARG	retinoic acid receptor gamma	12	53210567	53232980	protein_coding	HGNC:9866	3.1758779	2.0386069	1.9351078	3.3048502	1.7212178	1.6426872	2.3409798	0.4760809	0.8768945	0.6903626	1.9368524	2.7469624
ENSG00000013583	-2.0788656	0.0234541	2.997251	6.710027	0.0099923	0.5884943	ENSG00000013583	HEBP1	heme binding protein 1	12	12974870	13000265	protein_coding	HGNC:17176	2.6556506	4.5422099	3.2386276	3.4362242	2.0061450	2.8555245	-0.5959907	1.9990637	4.7010029	3.9072541	1.9899056	3.6399256

outPath = "output/day10/DEG"
Test = "day10.SCN2A.vs.WT"
qlf = glmQLFTest(fit, coef=2)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0     0    78
## NotSig  13417 13417 13417 13417 13273
## Up          0     0     0     0    66

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("SCN2A", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

SCN2AUp = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
SCN2ADown = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "day10.CHD2.vs.WT"
qlf = glmQLFTest(fit, coef=3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0     7   164
## NotSig  13417 13417 13417 13408 13146
## Up          0     0     0     2   107

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("CHD2", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

CHD2Up = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
CHD2Down = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "day10"
venn.diagram(list(CHD2 = CHD2Up, SCN2A = SCN2AUp), filename = paste(outPath,ExperimentName,Test,"up.png", sep="."), imagetype = "png", main = paste(Test, "up regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

venn.diagram(list(CHD2 = CHD2Down, SCN2A = SCN2ADown), filename = paste(outPath,ExperimentName,Test,"down.png", sep="."), imagetype = "png", main = paste(Test, "down regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

SCN2AUp.d10 = SCN2AUp
SCN2ADown.d10 = SCN2ADown
CHD2Up.d10 = CHD2Up
CHD2Down.d10 = CHD2Down

Venn diagram up regulated

Venn diagram down regulated

Note:

1c. Day 22 of transdifferentiation

Test the differences between WT, SCN2A and CHD2 at 22 days of transdifferentiation.

fit = test_a_diff_state(diffState = "day_22", countTable = counts.current)
qlf = glmQLFTest(fit, coef=2:3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## NotSig  10620 10620 10619 10617 10398
## Sig         0     0     1     3   222

d22.genes.expressed = rownames(qlf$table)
attach_annotations_by_p(qlf, 0.01) %>%
  kbl() %>%
  kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
  scroll_box(width = "100%", height = "300px")

	logFC.fSCN2A	logFC.fCHD2	logCPM	F	PValue	FDR	ensembl_gene_id	hgnc_symbol	entrezgene_description	chromosome_name	start_position	end_position	gene_biotype	hgnc_id	CON_1_d22	CON_2_d22	CON_3_d22	CON_4_d22	SCN2A_1_d22	SCN2A_2_d22	SCN2A_3_d22	CHD2_1_d22	CHD2_2_d22	CHD2	SCN2A	WT
ENSG00000115461	1.2154621	-1.8009508	9.854720	46.875451	0.0000017	0.0177274	ENSG00000115461	IGFBP5	insulin like growth factor binding protein 5	2	216672105	216695549	protein_coding	HGNC:5474	6.7393814	6.4262847	6.6384098	6.8382508	7.2831498	8.0650522	8.0668223	4.9227770	4.7471416	4.8376305	7.8490410	6.6685106
ENSG00000078018	-1.3681381	-2.3362726	5.580023	31.597306	0.0000141	0.0746568	ENSG00000078018	MAP2	microtubule associated protein 2	2	209424047	209734147	protein_coding	HGNC:6839	3.8906787	2.9556599	4.1916258	4.3579641	2.5426790	1.1316731	3.4181590	2.0545328	2.3787374	2.2257228	2.6405899	3.9394360
ENSG00000159167	-2.7883869	-3.0433089	4.577133	26.156255	0.0000302	0.1069264	ENSG00000159167	STC1	stanniocalcin 1	8	23841929	23854806	protein_coding	HGNC:11373	3.2154733	2.4458946	2.9473699	4.0597613	0.5654675	0.8295021	-0.1398079	0.6730000	-0.5578792	0.1850318	0.4732082	3.2901081
ENSG00000168280	-1.0994778	-2.5395448	6.223597	21.434091	0.0000960	0.2281226	ENSG00000168280	KIF5C	kinesin family member 5C	2	148875227	149026759	protein_coding	HGNC:6325	4.0712771	3.5658391	4.4124459	3.4232485	3.3610034	1.9651548	2.6938576	1.5036372	0.9857933	1.2678258	2.7830731	3.9230284
ENSG00000168237	-0.0847893	-3.1458674	7.835647	20.671764	0.0001133	0.2281226	ENSG00000168237	GLYCTK	glycerate kinase	3	52287089	52295257	protein_coding	HGNC:24247	6.6620413	6.3007557	7.9045898	7.8440020	7.1450860	7.2659996	7.7817415	3.7054372	4.1278118	3.9320271	7.4249114	7.3431489
ENSG00000228299	9.6140612	8.1125093	7.350232	19.372934	0.0001289	0.2281226	ENSG00000228299	HLA-C	major histocompatibility complex, class I, C	HSCHR6_MHC_DBB_CTG1	2526549	2529920	protein_coding	HGNC:4933	-0.1744309	-13.2877124	-13.2877124	-13.2877124	7.2452907	8.0898783	8.9249143	8.4055414	-13.2877124	7.4055418	8.2450971	-2.1739422
ENSG00000115648	0.9240299	2.5183624	5.132168	18.690796	0.0001890	0.2293797	ENSG00000115648	MLPH	melanophilin	2	237485428	237555322	protein_coding	HGNC:29643	4.9991954	3.4565139	2.8892152	2.8823265	5.1409111	3.3592836	5.0391195	5.1624346	5.9724117	5.6235353	4.7082816	3.8515492
ENSG00000053918	3.2971008	-1.5166940	3.230305	14.807817	0.0001897	0.2293797	ENSG00000053918	KCNQ1	potassium voltage-gated channel subfamily Q member 1	11	2444654	2849105	protein_coding	HGNC:6294	-0.5545890	-13.2877124	0.8324599	0.8526741	2.9156391	2.4274007	3.1530209	-1.6352841	-13.2877124	-2.6348360	2.8626176	0.0933962
ENSG00000157087	-0.3644653	-1.9549395	6.846559	18.416113	0.0001950	0.2293797	ENSG00000157087	ATP2B2	ATPase plasma membrane Ca2+ transporting 2	3	10324023	10708007	protein_coding	HGNC:815	4.3423509	3.8809880	4.8226802	4.6654509	4.9633393	3.8597498	4.4717238	2.6143916	3.0566014	2.8523736	4.5004434	4.4707689
ENSG00000120885	1.0273489	3.5229411	9.022523	18.007641	0.0002160	0.2293797	ENSG00000120885	CLU	clusterin	8	27596917	27614700	protein_coding	HGNC:2095	5.0519783	7.8031300	7.7372493	6.6230351	8.2595315	7.3569004	7.4159242	11.5159320	9.5834901	10.8516272	7.7395612	7.1509181
ENSG00000145423	2.5906621	-1.4595409	6.595934	17.620824	0.0002417	0.2303368	ENSG00000145423	SFRP2	secreted frizzled related protein 2	4	153780591	153789083	protein_coding	HGNC:10777	1.5544361	3.2694131	4.3346798	5.4979958	6.6153372	5.8548595	7.4741362	3.3306617	1.7283951	2.7413926	6.7975332	4.2844641
ENSG00000286140	0.4956782	-6.5192024	3.907978	18.772994	0.0002603	0.2303368	ENSG00000286140	DERPC	DERPC proline and glycine rich nuclear protein	16	69118010	69132588	protein_coding	HGNC:54084	1.5096082	2.3181826	2.1629560	2.7893854	2.5885506	3.1048975	2.5143139	-13.2877124	-13.2877124	-13.2877124	2.7606853	2.2649888
ENSG00000254245	-1.1678632	1.6349004	5.278198	16.646629	0.0003153	0.2443655	ENSG00000254245	PCDHGA3	protocadherin gamma subfamily A, 3	5	141343829	141512975	protein_coding	HGNC:8701	1.2392104	2.7642920	2.8836513	2.7971037	1.0871756	0.7963976	1.5495933	4.6210747	3.0932779	4.0506174	1.1781690	2.5536942
ENSG00000080573	1.1414736	-0.1581598	7.140399	16.496666	0.0003221	0.2443655	ENSG00000080573	COL5A3	collagen type V alpha 3 chain	19	9959561	10010504	protein_coding	HGNC:14864	3.7698707	4.0858953	3.7245103	3.6761382	5.1070779	4.6573297	5.0921053	3.8839023	3.3807937	3.6541686	4.9667009	3.8233428
ENSG00000204469	-6.6745690	-8.9709163	5.221519	15.225860	0.0003884	0.2750102	ENSG00000204469	PRRC2A	proline rich coiled-coil 2A	6	31620715	31637771	protein_coding	HGNC:13918	4.5172418	1.8884183	-13.2877124	3.5887977	-1.5316690	2.4126260	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.9184885	3.2717915
ENSG00000197467	-2.6202177	1.5028971	3.361000	13.250424	0.0004394	0.2851028	ENSG00000197467	COL13A1	collagen type XIII alpha 1 chain	10	69801880	69964275	protein_coding	HGNC:2190	1.3820170	2.0137499	1.1656277	2.1118553	-0.9006240	-13.2877124	-0.4973720	2.6554086	3.7415324	3.2983543	-1.2698009	1.7236027
ENSG00000205238	-0.6588671	0.8706292	7.649536	15.254509	0.0004564	0.2851028	ENSG00000205238	SPDYE2	speedy/RINGO cell cycle regulator family member E2	7	102551226	102563538	protein_coding	HGNC:33841	6.9073837	7.3250263	7.2613138	6.9818674	6.7947191	6.1093909	6.2217217	8.0214949	7.7638554	7.8984187	6.4076743	7.1298064
ENSG00000110076	-0.6362181	-4.0853868	4.475812	14.120380	0.0004985	0.2940902	ENSG00000110076	NRXN2	neurexin 2	11	64606174	64723197	protein_coding	HGNC:8009	4.8897311	1.5277029	2.1843777	2.9116599	0.4651648	2.4794468	1.2285041	-2.6802434	2.6624102	1.6975319	1.6323534	3.4789296
ENSG00000005020	-2.7332569	-0.6569980	3.945762	13.317089	0.0005909	0.3187422	ENSG00000005020	SKAP2	src kinase associated phosphoprotein 2	7	26667068	26995239	protein_coding	HGNC:15687	4.0150812	2.3796559	4.5114092	3.1291843	2.4240051	-0.1586580	3.4127226	2.7428362	4.0446672	3.5358647	2.4950138	3.7259792
ENSG00000183688	0.7962448	1.7178956	5.317373	14.383100	0.0006003	0.3187422	ENSG00000183688	RFLNB	refilin B	17	439978	445939	protein_coding	HGNC:28705	2.7973606	1.8863375	2.3141820	2.5081053	3.4765245	2.7401776	3.2859545	4.2358330	3.9822173	4.1145910	3.1998744	2.4134980
ENSG00000122783	0.3252861	2.1095878	6.629929	13.726128	0.0007233	0.3333062	ENSG00000122783	CYREN	cell cycle regulator of NHEJ	7	135092363	135170795	protein_coding	HGNC:22432	6.0384450	4.4427601	4.9441931	6.3857980	6.3147225	5.0817779	6.5776380	8.1519752	7.5734805	7.8915314	6.1222693	5.6573733
ENSG00000233151	4.0196391	6.5852888	4.532378	11.676727	0.0007500	0.3333062	ENSG00000233151	CYP21A2	cytochrome P450 family 21 subfamily A member 2	HSCHR6_MHC_COX_CTG1	3476620	3479992	protein_coding	HGNC:2600	-13.2877124	-13.2877124	-13.2877124	0.2051185	2.6383635	-13.2877124	3.4533437	-13.2877124	6.1168701	5.1168722	2.5176982	-1.7945059
ENSG00000166106	1.2195178	-0.9392369	5.016466	13.459585	0.0007994	0.3333062	ENSG00000166106	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif 15	11	130448645	130476645	protein_coding	HGNC:16305	2.1075911	0.7778014	1.7117112	2.2984269	3.4064263	2.5612907	3.0042375	0.9569034	0.7285806	0.8472545	3.0314585	1.8297408
ENSG00000170577	5.0094360	0.5934652	2.851396	12.401449	0.0008659	0.3333062	ENSG00000170577	SIX2	SIX homeobox 2	2	45005182	45009452	protein_coding	HGNC:10888	-13.2877124	-0.8984252	-13.2877124	-13.2877124	2.8518600	2.0545766	2.8857385	-1.0073563	-13.2877124	-2.0070663	2.6449609	-2.8976187
ENSG00000107551	0.5758707	2.2845082	4.199452	13.140351	0.0008741	0.3333062	ENSG00000107551	RASSF4	Ras association domain family member 4	10	44959407	44995891	protein_coding	HGNC:20793	1.4489966	0.0154419	0.4422928	0.5038362	2.3554372	1.2318256	1.1630124	3.0316713	3.2699446	3.1557214	1.6938219	0.7043594
ENSG00000104435	-0.7578305	-2.0730237	5.936616	13.084474	0.0008886	0.3333062	ENSG00000104435	STMN2	stathmin 2	8	79611117	79666158	protein_coding	HGNC:10577	4.9364823	5.1329160	4.9262776	5.7312044	4.0454245	4.1792688	4.9002866	3.6234135	2.3267694	3.1161097	4.4260799	5.2214575
ENSG00000127241	0.9020888	-1.3699098	8.236080	13.060429	0.0008901	0.3333062	ENSG00000127241	MASP1	MBL associated serine protease 1	3	187217282	187291980	protein_coding	HGNC:6901	6.6556987	6.4278299	6.2170083	7.6425060	7.3854554	7.2336384	7.3710187	6.4209114	5.4290593	6.0085949	7.3316419	6.8489954
ENSG00000147488	-0.5716525	-2.4595768	5.647996	12.969826	0.0009259	0.3333062	ENSG00000147488	ST18	ST18 C2H2C-type zinc finger transcription factor	8	52110838	52460959	protein_coding	HGNC:18695	4.1267364	3.7506849	5.1966399	4.2959017	4.5708094	3.6927304	5.1337380	1.3362857	1.3748603	1.3557019	4.5810432	4.4470027
ENSG00000165973	1.6861953	3.6981998	3.640160	11.322697	0.0009605	0.3333062	ENSG00000165973	NELL1	neural EGFL like 1	11	20669551	21575686	protein_coding	HGNC:7750	-1.4413679	-1.0380004	0.0708921	0.4339721	-13.2877124	-0.0216096	3.5648224	2.8706754	3.5128021	3.2271731	2.0952354	-0.2966627
ENSG00000167614	1.0607496	-4.1068808	3.951697	12.037345	0.0009972	0.3333062	ENSG00000167614	TTYH1	tweety family member 1	19	54415219	54436904	protein_coding	HGNC:13476	0.6688589	1.1415348	0.4347323	2.7093762	2.4925572	2.0782375	3.3369266	-13.2877124	0.7668436	-0.2330716	2.7337274	1.5469585
ENSG00000174804	1.4158827	0.4083915	6.077212	12.629228	0.0010279	0.3333062	ENSG00000174804	FZD4	frizzled class receptor 4	11	86945679	86955395	protein_coding	HGNC:4042	2.5438225	1.6009315	2.0121145	2.6147902	3.2958636	3.5405964	3.9960637	2.6525914	2.5988654	2.6259783	3.6405419	2.2497320
ENSG00000204033	-2.5751957	-6.8568055	3.502770	12.186484	0.0010600	0.3333062	ENSG00000204033	LRIT2	leucine rich repeat, Ig-like and transmembrane domains 2	10	84220571	84225544	protein_coding	HGNC:23443	-1.4720049	2.7270088	2.6640547	3.0865470	0.1891427	-0.8112598	-0.3634028	-13.2877124	-13.2877124	-13.2877124	-0.2703825	2.4471838
ENSG00000157005	0.9725873	-1.4842086	8.848434	12.492251	0.0010714	0.3333062	ENSG00000157005	SST	somatostatin	3	187668912	187670394	protein_coding	HGNC:11329	9.1151141	9.5829116	9.6651642	11.1733260	10.8000239	11.4581409	10.6472385	8.8498269	8.0641648	8.5098296	11.0131259	10.1172461
ENSG00000168802	1.0902952	4.2974119	3.369461	9.991134	0.0010770	0.3333062	ENSG00000168802	CHTF8	chromosome transmission fidelity factor 8	16	69118010	69132588	protein_coding	HGNC:24353	-13.2877124	2.8537077	-13.2877124	-13.2877124	1.9266242	1.1461267	-13.2877124	3.2977210	3.2086593	3.2538774	1.0035864	0.8537674
ENSG00000149212	1.0188947	-0.3744701	6.349448	12.345297	0.0011272	0.3333062	ENSG00000149212	SESN3	sestrin 3	11	95165513	95232541	protein_coding	HGNC:23060	2.4744207	2.4956547	1.8799222	2.8952359	3.5797290	5.1677911	3.4033315	2.6017227	1.6958544	2.2187499	4.2850029	2.4801030
ENSG00000112365	1.9168884	2.8529782	3.448981	11.206075	0.0011299	0.3333062	ENSG00000112365	ZBTB24	zinc finger and BTB domain containing 24	6	109460632	109483239	protein_coding	HGNC:21143	-2.3735067	-0.7650720	-1.2459643	-1.4665563	0.8635603	0.6032852	0.3094510	0.9988519	1.8958583	1.5159753	0.6097332	-1.3539565
ENSG00000176788	-0.2016400	-1.5218051	6.759060	11.972125	0.0012773	0.3520452	ENSG00000176788	BASP1	brain abundant membrane attached signal protein 1	5	17065598	17276843	protein_coding	HGNC:957	5.7277589	6.1997812	6.3846615	6.4812136	5.5910908	6.0635494	6.2520743	4.3311374	4.8690820	4.6250390	5.9947702	6.2259003
ENSG00000086570	-0.7487769	0.4181345	7.231664	11.957446	0.0012833	0.3520452	ENSG00000086570	FAT2	FAT atypical cadherin 2	5	151504092	151591331	protein_coding	HGNC:3596	3.2703054	3.0854811	3.0188944	3.4243590	2.2667781	2.4491852	2.5778923	3.6076440	3.5879964	3.5978536	2.4368918	3.2085995
ENSG00000018189	-0.0985046	-1.7409245	5.658187	11.953743	0.0012928	0.3520452	ENSG00000018189	RUFY3	RUN and FYVE domain containing 3	4	70704204	70808619	protein_coding	HGNC:30285	3.9388501	3.3857636	3.7553100	5.4862944	4.6295425	5.9232733	3.4767297	1.7915465	3.2493341	2.6972316	5.0085570	4.3943651
ENSG00000258388	-9.6601098	-9.6601098	5.861661	14.340726	0.0014022	0.3722803	ENSG00000258388	PPT2-EGFL8		6	32153845	32171978	protein_coding	HGNC:48343	5.9722763	4.4317228	-13.2877124	4.1945557	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	4.6819187
ENSG00000178814	2.8424301	1.4495904	3.787627	11.011780	0.0014546	0.3767717	ENSG00000178814	OPLAH	5-oxoprolinase, ATP-hydrolysing	8	144051266	144063965	protein_coding	HGNC:8149	1.9644851	-1.8616678	-0.1717145	0.3442274	3.8685074	3.9547719	1.7996241	1.8351629	-0.6177267	1.0771794	3.4851548	0.6633783
ENSG00000144893	2.9119905	-0.3538035	6.189553	11.511148	0.0015155	0.3771598	ENSG00000144893	MED12L	mediator complex subunit 12L	3	151085286	151437072	protein_coding	HGNC:16050	2.6738045	0.1089272	1.5590307	-0.1465280	2.4265004	3.1389696	4.7213450	1.7539895	-3.6853290	0.7868615	3.7571769	1.4994638
ENSG00000138792	4.4486123	3.4354732	3.291573	9.990191	0.0015271	0.3771598	ENSG00000138792	ENPEP	glutamyl aminopeptidase	4	110365733	110565285	protein_coding	HGNC:3355	-1.7024540	-13.2877124	-13.2877124	-13.2877124	1.1702898	1.2733279	0.7153443	0.5312592	-0.6959867	0.0443780	1.0725927	-3.7010461
ENSG00000180611	2.2076921	0.1880024	3.552860	10.854820	0.0016713	0.3950894	ENSG00000180611	MB21D2	Mab-21 domain containing 2	3	192796815	192917856	protein_coding	HGNC:30438	0.5369759	-0.4333855	0.2585141	0.7740748	2.7009390	2.8983005	2.1052982	0.7787855	0.2235869	0.5277300	2.6056991	0.3498714
ENSG00000102109	-0.5194391	-1.9857637	5.493957	11.217829	0.0016741	0.3950894	ENSG00000102109	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	X	48831096	48835610	protein_coding	HGNC:17301	5.9212418	5.6615316	6.5710235	5.9760811	5.5273355	5.5146339	5.8091323	4.5562152	3.2944753	4.0590965	5.6235716	6.0727532
ENSG00000152932	-1.3204969	-2.2028048	4.690510	10.927621	0.0018733	0.4287718	ENSG00000152932	RAB3C	RAB3C, member RAS oncogene family	5	58582221	58859394	protein_coding	HGNC:30269	1.3740457	4.0116798	4.7933908	5.3490858	0.6790445	-0.4321294	2.8636374	-0.1744455	-0.5934046	-0.3687700	1.6811834	4.4464616
ENSG00000239264	0.9432881	1.1014428	7.589479	10.725931	0.0019821	0.4287718	ENSG00000239264	TXNDC5	thioredoxin domain containing 5	6	7881517	7910788	protein_coding	HGNC:21073	5.2103216	5.2582689	5.3872643	5.4473387	6.7062434	5.7085592	6.1815991	6.8040277	6.1744205	6.5233008	6.2561154	5.3289578
ENSG00000248329	3.8146640	2.3359904	3.626628	9.242559	0.0020186	0.4287718	ENSG00000248329	APELA	apelin receptor early endogenous ligand	4	164877178	164898965	protein_coding	HGNC:48925	-0.0929540	-1.0597806	-13.2877124	-0.1728151	3.6165221	3.0307164	3.8296993	4.6963858	-13.2877124	3.6963913	3.5300737	-0.7955362
ENSG00000087074	0.1502397	-1.4313951	5.407235	10.687758	0.0020248	0.4287718	ENSG00000087074	PPP1R15A	protein phosphatase 1 regulatory subunit 15A	19	48872212	48876059	protein_coding	HGNC:14375	4.0502677	4.0572694	4.6062940	4.3191646	4.5376719	3.7976805	4.5541640	2.9525045	2.8474059	2.9009120	4.3368918	4.2767656
ENSG00000126603	2.8002668	4.8903187	3.499261	8.986899	0.0020566	0.4287718	ENSG00000126603	GLIS2	GLIS family zinc finger 2	16	4314761	4339597	protein_coding	HGNC:29450	-0.3908824	-13.2877124	-13.2877124	-13.2877124	1.8302574	-13.2877124	-13.2877124	2.8440457	2.5136471	2.6882841	0.2453760	-2.3903154
ENSG00000127995	1.6873341	-1.9207012	3.213817	9.669144	0.0021320	0.4287718	ENSG00000127995	CASD1	CAS1 domain containing 1	7	94509219	94557019	protein_coding	HGNC:16014	0.6095857	-0.2421541	0.2166808	0.8646137	1.2181848	2.1261578	1.8347104	-1.9367511	-2.1675134	-2.0475233	1.7738655	0.4206743
ENSG00000253953	2.2163484	0.7611827	3.921109	10.417983	0.0021391	0.4287718	ENSG00000253953	PCDHGB4	protocadherin gamma subfamily B, 4	5	141387698	141512975	protein_coding	HGNC:8711	0.0717489	-0.4335803	0.8614052	-0.6215971	2.6116766	1.3472206	2.5730822	0.6083305	0.9862507	0.8096301	2.2836397	0.0902329
ENSG00000148082	1.3926045	-0.7621476	5.025644	10.486639	0.0021991	0.4287718	ENSG00000148082	SHC3	SHC adaptor protein 3	9	89005771	89178818	protein_coding	HGNC:18181	-0.0679524	0.5905599	0.2075918	1.9872212	2.3172030	1.9383118	2.4992275	2.4221843	-0.3835538	1.6150316	2.2700352	0.9220661
ENSG00000204520	-7.5707900	-7.5707900	3.964003	12.576477	0.0022303	0.4287718	ENSG00000204520	MICA	MHC class I polypeptide-related sequence A	6	31399784	31415315	protein_coding	HGNC:7090	4.0112845	4.1973296	-13.2877124	4.1000571	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.6898571
ENSG00000106070	1.4434900	-0.1033140	4.396150	10.439823	0.0022605	0.4287718	ENSG00000106070	GRB10	growth factor receptor bound protein 10	7	50590063	50793462	protein_coding	HGNC:4564	3.0895668	1.9730466	1.2294218	1.9288312	2.7610176	3.8764508	2.4673470	1.7505379	0.8764686	1.3787103	3.1697020	2.2164986
ENSG00000274944	-1.1317878	-0.0753593	5.742414	10.377368	0.0022687	0.4287718	ENSG00000274944			1	38864501	38881617	protein_coding		4.2160504	3.8685449	4.3290617	4.9233905	2.9830323	3.1140665	2.9704863	4.0487147	4.0713635	4.0600835	3.0240042	4.3860446
ENSG00000242265	0.9107498	-2.7437944	6.452623	10.245421	0.0023830	0.4287718	ENSG00000242265	PEG10	paternally expressed 10	7	94656325	94669695	protein_coding	HGNC:14005	3.6743091	4.0973941	3.7151969	5.9802768	5.0884646	4.6587239	6.2638236	-0.3406216	2.5728618	1.7526600	5.5038216	4.7299436
ENSG00000077942	1.1745016	-0.7214730	8.986809	10.213985	0.0023968	0.4287718	ENSG00000077942	FBLN1	fibulin 1	22	45502238	45601135	protein_coding	HGNC:3600	6.8146830	7.2713206	7.3152248	7.4175935	8.2491994	8.0676406	8.6975668	7.2025119	5.1578459	6.5156167	8.3630088	7.2222701
ENSG00000110092	-0.9467891	-1.5242152	6.829618	10.138180	0.0024689	0.4287718	ENSG00000110092	CCND1	cyclin D1	11	69641156	69654474	protein_coding	HGNC:1582	4.1133444	6.1373005	7.0058541	6.7629950	5.2924917	4.6671134	4.5346707	3.0080413	4.2873939	3.7851142	4.8707952	6.3435274
ENSG00000148600	-3.8589711	-3.3488040	3.787410	8.828474	0.0025336	0.4287718	ENSG00000148600	CDHR1	cadherin related family member 1	10	84194537	84219621	protein_coding	HGNC:14550	-13.2877124	1.7456336	2.6290024	2.1532739	-13.2877124	-1.1247201	-0.1459070	-1.8659368	-0.3150000	-0.8913805	-1.1387043	1.8061036
ENSG00000229698	-4.9637719	-7.6966188	4.092576	9.320796	0.0025816	0.4287718	ENSG00000229698	HLA-F	major histocompatibility complex, class I, F	HSCHR6_MHC_SSTO_CTG1	1029074	1044770	protein_coding	HGNC:4963	6.0894158	-13.2877124	5.8315335	3.6022307	-13.2877124	0.8091625	3.1156735	-13.2877124	-13.2877124	-13.2877124	1.7963403	5.0999592
ENSG00000124225	1.9116165	0.1199893	4.646295	10.048367	0.0026110	0.4287718	ENSG00000124225	PMEPA1	prostate transmembrane protein, androgen induced 1	20	57648392	57711536	protein_coding	HGNC:14107	4.2629126	0.7638076	-0.9385722	3.6421898	4.4066973	4.9657224	5.0539404	3.7297281	5.0093581	4.5069972	4.8358921	3.0833693
ENSG00000184347	1.5369432	-0.1537926	7.116849	9.925170	0.0026772	0.4287718	ENSG00000184347	SLIT3	slit guidance ligand 3	5	168661740	169301139	protein_coding	HGNC:11087	3.8305179	4.0075769	1.9137741	3.9831096	4.8285083	5.6115702	5.6075453	3.9726308	2.9554119	3.5518765	5.3930537	3.6407528
ENSG00000179051	-0.2659859	-2.3153316	4.386277	9.908050	0.0026944	0.4287718	ENSG00000179051	RCC2	regulator of chromosome condensation 2	1	17406760	17439677	protein_coding	HGNC:30297	2.5630817	2.6854632	1.8204094	3.0144560	2.8298045	2.4663309	2.5720519	0.7171445	0.3744697	0.5559575	2.6309250	2.5822511
ENSG00000225859	2.1751185	0.6686480	5.453506	9.905518	0.0027305	0.4287718	ENSG00000225859	DDX39B	DExD-box helicase 39B	HSCHR6_MHC_MANN_CTG1	2835292	2851631	protein_coding	HGNC:13917	2.7015832	2.7320028	5.0183083	2.6303915	5.7460551	4.4403019	5.3688545	3.5509483	4.9153308	4.3887551	5.2817364	3.6934747
ENSG00000121898	-1.1962186	3.0942561	3.605255	8.559309	0.0028106	0.4287718	ENSG00000121898	CPXM2	carboxypeptidase X, M14 family member 2	10	123706207	123940267	protein_coding	HGNC:26977	-13.2877124	1.5012939	-13.2877124	0.5420847	-13.2877124	1.1032479	-13.2877124	2.4913485	3.7864174	3.2795694	-0.4815803	0.1000492
ENSG00000182108	-1.2319528	-0.1356314	6.563218	9.745620	0.0028733	0.4287718	ENSG00000182108	DEXI	Dexi homolog	16	10928891	10942468	protein_coding	HGNC:13267	3.9600051	4.9673928	5.1199148	5.2017904	3.4832360	3.9204332	4.1104058	4.7352293	5.2750828	5.0302615	3.8611941	4.8878279
ENSG00000164692	1.5532203	0.0013873	12.456120	9.709311	0.0029083	0.4287718	ENSG00000164692	COL1A2	collagen type I alpha 2 chain	7	94394895	94431227	protein_coding	HGNC:2198	10.1259203	9.2642410	8.3903293	9.8505353	10.4972851	10.4693268	11.4974508	9.9110441	8.7649111	9.4489214	10.9054669	9.5464444
ENSG00000139289	-0.9508426	-1.0289026	8.059266	9.684013	0.0029376	0.4287718	ENSG00000139289	PHLDA1	pleckstrin homology like domain family A member 1	12	76025447	76031776	protein_coding	HGNC:8933	5.6614926	4.6981308	5.1789294	5.4583924	4.5110533	3.9930714	4.4375943	4.5200291	3.8986078	4.2425217	4.3313778	5.2924792
ENSG00000134207	-1.3740526	-6.7330023	3.549973	10.046641	0.0029461	0.4287718	ENSG00000134207	SYT6	synaptotagmin 6	1	114089291	114153880	protein_coding	HGNC:18638	0.6237049	3.1698330	1.9942825	3.5890113	2.0581138	0.2426025	-0.3301387	-13.2877124	-13.2877124	-13.2877124	1.0339811	2.7310831
ENSG00000136997	0.9547388	-2.1263818	4.739893	9.583090	0.0030477	0.4287718	ENSG00000136997	MYC	MYC proto-oncogene, bHLH transcription factor	8	127735434	127742951	protein_coding	HGNC:7553	5.4268589	0.9957812	2.9123377	5.5504534	4.6007509	3.8367477	5.3676615	2.4208316	1.1712831	1.9273113	4.7340874	4.6352568
ENSG00000077279	-1.0816719	-3.8822139	5.019413	9.405814	0.0031414	0.4287718	ENSG00000077279	DCX	doublecortin	X	111293779	111412429	protein_coding	HGNC:2714	2.7783198	2.8259677	1.8965776	3.2427665	1.7313219	1.4074838	1.9974864	-13.2877124	-0.8656529	-1.8653900	1.7320660	2.7623907
ENSG00000185624	1.1165770	0.6098968	9.261682	9.501514	0.0031552	0.4287718	ENSG00000185624	P4HB	prolyl 4-hydroxylase subunit beta	17	81843159	81860856	protein_coding	HGNC:8548	7.6393985	7.6547997	7.4526223	8.4525255	8.4241572	8.5848563	8.5923619	8.5277992	7.7152658	8.1779950	8.5358508	7.8554852
ENSG00000233935	0.5466009	2.9004409	6.096533	9.390896	0.0033263	0.4287718	ENSG00000233935			HSCHR6_MHC_COX_CTG1	1206841	1207831	unprocessed_pseudogene		-13.2877124	5.3575830	6.0996609	3.8688770	6.0667744	5.3582563	4.7148631	7.3742830	8.0888554	7.7753655	5.4844936	4.9563852
ENSG00000165609	-1.0789321	0.5131832	5.288029	9.394920	0.0033263	0.4287718	ENSG00000165609	NUDT5	nudix hydrolase 5	10	12165330	12195891	protein_coding	HGNC:8052	4.2921533	4.2719533	5.7312933	3.9830484	3.0693084	3.8097975	3.1277057	4.6978888	4.7742901	4.7365951	3.3765627	4.7528513
ENSG00000187244	-1.1331906	1.0136080	5.447649	9.358999	0.0033748	0.4287718	ENSG00000187244	BCAM	basal cell adhesion molecule (Lutheran blood group)	19	44809071	44821421	protein_coding	HGNC:6722	3.2852544	4.2477372	5.4384757	3.0943866	3.9449615	3.4640556	1.7943289	5.1186728	5.0066593	5.0637529	3.3173501	4.3336541
ENSG00000138756	-1.0983250	-0.7037116	5.353587	9.328570	0.0034071	0.4287718	ENSG00000138756	BMP2K	BMP2 inducible kinase	4	78776342	78916365	protein_coding	HGNC:18041	2.9762696	2.7785255	3.7415815	3.5349537	1.9410740	2.0436087	4.9993843	2.4191079	2.0173219	2.2321570	3.7351256	3.3110024
ENSG00000284753	-0.7183719	-1.1263574	7.522214	9.304538	0.0034127	0.4287718	ENSG00000284753	EEF1AKMT4	EEF1A lysine methyltransferase 4	3	184249672	184258759	protein_coding	HGNC:53611	6.8690003	6.6337439	7.4434559	7.1904638	6.1633691	6.0327867	6.6918765	5.6734531	6.0742933	5.8877499	6.3251057	7.0669434
ENSG00000225073	-2.9756550	2.0275098	3.120446	8.968612	0.0034374	0.4287718	ENSG00000225073	DDX39B	DExD-box helicase 39B	HSCHR6_MHC_COX_CTG1	3007552	3023908	protein_coding	HGNC:13917	2.7015832	1.4532410	-13.2877124	1.6392868	-0.9594750	-13.2877124	-13.2877124	2.9630318	1.8178708	2.5012116	-2.5438768	1.6274431
ENSG00000013297	1.0068560	-0.5401569	7.224316	9.250216	0.0034883	0.4287718	ENSG00000013297	CLDN11	claudin 11	3	170418868	170454733	protein_coding	HGNC:8514	5.8625523	4.8299809	5.4294671	6.3573889	6.9904513	6.3607516	7.1728680	4.5441961	5.5239076	5.1156646	6.8811414	5.7259655
ENSG00000129757	1.6442648	-0.7193743	4.607129	9.258687	0.0035448	0.4287718	ENSG00000129757	CDKN1C	cyclin dependent kinase inhibitor 1C	11	2883213	2885775	protein_coding	HGNC:1786	3.3763097	1.7399224	1.7308004	3.6750575	4.7294796	4.7920510	4.0940213	2.8126169	2.1475317	2.5180652	4.5710834	2.8980493
ENSG00000148798	-0.4243527	-1.7654131	5.847229	9.213513	0.0035527	0.4287718	ENSG00000148798	INA	internexin neuronal intermediate filament protein alpha	10	103277138	103290346	protein_coding	HGNC:6057	4.5302429	4.4257669	4.1631346	4.2637918	3.0417453	4.2729351	4.1650510	2.5317702	2.5886175	2.5604738	3.9230342	4.3527037
ENSG00000171759	-0.6065601	-1.8494324	5.884319	9.201612	0.0035697	0.4287718	ENSG00000171759	PAH	phenylalanine hydroxylase	12	102836889	102958410	protein_coding	HGNC:8582	8.8615744	8.0264001	9.2103454	9.7189878	8.8526635	7.7970263	8.6547599	7.6677661	6.3672376	7.1593396	8.5021416	9.0774946
ENSG00000113209	0.0077013	-3.2293513	3.941841	8.842074	0.0035737	0.4287718	ENSG00000113209	PCDHB5	protocadherin beta 5	5	141135206	141138615	protein_coding	HGNC:8690	1.3686896	2.3037854	1.8251290	2.7414154	1.0281794	2.0283517	2.7971047	-0.7127145	0.4630961	-0.0081976	2.1231447	2.1497897
ENSG00000131016	1.5815387	0.0096817	5.195991	9.217056	0.0035742	0.4287718	ENSG00000131016	AKAP12	A-kinase anchoring protein 12	6	151239967	151358559	protein_coding	HGNC:370	0.4420326	0.9111708	2.1448236	1.2619291	2.8650187	2.8657476	3.3117439	0.3649803	1.9951936	1.3990508	3.0299973	1.3305056
ENSG00000158445	-1.3186466	-1.0829731	4.874255	9.218540	0.0035786	0.4287718	ENSG00000158445	KCNB1	potassium voltage-gated channel subfamily B member 1	20	49293394	49484297	protein_coding	HGNC:6231	2.4195874	2.0464020	2.7486592	2.8005355	1.5609194	0.5791145	1.3624834	0.8761637	1.7768982	1.3957138	1.2256087	2.5341137
ENSG00000224501	-0.7701764	2.7692727	4.439228	8.984811	0.0036273	0.4287718	ENSG00000224501	HSPA1B	heat shock protein family A (Hsp70) member 1B	HSCHR6_MHC_COX_CTG1	3304988	3307511	protein_coding	HGNC:5233	-13.2877124	-13.2877124	1.8701497	3.4156727	0.8843494	-13.2877124	1.7486579	3.9161664	4.8437891	4.4532830	0.7953489	1.8406916
ENSG00000164284	-1.2164107	-1.1996461	5.215254	9.161019	0.0036509	0.4287718	ENSG00000164284	GRPEL2	GrpE like 2, mitochondrial	5	149345430	149354583	protein_coding	HGNC:21060	3.5707510	2.8382699	3.8281328	3.6369077	3.1624292	2.6762112	1.7996241	2.3497242	2.8834601	2.6411351	2.6497233	3.5133966
ENSG00000183718	-1.1399504	-0.5549888	6.630051	8.983970	0.0038884	0.4287718	ENSG00000183718	TRIM52	tripartite motif containing 52	5	181254077	181261150	protein_coding	HGNC:19024	5.7053109	5.5212567	6.0268919	5.6477059	4.7228012	4.5606351	4.7317219	5.0859259	5.3237322	5.2097236	4.6738345	5.7376878
ENSG00000149968	-4.9328593	-3.8525626	4.674612	8.027462	0.0038952	0.4287718	ENSG00000149968	MMP3	matrix metallopeptidase 3	11	102835801	102843609	protein_coding	HGNC:7173	1.3861703	-13.2877124	2.8594655	6.7411634	-0.5219725	0.0565891	-0.4868752	1.3169034	0.0753629	0.8257588	-0.2921855	4.8685002
ENSG00000101460	0.2070814	1.5555497	5.833240	8.981411	0.0039063	0.4287718	ENSG00000101460	MAP1LC3A	microtubule associated protein 1 light chain 3 alpha	20	34546854	34560345	protein_coding	HGNC:6838	4.9437838	5.8269495	4.9154398	6.0734879	6.3645221	6.0564660	5.4147488	7.7593890	6.7417767	7.3385046	5.9970652	5.5318933
ENSG00000170390	-0.9098780	-2.4582871	4.038070	8.918845	0.0039142	0.4287718	ENSG00000170390	DCLK2	doublecortin like kinase 2	4	150078445	150257438	protein_coding	HGNC:19002	1.9972071	1.8171357	2.8232492	2.2616614	1.3318502	0.5521104	1.7783604	0.0067404	-0.6387841	-0.2802146	1.3052591	2.2771705
ENSG00000100629	2.7069922	3.2800999	3.137887	7.710032	0.0039899	0.4287718	ENSG00000100629	CEP128	centrosomal protein 128	14	80476983	80959517	protein_coding	HGNC:20359	-13.2877124	1.2425702	-1.6574362	0.5367572	1.6040405	1.4529111	-0.8107840	3.0590022	1.0054733	2.3703822	1.0812503	0.0475412
ENSG00000011028	0.9103826	0.2508215	9.096854	8.911028	0.0040010	0.4287718	ENSG00000011028	MRC2	mannose receptor C-type 2	17	62627670	62693597	protein_coding	HGNC:16875	6.1938101	5.9527798	5.9598909	6.0636948	7.5139225	6.8082501	7.1436629	6.3943201	6.0083553	6.2142066	7.1840376	6.0458972
ENSG00000237206	-3.0178448	-5.5229582	4.163669	8.217566	0.0040649	0.4287718	ENSG00000237206	IMPDH1P4		X	43278125	43279658	processed_pseudogene	HGNC:33959	4.7274424	2.0490700	-0.1577066	5.8086863	0.7826644	-13.2877124	2.4040974	-0.3804424	-13.2877124	-1.3802546	1.2251614	4.4524927
ENSG00000214176	-1.5273632	0.3005208	4.635458	8.848042	0.0041092	0.4287718	ENSG00000214176	PLEKHM1P1		17	64785259	64829208	transcribed_unprocessed_pseudogene	HGNC:35411	2.4302293	2.0264304	2.7357875	2.9381604	1.5685444	2.6935492	0.8617887	2.3913608	3.8126758	3.2703980	1.9071949	2.5722414
ENSG00000142552	1.1989766	1.0505510	6.924750	8.840585	0.0041215	0.4287718	ENSG00000142552	RCN3	reticulocalbin 3	19	49528003	49546962	protein_coding	HGNC:21145	5.2512972	6.1268831	5.2427169	5.8470691	6.5337028	6.8454212	7.1357517	7.1172814	6.1781525	6.7228211	6.8591107	5.6681651
ENSG00000111799	1.0524832	-0.3315360	6.692690	8.836377	0.0041290	0.4287718	ENSG00000111799	COL12A1	collagen type XII alpha 1 chain	6	75084326	75206267	protein_coding	HGNC:2188	2.5654354	3.2379753	1.7698957	4.9416354	3.2056381	3.6199185	4.3947962	2.9180734	3.8585955	3.4636578	3.8263278	3.6292284
ENSG00000091129	-1.2609972	-2.5766784	4.998171	8.861025	0.0041326	0.4287718	ENSG00000091129	NRCAM	neuronal cell adhesion molecule	7	108147623	108456717	protein_coding	HGNC:7994	3.7648677	4.9024440	2.5712975	4.1007887	3.9043890	3.2412149	3.5237407	-1.6439599	0.9407095	0.1631445	3.5822083	4.0575062
ENSG00000128699	-2.7005699	0.0973517	3.896304	8.241915	0.0041392	0.4287718	ENSG00000128699	ORMDL1	ORMDL sphingolipid biosynthesis regulator 1	2	189766012	189784364	protein_coding	HGNC:16036	3.0107090	4.2942497	3.8243084	1.9542641	0.3097525	1.3996655	-0.6556987	3.6453799	3.9281805	3.7936986	0.5890175	3.5147607
ENSG00000106511	4.4061047	4.0736191	3.424041	7.881008	0.0041460	0.4287718	ENSG00000106511	MEOX2	mesenchyme homeobox 2	7	15611212	15686683	protein_coding	HGNC:7014	-13.2877124	-1.0179750	-0.9088269	-13.2877124	1.8384355	1.6131167	3.5881074	3.3320474	-1.3637499	2.3866674	2.6370326	-1.9620876
ENSG00000168477	3.0385896	4.2795468	4.131288	7.927390	0.0042023	0.4287718	ENSG00000168477	TNXB	tenascin XB	6	32041153	32115334	protein_coding	HGNC:11976	-1.1406792	-13.2877124	-13.2877124	-13.2877124	1.8195668	-13.2877124	3.0645763	0.4419986	1.7236001	1.2206643	1.9874511	-3.1397253
ENSG00000185627	1.3400485	0.2377634	4.689533	8.825606	0.0042160	0.4287718	ENSG00000185627	PSMD13	proteasome 26S subunit, non-ATPase 13	11	236966	252984	protein_coding	HGNC:9558	2.7913617	4.2875254	3.5079927	3.8035858	4.6733912	4.7091920	4.8597590	3.1414621	3.7709761	3.4902852	4.7497316	3.6946462
ENSG00000075043	-2.1994908	-2.3725545	4.639640	8.750415	0.0042590	0.4287718	ENSG00000075043	KCNQ2	potassium voltage-gated channel subfamily Q member 2	20	63400208	63472677	protein_coding	HGNC:6296	3.1177097	0.3758190	1.4678987	4.2226695	-0.6960451	1.1980088	-0.3763241	-0.8240756	1.8213661	1.0352720	0.2954832	2.9733405
ENSG00000152580	1.0574497	-0.3063813	5.439487	8.772427	0.0042605	0.4287718	ENSG00000152580	IGSF10	immunoglobulin superfamily member 10	3	151425384	151461061	protein_coding	HGNC:26384	2.5572143	3.3803137	1.5150529	1.7353874	1.8953844	2.2814704	3.1595748	1.2495904	0.5909766	0.9575447	2.5457712	2.4909862
ENSG00000133433	-4.3829950	2.6851651	3.139940	8.986392	0.0042796	0.4287718	ENSG00000133433	GSTT2B	glutathione S-transferase theta 2B	22	23957414	23961195	protein_coding	HGNC:33437	2.8912368	-13.2877124	3.0599253	-13.2877124	-13.2877124	-13.2877124	-13.2877124	4.1530527	4.5632170	4.3726625	-13.2877124	1.9780634
ENSG00000168646	1.3068478	1.3498782	5.204400	8.706255	0.0044028	0.4313448	ENSG00000168646	AXIN2	axin 2	17	65528563	65561648	protein_coding	HGNC:904	1.8569729	3.3997448	2.5545731	2.1519857	3.5952640	4.3446904	4.0019497	3.9959806	3.1917079	3.6491788	4.0127381	2.6144738
ENSG00000167194	-1.2218006	-1.5017236	6.838620	8.650680	0.0044600	0.4313448	ENSG00000167194	C16orf92	chromosome 16 open reading frame 92	16	30023198	30027736	protein_coding	HGNC:26346	7.5980307	7.8621361	8.4976735	7.2177287	6.9124641	6.1600109	6.8219465	5.4780698	6.8270342	6.3047879	6.6682228	7.8714786
ENSG00000231945	3.8672056	2.2851958	3.723439	7.682559	0.0044765	0.4313448	ENSG00000231945	VARS1	valyl-tRNA synthetase 1	HSCHR6_MHC_SSTO_CTG1	3076809	3094270	protein_coding	HGNC:12651	-13.2877124	2.9477286	1.6345826	-13.2877124	3.9421330	3.4833975	2.9152440	-13.2877124	4.4787320	3.4787385	3.5066842	1.4356969
ENSG00000165124	1.6017275	0.1472836	4.161927	8.666722	0.0045082	0.4313448	ENSG00000165124	SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	9	110365248	110579880	protein_coding	HGNC:15985	0.6463138	1.6491891	0.8977833	0.7009599	2.0161201	1.0922129	1.6648696	1.2182784	1.2962354	1.2577831	1.6396647	1.0339558
ENSG00000087116	1.6381750	0.1899116	5.347694	8.610366	0.0045720	0.4313448	ENSG00000087116	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif 2	5	179110853	179345461	protein_coding	HGNC:218	2.3586857	0.9220540	1.1408271	1.0849643	2.8336928	3.1517827	3.6698233	2.0737013	1.2470410	1.7187877	3.2602024	1.5046504
ENSG00000273579	-2.6104231	-0.3806555	4.594024	8.407303	0.0046392	0.4313448	ENSG00000273579	C22orf15	chromosome 22 open reading frame 15	HSCHR22_1_CTG7	449	2223	protein_coding	HGNC:15558	5.3603064	5.2121093	4.6026697	3.2329953	1.5888674	-13.2877124	2.4317885	4.0120558	4.6490088	4.3654024	1.4860877	4.8053582
ENSG00000152049	-0.1731529	-3.4937966	5.137625	8.431988	0.0047669	0.4313448	ENSG00000152049	KCNE4	potassium voltage-gated channel subfamily E regulatory subunit 4	2	223052190	223198399	protein_coding	HGNC:6244	4.4404752	2.6221106	2.2564992	4.2200811	3.2535817	2.2535594	4.1157755	-0.0724873	0.1100024	0.0216418	3.3988429	3.6804485
ENSG00000265188	-1.0587682	-0.3303832	7.222717	8.486549	0.0047757	0.4313448	ENSG00000265188			18	5240255	5241167	processed_pseudogene		7.7706445	7.7763960	8.2015755	8.2201507	6.6854408	6.4499758	7.4765019	7.5226118	7.7080427	7.6183040	6.9403406	8.0087194
ENSG00000167281	-1.2208723	-1.5464322	5.206941	8.495641	0.0048024	0.4313448	ENSG00000167281	RBFOX3	RNA binding fox-1 homolog 3	17	79089345	79611051	protein_coding	HGNC:27097	3.5875257	4.7695503	4.8513756	5.0723739	3.0976740	6.2294224	3.5368940	2.6468449	2.9617009	2.8128453	4.9879047	4.6697485
ENSG00000274287	7.4401098	0.0000000	3.427692	10.787199	0.0048491	0.4313448	ENSG00000274287	SCRIB	scribble planar cell polarity protein	HSCHR8_3_CTG7	267967	292426	protein_coding	HGNC:30377	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.1013647	2.3669253	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.1954323	-13.2877124
ENSG00000285991	0.7139603	-3.2688554	4.265035	8.141456	0.0048529	0.4313448	ENSG00000285991			6	149817937	149896011	protein_coding		1.7718919	1.3045835	2.1635267	0.5116472	0.3181849	1.8719272	3.2136568	-1.8075230	-1.9010200	-1.8535142	2.2412263	1.5596023
ENSG00000100416	0.7234801	1.5370818	5.182004	8.470939	0.0048580	0.4313448	ENSG00000100416	TRMU	tRNA mitochondrial 2-thiouridylase	22	46330875	46357340	protein_coding	HGNC:25481	3.1865584	3.3053660	3.0463821	4.1410795	4.6679098	5.1275770	4.1490724	5.7445174	4.1845272	5.1658388	4.7026697	3.4884919
ENSG00000116132	0.6799501	-0.2830854	6.922411	8.443599	0.0048631	0.4313448	ENSG00000116132	PRRX1	paired related homeobox 1	1	170662728	170739421	protein_coding	HGNC:9142	6.0888863	5.0262286	5.2937703	5.3380810	6.1979435	6.4967551	5.8357480	5.0079404	4.3460707	4.7146335	6.2018385	5.4945071
ENSG00000072682	1.0447225	0.4800907	6.911663	8.438557	0.0048740	0.4313448	ENSG00000072682	P4HA2	prolyl 4-hydroxylase subunit alpha 2	5	132190147	132295315	protein_coding	HGNC:8547	5.7447451	5.9514185	6.4477921	6.5702442	7.1553120	7.1059454	7.5858154	6.7687605	5.7904497	6.3609891	7.2989511	6.2183013
ENSG00000135956	0.3127950	0.9918446	6.334776	8.407702	0.0049424	0.4318293	ENSG00000135956	TMEM127	transmembrane protein 127	2	96248500	96266047	protein_coding	HGNC:26038	5.2867790	2.9487186	4.6533015	3.3638649	3.6701692	5.2464254	5.5814047	5.4064141	4.7027115	5.0970499	5.0381482	4.3613655
ENSG00000145604	-0.0674108	2.3094997	3.231060	7.785965	0.0049997	0.4318293	ENSG00000145604	SKP2	S-phase kinase associated protein 2	5	36151989	36196849	protein_coding	HGNC:10901	-1.5587375	0.6644583	-0.1612354	2.5400870	0.7791345	1.3547788	-0.0948478	3.8541506	3.1278861	3.5362447	0.7963353	1.1101828
ENSG00000175595	-1.6277830	-2.1030738	3.627374	8.192174	0.0050014	0.4318293	ENSG00000175595	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit	16	13920138	13952348	protein_coding	HGNC:3436	3.3597654	2.4699690	1.6349162	4.0262887	-0.2921625	2.6742810	1.2637616	0.0968178	0.4194073	0.2671103	1.6782360	3.1377484
ENSG00000130226	3.0639949	-0.1550017	3.100887	7.284152	0.0052204	0.4349949	ENSG00000130226	DPP6	dipeptidyl peptidase like 6	7	153748133	154894285	protein_coding	HGNC:3010	-1.1606015	-13.2877124	-13.2877124	0.8572732	2.7175543	0.0806781	2.0355532	-13.2877124	-0.8903132	-1.8900458	1.9677689	-0.8242284
ENSG00000140543	2.3519019	0.4327232	3.175403	7.754878	0.0052253	0.4349949	ENSG00000140543	DET1	DET1 partner of COP1 E3 ubiquitin ligase	15	88494440	88546681	protein_coding	HGNC:25477	-0.7065707	0.2392966	0.2827399	-0.3226316	2.5322514	1.3800367	2.7252545	0.0323915	0.9970416	0.5938839	2.3219527	-0.0704721
ENSG00000237733	-6.5282245	-2.1057215	3.258837	8.962478	0.0052512	0.4349949	ENSG00000237733	RNF39	ring finger protein 39	HSCHR6_MHC_MANN_CTG1	1331016	1336637	protein_coding	HGNC:18064	3.2868770	2.1013391	2.9263995	2.4978974	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.5280331	0.5280832	-13.2877124	2.7709227
ENSG00000143369	-0.1883317	0.8359761	8.253523	8.232335	0.0053192	0.4349949	ENSG00000143369	ECM1	extracellular matrix protein 1	1	150508062	150513789	protein_coding	HGNC:3153	7.1287008	7.2200385	6.8412514	6.7307894	7.1248110	6.9069356	6.5760270	7.8116607	7.8603092	7.8361899	6.8866221	6.9940909
ENSG00000151150	-1.4795040	-3.1532331	4.294317	8.137380	0.0053368	0.4349949	ENSG00000151150	ANK3	ankyrin 3	10	60026298	60733490	protein_coding	HGNC:494	2.1518770	4.0123221	2.9873862	1.8235924	-0.0957834	2.4589011	-0.1018102	-13.2877124	-0.1084097	-1.1082542	1.2958417	3.0023097
ENSG00000204463	-7.4664971	1.6041210	5.071158	9.043889	0.0053494	0.4349949	ENSG00000204463	BAG6	BAG cochaperone 6	6	31639028	31652705	protein_coding	HGNC:13919	-13.2877124	1.3095802	4.5203894	2.9801151	-13.2877124	-13.2877124	-13.2877124	5.2280725	2.9699578	4.5019405	-13.2877124	3.0582630
ENSG00000138119	1.2282000	0.1992036	5.765165	8.216839	0.0053730	0.4349949	ENSG00000138119	MYOF	myoferlin	10	93306429	93482334	protein_coding	HGNC:3656	1.8822991	2.4482645	1.4233184	2.9032414	3.3631050	4.0441808	3.8811218	2.7731710	1.8801060	2.3946664	3.7908257	2.2710733
ENSG00000146221	-1.5177810	-1.8557893	6.635486	8.159539	0.0054971	0.4349949	ENSG00000146221	TCTE1	t-complex-associated-testis-expressed 1	6	44278734	44297698	protein_coding	HGNC:11693	5.4675470	5.9553555	5.4558512	5.0694377	2.3019218	3.9407953	4.7835570	4.1452634	2.9664964	3.6730634	3.9948738	5.5217327
ENSG00000143341	0.7724519	-0.2244021	6.844883	8.127478	0.0055675	0.4349949	ENSG00000143341	HMCN1	hemicentin 1	1	185734391	186190949	protein_coding	HGNC:19194	2.8563396	3.8990044	2.1698285	2.6779885	3.3494404	4.0845814	4.8242772	3.1644233	2.4509024	2.8513317	4.2091667	3.0469850
ENSG00000074181	0.9305804	0.1344988	6.438354	8.112033	0.0056076	0.4349949	ENSG00000074181	NOTCH3	notch receptor 3	19	15159038	15200995	protein_coding	HGNC:7883	2.7526687	2.8495614	2.1140105	3.1613148	3.7979116	3.9934409	3.5473405	3.0458525	3.3047095	3.1810789	3.7910221	2.7667444
ENSG00000128050	-1.0320997	-0.7023855	6.116953	8.113268	0.0056120	0.4349949	ENSG00000128050	PAICS	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	4	56435741	56464578	protein_coding	HGNC:8587	4.2637672	3.3129377	3.7189388	3.9289901	2.8416473	3.0982592	2.6091599	3.6491169	3.1764286	3.4320458	2.8635230	3.8466673
ENSG00000183049	-2.6662782	-0.3539371	3.500310	7.460347	0.0056732	0.4349949	ENSG00000183049	CAMK1D	calcium/calmodulin dependent protein kinase ID	10	12349547	12835545	protein_coding	HGNC:19341	0.4982304	0.2306137	1.1634569	-0.4718208	-1.8962647	-2.3071301	-2.8655214	-0.0499303	1.0128075	0.5771591	-2.3030283	0.4716564
ENSG00000137142	-0.4207992	-1.0417564	6.250394	8.069050	0.0057149	0.4349949	ENSG00000137142	IGFBPL1	insulin like growth factor binding protein like 1	9	38406528	38424454	protein_coding	HGNC:20081	4.6196143	4.2080548	4.6408799	4.7338562	4.2042896	3.9110715	4.2361565	3.4249876	3.5383878	3.4828018	4.1244117	4.5641227
ENSG00000125734	1.4770669	0.8628655	4.276008	8.100962	0.0057240	0.4349949	ENSG00000125734	GPR108	G protein-coupled receptor 108	19	6729914	6737580	protein_coding	HGNC:17829	3.5055529	3.2959659	2.4313071	3.1829063	4.6968216	3.6571640	3.8679620	3.5605363	3.9058801	3.7435169	4.1470727	3.1559983
ENSG00000128564	-1.6976152	-1.3610587	4.975245	8.070837	0.0057633	0.4349949	ENSG00000128564	VGF	VGF nerve growth factor inducible	7	101162509	101165569	protein_coding	HGNC:12684	4.7188771	4.5188108	4.5626734	3.8812955	2.9881399	1.5412373	3.0248108	2.1050223	3.3241251	2.8396859	2.6617277	4.4533048
ENSG00000204624	-2.1146580	-2.5966127	4.282143	7.954449	0.0058148	0.4349949	ENSG00000204624	DISP3	dispatched RND transporter family member 3	1	11479155	11537551	protein_coding	HGNC:29251	1.2823752	2.0436136	1.9133000	3.7429971	-2.2336508	1.9804922	0.7966600	0.6114160	-2.6165606	-0.2422820	0.9747672	2.5674878
ENSG00000112246	1.0933997	2.1793292	4.514278	8.046413	0.0058552	0.4349949	ENSG00000112246	SIM1	SIM bHLH transcription factor 1	6	100385009	100464921	protein_coding	HGNC:10882	-3.0099833	0.8295411	0.8470925	2.1145213	0.5126567	1.3730440	2.2169105	2.2680022	3.0461991	2.7089469	1.5303719	1.0055063
ENSG00000196352	1.5939106	0.7087874	5.341813	8.023112	0.0058708	0.4349949	ENSG00000196352	CD55	CD55 molecule (Cromer blood group)	1	207321519	207386804	protein_coding	HGNC:2665	4.3989807	2.1397717	4.1632416	3.4452954	5.2359703	4.9959683	5.2091597	4.4569693	4.2626323	4.3630708	5.1509593	3.7632437
ENSG00000106333	0.9577534	0.6803134	7.872098	8.002408	0.0058761	0.4349949	ENSG00000106333	PCOLCE	procollagen C-endopeptidase enhancer	7	100602363	100608175	protein_coding	HGNC:8738	6.9611863	6.6907630	6.7855181	6.7472407	7.6936402	7.4915330	8.0451573	7.7952536	7.0216313	7.4596882	7.7618211	6.7997789
ENSG00000136999	-2.3287477	-2.5646982	4.084775	7.834218	0.0058881	0.4349949	ENSG00000136999	CCN3	cellular communication network factor 3	8	119416446	119424434	protein_coding	HGNC:7885	2.0562769	3.4228580	4.0279396	3.8505414	1.7754459	-0.4493239	0.5864112	1.8099499	-13.2877124	0.8099906	0.9151591	3.5116597
ENSG00000113212	-0.7743873	-2.9250957	3.801585	7.811054	0.0058982	0.4349949	ENSG00000113212	PCDHB7	protocadherin beta 7	5	141172644	141176383	protein_coding	HGNC:8692	1.6724873	2.3276514	2.1532505	2.0317311	1.8708192	1.4566490	-0.0973599	-0.2846601	-2.1004160	-0.9239527	1.2901973	2.0656371
ENSG00000180447	1.1312694	-0.4053562	4.992494	7.980349	0.0059939	0.4371239	ENSG00000180447	GAS1	growth arrest specific 1	9	86944362	86947506	protein_coding	HGNC:4165	2.9545254	2.5243022	1.8010688	3.1646824	4.1858340	3.2431850	3.8888114	2.5845361	1.8820510	2.2756350	3.8238041	2.6980437
ENSG00000100968	1.3122341	-0.0034281	5.307020	7.966868	0.0060094	0.4371239	ENSG00000100968	NFATC4	nuclear factor of activated T cells 4	14	24365673	24379604	protein_coding	HGNC:7778	2.4096405	1.9739404	4.7088996	3.2605939	4.6613416	5.7011489	5.4589492	3.1869765	4.5262768	4.0067612	5.3376601	3.4911630
ENSG00000206435	8.7713842	0.0000000	4.544569	9.917605	0.0061821	0.4466241	ENSG00000206435	HLA-C	major histocompatibility complex, class I, C	HSCHR6_MHC_SSTO_CTG1	2570707	2574099	protein_coding	HGNC:4933	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.4061415	7.0861003	-13.2877124	-13.2877124	-13.2877124	-13.2877124	5.6095266	-13.2877124
ENSG00000133083	1.1989274	-0.3310637	5.251683	7.863617	0.0062897	0.4502563	ENSG00000133083	DCLK1	doublecortin like kinase 1	13	35768652	36131382	protein_coding	HGNC:2700	2.4552020	2.7279213	1.4549818	2.5952002	4.0440093	3.4800980	3.2028794	3.0265342	1.0636141	2.3559550	3.6191099	2.3849591
ENSG00000130635	1.4021842	0.2356279	10.688110	7.836971	0.0063176	0.4502563	ENSG00000130635	COL5A1	collagen type V alpha 1 chain	9	134641803	134844843	protein_coding	HGNC:2209	6.9270598	7.2012251	5.8185884	6.6953617	8.1819054	7.7001257	8.4132381	7.5683774	6.0063233	6.9891765	8.1280186	6.7445648
ENSG00000118971	-0.3231362	-1.3184605	8.048275	7.793588	0.0064405	0.4502563	ENSG00000118971	CCND2	cyclin D2	12	4269771	4305353	protein_coding	HGNC:1583	4.8798649	5.4253738	5.0378243	6.3577985	4.8974893	5.0457979	5.3897067	4.0067573	4.2247455	4.1198649	5.1259998	5.5490589
ENSG00000272674	0.0471595	-2.2492789	4.523672	7.794279	0.0064492	0.4502563	ENSG00000272674	PCDHB16	protocadherin beta 16	5	141182387	141186226	protein_coding	HGNC:14546	4.0376383	2.2135293	0.7611346	2.5590468	2.7026569	1.6019213	1.9976028	0.0877561	-0.4350658	-0.1501000	2.1740686	2.8404131
ENSG00000205978	0.3759911	-4.7604448	4.213784	7.481156	0.0064773	0.4502563	ENSG00000205978	NYNRIN	NYN domain and retroviral integrase containing	14	24399003	24419283	protein_coding	HGNC:20165	1.7218101	0.4809992	-0.4159245	1.5651521	-0.7979823	1.1125440	2.4020299	-2.9505254	-13.2877124	-3.9494105	1.4191581	1.0708763
ENSG00000108821	1.6012224	0.2835851	13.223743	7.777242	0.0064867	0.4502563	ENSG00000108821	COL1A1	collagen type I alpha 1 chain	17	50184101	50201632	protein_coding	HGNC:2197	11.2463341	10.5483855	9.8668102	10.7105311	11.5061251	11.8747109	12.7913025	11.4349320	9.9779847	10.8830542	12.1624559	10.6742453
ENSG00000188517	2.8014503	0.0088735	3.120551	7.016486	0.0065879	0.4543086	ENSG00000188517	COL25A1	collagen type XXV alpha 1 chain	4	108808725	109302752	protein_coding	HGNC:18603	-2.1057092	-13.2877124	-0.3257491	-0.2075977	4.6972044	1.8051649	2.3571880	-13.2877124	0.4407726	-0.5591211	3.5260754	-1.0768134
ENSG00000272899	-1.4148774	-3.0807599	5.521882	7.735182	0.0066616	0.4564302	ENSG00000272899	SPMIP1	sperm microtubule inner protein 1	7	128866330	128872047	protein_coding	HGNC:52392	2.1650874	2.6513486	5.2516276	4.4687341	1.9378506	1.9933360	3.4389297	0.8893287	1.0209232	0.9566254	2.6367364	4.1498971
ENSG00000285362	4.3010726	2.8749445	3.828361	6.791732	0.0067086	0.4566981	ENSG00000285362			HSCHR7_3_CTG4_4	253977	254270	protein_coding		-13.2877124	-0.2263581	-13.2877124	-0.4254102	4.0136770	3.4676455	-13.2877124	-13.2877124	3.0446323	2.0446498	3.1813841	-1.3222737
ENSG00000079689	-4.9647721	-2.3322238	3.623991	7.382232	0.0069470	0.4607281	ENSG00000079689	SCGN	secretagogin, EF-hand calcium binding protein	6	25652201	25701783	protein_coding	HGNC:16941	-0.1571740	4.9354718	4.1699647	2.6985828	-13.2877124	-13.2877124	-0.0152707	2.0206057	0.5339929	1.4608663	-1.5999417	3.8070759
ENSG00000135437	-0.0961390	2.4257742	3.502740	7.270975	0.0069696	0.4607281	ENSG00000135437	RDH5	retinol dehydrogenase 5	12	55720367	55724705	protein_coding	HGNC:9940	2.9090309	4.1310014	-13.2877124	4.1065705	3.2842387	-13.2877124	3.8832700	5.3332289	4.8471695	5.1105729	3.0296679	3.4011780
ENSG00000025039	-0.7923951	-2.8896603	3.763954	7.444591	0.0069699	0.4607281	ENSG00000025039	RRAGD	Ras related GTP binding D	6	89364616	89412273	protein_coding	HGNC:19903	2.0548735	1.9192329	0.8196772	2.9775913	0.1981056	3.1070998	1.2290944	-0.9804546	-1.5073408	-1.2199772	2.0129114	2.1357813
ENSG00000135185	-1.2713751	0.5366262	4.598665	7.618665	0.0069951	0.4607281	ENSG00000135185	TMEM243	transmembrane protein 243	7	87196160	87220587	protein_coding	HGNC:21707	5.0952562	5.1947237	6.2304970	6.4652926	5.4429972	3.3361968	4.6524244	6.5138625	5.6006114	6.1283247	4.7142444	5.8719289
ENSG00000085871	-1.3954193	-2.2220853	3.591343	7.442382	0.0070475	0.4607281	ENSG00000085871	MGST2	microsomal glutathione S-transferase 2	4	139665768	139740745	protein_coding	HGNC:7063	3.9094650	4.9891103	4.4293401	4.4980325	3.6112157	3.5365601	1.1387548	2.3051633	1.7542547	2.0558471	3.1169389	4.5066626
ENSG00000137285	1.3416318	-0.0741214	6.239504	7.536871	0.0072343	0.4607281	ENSG00000137285	TUBB2B	tubulin beta 2B class IIb	6	3223324	3231730	protein_coding	HGNC:30829	4.4626807	4.8243355	3.0297801	5.4407154	5.6230173	6.0281825	6.2421609	4.3659083	4.7036050	4.5446146	5.9867318	4.6721543
ENSG00000166428	-0.9042634	0.4047889	6.684069	7.524184	0.0072723	0.4607281	ENSG00000166428	PLD4	phospholipase D family member 4	14	104924713	104937761	protein_coding	HGNC:23792	4.9267799	4.5310843	5.1229968	4.0584620	4.0053876	3.8324228	3.9425315	4.4418486	5.7840372	5.2637041	3.9285418	4.7148802
ENSG00000285938	0.2597741	1.6691961	4.205322	7.546736	0.0073020	0.4607281	ENSG00000285938	BCL6-AS1	BCL6 antisense RNA 1	3	187743686	187793553	lncRNA	HGNC:51843	2.8022331	3.2733106	2.9800094	3.9775184	3.6577735	3.9041508	3.1832323	5.4525560	4.3031177	4.9894052	3.6118062	3.3322181
ENSG00000206466	-3.4073422	-3.9775927	3.879305	6.777482	0.0074282	0.4607281	ENSG00000206466	GABBR1	gamma-aminobutyric acid type B receptor subunit 1	HSCHR6_MHC_MCF_CTG1	821016	898553	protein_coding	HGNC:4070	-13.2877124	3.4642513	2.9129108	3.4304370	-13.2877124	-13.2877124	0.3307029	0.7571778	-13.2877124	-0.2427369	-1.2540303	2.8752594
ENSG00000188322	-1.1349406	-3.8716705	3.729095	7.067061	0.0074892	0.4607281	ENSG00000188322	SBK1	SH3 domain binding kinase 1	16	28259246	28323849	protein_coding	HGNC:17699	1.6872739	1.2645202	-1.0903022	2.7330664	-0.1505659	1.4366085	-0.1195527	-2.3045406	-2.5335264	-2.4144951	0.5939778	1.6714389
ENSG00000061656	-1.9387831	-2.0836150	3.754607	7.274735	0.0075653	0.4607281	ENSG00000061656	SPAG4	sperm associated antigen 4	20	35615829	35621094	protein_coding	HGNC:11214	4.0090978	4.5777019	3.6223293	4.6570480	3.1330515	2.0408423	0.9184572	3.0055811	0.2123676	2.2000014	2.3004005	4.2765944
ENSG00000166741	1.1748094	0.1148829	5.183245	7.441269	0.0075967	0.4607281	ENSG00000166741	NNMT	nicotinamide N-methyltransferase	11	114257787	114313536	protein_coding	HGNC:7861	4.5403241	4.3211009	4.2199410	5.9206439	5.1485007	5.9692185	5.7457471	5.2864284	4.3733016	4.9009339	5.6608493	4.9362492
ENSG00000107736	-1.3515631	-0.5743849	5.912052	7.433514	0.0075971	0.4607281	ENSG00000107736	CDH23	cadherin related 23	10	71396920	71815947	protein_coding	HGNC:13733	3.9464344	4.0523215	3.7057716	3.2587812	1.4415531	1.9764700	2.9513565	3.1349155	2.2650678	2.7645795	2.2616494	3.7715587
ENSG00000259192	-2.0505017	-3.3603133	3.205361	6.784399	0.0076074	0.4607281	ENSG00000259192			15	38458760	38459540	processed_pseudogene		4.8027249	4.8863310	4.0242303	3.3104572	3.1583937	2.7093332	-13.2877124	0.9767969	0.6961897	0.8433053	2.3663124	4.3867694
ENSG00000171246	-0.6496216	-2.3665437	5.046413	7.437721	0.0076172	0.4607281	ENSG00000171246	NPTX1	neuronal pentraxin 1	17	80466834	80477843	protein_coding	HGNC:7952	3.2328942	1.8419554	3.4834098	2.1992442	2.5232628	1.6255057	2.3858413	-0.8531441	1.0335668	0.3788756	2.2286439	2.8461531
ENSG00000185008	-1.3740743	-1.5996680	4.790371	7.432890	0.0076593	0.4607281	ENSG00000185008	ROBO2	roundabout guidance receptor 2	3	75906695	77649964	protein_coding	HGNC:10250	0.3598922	3.5787274	2.6501704	4.1373714	4.0375723	3.0318204	2.4781984	0.1331979	3.4161900	2.5572768	3.3302040	3.2136344
ENSG00000149257	1.1379504	0.1854030	8.802167	7.401552	0.0076800	0.4607281	ENSG00000149257	SERPINH1	serpin family H member 1	11	75562056	75572783	protein_coding	HGNC:1546	7.2153154	7.3002662	6.8718639	7.0887086	8.1019334	8.1523839	8.8414337	8.0432376	6.2751082	7.4146167	8.4065167	7.1278840
ENSG00000133110	1.8717287	-0.5984578	9.413543	7.398558	0.0076905	0.4607281	ENSG00000133110	POSTN	periostin	13	37562583	37598844	protein_coding	HGNC:16953	7.8230384	6.5364456	5.6339844	5.5089182	7.4256274	8.3714977	9.4726499	5.2459880	6.6630805	6.1219520	8.6601025	6.6951169
ENSG00000074582	-1.5415973	-0.1860704	4.389194	7.379104	0.0077362	0.4607281	ENSG00000074582	BCS1L	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	2	218658764	218663443	protein_coding	HGNC:1020	4.6675779	5.1105113	5.2770522	4.8382321	3.7715193	2.9819626	3.3806810	5.0375593	4.4316407	4.7661790	3.4138093	4.9925722
ENSG00000138161	1.4380528	3.3449402	4.384803	7.295108	0.0077375	0.4607281	ENSG00000138161	CUZD1	CUB and zona pellucida like domains 1	10	122832158	122846175	protein_coding	HGNC:17937	-0.7351129	2.8714599	-13.2877124	0.6920379	2.6755457	3.4988965	1.7101714	5.4971895	2.6537628	4.6853746	2.8050074	1.2531555
ENSG00000168487	1.0461928	0.0670331	5.947279	7.388319	0.0077422	0.4607281	ENSG00000168487	BMP1	bone morphogenetic protein 1	8	22165140	22212326	protein_coding	HGNC:1067	4.5594090	3.8090030	3.5348738	4.8034665	4.9393388	5.3931443	5.6298691	4.4673102	3.8271249	4.1824396	5.3484219	4.2688423
ENSG00000169371	-0.0468275	-2.8586328	3.950473	7.234619	0.0077564	0.4607281	ENSG00000169371	SNUPN	snurportin 1	15	75598083	75626469	protein_coding	HGNC:14245	3.0292313	3.9906576	4.2639145	4.8085855	2.6273325	3.6470525	4.4992784	1.2291480	-0.6019671	0.5864717	3.7838987	4.1557509
ENSG00000158714	-1.6803791	0.1863237	4.675701	7.374243	0.0077656	0.4607281	ENSG00000158714	SLAMF8	SLAM family member 8	1	159826811	159837492	protein_coding	HGNC:21391	3.3170901	2.8609884	3.3463845	2.6725417	2.1709422	0.1705955	0.9402675	2.6773161	3.6225254	3.2259836	1.3310516	3.0780175
ENSG00000131503	-0.3376403	-1.4449974	6.009199	7.367405	0.0078158	0.4611346	ENSG00000131503	ANKHD1	ankyrin repeat and KH domain containing 1	5	140401814	140539856	protein_coding	HGNC:24714	3.3705513	4.9107575	4.8463350	4.7639325	5.0418094	4.5613225	5.1129906	4.6184520	3.1660571	4.0677910	4.9253325	4.5903619
ENSG00000176907	-0.9868036	-3.7482177	3.655600	6.973074	0.0078631	0.4613609	ENSG00000176907	TCIM	transcriptional and immune response regulator	8	40153482	40155310	protein_coding	HGNC:1357	4.0004657	1.9802820	2.9667741	2.7442145	2.9070647	2.3484642	-0.5172013	-0.7129273	-0.9541237	-0.8284908	2.1475724	3.1072267
ENSG00000147889	-1.1759627	-1.1966719	5.328688	7.340201	0.0079508	0.4639420	ENSG00000147889	CDKN2A	cyclin dependent kinase inhibitor 2A	9	21967752	21995301	protein_coding	HGNC:1787	4.9838344	5.7761367	6.5278007	6.4808989	5.1353811	4.3559766	4.7461473	4.6478971	4.9722561	4.8191731	4.7807090	6.0662754
ENSG00000136237	-2.7502697	-1.4540787	3.105058	6.659173	0.0080462	0.4645911	ENSG00000136237	RAPGEF5	Rap guanine nucleotide exchange factor 5	7	22118236	22357154	protein_coding	HGNC:16862	-0.3704895	0.6529582	1.1715681	3.9746726	-2.3021266	-1.7146712	-2.2713219	1.6861809	-1.6850924	0.8192676	-2.0698031	2.3448311
ENSG00000135083	-1.3194078	-1.6942553	4.182458	7.303998	0.0080706	0.4645911	ENSG00000135083	CCNJL	cyclin J like	5	160249083	160345396	protein_coding	HGNC:25876	2.1734722	2.2564213	3.5988506	3.6435064	0.9069252	3.3120844	1.8387784	0.5089661	0.9294638	0.7344812	2.3584072	3.0833058
ENSG00000147642	-1.4034123	-1.2169558	5.037347	7.303391	0.0081077	0.4645911	ENSG00000147642	SYBU	syntabulin	8	109573978	109691791	protein_coding	HGNC:26011	3.6059181	5.8371862	4.7360218	4.8131748	4.4581379	3.0816781	3.7817163	4.5085319	1.8851097	3.7254925	3.8810009	4.9554518
ENSG00000137332	-7.0071996	-7.0071996	3.505534	8.422030	0.0081369	0.4645911	ENSG00000137332	DDR1	discoidin domain receptor tyrosine kinase 1	HSCHR6_MHC_COX_CTG1	2360744	2379927	protein_coding	HGNC:2730	2.7049408	-13.2877124	1.6709590	4.3447735	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	2.9080395
ENSG00000090539	1.1611039	1.1048124	5.472657	7.251410	0.0082719	0.4697718	ENSG00000090539	CHRD	chordin	3	184380054	184390736	protein_coding	HGNC:1949	4.0623576	2.5779861	2.4792099	3.7131615	4.4094721	4.5316202	3.1782769	4.9838789	3.9601096	4.5609619	4.1546772	3.3704726
ENSG00000106571	1.3449568	0.8250032	5.578501	7.234091	0.0083316	0.4706446	ENSG00000106571	GLI3	GLI family zinc finger 3	7	41960949	42264100	protein_coding	HGNC:4319	4.7019417	1.6179788	3.3295662	3.4140689	5.0638246	3.2511649	4.1948315	4.2896336	1.8408556	3.5322858	4.3524351	3.6383380
ENSG00000026025	0.9023242	0.0016878	9.888308	7.195352	0.0084421	0.4706926	ENSG00000026025	VIM	vimentin	10	17228241	17237593	protein_coding	HGNC:12692	8.9061182	8.4267666	8.3651662	8.9399801	9.7781856	9.4890732	10.1158313	9.0675107	8.5636846	8.8374803	9.8171359	8.6836393
ENSG00000151458	-0.2326727	-1.5773379	5.226380	7.181575	0.0085500	0.4706926	ENSG00000151458	ANKRD50	ankyrin repeat domain containing 50	4	124664048	124712732	protein_coding	HGNC:29223	2.5453877	2.5656474	2.4859476	3.0405844	2.9722008	2.0448298	2.4273678	1.8748300	0.5490284	1.3591512	2.5321242	2.6774022
ENSG00000120742	0.9093296	0.4544342	6.020022	7.157124	0.0086081	0.4706926	ENSG00000120742	SERP1	stress associated endoplasmic reticulum protein 1	3	150541998	150603228	protein_coding	HGNC:10759	5.1712854	4.9572274	5.3528441	5.9242948	5.8997445	5.1266688	6.2561618	5.7532842	4.9319256	5.4002845	5.8335242	5.3982631
ENSG00000162493	2.0382658	1.1194339	4.112959	7.109871	0.0087467	0.4706926	ENSG00000162493	PDPN	podoplanin	1	13583465	13617957	protein_coding	HGNC:29602	1.1008546	2.8897786	-1.1820199	1.8902362	3.7119177	3.7610110	2.5530434	3.3594087	3.6065138	3.4882453	3.4387352	1.7765332
ENSG00000103855	0.4358296	-0.5843700	7.520227	7.108205	0.0087918	0.4706926	ENSG00000103855	CD276	CD276 molecule	15	73683966	73714514	protein_coding	HGNC:19137	6.0766837	5.4810146	6.0826436	6.0468441	6.8024397	5.8994884	6.0287143	5.2829896	5.0402779	5.1667319	6.3013350	5.9427634
ENSG00000151388	0.0456942	-1.1929594	6.388562	7.105734	0.0088090	0.4706926	ENSG00000151388	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12	5	33523535	33892019	protein_coding	HGNC:14605	3.6793375	3.3284826	3.0281434	3.7323439	3.7057861	3.2928063	4.0047113	2.7169891	1.7749877	2.3215449	3.6967642	3.4693992
ENSG00000249663	0.5466009	-7.3550918	4.675219	7.384077	0.0088551	0.4706926	ENSG00000249663			HSCHR6_MHC_MCF_CTG1	985707	986697	unprocessed_pseudogene		-13.2877124	5.3575830	6.0996609	3.8688770	6.0667744	5.3582563	4.7148631	-13.2877124	-13.2877124	-13.2877124	5.4844936	4.9563852
ENSG00000166598	0.7598286	0.1118668	7.949517	7.080596	0.0089051	0.4706926	ENSG00000166598	HSP90B1	heat shock protein 90 beta family member 1	12	103930107	103953931	protein_coding	HGNC:12028	6.9641059	6.4592486	6.9440919	6.6362539	7.2413154	7.0498136	7.6040456	6.7765482	6.4824132	6.6369637	7.3169853	6.7663715
ENSG00000116985	-1.2880269	-0.2417715	4.819554	7.096775	0.0089153	0.4706926	ENSG00000116985	BMP8B	bone morphogenetic protein 8b	1	39757182	39788865	protein_coding	HGNC:1075	2.5306394	2.4989935	2.8176095	2.6457501	1.8995376	0.8086437	0.9306594	2.3298567	2.3735522	2.3518700	1.3003475	2.6287344
ENSG00000143155	1.8472356	1.7097194	3.934064	7.014867	0.0089664	0.4706926	ENSG00000143155	TIPRL	TOR signaling pathway regulator	1	168178962	168202109	protein_coding	HGNC:30231	2.7661885	2.2722750	0.2929690	1.4865347	2.5548351	3.0395099	2.1398440	3.0146925	1.5795331	2.4686641	2.6249012	1.9691262
ENSG00000075426	1.0529477	0.0148684	7.155648	7.065051	0.0089720	0.4706926	ENSG00000075426	FOSL2	FOS like 2, AP-1 transcription factor subunit	2	28392448	28417317	protein_coding	HGNC:3798	5.1009508	3.5078612	4.0657859	4.5574552	4.5353933	4.7231433	6.0802513	4.2865470	3.7200776	4.0309381	5.2886384	4.4260654
ENSG00000119878	-2.1730145	0.1565773	3.855421	6.797208	0.0090350	0.4706926	ENSG00000119878	CRIPT	CXXC repeat containing interactor of PDZ3 domain	2	46616416	46685037	protein_coding	HGNC:14312	3.5953881	2.8993479	2.4415045	3.3037087	1.8492527	-0.0622247	-0.3898197	3.6607738	2.8241053	3.3022598	0.8275874	3.1232734
ENSG00000144642	1.3159493	-0.2775925	4.688379	7.045265	0.0091751	0.4706926	ENSG00000144642	RBMS3	RNA binding motif single stranded interacting protein 3	3	28574791	30010391	protein_coding	HGNC:13427	2.3293363	2.7669841	1.9639623	1.2969806	2.7961731	4.2520937	4.7553581	2.2894940	2.1187703	2.2066560	4.1432222	2.1851558
ENSG00000147459	0.1805943	1.2508730	5.127729	7.028931	0.0092006	0.4706926	ENSG00000147459	DOCK5	dedicator of cytokinesis 5	8	25184689	25418082	protein_coding	HGNC:23476	3.9591777	0.6268092	1.7418639	3.0008996	0.6689333	1.6734045	1.0399336	3.0214938	3.5092693	3.2858987	1.1881255	2.8302257
ENSG00000116984	-0.8730139	0.3271773	5.478945	7.011452	0.0092470	0.4706926	ENSG00000116984	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	1	236795260	236921278	protein_coding	HGNC:7468	2.8637732	2.4105362	2.6116136	3.1328415	2.9521705	2.6728763	2.6773795	3.6170133	2.6090514	3.1993267	2.7735073	2.7802767
ENSG00000056736	-0.7440752	-0.5695072	7.426486	6.998138	0.0092566	0.4706926	ENSG00000056736	IL17RB	interleukin 17 receptor B	3	53846568	53865794	protein_coding	HGNC:18015	6.5645315	6.4767359	6.7742142	6.8704097	6.3439574	5.5271593	5.6598235	6.2249791	5.9347811	6.0871645	5.8899784	6.6800856
ENSG00000017483	2.2271861	3.3080199	4.008996	6.712645	0.0092772	0.4706926	ENSG00000017483	SLC38A5	solute carrier family 38 member 5	X	48458537	48470260	protein_coding	HGNC:18070	-0.7622625	3.6100651	-13.2877124	-13.2877124	4.5737177	4.0224334	4.5837792	4.3200475	5.4152385	4.9691633	4.4160454	1.6781165
ENSG00000052795	-1.8212050	-0.6937070	4.702251	6.995576	0.0092875	0.4706926	ENSG00000052795	FNIP2	folliculin interacting protein 2	4	158769026	158908050	protein_coding	HGNC:29280	2.1657473	2.6303691	2.3388129	2.5249117	1.7980202	0.4980221	1.8436109	-0.0216696	4.1548918	3.2325458	1.4988932	2.4258001
ENSG00000227761	0.2184729	-3.5151641	5.722842	6.972514	0.0093121	0.4706926	ENSG00000227761	BAG6	BAG cochaperone 6	HSCHR6_MHC_DBB_CTG1	2886791	2900476	protein_coding	HGNC:13919	5.8044424	6.1845245	5.4897944	5.3277685	5.3935787	6.4363635	4.9435251	4.1876889	-13.2877124	3.1876968	5.7316574	5.7395610
ENSG00000275650	-3.3332857	-0.3263661	3.974480	6.465136	0.0093907	0.4706926	ENSG00000275650	TTYH1	tweety family member 1	HSCHR19_4_CTG3_1	397719	419194	protein_coding	HGNC:13476	2.8317437	2.1833833	3.0847161	2.2516231	0.7659717	-1.1750546	-1.7212444	3.1413672	-0.3844594	2.2614804	-0.2941436	2.6385101
ENSG00000024422	1.0382419	0.0635523	7.302118	6.939428	0.0095163	0.4706926	ENSG00000024422	EHD2	EH domain containing 2	19	47713422	47743134	protein_coding	HGNC:3243	5.2889501	4.5809507	4.4806611	5.9699061	6.2466679	5.7292548	6.3936360	5.3920180	4.2957806	4.9456091	6.1501502	5.2097879
ENSG00000146966	1.0263557	-0.5396581	4.587767	6.961473	0.0095448	0.4706926	ENSG00000146966	DENND2A	DENN domain containing 2A	7	140518420	140673993	protein_coding	HGNC:22212	1.6704950	1.8376954	2.3802568	3.4304449	4.0380280	5.1624376	2.6800497	1.6437832	1.4964506	1.5719966	4.2890912	2.5074846
ENSG00000271425	-2.6602871	-0.6240434	3.789386	6.586241	0.0095533	0.4706926	ENSG00000271425	NBPF10	NBPF member 10	1	146064711	146229000	protein_coding	HGNC:31992	-0.4440739	-0.1699118	1.6976377	0.9333687	-1.8446704	-1.8112598	-13.2877124	-0.0890187	0.2561882	0.0938853	-2.4125751	0.7607270
ENSG00000179242	-2.3777262	-6.6559434	3.363578	6.801682	0.0095944	0.4706926	ENSG00000179242	CDH4	cadherin 4	20	61252261	61940617	protein_coding	HGNC:1763	1.1451453	1.8824975	1.8562698	-1.0063822	-13.2877124	-13.2877124	0.0193461	-13.2877124	-13.2877124	-13.2877124	-1.5653317	1.3244230
ENSG00000235220	-1.7239301	1.7915850	4.814778	6.850353	0.0096156	0.4706926	ENSG00000235220	HLA-F	major histocompatibility complex, class I, F	HSCHR6_MHC_DBB_CTG1	985849	1001601	protein_coding	HGNC:4963	-13.2877124	4.9119960	6.0710233	6.1341781	1.9829144	-13.2877124	5.0229846	6.7775854	5.8960912	6.4031411	3.6035539	5.3886538
ENSG00000197956	0.0596150	0.8572351	8.045740	6.915764	0.0096217	0.4706926	ENSG00000197956	S100A6	S100 calcium binding protein A6	1	153534599	153536244	protein_coding	HGNC:10496	10.0371185	9.6813386	10.5951212	10.2418955	10.6368189	9.9193737	10.1232480	10.7905992	10.9995444	10.8988508	10.2589124	10.1766483
ENSG00000105825	0.3592981	-2.3058548	7.136469	6.908296	0.0096630	0.4706926	ENSG00000105825	TFPI2	tissue factor pathway inhibitor 2	7	93885396	93890753	protein_coding	HGNC:11761	7.6945941	4.9450031	6.0393700	7.7100904	7.9774567	7.1017150	7.8923504	5.2216552	4.1512550	4.7835305	7.7073001	7.0031766
ENSG00000160908	-0.7254339	0.0400841	7.074022	6.901715	0.0096889	0.4706926	ENSG00000160908	ZNF394	zinc finger protein 394	7	99473877	99504857	protein_coding	HGNC:18832	4.7619494	4.5852866	4.8396938	4.7339294	4.1872966	3.7062662	4.1187969	4.6915889	4.6717635	4.6817101	4.0192251	4.7331265
ENSG00000214021	-1.0337385	-0.4483342	5.539968	6.909777	0.0096917	0.4706926	ENSG00000214021	TTLL3	tubulin tyrosine ligase like 3	3	9808086	9855138	protein_coding	HGNC:24483	5.1573670	5.0278049	4.1556639	4.6762006	3.6479730	3.9440659	3.3861361	4.6131667	4.5075654	4.5613322	3.6774090	4.8034916
ENSG00000167779	1.9950705	-0.0139422	3.449192	6.745263	0.0097139	0.4706926	ENSG00000167779	IGFBP6	insulin like growth factor binding protein 6	12	53097436	53102345	protein_coding	HGNC:5475	1.7485600	2.6546296	3.5589073	0.1145643	3.7393194	4.3908570	4.5339119	1.6968529	2.6058176	2.2217679	4.2605139	2.4934519
ENSG00000284218	2.5210263	-4.7575956	3.556149	6.967859	0.0097262	0.4706926	ENSG00000284218	NPIPB5	nuclear pore complex interacting protein family member B5	HG926_PATCH	568655	591235	protein_coding	HGNC:37233	2.1957287	-13.2877124	-13.2877124	-13.2877124	2.8014143	3.0860733	2.4760319	-13.2877124	-13.2877124	-13.2877124	2.8091882	0.1958225
ENSG00000155980	-0.7880497	-1.6434028	6.233959	6.888956	0.0097586	0.4706926	ENSG00000155980	KIF5A	kinesin family member 5A	12	57546026	57586633	protein_coding	HGNC:6323	3.7057047	3.7293829	3.6376437	4.6625047	2.8488290	3.0355639	4.2013836	1.3761609	2.8259645	2.2759972	3.4940154	4.0018587
ENSG00000156113	-1.7039467	-1.1443363	4.492796	6.884046	0.0097950	0.4706926	ENSG00000156113	KCNMA1	potassium calcium-activated channel subfamily M alpha 1	10	76869601	77638369	protein_coding	HGNC:6284	3.9195372	4.1766118	3.6372863	2.2538628	0.1859021	2.5038250	0.9544740	2.7459356	1.6077469	2.2862898	1.5438710	3.6561667
ENSG00000230224	-1.3101467	0.9912735	3.936546	6.758667	0.0098767	0.4724805	ENSG00000230224	PHB1P9		10	100248271	100249095	processed_pseudogene	HGNC:39288	4.0453682	4.7611001	4.2584218	3.8609147	1.0299694	3.1691105	3.6617931	5.2431337	5.2187053	5.2309712	2.9814437	4.2723198

outPath = "output/day22/DEG"
Test = "day22.SCN2A.vs.WT"
qlf = glmQLFTest(fit, coef=2)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0     0    80
## NotSig  10620 10620 10620 10620 10420
## Up          0     0     0     0   120

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("SCN2A", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

SCN2AUp = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
SCN2ADown = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "day22.CHD2.vs.WT"
qlf = glmQLFTest(fit, coef=3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0    11   119
## NotSig  10620 10620 10620 10600 10438
## Up          0     0     0     9    63

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("CHD2", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

CHD2Up = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
CHD2Down = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "day22"
venn.diagram(list(CHD2 = CHD2Up, SCN2A = SCN2AUp), filename = paste(outPath,ExperimentName,Test,"up.png", sep="."), imagetype = "png", main = paste(Test, "up regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

venn.diagram(list(CHD2 = CHD2Down, SCN2A = SCN2ADown), filename = paste(outPath,ExperimentName,Test,"down.png", sep="."), imagetype = "png", main = paste(Test, "down regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

SCN2AUp.d22 = SCN2AUp
SCN2ADown.d22 = SCN2ADown
CHD2Up.d22 = CHD2Up
CHD2Down.d22 = CHD2Down

Venn diagram up regulated

Venn diagram down regulated

Note:

1d. Day 28 of transdifferentiation

Test the differences between WT, SCN2A and CHD2 at 28 days of transdifferentiation.

fit = test_a_diff_state(diffState = "day_28", countTable = counts.current)
qlf = glmQLFTest(fit, coef=2:3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## NotSig  12565 12564 12562 12465 12194
## Sig         0     1     3   100   371

d28.genes.expressed = rownames(qlf$table)
attach_annotations_by_p(qlf, 0.01) %>%
  kbl() %>%
  kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
  scroll_box(width = "100%", height = "300px")

	logFC.fSCN2A	logFC.fCHD2	logCPM	F	PValue	FDR	ensembl_gene_id	hgnc_symbol	entrezgene_description	chromosome_name	start_position	end_position	gene_biotype	hgnc_id	CON_2_d28	CON_3_d28	SCN2A_1_d28	SCN2A_2_d28	SCN2A_3_d28	CHD2_1_d28	CHD2	SCN2A	WT
ENSG00000254875	-7.0121747	4.5922599	6.182148	183.160652	0.0000006	0.0071402	ENSG00000254875			HSCHR6_MHC_QBL_CTG1	3377039	3395179	protein_coding		-13.2877124	2.9947996	-13.2877124	-13.2877124	-13.2877124	6.5582973	6.5582973	-13.2877124	1.9948179
ENSG00000125618	4.8072272	4.6335146	6.589851	52.019731	0.0000085	0.0459550	ENSG00000125618	PAX8	paired box 8	2	113215997	113278921	protein_coding	HGNC:8622	0.1328690	1.7446167	6.0542638	6.4813315	6.6035017	6.1229497	6.1229497	6.3982630	1.1530043
ENSG00000138161	-0.9064724	3.0801458	5.309977	49.680788	0.0000110	0.0459550	ENSG00000138161	CUZD1	CUB and zona pellucida like domains 1	10	122832158	122846175	protein_coding	HGNC:17937	3.3457298	3.7919178	1.7969690	2.9436127	2.6307857	6.4545832	6.4545832	2.5328887	3.5860047
ENSG00000111452	6.4916953	3.7957978	4.779534	34.512319	0.0000262	0.0823220	ENSG00000111452	ADGRD1	adhesion G protein-coupled receptor D1	12	130953907	131141469	protein_coding	HGNC:19893	0.7884084	-13.2877124	5.7878978	2.6261840	5.6870835	0.4612079	0.4612079	5.2345082	-0.2115081
ENSG00000228299	11.5437795	11.4795632	7.962628	44.496164	0.0000358	0.0857995	ENSG00000228299	HLA-C	major histocompatibility complex, class I, C	HSCHR6_MHC_DBB_CTG1	2526549	2529920	protein_coding	HGNC:4933	-13.2877124	-13.2877124	7.6348425	8.2729494	9.0187454	8.8306809	8.8306809	8.4189333	-13.2877124
ENSG00000145423	4.7692961	1.1610501	7.051131	35.179087	0.0000461	0.0857995	ENSG00000145423	SFRP2	secreted frizzled related protein 2	4	153780591	153789083	protein_coding	HGNC:10777	2.8773589	0.8702653	6.7661901	6.5944726	7.7625395	3.4768823	3.4768823	7.1382993	2.1978711
ENSG00000079689	-3.4914999	-2.5150197	5.723437	34.923849	0.0000478	0.0857995	ENSG00000079689	SCGN	secretagogin, EF-hand calcium binding protein	6	25652201	25701783	protein_coding	HGNC:16941	6.7792409	6.1970074	3.8023501	2.3278561	4.1795107	4.0820088	4.0820085	3.6280772	6.5172987
ENSG00000197915	3.3699608	2.1141694	8.645960	32.864357	0.0000597	0.0938171	ENSG00000197915	HRNR	hornerin	1	152212076	152224193	protein_coding	HGNC:20846	2.2521068	2.9636541	5.5176265	5.8548600	6.6588550	4.7988627	4.7988627	6.0926223	2.6513105
ENSG00000169429	0.6602023	-3.8122724	7.300495	30.531994	0.0000805	0.1024432	ENSG00000169429	CXCL8	C-X-C motif chemokine ligand 8	4	73740519	73743716	protein_coding	HGNC:6025	6.7515008	6.1921794	7.1615457	7.4836679	7.4201490	4.0877764	4.0877768	7.3617102	6.4987776
ENSG00000131016	1.7062621	-1.6240596	6.241831	30.456414	0.0000815	0.1024432	ENSG00000131016	AKAP12	A-kinase anchoring protein 12	6	151239967	151358559	protein_coding	HGNC:370	2.4868335	2.0798290	4.2061944	3.9712598	4.5322602	0.9033599	0.9033599	4.2550414	2.2976366
ENSG00000013297	2.5040431	-1.1361923	5.802945	29.571010	0.0000925	0.1057115	ENSG00000013297	CLDN11	claudin 11	3	170418868	170454733	protein_coding	HGNC:8514	3.2364012	2.6385331	5.7834774	5.0491519	5.8808174	1.8976354	1.8976354	5.6158399	2.9682183
ENSG00000277221	0.3011525	3.3632202	6.504289	27.697132	0.0001201	0.1179329	ENSG00000277221	LRRC37A2	leucine rich repeat containing 37A	HSCHR17_2_CTG5	1030000	1075355	protein_coding	HGNC:32404	3.1883125	1.9464734	3.1040707	3.5844660	2.5896520	6.2078065	6.2078065	3.1491413	2.6970792
ENSG00000182752	2.2850058	-0.0288724	7.671587	27.535523	0.0001220	0.1179329	ENSG00000182752	PAPPA	pappalysin 1	9	116153791	116402321	protein_coding	HGNC:8602	3.9613796	2.4588654	5.0680160	5.0802626	5.6722293	2.5658087	2.5658087	5.3021798	3.3974751
ENSG00000268173	0.0000000	9.1790021	3.810609	49.684145	0.0001353	0.1184441	ENSG00000268173			19	18153158	18178117	protein_coding		-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.8130189	3.8130187	-13.2877124	-13.2877124
ENSG00000276458	7.0462564	8.4038359	4.090972	31.089479	0.0001414	0.1184441	ENSG00000276458	LENG8	leukocyte receptor cluster member 8	HSCHR19LRC_COX1_CTG3_1	355231	368530	protein_coding	HGNC:15500	-13.2877124	-13.2877124	1.9837714	2.0199634	2.1902953	3.3069647	3.3069647	2.0675217	-13.2877124
ENSG00000105647	-0.1787816	-8.8832093	5.591344	24.539231	0.0001930	0.1206367	ENSG00000105647	PIK3R2	phosphoinositide-3-kinase regulatory subunit 2	19	18153163	18170540	protein_coding	HGNC:8980	3.5666737	4.2211849	3.6836972	3.3098511	4.4880511	-13.2877124	-13.2877124	3.9135252	3.9307317
ENSG00000106483	5.8656951	3.8697308	5.524786	21.135610	0.0002003	0.1206367	ENSG00000106483	SFRP4	secreted frizzled related protein 4	7	37905932	38025695	protein_coding	HGNC:10778	-0.2173398	-13.2877124	4.2865125	4.3716741	5.7044386	2.8836343	2.8836343	4.9442494	-1.2171721
ENSG00000227715	-10.7421649	-13.5654075	9.002246	18.278671	0.0002109	0.1206367	ENSG00000227715	HLA-A	major histocompatibility complex, class I, A	HSCHR6_MHC_MCF_CTG1	1286636	1289979	protein_coding	HGNC:4931	0.1153289	11.2405592	0.6792643	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-0.9055180	10.2412050
ENSG00000237988	-3.3670828	-7.8174545	3.734560	20.477564	0.0002122	0.1206367	ENSG00000237988	OR2I1P	olfactory receptor family 2 subfamily I member 1 pseudogene	6	29550407	29557773	protein_coding	HGNC:8258	2.5579298	2.4643452	-2.1844770	0.1685933	-1.5734712	-13.2877124	-13.2877124	-0.8365417	2.5118962
ENSG00000163347	4.3029826	2.5852993	4.433153	21.438239	0.0002248	0.1206367	ENSG00000163347	CLDN1	claudin 1	3	190305707	190322446	protein_coding	HGNC:2032	-2.0925186	-0.4282397	4.0492864	2.8491074	3.1531990	1.6666698	1.6666698	3.4443955	-1.0326263
ENSG00000166833	-1.6282638	-2.3839526	6.804129	23.529549	0.0002271	0.1206367	ENSG00000166833	NAV2	neuron navigator 2	11	19350724	20121601	protein_coding	HGNC:15997	3.5909468	4.4672501	2.7269199	3.8148196	4.3296342	1.7311298	1.7311298	3.7655399	4.0946342
ENSG00000172156	3.4411629	1.2905074	8.029249	23.470661	0.0002291	0.1206367	ENSG00000172156	CCL11	C-C motif chemokine ligand 11	17	34285742	34288334	protein_coding	HGNC:10610	5.8218930	5.1823521	9.1563066	8.0250006	9.7096964	6.9182779	6.9182777	9.1193033	5.5372743
ENSG00000116147	-3.0957394	-2.4548814	3.918697	21.176913	0.0002303	0.1206367	ENSG00000116147	TNR	tenascin R	1	175315194	175743595	protein_coding	HGNC:11953	3.1628089	1.6274107	-2.1033701	-0.6845033	-0.7284620	-1.3140796	-1.3140796	-1.0404960	2.5903981
ENSG00000267954	0.0536594	2.2384151	5.595008	23.442089	0.0002329	0.1206367	ENSG00000267954			HSCHR22_1_CTG7	18645	20320	protein_coding		5.6632429	5.8761516	5.8843942	6.2668160	5.5872645	8.0752027	8.0752027	5.9397741	5.7736211
ENSG00000148600	-2.5348499	-1.7710111	5.068123	23.033645	0.0002518	0.1206367	ENSG00000148600	CDHR1	cadherin related family member 1	10	84194537	84219621	protein_coding	HGNC:14550	2.9229386	4.4511508	1.3472223	1.8485987	1.9017111	1.4551349	1.4551349	1.7198817	3.8805866
ENSG00000143333	-2.2245681	-1.4758977	5.523720	22.953770	0.0002549	0.1206367	ENSG00000143333	RGS16	regulator of G protein signaling 16	1	182598623	182604389	protein_coding	HGNC:9997	5.1235423	5.2739998	3.1913577	2.6000925	3.3865509	3.7762168	3.7762168	3.0962659	5.2007315
ENSG00000167194	-1.2002195	-2.0670899	7.516941	22.611926	0.0002646	0.1206367	ENSG00000167194	C16orf92	chromosome 16 open reading frame 92	16	30023198	30027736	protein_coding	HGNC:26346	8.6684811	8.9463685	7.5929641	7.6744114	7.8941213	6.7989058	6.7989059	7.7261820	8.8141053
ENSG00000235952	-5.8775361	-11.7031136	10.488666	22.289832	0.0002799	0.1206367	ENSG00000235952			HSCHR6_MHC_QBL_CTG1	1197034	1198026	unprocessed_pseudogene		7.9166977	13.4670368	7.0384190	6.7123820	5.8129833	0.5766479	0.5766479	6.6075167	12.4974991
ENSG00000180616	-1.7725384	0.2549073	6.347463	21.435911	0.0003272	0.1206367	ENSG00000180616	SSTR2	somatostatin receptor 2	17	73165010	73176633	protein_coding	HGNC:11331	3.5762648	4.0736775	2.5582490	2.1430107	1.5849154	4.1408043	4.1408043	2.1491133	3.8463031
ENSG00000159307	-2.6159727	1.4912410	4.278309	19.011090	0.0003309	0.1206367	ENSG00000159307	SCUBE1	signal peptide, CUB domain and EGF like domain containing 1	22	43197280	43343372	protein_coding	HGNC:13441	1.3198561	0.0996601	1.2209812	-1.6778780	-1.0986940	2.4291052	2.4291052	0.0521988	0.8350889
ENSG00000230341	5.1015599	9.0032184	3.883798	22.349621	0.0003406	0.1206367	ENSG00000230341	PPP1R18	protein phosphatase 1 regulatory subunit 18	HSCHR6_MHC_APD_CTG1	2005896	2017402	protein_coding	HGNC:29413	-13.2877124	-13.2877124	-13.2877124	0.5545014	0.6261223	3.8210185	3.8210185	0.0058412	-13.2877124
ENSG00000170961	2.7993306	1.6887002	5.894506	21.188716	0.0003434	0.1206367	ENSG00000170961	HAS2	hyaluronan synthase 2	8	121612116	121641440	protein_coding	HGNC:4819	1.8321374	1.2487953	3.9707962	4.5258680	4.8856972	3.3436489	3.3436489	4.5084009	1.5697516
ENSG00000069702	2.7142275	0.6896955	6.440938	21.123041	0.0003451	0.1206367	ENSG00000069702	TGFBR3	transforming growth factor beta receptor 3	1	91680343	91906335	protein_coding	HGNC:11774	2.0582846	1.1377311	4.6742223	5.7590314	5.1225048	4.2675498	4.2675498	5.2545318	1.6702181
ENSG00000086062	2.1244917	1.3882162	7.183830	21.030299	0.0003497	0.1206367	ENSG00000086062	B4GALT1	beta-1,4-galactosyltransferase 1	9	33100493	33167336	protein_coding	HGNC:924	3.6428483	3.2630284	5.4445310	5.6386486	6.0056036	4.9308138	4.9308140	5.7153149	3.4654012
ENSG00000134802	2.5391280	-0.9483755	5.655485	20.973176	0.0003566	0.1206367	ENSG00000134802	SLC43A3	solute carrier family 43 member 3	11	57406954	57427580	protein_coding	HGNC:17466	3.6604881	1.7602112	5.9839448	5.1814551	6.3856815	3.4007382	3.4007382	5.9322745	3.0029199
ENSG00000180044	-2.7110914	-3.0542803	5.823926	20.980676	0.0003594	0.1206367	ENSG00000180044	C3orf80	chromosome 3 open reading frame 80	3	160225422	160228213	protein_coding	HGNC:40048	5.6908018	7.6089526	4.8273842	3.2291590	3.8537595	3.9942003	3.9942004	4.1217415	6.9476262
ENSG00000122641	2.0536652	-0.9664633	6.933795	20.738785	0.0003689	0.1206367	ENSG00000122641	INHBA	inhibin subunit beta A	7	41667168	41705834	protein_coding	HGNC:6066	3.8218046	3.3648458	5.2025293	5.8375949	6.7014600	2.0030463	2.0030463	6.0449960	3.6113421
ENSG00000185070	2.4954760	2.1857797	6.773473	20.556458	0.0003822	0.1206367	ENSG00000185070	FLRT2	fibronectin leucine rich transmembrane protein 2	14	85530144	85654428	protein_coding	HGNC:3761	5.0569697	3.6850817	6.5616874	6.4934534	6.9772845	5.8396490	5.8396490	6.6937840	4.5282981
ENSG00000206538	1.8136773	-0.4990604	5.606004	20.556165	0.0003833	0.1206367	ENSG00000206538	VGLL3	vestigial like family member 3	3	86876388	86991149	protein_coding	HGNC:24327	3.8996678	2.2143602	5.7701784	5.1996569	3.4178610	0.4697558	0.4697558	5.0876403	3.2902657
ENSG00000126500	-2.0698348	-1.3418486	6.103639	20.563056	0.0003840	0.1206367	ENSG00000126500	FLRT1	fibronectin leucine rich transmembrane protein 1	11	64035931	64119173	protein_coding	HGNC:3760	5.0071253	4.9236354	2.6047277	3.4701005	2.7796684	3.6864677	3.6864677	3.0018838	4.9659843
ENSG00000237724	5.4105337	8.9025091	3.840826	22.052063	0.0004062	0.1218709	ENSG00000237724	HSPA1A	heat shock protein family A (Hsp70) member 1A	HSCHR6_MHC_COX_CTG1	3292715	3295197	protein_coding	HGNC:5232	-13.2877124	-13.2877124	1.6035316	1.7373662	-13.2877124	4.6786534	4.6786534	1.0870602	-13.2877124
ENSG00000158169	-2.1381657	-0.7360423	8.708572	20.200192	0.0004074	0.1218709	ENSG00000158169	FANCC	FA complementation group C	9	95099054	95426796	protein_coding	HGNC:3584	7.4114142	8.4572073	6.3867768	5.9008821	5.4700684	7.4224607	7.4224607	5.9677393	8.0270663
ENSG00000164694	4.4223485	2.9717118	7.536335	19.950492	0.0004305	0.1258023	ENSG00000164694	FNDC1	fibronectin type III domain containing 1	6	159169400	159272108	protein_coding	HGNC:21184	1.9522098	-0.8750182	4.9745284	5.6220783	6.1281218	4.1805780	4.1805780	5.6499465	1.1423860
ENSG00000144802	1.3447104	-1.8565754	5.349349	19.801511	0.0004415	0.1260886	ENSG00000144802	NFKBIZ	NFKB inhibitor zeta	3	101827991	101861022	protein_coding	HGNC:29805	3.0267806	2.6910562	4.4138584	4.8722912	4.3788649	1.6165525	1.6165525	4.5730934	2.8686621
ENSG00000157551	2.1424971	-2.5647338	5.170742	19.476830	0.0004729	0.1320398	ENSG00000157551	KCNJ15	potassium inwardly rectifying channel subfamily J member 15	21	38155549	38307357	protein_coding	HGNC:6261	4.0083727	2.7244261	5.0102479	6.7824090	5.7506195	0.2365453	0.2365453	6.0308410	3.5047537
ENSG00000164125	3.7660812	4.0053393	5.485989	18.943576	0.0005044	0.1377871	ENSG00000164125	GASK1B	golgi associated kinase 1B	4	158124474	158173318	protein_coding	HGNC:25312	0.5055922	-2.4421518	3.6209945	4.1191450	4.0030970	4.2955801	4.2955801	3.9296433	-0.3185822
ENSG00000115380	4.5286147	2.0999007	7.341329	18.388430	0.0005854	0.1550487	ENSG00000115380	EFEMP1	EGF containing fibulin extracellular matrix protein 1	2	55865967	55924139	protein_coding	HGNC:3218	2.9205113	-1.6300679	7.1176894	7.5453971	6.9379662	4.8278338	4.8278338	7.2233527	1.9807960
ENSG00000163739	2.2643339	0.4134269	9.266314	18.282094	0.0005923	0.1550487	ENSG00000163739	CXCL1	C-X-C motif chemokine ligand 1	4	73869393	73871308	protein_coding	HGNC:4602	9.0275670	7.5182832	10.6206762	10.9366629	10.8555784	8.8870610	8.8870610	10.8104226	8.4618997
ENSG00000137313	0.0000000	8.5975565	3.322775	29.457464	0.0006226	0.1596511	ENSG00000137313	TRIM26	tripartite motif containing 26	HSCHR6_MHC_QBL_CTG1	1439551	1468529	protein_coding	HGNC:12962	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.9431950	3.9431946	-13.2877124	-13.2877124
ENSG00000196141	2.0537504	1.2569002	6.845394	17.487421	0.0006989	0.1662178	ENSG00000196141	SPATS2L	spermatogenesis associated serine rich 2 like	2	200305881	200482264	protein_coding	HGNC:24574	4.1443738	3.9580548	7.2846109	7.5552514	6.9414392	5.8029078	5.8029079	7.2820356	4.0542199
ENSG00000154175	3.1930478	1.3695063	7.140718	17.483988	0.0007004	0.1662178	ENSG00000154175	ABI3BP	ABI family member 3 binding protein	3	100749156	100993515	protein_coding	HGNC:17265	5.0355052	4.8545220	6.7815164	6.1344509	8.3601698	5.7517444	5.7517443	7.4061592	4.9478499
ENSG00000142319	-6.5097998	1.9054088	3.718586	22.927027	0.0007126	0.1662178	ENSG00000142319	SLC6A3	solute carrier family 6 member 3	5	1392794	1445440	protein_coding	HGNC:11049	2.3974588	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.4565652	3.4565652	-13.2877124	1.3974859
ENSG00000128342	-0.0548543	-2.9059821	6.130639	17.394059	0.0007129	0.1662178	ENSG00000128342	LIF	LIF interleukin 6 family cytokine	22	30240453	30246759	protein_coding	HGNC:6596	5.2974121	5.5126231	4.2415054	5.8196506	6.0525775	3.2133448	3.2133448	5.5624496	5.4090269
ENSG00000138356	3.8537815	1.2971622	5.192066	17.255155	0.0007143	0.1662178	ENSG00000138356	AOX1	aldehyde oxidase 1	2	200586014	200677064	protein_coding	HGNC:553	3.6942816	1.3778312	6.1741552	3.6274724	4.3047078	1.1125026	1.1125026	5.1200888	2.9582304
ENSG00000149968	-2.8796836	-4.7003720	7.347703	17.272519	0.0007323	0.1672939	ENSG00000149968	MMP3	matrix metallopeptidase 3	11	102835801	102843609	protein_coding	HGNC:7173	7.3744286	8.2508388	6.1691607	3.2723210	4.2677025	3.1907157	3.1907157	5.0716209	7.8781852
ENSG00000242265	1.5026720	0.0914741	6.786674	16.979032	0.0007785	0.1746747	ENSG00000242265	PEG10	paternally expressed 10	7	94656325	94669695	protein_coding	HGNC:14005	4.1693309	3.3218285	5.4600824	4.6737546	6.0923629	3.7981058	3.7981055	5.5212047	3.8069375
ENSG00000205238	-0.5812215	1.3718476	7.584824	16.893938	0.0007928	0.1747576	ENSG00000205238	SPDYE2	speedy/RINGO cell cycle regulator family member E2	7	102551226	102563538	protein_coding	HGNC:33841	7.2159333	6.9211719	6.1338332	6.7098410	6.8728184	8.5102757	8.5102757	6.6053571	7.0760674
ENSG00000124875	1.6319297	-2.4670129	7.231044	16.747279	0.0008183	0.1760930	ENSG00000124875	CXCL6	C-X-C motif chemokine ligand 6	4	73836640	73849064	protein_coding	HGNC:10643	6.8191241	4.6767856	8.2982707	7.8374648	8.0170988	4.4060707	4.4060706	8.0635240	6.1136859
ENSG00000185215	2.6010876	0.6773415	5.430722	16.751125	0.0008269	0.1760930	ENSG00000185215	TNFAIP2	TNF alpha induced protein 2	14	103121476	103137439	protein_coding	HGNC:11895	2.4381821	2.5502892	5.9721791	4.7478481	6.2671158	4.4733624	4.4733622	5.7958345	2.4953242
ENSG00000169594	1.9779217	1.4058107	6.310153	16.381153	0.0008887	0.1811391	ENSG00000169594	BNC1	basonuclin zinc finger protein 1	15	83255884	83284664	protein_coding	HGNC:1081	2.8129241	2.4356267	4.8575025	5.0712348	4.6026261	4.0220806	4.0220806	4.8564169	2.6365743
ENSG00000138821	2.3207975	1.0260374	5.440381	16.339665	0.0009037	0.1811391	ENSG00000138821	SLC39A8	solute carrier family 39 member 8	4	102251080	102431258	protein_coding	HGNC:20862	1.8532436	2.0936765	3.9947339	4.2329856	4.9446340	3.0866613	3.0866613	4.4493664	1.9784629
ENSG00000015568	-3.6060970	-0.2875283	4.617021	14.974118	0.0009176	0.1811391	ENSG00000015568	RGPD5	RANBP2 like and GRIP domain containing 5	2	109792758	109857705	protein_coding	HGNC:32418	2.1141844	3.9733945	1.1179915	-13.2877124	0.1992847	2.9902126	2.9902126	0.1456449	3.3246012
ENSG00000116016	2.3095346	0.3575401	8.804888	16.152879	0.0009329	0.1811391	ENSG00000116016	EPAS1	endothelial PAS domain protein 1	2	46293667	46386697	protein_coding	HGNC:3374	5.4748815	4.5477027	7.5418919	7.1361455	7.6765680	5.5806374	5.5806373	7.4692534	5.0845282
ENSG00000141753	2.6893559	2.6671284	9.552985	16.049727	0.0009548	0.1811391	ENSG00000141753	IGFBP4	insulin like growth factor binding protein 4	17	40443450	40457725	protein_coding	HGNC:5473	6.7534944	5.2279505	8.7544333	9.1173742	9.2171389	8.9728760	8.9728761	9.0429567	6.1836175
ENSG00000180447	2.9452056	1.6111727	5.474220	16.083680	0.0009593	0.1811391	ENSG00000180447	GAS1	growth arrest specific 1	9	86944362	86947506	protein_coding	HGNC:4165	2.1384128	0.1308584	4.3931200	4.5783845	4.7500910	3.1893567	3.1893567	4.5812084	1.4588334
ENSG00000112208	1.8040228	0.4075952	9.137343	16.016125	0.0009620	0.1811391	ENSG00000112208	BAG2	BAG cochaperone 2	6	57172326	57189833	protein_coding	HGNC:938	5.2202973	4.9550480	6.5052041	6.9613571	7.4226090	5.5738679	5.5738680	7.0112960	5.0937600
ENSG00000128052	4.4637637	6.2905840	3.897693	14.655282	0.0009659	0.1811391	ENSG00000128052	KDR	kinase insert domain receptor	4	55078481	55125595	protein_coding	HGNC:6307	-2.8115738	-13.2877124	1.0671782	1.7620609	-0.8152094	2.8557155	2.8557155	1.0132786	-3.8105613
ENSG00000136244	1.9304726	-1.8594792	5.253945	15.760900	0.0010272	0.1853222	ENSG00000136244	IL6	interleukin 6	7	22725884	22732002	protein_coding	HGNC:6018	5.5567604	4.4561622	7.0166717	5.9759359	7.4999600	3.3740245	3.3740240	6.9597829	5.1089635
ENSG00000273608	-1.6437121	-3.3734568	4.729052	15.804270	0.0010289	0.1853222	ENSG00000273608	SRCIN1	SRC kinase signaling inhibitor 1	HSCHR17_7_CTG4	2565317	2641249	protein_coding	HGNC:29506	2.2912331	3.5177868	2.0226263	1.3376426	1.7953655	1.1850241	1.1850241	1.7458315	3.0311128
ENSG00000254245	-1.7027613	0.9112202	5.727044	15.721758	0.0010442	0.1853222	ENSG00000254245	PCDHGA3	protocadherin gamma subfamily A, 3	5	141343829	141512975	protein_coding	HGNC:8701	3.8841005	3.3608310	2.4935946	2.7080722	2.4050448	4.6397127	4.6397127	2.5412499	3.6460608
ENSG00000123610	2.8170321	1.6501504	5.869605	15.682697	0.0010472	0.1853222	ENSG00000123610	TNFAIP6	TNF alpha induced protein 6	2	151357592	151380046	protein_coding	HGNC:11898	3.8361455	2.4576673	6.4446871	5.6580282	6.6096417	5.0650568	5.0650568	6.2931199	3.3056401
ENSG00000163734	2.0102109	-0.7230929	6.727039	15.390757	0.0011111	0.1895901	ENSG00000163734	CXCL3	C-X-C motif chemokine ligand 3	4	74036589	74038807	protein_coding	HGNC:4604	6.1078351	4.5120304	7.7102145	7.8885862	7.3671386	4.8101287	4.8101289	7.6712029	5.5201695
ENSG00000120738	2.1117388	-0.2529367	7.571427	15.386449	0.0011116	0.1895901	ENSG00000120738	EGR1	early growth response 1	5	138465479	138469303	protein_coding	HGNC:3238	4.9497716	3.6583343	6.9348170	6.9895951	6.0871129	4.3002997	4.3002995	6.7252374	4.4439759
ENSG00000064666	2.1898197	1.3714629	5.633172	15.375409	0.0011221	0.1895901	ENSG00000064666	CNN2	calponin 2	19	1026586	1039068	protein_coding	HGNC:2156	2.9458983	3.0010268	4.8167584	5.1674422	5.6662247	4.3801586	4.3801586	5.2593036	2.9737259
ENSG00000181291	-3.1283331	-1.0643656	4.428703	14.679201	0.0011317	0.1895901	ENSG00000181291	TMEM132E	transmembrane protein 132E	17	34579487	34639318	protein_coding	HGNC:26991	2.9049160	3.4228733	0.5357872	-2.4316293	-0.2677829	2.0844780	2.0844780	-0.2829745	3.1870156
ENSG00000170345	3.2295707	2.5024718	4.125979	14.749522	0.0011489	0.1899474	ENSG00000170345	FOS	Fos proto-oncogene, AP-1 transcription factor subunit	14	75278826	75283190	protein_coding	HGNC:3796	1.4022130	2.4452163	4.8342854	5.5194586	5.6297284	3.5944690	3.5944685	5.3681827	2.0159863
ENSG00000152766	5.7887437	0.7155386	6.832660	14.928486	0.0011913	0.1919141	ENSG00000152766	ANKRD22	ankyrin repeat domain 22	10	88819896	88851844	protein_coding	HGNC:28321	0.9004584	-13.2877124	4.0716642	7.1644331	4.6353698	0.7531655	0.7531655	5.9473630	-0.0994643
ENSG00000184347	2.6359198	2.1071523	7.078170	15.077351	0.0011966	0.1919141	ENSG00000184347	SLIT3	slit guidance ligand 3	5	168661740	169301139	protein_coding	HGNC:11087	2.8961472	1.3149934	4.9385105	4.9424729	5.6272155	4.5829774	4.5829774	5.2073785	2.3121380
ENSG00000272899	-2.0242414	-2.4542598	5.221560	15.104930	0.0012066	0.1919141	ENSG00000272899	SPMIP1	sperm microtubule inner protein 1	7	128866330	128872047	protein_coding	HGNC:52392	3.7427934	4.5143232	1.5668707	2.0456799	2.8883571	1.7430733	1.7430733	2.2725766	4.1795304
ENSG00000162595	2.9245794	2.3912059	4.396579	14.733100	0.0012533	0.1947962	ENSG00000162595	DIRAS3	DIRAS family GTPase 3	1	68045886	68051717	protein_coding	HGNC:687	0.8891674	1.4194990	3.9002453	3.9228181	4.7770304	3.9922858	3.9922858	4.2609085	1.1785655
ENSG00000122194	2.6413692	4.1938004	4.002102	14.180666	0.0012599	0.1947962	ENSG00000122194	PLG	plasminogen	6	160702194	160754097	protein_coding	HGNC:9071	1.9551900	2.6249527	5.4635894	5.5373713	3.5623135	6.6515499	6.6515499	5.0928627	2.3285938
ENSG00000088826	1.8881776	0.6517070	6.440265	14.822475	0.0012713	0.1947962	ENSG00000088826	SMOX	spermine oxidase	20	4120980	4187747	protein_coding	HGNC:15862	4.3472170	3.6039568	6.0898832	5.8180766	6.2586092	4.7739923	4.7739921	6.0667830	4.0229315
ENSG00000163661	2.4622247	-0.3310056	7.046678	14.739267	0.0012961	0.1958421	ENSG00000163661	PTX3	pentraxin 3	3	157436850	157443633	protein_coding	HGNC:9692	5.0769891	3.2895005	7.5222687	6.4783175	7.0785211	4.2333123	4.2333121	7.0880086	4.4439978
ENSG00000205213	2.6022429	0.2031137	4.208690	14.617189	0.0013226	0.1958421	ENSG00000205213	LGR4	leucine rich repeat containing G protein-coupled receptor 4	11	27365961	27472790	protein_coding	HGNC:13299	-0.3958717	-0.0533769	2.4498041	2.0665931	2.8976329	0.0159100	0.0159100	2.5113339	-0.2144846
ENSG00000238083	0.6135158	1.9042536	8.186428	14.614688	0.0013346	0.1958421	ENSG00000238083	LRRC37A2	leucine rich repeat containing 37A	17	46511508	46556910	protein_coding	HGNC:32404	5.1844892	6.1822914	6.5680013	6.5996150	6.2024748	7.6977637	7.6977637	6.4676103	5.7679868
ENSG00000213024	1.6307818	0.5833265	6.914486	14.571709	0.0013492	0.1958421	ENSG00000213024	NUP62	nucleoporin 62	19	49906825	49929764	protein_coding	HGNC:8066	5.0081204	4.0368524	5.1772530	5.8638187	5.8534301	4.7588321	4.7588319	5.6652014	4.6027241
ENSG00000081041	1.3661716	-0.3775781	6.028193	14.489944	0.0013777	0.1958421	ENSG00000081041	CXCL2	C-X-C motif chemokine ligand 2	4	74097040	74099196	protein_coding	HGNC:4603	5.4424070	5.4720792	6.6541496	7.1245141	6.8574808	4.9700495	4.9700493	6.8916372	5.4573195
ENSG00000103512	3.0653226	-5.5118560	4.770406	14.374751	0.0014171	0.1958421	ENSG00000103512	NOMO1	NODAL modulator 1	16	14833721	14896157	protein_coding	HGNC:30060	-13.2877124	1.5509972	3.8146197	3.8967648	2.7771440	-13.2877124	-13.2877124	3.5777593	0.5510464
ENSG00000173826	-1.5423445	1.4804385	4.208685	14.066244	0.0014300	0.1958421	ENSG00000173826	KCNH6	potassium voltage-gated channel subfamily H member 6	17	63523334	63548977	protein_coding	HGNC:18862	2.3633480	2.7003556	0.7171743	1.5837087	1.0694712	4.3634885	4.3634885	1.1677895	2.5416700
ENSG00000143702	0.5638069	-2.9773738	5.773875	14.311479	0.0014392	0.1958421	ENSG00000143702	CEP170	centrosomal protein 170	1	243124428	243255793	protein_coding	HGNC:28920	4.2496927	5.0712298	5.6117982	5.1360270	4.6790127	-0.0110979	-0.0110979	5.1922192	4.7181654
ENSG00000170356	3.7516354	0.9365562	4.896447	14.052389	0.0014722	0.1958421	ENSG00000170356	OR2A20P	olfactory receptor family 2 subfamily A member 20 pseudogene	7	144250671	144251603	transcribed_unprocessed_pseudogene	HGNC:15413	1.7632395	-13.2877124	4.2131104	4.8057144	3.7313378	1.3660189	1.3660189	4.3170280	0.7632824
ENSG00000196352	2.2476741	0.5356302	6.287182	14.186019	0.0014857	0.1958421	ENSG00000196352	CD55	CD55 molecule (Cromer blood group)	1	207321519	207386804	protein_coding	HGNC:2665	4.3608856	3.4698013	6.2941421	5.7961198	6.7700294	4.6170816	4.6170816	6.3409126	3.9830748
ENSG00000148926	1.4541779	-1.0805283	5.968962	14.177343	0.0014878	0.1958421	ENSG00000148926	ADM	adrenomedullin	11	10305073	10307397	protein_coding	HGNC:259	4.8455845	4.4162206	5.6631028	6.6003619	6.2023147	3.5886233	3.5886235	6.2051348	4.6468170
ENSG00000248288	3.9964976	0.3041322	3.297507	12.420461	0.0014946	0.1958421	ENSG00000248288			5	65209921	65210948	processed_pseudogene		0.6944078	0.7781488	4.4307565	4.8287570	5.7119399	1.1407630	1.1407630	5.0931330	0.7368862
ENSG00000138061	1.9047940	0.1898090	6.206006	14.158414	0.0014950	0.1958421	ENSG00000138061	CYP1B1	cytochrome P450 family 1 subfamily B member 1	2	38066973	38109902	protein_coding	HGNC:2597	3.3911088	2.4345420	5.1471204	4.7310654	5.0085658	2.8608500	2.8608500	4.9724448	2.9906948
ENSG00000133687	5.2569103	4.7838382	3.877434	12.996444	0.0015113	0.1958421	ENSG00000133687	TMTC1	transmembrane O-mannosyltransferase targeting cadherins 1	12	29500840	29784759	protein_coding	HGNC:24099	1.9557071	-13.2877124	2.4090523	1.4661666	2.2115876	1.4519960	1.4519960	2.0824720	0.9557443
ENSG00000275331	4.4108891	5.1740323	4.078997	12.351034	0.0015132	0.1958421	ENSG00000275331	ABCC6	ATP binding cassette subfamily C member 6	HSCHR16_1_CTG1	1806848	1881517	protein_coding	HGNC:57	-13.2877124	-1.8996789	2.4167063	1.6912943	0.5166072	2.4891385	2.4891385	1.7369015	-2.8991407
ENSG00000060718	3.7044696	-5.2413786	5.087007	13.976560	0.0015402	0.1958421	ENSG00000060718	COL11A1	collagen type XI alpha 1 chain	1	102876467	103108872	protein_coding	HGNC:2186	-0.4326103	1.6653396	2.2968805	3.9771542	4.5791042	-13.2877124	-13.2877124	3.8928867	0.9682021
ENSG00000117971	-1.8819403	-0.9568915	5.340190	14.081617	0.0015430	0.1958421	ENSG00000117971	CHRNB4	cholinergic receptor nicotinic beta 4 subunit	15	78624111	78727754	protein_coding	HGNC:1964	4.2567584	6.2022660	3.4987233	4.5974932	2.5271554	3.8404017	3.8404018	3.7823173	5.5352586
ENSG00000075420	1.5908349	0.5924912	6.949672	13.932264	0.0015796	0.1984714	ENSG00000075420	FNDC3B	fibronectin type III domain containing 3B	3	172039578	172401669	protein_coding	HGNC:24670	3.7347495	4.1189710	4.7986286	6.0942931	5.4675669	4.5958737	4.5958736	5.5484641	3.9396131
ENSG00000162407	1.7045327	2.2767233	6.614886	13.755994	0.0016529	0.2056263	ENSG00000162407	PLPP3	phospholipid phosphatase 3	1	56494761	56645301	protein_coding	HGNC:9229	3.6026154	4.3403152	4.8906317	4.9765660	6.3495532	6.5789260	6.5789260	5.5718270	4.0181116
ENSG00000173376	1.5098533	1.7240439	5.631778	13.728287	0.0016701	0.2057335	ENSG00000173376	NDNF	neuron derived neurotrophic factor	4	121035613	121073021	protein_coding	HGNC:26256	2.7022960	2.9590490	4.6115748	4.3528135	4.3872314	4.6168512	4.6168512	4.4551781	2.8363768
ENSG00000151150	-1.8384147	-2.9692374	5.167339	13.590543	0.0017451	0.2086028	ENSG00000151150	ANK3	ankyrin 3	10	60026298	60733490	protein_coding	HGNC:494	3.0157323	3.5624007	2.7475096	3.1256777	3.1202882	-0.1148708	-0.1148708	3.0083522	3.3148061
ENSG00000172817	3.1455873	1.4887291	4.145323	13.256341	0.0017468	0.2086028	ENSG00000172817	CYP7B1	cytochrome P450 family 7 subfamily B member 1	8	64587763	64798737	protein_coding	HGNC:2652	-0.9522522	2.3496506	2.2398495	4.4873511	5.2897169	0.1626805	0.1626805	4.4653256	1.4889864
ENSG00000115459	-1.9085896	-2.1614980	4.603585	13.589120	0.0017491	0.2086028	ENSG00000115459	ELMOD3	ELMO domain containing 3	2	85354394	85391752	protein_coding	HGNC:26158	5.5152407	5.6443437	4.4081879	4.4752177	1.6246512	4.1643180	4.1643181	3.9559953	5.5812358
ENSG00000153823	2.1309514	1.0855822	5.302544	13.501665	0.0017767	0.2086028	ENSG00000153823	PID1	phosphotyrosine interaction domain containing 1	2	228850526	229271287	protein_coding	HGNC:26084	2.1255671	3.2354965	4.0346859	4.8171258	4.9206563	3.5362663	3.5362668	4.6413004	2.7847385
ENSG00000147488	-1.1141048	-1.7064512	6.634919	13.454879	0.0017842	0.2086028	ENSG00000147488	ST18	ST18 C2H2C-type zinc finger transcription factor	8	52110838	52460959	protein_coding	HGNC:18695	5.1920498	6.1572070	5.4585558	4.0334086	4.2926521	3.7017299	3.7017298	4.7359981	5.7538775
ENSG00000204463	-6.8277536	0.9939717	3.555705	16.967810	0.0017946	0.2086028	ENSG00000204463	BAG6	BAG cochaperone 6	6	31639028	31652705	protein_coding	HGNC:13919	2.0027749	1.6626366	-13.2877124	-13.2877124	-13.2877124	3.6451892	3.6451892	-13.2877124	1.8427070
ENSG00000144893	3.4365644	1.2479612	5.765125	13.435301	0.0018096	0.2086028	ENSG00000144893	MED12L	mediator complex subunit 12L	3	151085286	151437072	protein_coding	HGNC:16050	-0.2322062	0.3116612	2.0589208	2.4068626	4.9164539	0.8674782	0.8674782	3.7249945	0.0652056
ENSG00000167460	1.4221561	0.2052642	8.254068	13.304038	0.0018534	0.2108491	ENSG00000167460	TPM4	tropomyosin 4	19	16067021	16103005	protein_coding	HGNC:12013	6.2214761	5.7249355	7.4945060	7.5931171	7.7191782	6.3431583	6.3431583	7.6052051	5.9944634
ENSG00000230624	-8.1450125	0.3295881	4.446403	16.679702	0.0018744	0.2108491	ENSG00000230624	DDX39B	DExD-box helicase 39B	HSCHR6_MHC_DBB_CTG1	2777992	2794348	protein_coding	HGNC:13917	1.2504268	3.9720233	-13.2877124	-13.2877124	-13.2877124	3.4830155	3.4830155	-13.2877124	3.1756712
ENSG00000278312	0.0000000	8.1814889	2.996294	19.841974	0.0018794	0.2108491	ENSG00000278312	LENG9	leukocyte receptor cluster member 9	HSCHR19LRC_COX1_CTG3_1	368305	370225	protein_coding	HGNC:16306	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	4.3809492	4.3809490	-13.2877124	-13.2877124
ENSG00000151790	-0.1701599	2.5999557	4.159511	13.038515	0.0019872	0.2209690	ENSG00000151790	TDO2	tryptophan 2,3-dioxygenase	4	155854738	155920406	protein_coding	HGNC:11708	2.6477471	2.3016400	2.2632400	3.1130390	1.0651925	5.1704571	5.1704571	2.3734316	2.4850478
ENSG00000149257	1.9539143	1.4657381	8.189845	12.915149	0.0020527	0.2221031	ENSG00000149257	SERPINH1	serpin family H member 1	11	75562056	75572783	protein_coding	HGNC:1546	5.7735641	4.8537655	7.2994719	8.0112659	8.0404828	7.3056549	7.3056550	7.8219245	5.3857589
ENSG00000148344	1.8359364	0.7695242	5.992005	12.861977	0.0020868	0.2221031	ENSG00000148344	PTGES	prostaglandin E synthase	9	129738331	129753042	protein_coding	HGNC:9599	4.2973198	3.4485779	5.7445057	6.0535191	5.9682210	4.8044715	4.8044713	5.9278747	3.9344835
ENSG00000081692	-1.7448097	-0.5835000	7.661316	12.791597	0.0021221	0.2221031	ENSG00000081692	JMJD4	jumonji domain containing 4	1	227730425	227735411	protein_coding	HGNC:25724	6.6277524	6.7779612	5.8539729	5.0803334	4.0408881	6.3089339	6.3089340	5.1716796	6.7048108
ENSG00000237412	-2.5734323	-4.2835759	3.621398	12.092047	0.0021224	0.2221031	ENSG00000237412	PRSS56	serine protease 56	2	232520388	232525716	protein_coding	HGNC:39433	3.4639471	4.7363760	2.4271247	2.6364089	1.2462409	-0.9002874	-0.9002874	2.2191168	4.2361196
ENSG00000073756	-0.7666899	-2.4798161	5.850772	12.792828	0.0021251	0.2221031	ENSG00000073756	PTGS2	prostaglandin-endoperoxide synthase 2	1	186671791	186680922	protein_coding	HGNC:9605	5.1098687	4.4512665	4.1994277	3.1549880	3.7720387	3.2370411	3.2370411	3.7704990	4.8178279
ENSG00000224006	-7.3177714	-7.3177714	3.205484	15.991049	0.0021338	0.2221031	ENSG00000224006			HSCHR6_MHC_COX_CTG1	1485506	1486509	unprocessed_pseudogene		4.7335124	4.5074100	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	4.6248864
ENSG00000164082	-2.2654983	-3.0607511	3.917332	12.459661	0.0021798	0.2221031	ENSG00000164082	GRM2	glutamate metabotropic receptor 2	3	51707068	51718613	protein_coding	HGNC:4594	3.2128308	2.8956231	2.0631654	0.9042089	-0.0816412	0.8882332	0.8882332	1.2214694	3.0629275
ENSG00000167996	1.2817077	0.3296882	11.610018	12.648370	0.0022041	0.2221031	ENSG00000167996	FTH1	ferritin heavy chain 1	11	61959718	61967634	protein_coding	HGNC:3976	11.0859067	11.1034913	12.4884986	12.3376742	12.5335624	11.4856247	11.4856246	12.4556496	11.0947257
ENSG00000138622	-3.7613971	-1.1486914	3.291962	10.311604	0.0022118	0.2221031	ENSG00000138622	HCN4	hyperpolarization activated cyclic nucleotide gated potassium channel 4	15	73319859	73368958	protein_coding	HGNC:16882	0.8383629	1.5026799	-1.7760635	-2.7434724	-13.2877124	0.0828388	0.0828388	-2.7647906	1.2084255
ENSG00000229698	-5.8340145	-9.1876761	4.813869	10.261416	0.0022558	0.2221031	ENSG00000229698	HLA-F	major histocompatibility complex, class I, F	HSCHR6_MHC_SSTO_CTG1	1029074	1044770	protein_coding	HGNC:4963	-13.2877124	7.2595303	-13.2877124	1.7509336	3.7934976	-13.2877124	-13.2877124	2.5220585	6.2595313
ENSG00000168237	-0.6791922	-2.8988876	6.845265	12.552461	0.0022630	0.2221031	ENSG00000168237	GLYCTK	glycerate kinase	3	52287089	52295257	protein_coding	HGNC:24247	5.4822340	7.1264171	5.9142222	5.9617085	6.2188566	3.7038325	3.7038327	6.0379185	6.5268757
ENSG00000125538	-1.8648074	-2.6795071	4.905980	12.604787	0.0022652	0.2221031	ENSG00000125538	IL1B	interleukin 1 beta	2	112829751	112836816	protein_coding	HGNC:5992	5.0431351	5.3851195	2.8501017	4.2006149	2.7222586	2.5743622	2.5743622	3.4238727	5.2242369
ENSG00000100095	-1.3120244	-1.5452835	6.031172	12.535577	0.0022790	0.2221031	ENSG00000100095	SEZ6L	seizure related 6 homolog like	22	26169462	26383597	protein_coding	HGNC:10763	4.4421449	4.8740459	3.4307413	4.0296436	3.1783018	3.4159172	3.4159168	3.5916782	4.6741979
ENSG00000126785	2.9452064	2.2878770	3.890339	12.168271	0.0022817	0.2221031	ENSG00000126785	RHOJ	ras homolog family member J	14	63204114	63293508	protein_coding	HGNC:688	-0.5572104	-0.4775043	2.8299709	3.8311842	2.8490255	3.4667670	3.4667670	3.2504005	-0.5168070
ENSG00000134352	1.3330970	0.2001732	6.291348	12.519815	0.0022843	0.2221031	ENSG00000134352	IL6ST	interleukin 6 cytokine family signal transducer	5	55935095	55995022	protein_coding	HGNC:6021	4.3333144	2.1372058	3.7960539	5.6890822	5.6713240	4.2360670	4.2360670	5.2785312	3.6180953
ENSG00000024422	1.4210738	0.7998886	6.879480	12.478480	0.0023090	0.2221031	ENSG00000024422	EHD2	EH domain containing 2	19	47713422	47743134	protein_coding	HGNC:3243	4.3133535	3.9818968	5.7663332	5.6680055	5.7729437	4.9025643	4.9025642	5.7365527	4.1571230
ENSG00000154736	2.2449731	1.3232082	7.620914	12.477428	0.0023093	0.2221031	ENSG00000154736	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5	21	26917922	26967088	protein_coding	HGNC:221	3.0606835	1.7111579	4.7025060	4.7857090	5.2674930	3.9731182	3.9731182	4.9407799	2.5382792
ENSG00000189058	1.0790787	3.0053660	4.184999	12.527356	0.0023156	0.2221031	ENSG00000189058	APOD	apolipoprotein D	3	195568705	195584033	protein_coding	HGNC:612	2.9318549	3.4296853	4.6501457	3.5845800	4.6815731	6.1835785	6.1835785	4.3870005	3.2021378
ENSG00000143867	1.3799096	3.5313493	4.251602	12.445055	0.0023349	0.2222548	ENSG00000143867	OSR1	odd-skipped related transcription factor 1	2	19351485	19358623	protein_coding	HGNC:8111	1.5264940	-0.0519449	2.3006890	2.7481394	2.9440959	4.6515528	4.6515528	2.6886551	0.9431652
ENSG00000149131	3.5286235	2.8718395	4.771297	12.183051	0.0023893	0.2239441	ENSG00000149131	SERPING1	serpin family G member 1	11	57597387	57619171	protein_coding	HGNC:1228	1.1898960	1.2139637	5.4289234	3.6659888	4.6439303	3.8088743	3.8088743	4.7508538	1.2019801
ENSG00000216490	-1.1935171	-7.9431015	4.263430	12.400071	0.0023973	0.2239441	ENSG00000216490	IFI30	IFI30 lysosomal thiol reductase	19	18173162	18178117	protein_coding	HGNC:5398	5.2350662	5.3567262	4.7904158	4.3003786	2.6597531	-13.2877124	-13.2877124	4.1617773	5.2971782
ENSG00000118503	1.5984197	-0.2794634	5.250112	12.345436	0.0024062	0.2239441	ENSG00000118503	TNFAIP3	TNF alpha induced protein 3	6	137867214	137883314	protein_coding	HGNC:11896	2.5726751	3.3718148	4.6395399	4.5960946	5.0859231	1.6819718	1.6819718	4.7913792	3.0268841
ENSG00000147257	7.4622336	3.2493460	3.677069	13.563434	0.0024288	0.2239441	ENSG00000147257	GPC3	glypican 3	X	133535745	133987100	protein_coding	HGNC:4451	-13.2877124	-13.2877124	1.7266691	3.6022062	3.8624836	-1.0317839	-1.0317839	3.3218917	-13.2877124
ENSG00000111799	2.3613418	0.5289573	7.789569	12.240783	0.0024639	0.2239441	ENSG00000111799	COL12A1	collagen type XII alpha 1 chain	6	75084326	75206267	protein_coding	HGNC:2188	3.6718448	2.4067075	4.5107181	5.9367990	5.6452658	3.9849108	3.9849108	5.4822229	3.1737269
ENSG00000011347	-1.3899884	0.0353958	8.854907	12.239267	0.0024644	0.2239441	ENSG00000011347	SYT7	synaptotagmin 7	11	61513714	61581148	protein_coding	HGNC:11514	7.2792736	7.3952168	6.5848219	5.6775756	5.5706939	7.4080247	7.4080247	6.0201512	7.3384095
ENSG00000168394	4.5121048	3.8165623	4.812099	11.494066	0.0024911	0.2239441	ENSG00000168394	TAP1	transporter 1, ATP binding cassette subfamily B member	6	32845209	32853816	protein_coding	HGNC:43	-13.2877124	0.8091889	3.7401170	4.4753084	6.0875277	4.1718703	4.1718703	5.1100429	-0.1907288
ENSG00000080644	-1.2590700	-0.9864462	9.075928	12.183803	0.0025024	0.2239441	ENSG00000080644	CHRNA3	cholinergic receptor nicotinic alpha 3 subunit	15	78593052	78621295	protein_coding	HGNC:1957	9.8357369	10.1521010	8.8605984	8.8771259	8.4188273	8.9142737	8.9142736	8.7338878	10.0025734
ENSG00000114544	-1.2669217	0.9389255	6.328518	12.172143	0.0025198	0.2239441	ENSG00000114544	SLC41A3	solute carrier family 41 member 3	3	126006357	126101561	protein_coding	HGNC:31046	4.9643788	5.6004014	4.5794036	3.8914148	3.1572273	6.1272974	6.1272973	3.9900109	5.3171593
ENSG00000167615	4.3207153	-2.6898873	3.315870	10.774503	0.0025370	0.2239441	ENSG00000167615	LENG8	leukocyte receptor cluster member 8	19	54449190	54462016	protein_coding	HGNC:15500	-1.6256939	-13.2877124	1.8428312	1.7000468	2.1159385	-13.2877124	-13.2877124	1.8967198	-2.6252487
ENSG00000212807	7.2619048	5.7019945	3.615597	13.369565	0.0025487	0.2239441	ENSG00000212807	OR2A42	olfactory receptor family 2 subfamily A member 42	7	144228244	144239605	protein_coding	HGNC:31230	-13.2877124	-13.2877124	2.6917434	1.0782218	1.7513909	0.3700035	0.3700035	1.9926716	-13.2877124
ENSG00000144645	2.2008287	1.3190529	4.928067	12.060067	0.0026194	0.2271015	ENSG00000144645	OSBPL10	oxysterol binding protein like 10	3	31657912	32077580	protein_coding	HGNC:16395	2.5959180	-0.2464280	3.7754832	3.0628401	2.2064297	3.2218785	3.2218785	3.1519445	1.7842355
ENSG00000140937	2.0902395	1.8198722	7.005668	12.020324	0.0026207	0.2271015	ENSG00000140937	CDH11	cadherin 11	16	64943753	65126112	protein_coding	HGNC:1750	5.1673746	4.9305373	5.7262082	6.9634492	7.5837344	7.4424701	7.4424701	6.9447477	5.0538104
ENSG00000142798	2.1452012	0.9339347	7.997604	11.958186	0.0026652	0.2293482	ENSG00000142798	HSPG2	heparan sulfate proteoglycan 2	1	21822244	21937310	protein_coding	HGNC:5273	3.9826948	3.4696852	4.5112926	4.6494330	5.4504484	3.9701972	3.9701975	4.9327689	3.7488734
ENSG00000116729	1.5837905	0.3842221	5.561634	11.946167	0.0026832	0.2293482	ENSG00000116729	WLS	Wnt ligand secretion mediator	1	68098473	68233120	protein_coding	HGNC:30238	3.3540636	3.4992581	5.3189383	5.4889087	5.5493614	3.6175225	3.6175230	5.4556609	3.4284868
ENSG00000105825	2.0641493	-0.9072504	9.110560	11.817407	0.0027726	0.2345097	ENSG00000105825	TFPI2	tissue factor pathway inhibitor 2	7	93885396	93890753	protein_coding	HGNC:11761	7.9985798	6.7850286	9.6738600	8.4513120	10.5448545	6.8849610	6.8849605	9.7926398	7.5158110
ENSG00000063438	-2.3407982	0.9096889	4.112743	11.234593	0.0027809	0.2345097	ENSG00000063438	AHRR	aryl hydrocarbon receptor repressor	5	321714	438291	protein_coding	HGNC:346	4.3119049	4.9712115	1.9194907	-0.7749225	2.7585710	5.4792343	5.4792343	1.8920117	4.6788976
ENSG00000163735	1.1511487	-1.1803526	6.095099	11.740459	0.0028366	0.2376141	ENSG00000163735	CXCL5	C-X-C motif chemokine ligand 5	4	73995642	73998677	protein_coding	HGNC:10642	3.3677412	4.7888249	5.3896432	5.3725894	5.6104890	3.0692938	3.0692938	5.4617103	4.2466100
ENSG00000122783	0.7934244	2.1329464	6.221925	11.708282	0.0028651	0.2383074	ENSG00000122783	CYREN	cell cycle regulator of NHEJ	7	135092363	135170795	protein_coding	HGNC:22432	5.5386043	4.9622027	6.0868128	5.4541140	6.6491635	7.6120587	7.6120587	6.1441555	5.2790002
ENSG00000106089	-1.8791262	-1.9470278	4.569159	11.726251	0.0028828	0.2383074	ENSG00000106089	STX1A	syntaxin 1A	7	73699206	73719672	protein_coding	HGNC:11433	4.1264728	4.8276822	3.2915085	3.7597126	2.2892434	3.4682465	3.4682465	3.2339177	4.5192667
ENSG00000163682	1.1961466	-4.2965972	5.549563	11.595475	0.0029599	0.2400267	ENSG00000163682	RPL9	ribosomal protein L9	4	39452587	39458931	protein_coding	HGNC:10369	4.0282259	6.6436836	7.2676297	7.3614973	6.6842622	1.5113496	1.5113496	7.1340136	5.8617588
ENSG00000129009	2.6959442	3.6796223	5.384763	11.596385	0.0029775	0.2400267	ENSG00000129009	ISLR	immunoglobulin superfamily containing leucine rich repeat	15	74173710	74176872	protein_coding	HGNC:6133	2.5537672	-1.3867022	4.7653382	5.3135251	4.6918075	5.8785845	5.8785845	4.9512286	1.6448004
ENSG00000196549	2.0537462	0.4838001	7.424784	11.563023	0.0029821	0.2400267	ENSG00000196549	MME	membrane metalloendopeptidase	3	155024124	155183704	protein_coding	HGNC:7154	5.6981785	4.5089983	6.6762119	7.6155252	7.4334616	5.0571078	5.0571080	7.2953528	5.2227961
ENSG00000087245	1.1925727	0.6093603	10.549180	11.560654	0.0029833	0.2400267	ENSG00000087245	MMP2	matrix metallopeptidase 2	16	55389700	55506691	protein_coding	HGNC:7166	8.1854068	8.1976407	9.4331416	9.7625078	9.6229708	8.9982109	8.9982107	9.6124786	8.1915365
ENSG00000198369	2.0582825	0.6731699	4.544290	11.581022	0.0030027	0.2400267	ENSG00000198369	SPRED2	sprouty related EVH1 domain containing 2	2	65310851	65432637	protein_coding	HGNC:17722	2.3304775	2.0638556	4.9831714	4.2975223	3.4332654	1.5084565	1.5084565	4.3714590	2.2033171
ENSG00000071967	2.2031710	1.3126488	5.537696	11.541902	0.0030182	0.2400267	ENSG00000071967	CYBRD1	cytochrome b reductase 1	2	171522247	171558129	protein_coding	HGNC:20797	2.1709861	1.2663830	3.7799790	4.5029414	5.4055573	4.5461675	4.5461675	4.7151184	1.7884535
ENSG00000169604	1.9793946	0.5102013	7.662923	11.410278	0.0031163	0.2462693	ENSG00000169604	ANTXR1	ANTXR cell adhesion molecule 1	2	69013176	69249327	protein_coding	HGNC:21014	4.9897997	3.5660365	6.1339877	6.1376796	6.7813719	4.8629497	4.8629497	6.3844999	4.4468570
ENSG00000134363	1.1623133	-0.7037321	5.218440	11.374820	0.0031605	0.2482018	ENSG00000134363	FST	follistatin	5	53480626	53487134	protein_coding	HGNC:3971	3.1581043	3.8515064	4.5562484	4.9826883	4.5792088	3.3744030	3.3744024	4.7197278	3.5460697
ENSG00000196569	2.4203874	1.5480099	6.630777	11.289529	0.0032325	0.2512120	ENSG00000196569	LAMA2	laminin subunit alpha 2	6	128883138	129516566	protein_coding	HGNC:6482	2.6800207	0.2244133	3.7108680	3.8087180	4.2539149	3.0254316	3.0254316	3.9444387	1.9216180
ENSG00000169136	1.6564296	0.2587789	5.163154	11.286821	0.0032497	0.2512120	ENSG00000169136	ATF5	activating transcription factor 5	19	49928702	49933935	protein_coding	HGNC:790	3.3344074	3.2757349	4.6902203	4.7188088	5.5117253	3.5688147	3.5688141	5.0264132	3.3053694
ENSG00000163430	2.2998138	0.7132435	9.138148	11.256292	0.0032589	0.2512120	ENSG00000163430	FSTL1	follistatin like 1	3	120392293	120451016	protein_coding	HGNC:3972	6.7972363	3.7076507	8.2255258	8.3254150	8.6697285	6.7150520	6.7150520	8.4197193	5.9574777
ENSG00000116962	2.4819172	0.5381991	7.416616	11.187075	0.0033272	0.2543081	ENSG00000116962	NID1	nidogen 1	1	235975830	236065109	protein_coding	HGNC:7821	3.6523804	1.7923640	5.2054776	5.3329218	6.1555789	3.6319367	3.6319367	5.6292763	3.0034128
ENSG00000146221	-1.6013825	-1.0346362	6.841226	11.176677	0.0033395	0.2543081	ENSG00000146221	TCTE1	t-complex-associated-testis-expressed 1	6	44278734	44297698	protein_coding	HGNC:11693	6.2508478	5.4916663	4.2239208	4.4068164	4.7235861	4.9783748	4.9783746	4.4663896	5.9206287
ENSG00000017427	3.7297585	3.0257552	5.109157	11.004979	0.0034122	0.2582760	ENSG00000017427	IGF1	insulin like growth factor 1	12	102395874	102481744	protein_coding	HGNC:5464	1.6419709	-2.1736122	4.5949697	3.0800970	5.1163329	3.2709629	3.2709629	4.4878079	0.7409595
ENSG00000007520	-1.0819750	0.1652468	6.545569	11.045803	0.0034724	0.2603356	ENSG00000007520	TSR3	TSR3 ribosome maturation factor	16	1349240	1351878	protein_coding	HGNC:14175	6.7705480	6.9633336	6.0482245	5.6210908	6.0006083	7.0911407	7.0911406	5.9022316	6.8701587
ENSG00000204713	0.1291695	-7.8352308	4.769956	11.036537	0.0034985	0.2603356	ENSG00000204713	TRIM27	tripartite motif containing 27	6	28903002	28923988	protein_coding	HGNC:9975	4.0497891	2.4479798	3.7818287	2.9635180	3.7768814	-13.2877124	-13.2877124	3.5550836	3.4606338
ENSG00000165389	1.6035763	2.3949358	4.705384	11.061320	0.0035015	0.2603356	ENSG00000165389	SPTSSA	serine palmitoyltransferase small subunit A	14	34432788	34462240	protein_coding	HGNC:20361	1.6390941	1.8565523	3.8354263	3.4915481	2.9015535	4.2148703	4.2148703	3.4592131	1.7519166
ENSG00000221970	6.8538796	0.0000000	3.149002	12.042041	0.0035450	0.2604132	ENSG00000221970	OR2A1	olfactory receptor family 2 subfamily A member 1	7	144312419	144322737	protein_coding	HGNC:8229	-13.2877124	-13.2877124	0.7130500	2.2782634	1.6793107	-13.2877124	-13.2877124	1.6919736	-13.2877124
ENSG00000172345	2.4981823	3.4906486	5.204681	10.986774	0.0035592	0.2604132	ENSG00000172345	STARD5	StAR related lipid transfer domain containing 5	15	81309053	81324183	protein_coding	HGNC:18065	0.9509596	1.2868622	2.5594115	4.1909091	3.8551650	4.0123508	4.0123508	3.6866918	1.1286649
ENSG00000149527	-7.1244954	-7.1244954	3.062583	13.378358	0.0036007	0.2604132	ENSG00000149527	PLCH2	phospholipase C eta 2	1	2425980	2505532	protein_coding	HGNC:29037	-13.2877124	2.8749529	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.8749728
ENSG00000108691	1.4484606	-0.3415178	8.143179	10.902453	0.0036192	0.2604132	ENSG00000108691	CCL2	C-C motif chemokine ligand 2	17	34255274	34257208	protein_coding	HGNC:10618	8.4272317	7.8793505	9.2424297	9.6331556	10.2703298	7.9033213	7.9033215	9.7785181	8.1791443
ENSG00000144229	-2.2782703	-7.3979011	3.546598	10.466641	0.0036436	0.2604132	ENSG00000144229	THSD7B	thrombospondin type 1 domain containing 7B	2	136765545	137677718	protein_coding	HGNC:29348	2.9622656	2.7253104	-2.5204052	-0.1671958	0.4122276	-13.2877124	-13.2877124	-0.3245725	2.8486474
ENSG00000166147	2.3268991	0.8793650	8.682388	10.874919	0.0036492	0.2604132	ENSG00000166147	FBN1	fibrillin 1	15	48408313	48645721	protein_coding	HGNC:3603	3.9074852	2.1511435	5.6292580	5.7400446	6.0985790	4.3003478	4.3003478	5.8368487	3.2815484
ENSG00000140807	-2.3072208	-1.1878397	4.561020	10.863759	0.0036527	0.2604132	ENSG00000140807	NKD1	NKD inhibitor of WNT signaling pathway 1	16	50548396	50649249	protein_coding	HGNC:17045	0.9627459	1.3638456	-0.4122683	-2.4944667	-0.9157534	2.6544168	2.6544168	-1.0400183	1.1771904
ENSG00000115602	4.0583453	0.7845832	5.355486	10.800169	0.0036684	0.2604132	ENSG00000115602	IL1RL1	interleukin 1 receptor like 1	2	102311502	102352037	protein_coding	HGNC:5998	0.9986584	-13.2877124	5.4229804	4.9652978	3.3244974	1.5441678	1.5441678	4.8100919	-0.0012694
ENSG00000286169	-1.9117865	-1.3703984	4.807855	10.850096	0.0037270	0.2615023	ENSG00000286169	NA	NA	NA	NA	NA	NA	NA	2.5714708	4.0642573	0.8415578	1.4550355	1.2547156	1.6933344	1.6933344	1.2057716	3.5028968
ENSG00000149212	1.4197260	0.6510070	6.338456	10.802860	0.0037323	0.2615023	ENSG00000149212	SESN3	sestrin 3	11	95165513	95232541	protein_coding	HGNC:23060	2.2100724	2.1359475	3.5480961	3.6543560	3.7953995	2.6999622	2.6999622	3.6695185	2.1734860
ENSG00000168280	-0.6873626	-2.2185247	6.758797	10.784636	0.0037512	0.2615023	ENSG00000168280	KIF5C	kinesin family member 5C	2	148875227	149026759	protein_coding	HGNC:6325	4.6377707	4.2516058	4.1581635	3.7793914	3.7595447	2.6284442	2.6284442	3.9110126	4.4575704
ENSG00000099974	2.8766175	-6.1501444	5.219563	10.765321	0.0038048	0.2615023	ENSG00000099974	DDTL	D-dopachrome tautomerase like	22	23966888	23972556	protein_coding	HGNC:33446	3.5298584	-13.2877124	5.5181954	6.2483967	4.6163734	-13.2877124	-13.2877124	5.6086336	2.5298709
ENSG00000107249	2.0561338	-0.3251892	4.489237	10.771431	0.0038081	0.2615023	ENSG00000107249	GLIS3	GLIS family zinc finger 3	9	3824127	4348392	protein_coding	HGNC:28510	0.2667122	0.4984429	3.6439015	2.5142809	4.4558522	-0.2962366	-0.2962366	3.7426891	0.3872247
ENSG00000183214	6.9485427	8.5088741	4.107836	11.758127	0.0038128	0.2615023	ENSG00000183214	MICA	MHC class I polypeptide-related sequence A	HSCHR6_MHC_QBL_CTG1	2655411	2671966	protein_coding	HGNC:7090	-13.2877124	-13.2877124	2.8813992	0.7262994	4.2268709	4.6330651	4.6330651	3.2093356	-13.2877124
ENSG00000054938	2.7416416	1.1006649	4.804052	10.735719	0.0038294	0.2615023	ENSG00000054938	CHRDL2	chordin like 2	11	74696429	74731426	protein_coding	HGNC:24168	2.6356200	0.7162420	5.3179336	4.1404935	5.0071367	3.0422591	3.0422591	4.9018260	1.9740370
ENSG00000118971	-0.4172238	-1.5752034	7.871028	10.691370	0.0038572	0.2619771	ENSG00000118971	CCND2	cyclin D2	12	4269771	4305353	protein_coding	HGNC:1583	5.1949374	5.7178991	5.1012572	5.4088252	5.2260173	3.9415644	3.9415646	5.2509267	5.4799855
ENSG00000112306	0.8596966	-1.2625276	6.119184	10.649570	0.0039094	0.2631496	ENSG00000112306	RPS12	ribosomal protein S12	6	132814569	132817564	protein_coding	HGNC:10385	7.3314061	7.8915170	8.6824537	8.2147026	9.0404192	6.4565204	6.4565205	8.6847160	7.6384747
ENSG00000115648	0.0792648	2.4755403	5.162186	10.684633	0.0039164	0.2631496	ENSG00000115648	MLPH	melanophilin	2	237485428	237555322	protein_coding	HGNC:29643	4.6952889	2.7147069	3.1533032	4.2166444	5.3076409	6.1142610	6.1142610	4.4831747	4.0211217
ENSG00000100968	1.6866674	0.8715488	5.220277	10.635248	0.0039468	0.2637863	ENSG00000100968	NFATC4	nuclear factor of activated T cells 4	14	24365673	24379604	protein_coding	HGNC:7778	3.5319558	1.9552548	5.1550661	4.3467940	6.2036864	3.7855999	3.7855999	5.4338899	2.9490631
ENSG00000206452	7.7335511	9.9010843	8.539787	9.717178	0.0040036	0.2651053	ENSG00000206452	HLA-C	major histocompatibility complex, class I, C	HSCHR6_MHC_QBL_CTG1	2524181	2527552	protein_coding	HGNC:4933	-13.2877124	0.8723954	9.2629431	7.0227320	-13.2877124	10.1216506	10.1216506	7.9549605	-0.1275258
ENSG00000104067	1.4623362	0.2004469	5.414445	10.576407	0.0040088	0.2651053	ENSG00000104067	TJP1	tight junction protein 1	15	29699367	29968915	protein_coding	HGNC:11827	1.6293221	3.6180274	2.8273260	3.0725770	3.3776779	3.7563504	3.7563504	3.1101579	2.9422215
ENSG00000151388	0.8775566	-1.4405889	5.189965	10.544210	0.0040476	0.2653668	ENSG00000151388	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12	5	33523535	33892019	protein_coding	HGNC:14605	2.5597458	1.5045085	2.3924034	2.8317107	2.2187071	0.9234520	0.9234520	2.5045571	2.1265299
ENSG00000137857	-1.2989462	-0.5864652	9.718098	10.527463	0.0040549	0.2653668	ENSG00000137857	DUOX1	dual oxidase 1	15	45129933	45165576	protein_coding	HGNC:3062	9.4621522	10.1917269	8.6133701	8.5703176	7.4787340	9.1081647	9.1081648	8.3070163	9.8725748
ENSG00000005108	-1.5088101	-3.1604914	4.176576	10.527432	0.0040969	0.2662855	ENSG00000005108	THSD7A	thrombospondin type 1 domain containing 7A	7	11370365	11832198	protein_coding	HGNC:22207	3.3204343	1.7005596	0.7931792	-0.3779524	0.3712176	-1.7726976	-1.7726976	0.3394647	2.7268225
ENSG00000132854	3.6123104	4.8441321	3.645116	9.410010	0.0041196	0.2662855	ENSG00000132854	KANK4	KN motif and ankyrin repeat domains 4	1	62236165	62319434	protein_coding	HGNC:27263	-0.2788339	-13.2877124	2.2932186	1.6037025	0.1832807	2.4485767	2.4485767	1.5971211	-1.2786588
ENSG00000180822	1.3805305	0.2181207	8.730676	10.465894	0.0041326	0.2662855	ENSG00000180822	PSMG4	proteasome assembly chaperone 4	6	3231403	3303373	protein_coding	HGNC:21108	7.0359214	6.6068191	8.0078697	8.5325174	8.2239886	7.1466350	7.1466349	8.2709788	6.8372659
ENSG00000160221	2.3848789	4.6334624	3.714567	9.743965	0.0041682	0.2672127	ENSG00000160221	GATD3	glutamine amidotransferase class 1 domain containing 3	21	44133610	44210114	protein_coding	HGNC:1273	0.5629101	0.9768512	1.2253786	3.9804858	-0.4195303	5.1450429	5.1450429	2.6531268	0.7846757
ENSG00000140285	1.7129737	0.2369533	4.973785	10.422847	0.0042191	0.2688391	ENSG00000140285	FGF7	fibroblast growth factor 7	15	49423237	49488775	protein_coding	HGNC:3685	3.5201011	3.4737892	5.2052571	4.8783178	5.9423366	4.7004757	4.7004758	5.4127436	3.4971307
ENSG00000126353	2.1906257	2.2498180	5.270044	10.413920	0.0042364	0.2688391	ENSG00000126353	CCR7	C-C motif chemokine receptor 7	17	40551081	40565472	protein_coding	HGNC:1608	2.8183197	2.5613124	4.2484035	5.0962161	5.9482286	4.7194947	4.7194947	5.2599911	2.6955315
ENSG00000176809	-1.6572873	0.7828978	4.311925	10.270710	0.0043229	0.2728550	ENSG00000176809	LRRC37A3	leucine rich repeat containing 37 member A3	17	64854130	64919480	protein_coding	HGNC:32427	4.2912172	3.7372791	4.3040364	4.9821995	-0.6583489	5.6146289	5.6146289	4.1153304	4.0406724
ENSG00000143878	1.7832164	1.0732009	6.451645	10.308747	0.0043431	0.2728550	ENSG00000143878	RHOB	ras homolog family member B	2	20447074	20449440	protein_coding	HGNC:668	3.9305532	3.9419263	5.4940428	5.3837288	6.3991459	5.0721471	5.0721470	5.8347246	3.9362507
ENSG00000083307	-2.1583674	1.9762331	3.346575	8.770729	0.0043701	0.2731877	ENSG00000083307	GRHL2	grainyhead like transcription factor 2	8	101492439	101669726	protein_coding	HGNC:2799	0.8468150	-0.3366226	-13.2877124	-1.3201583	-0.7407601	2.4539892	2.4539892	-1.5863843	0.3731860
ENSG00000203734	-2.5747541	-0.1327286	3.705060	9.501048	0.0044624	0.2740682	ENSG00000203734	ECT2L	epithelial cell transforming 2 like	6	138795911	138904070	protein_coding	HGNC:21118	1.5557318	2.4932817	-1.0574697	-0.4410702	0.1384685	1.9932334	1.9932334	-0.3722077	2.0993627
ENSG00000197496	2.8469714	2.3781959	4.723482	10.199060	0.0044781	0.2740682	ENSG00000197496	SLC2A10	solute carrier family 2 member 10	20	46709649	46736347	protein_coding	HGNC:13444	-0.0890064	0.4759751	2.4349991	2.7619575	3.9789887	2.6703312	2.6703312	3.2203024	0.2209663
ENSG00000136960	1.2169962	0.7578669	6.749241	10.205827	0.0044825	0.2740682	ENSG00000136960	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	8	119557086	119673453	protein_coding	HGNC:3357	4.3891989	4.7336158	5.9947889	5.9025151	5.5211222	5.2675567	5.2675568	5.8202625	4.5716610
ENSG00000160613	1.6673173	-0.7462617	8.688165	10.195528	0.0044952	0.2740682	ENSG00000160613	PCSK7	proprotein convertase subtilisin/kexin type 7	11	117204337	117232525	protein_coding	HGNC:8748	6.0473767	5.2736285	7.0627959	8.0431271	7.4066064	5.4131935	5.4131936	7.5625857	5.7117647
ENSG00000198513	1.4396812	0.5159056	5.349903	10.206679	0.0044970	0.2740682	ENSG00000198513	ATL1	atlastin GTPase 1	14	50532509	50634017	protein_coding	HGNC:11231	2.7185666	3.4994470	4.7867772	4.3483885	4.6111148	3.5194511	3.5194511	4.5932081	3.1612071
ENSG00000135047	1.2681201	0.8085593	6.546767	10.181444	0.0045177	0.2740682	ENSG00000135047	CTSL	cathepsin L	9	87724051	87731469	protein_coding	HGNC:2537	5.3018505	5.2234076	6.7881007	6.8398164	6.4072417	6.0655978	6.0655977	6.6908700	5.2631621
ENSG00000138092	1.3471709	1.2213346	7.655206	10.166436	0.0045369	0.2740682	ENSG00000138092	CENPO	centromere protein O	2	24793136	24822376	protein_coding	HGNC:28152	4.7097178	5.8239262	6.6986204	7.5694419	7.8688801	7.3577655	7.3577655	7.4582666	5.3718146
ENSG00000179409	-1.3026620	-1.3762843	6.112507	10.111835	0.0046248	0.2776625	ENSG00000179409	GEMIN4	gem nuclear organelle associated protein 4	17	744421	753999	protein_coding	HGNC:15717	4.8967176	5.0532191	4.0133209	3.5085566	2.9710491	3.2228988	3.2228988	3.5595114	4.9770894
ENSG00000159216	1.4665141	0.9037273	5.814868	10.100954	0.0046406	0.2776625	ENSG00000159216	RUNX1	RUNX family transcription factor 1	21	34787801	36004667	protein_coding	HGNC:10471	2.7339675	2.2905155	4.5331755	4.5814906	4.1502005	3.5791915	3.5791915	4.4341092	2.5292133
ENSG00000171408	2.0562576	1.9091267	4.921996	10.100643	0.0046786	0.2778876	ENSG00000171408	PDE7B	phosphodiesterase 7B	6	135851701	136195574	protein_coding	HGNC:8792	0.8029319	0.6627041	3.4219380	3.1632606	3.1692623	2.6995778	2.6995778	3.2566180	0.7345210
ENSG00000137573	3.1472175	-0.2527120	6.384342	10.057178	0.0047137	0.2778876	ENSG00000137573	SULF1	sulfatase 1	8	69466624	69660915	protein_coding	HGNC:20391	3.6577484	1.6620838	4.4664312	5.7504273	7.3656474	2.2874342	2.2874342	6.3271074	2.9805447
ENSG00000231608	-4.0188360	4.0029591	3.012370	11.243871	0.0047191	0.2778876	ENSG00000231608	TNXB	tenascin XB	HSCHR6_MHC_DBB_CTG1	3282563	3358976	protein_coding	HGNC:11976	-1.9383537	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.2509222	1.2509222	-13.2877124	-2.9378009
ENSG00000137193	3.3442875	1.2597292	3.276980	9.277402	0.0047328	0.2778876	ENSG00000137193	PIM1	Pim-1 proto-oncogene, serine/threonine kinase	6	37170152	37175428	protein_coding	HGNC:8986	-0.7072489	-1.6270925	2.6814488	3.6385936	3.7440611	0.3158711	0.3158711	3.4270946	-1.0950697
ENSG00000114770	-1.6267142	-0.0728753	4.847474	9.997452	0.0048478	0.2826486	ENSG00000114770	ABCC5	ATP binding cassette subfamily C member 5	3	183919934	184017939	protein_coding	HGNC:56	4.7635115	4.2925325	5.0244227	2.2244312	2.6021122	4.6796762	4.6796760	3.8510444	4.5471567
ENSG00000183570	-3.1948549	0.0515763	3.857212	8.880762	0.0049124	0.2826486	ENSG00000183570	PCBP3	poly(rC) binding protein 3	21	45643694	45942454	protein_coding	HGNC:8651	4.5587173	4.2285388	-13.2877124	2.0988938	-0.3470538	3.6333566	3.6333566	0.7570506	4.4030532
ENSG00000225987	-3.4308859	-0.2500819	3.021062	8.358323	0.0049136	0.2826486	ENSG00000225987	PBX2	PBX homeobox 2	HSCHR6_MHC_APD_CTG1	3517335	3522785	protein_coding	HGNC:8633	4.0185675	3.5367251	0.8096375	-1.1830416	0.2997862	3.6135561	3.6135561	0.1907855	3.7976696
ENSG00000107562	3.3048661	2.5909603	6.972949	9.892572	0.0049620	0.2826486	ENSG00000107562	CXCL12	C-X-C motif chemokine ligand 12	10	44370165	44386493	protein_coding	HGNC:10672	3.9076610	1.3140340	6.5629003	5.5934426	7.7385334	5.7695305	5.7695305	6.8923561	3.1288188
ENSG00000214736	2.5866605	3.2779469	3.633122	9.509092	0.0049788	0.2826486	ENSG00000214736	TOMM6	translocase of outer mitochondrial membrane 6	6	41787662	41789898	protein_coding	HGNC:34528	1.7477539	3.0105407	5.3527056	5.1136446	5.5762948	5.9675146	5.9675146	5.3598683	2.5131137
ENSG00000214278	-3.2046576	-1.2006137	3.198508	8.434265	0.0049998	0.2826486	ENSG00000214278			5	403731	404546	processed_pseudogene		3.6351253	5.3031142	1.8752866	0.8968600	1.4796186	3.4952243	3.4952243	1.4715350	4.6978387
ENSG00000241318	3.4677735	0.9652015	3.952056	9.497271	0.0050216	0.2826486	ENSG00000241318	WDR82P2		1	91534666	91535593	processed_pseudogene	HGNC:33513	2.5144515	-13.2877124	5.5977149	5.0807576	4.9038507	2.6360213	2.6360213	5.2250354	1.5144768
ENSG00000275832	-0.9344770	-8.8420061	5.202183	9.858661	0.0050271	0.2826486	ENSG00000275832	ARHGAP23	Rho GTPase activating protein 23	17	38419280	38512385	protein_coding	HGNC:29293	5.8245703	6.4817681	5.1062449	5.2996707	5.9221295	-13.2877124	-13.2877124	5.4861811	6.1902721
ENSG00000187257	-1.7997330	0.7991375	3.938251	9.588724	0.0050450	0.2826486	ENSG00000187257	RSBN1L	round spermatid basic protein 1 like	7	77696459	77783022	protein_coding	HGNC:24765	0.9550003	1.6782387	0.1477508	-0.6274668	-1.0479468	2.1994358	2.1994358	-0.4222310	1.3614736
ENSG00000011021	-0.2878461	-2.2763106	5.421997	9.801906	0.0051076	0.2826486	ENSG00000011021	CLCN6	chloride voltage-gated channel 6	1	11806096	11848079	protein_coding	HGNC:2024	2.8556122	3.6372032	2.7902664	3.1673045	3.2660817	2.4481369	2.4481369	3.0886810	3.2987020
ENSG00000231345	3.8918545	0.4198586	5.548700	9.773259	0.0051398	0.2826486	ENSG00000231345	BEND3P1		10	50658529	50660472	transcribed_processed_pseudogene	HGNC:45014	1.7173033	-0.6620195	2.8832235	5.9343763	5.0119992	1.5034668	1.5034668	5.0703791	0.9709287
ENSG00000101955	2.6670914	-4.6101222	3.633709	9.620459	0.0051405	0.2826486	ENSG00000101955	SRPX	sushi repeat containing protein X-linked	X	38149336	38220924	protein_coding	HGNC:11309	0.6226661	2.3311554	3.2658179	2.6293631	4.5193881	-13.2877124	-13.2877124	3.6907758	1.7162886
ENSG00000171867	1.1091151	0.3288057	6.865774	9.773822	0.0051427	0.2826486	ENSG00000171867	PRNP	prion protein (Kanno blood group)	20	4686350	4701590	protein_coding	HGNC:9449	5.3843531	4.9543904	5.8381834	6.1372746	6.5504685	6.0968668	6.0968669	6.2050945	5.1853306
ENSG00000007402	-2.0439565	-1.7045102	5.604015	9.788789	0.0051579	0.2826486	ENSG00000007402	CACNA2D2	calcium voltage-gated channel auxiliary subunit alpha2delta 2	3	50362613	50504244	protein_coding	HGNC:1400	4.0253141	4.3721045	2.7074667	1.1331742	2.8477755	2.8130777	2.8130777	2.4081719	4.2091044
ENSG00000070047	-6.9941753	-6.9941753	2.966571	11.766570	0.0051834	0.2826486	ENSG00000070047	PHRF1	PHD and ring finger domains 1	11	576470	612222	protein_coding	HGNC:24351	-1.0311941	2.4750026	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.5966938
ENSG00000189212	-2.5758588	-0.4730786	3.473711	8.921180	0.0051956	0.2826486	ENSG00000189212	DPY19L2P1		7	35081590	35186041	transcribed_unprocessed_pseudogene	HGNC:22305	1.8265900	2.2712180	-0.2333641	-0.7456599	-0.2937886	1.6529008	1.6529008	-0.4068528	2.0659655
ENSG00000214595	-1.6068330	-1.6122165	5.271833	9.761750	0.0052049	0.2826486	ENSG00000214595	EML6	EMAP like 6	2	54723499	54972025	protein_coding	HGNC:35412	2.8276357	4.6663424	3.6660815	2.8884111	2.2829133	2.3580606	2.3580606	3.0568842	4.0220040
ENSG00000137507	3.1294418	0.5661376	7.072341	9.726752	0.0052274	0.2826486	ENSG00000137507	LRRC32	leucine rich repeat containing 32	11	76657524	76670747	protein_coding	HGNC:4161	3.3776110	0.9857547	5.3992240	5.3335751	6.7945988	3.2432531	3.2432531	6.0115244	2.6292235
ENSG00000087116	2.0162243	0.9663607	5.268514	9.733372	0.0052413	0.2826486	ENSG00000087116	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif 2	5	179110853	179345461	protein_coding	HGNC:218	1.9140417	0.6144601	2.9046504	3.4823355	3.6351268	1.9497605	1.9497605	3.3733691	1.4058889
ENSG00000064042	2.0054393	1.7021433	4.722979	9.703957	0.0053142	0.2853535	ENSG00000064042	LIMCH1	LIM and calponin homology domains 1	4	41359607	41700044	protein_coding	HGNC:29191	2.5177121	1.9427997	3.2068585	3.1108805	5.9063097	2.5116080	2.5116080	4.6976316	2.2587061
ENSG00000162496	2.2679677	-0.2355091	4.049226	9.630582	0.0053919	0.2860732	ENSG00000162496	DHRS3	dehydrogenase/reductase 3	1	12567909	12620133	protein_coding	HGNC:17693	1.2122331	1.2924072	2.8250417	3.9055695	4.1849209	1.7719726	1.7719726	3.7463375	1.2528770
ENSG00000010278	-1.5966739	-0.0923921	5.807647	9.637314	0.0054045	0.2860732	ENSG00000010278	CD9	CD9 molecule	12	6199715	6238271	protein_coding	HGNC:1709	5.9185027	6.5923515	5.0018523	5.3295933	3.7230593	6.2484980	6.2484980	4.8322085	6.2944169
ENSG00000166741	2.6424006	1.9572968	6.048413	9.629555	0.0054110	0.2860732	ENSG00000166741	NNMT	nicotinamide N-methyltransferase	11	114257787	114313536	protein_coding	HGNC:7861	4.3591048	2.8854820	6.3734695	6.5979569	7.4489880	5.3943115	5.3943114	6.8847154	3.8027929
ENSG00000090376	4.8593300	4.1530647	3.507042	9.020590	0.0054286	0.2860732	ENSG00000090376	IRAK3	interleukin 1 receptor associated kinase 3	12	66189195	66254622	protein_coding	HGNC:17020	-3.4941416	-13.2877124	0.2109910	1.5767620	2.2115390	0.1112050	0.1112050	1.5479714	-4.4925169
ENSG00000231834	-6.0967958	0.4295205	5.376152	8.137820	0.0054414	0.2860732	ENSG00000231834	HLA-A	major histocompatibility complex, class I, A	HSCHR6_MHC_MANN_CTG1	1195801	1200442	protein_coding	HGNC:4931	-13.2877124	7.5483690	-13.2877124	-13.2877124	1.0954829	6.9690660	6.9690660	-0.4893445	6.5483697
ENSG00000049323	1.4450369	-0.2693686	7.145673	9.495686	0.0056306	0.2911715	ENSG00000049323	LTBP1	latent transforming growth factor beta binding protein 1	2	32946953	33399509	protein_coding	HGNC:6714	4.0465657	4.4618785	5.2183780	5.2803011	5.5320653	3.5108365	3.5108366	5.3500714	4.2691155
ENSG00000008394	1.6830474	-2.1381924	4.420224	9.518573	0.0056477	0.2911715	ENSG00000008394	MGST1	microsomal glutathione S-transferase 1	12	16347142	16609259	protein_coding	HGNC:7061	4.4172208	2.9211621	5.7550334	6.0545769	6.1246528	1.6427358	1.6427358	5.9867799	3.8550032
ENSG00000159403	2.0479293	0.9614136	7.526305	9.464721	0.0056884	0.2911715	ENSG00000159403	C1R	complement C1r	12	7080214	7092540	protein_coding	HGNC:1246	5.6062427	3.7919230	6.8310834	7.2159383	8.0678481	6.5646941	6.5646941	7.4672007	4.9672678
ENSG00000134853	2.0425537	1.5172357	6.741390	9.453922	0.0057120	0.2911715	ENSG00000134853	PDGFRA	platelet derived growth factor receptor alpha	4	54229280	54298245	protein_coding	HGNC:8803	2.8195347	1.7958754	5.3828009	5.2651845	6.1325460	4.0133794	4.0133794	5.6471191	2.3966538
ENSG00000135835	-0.9639906	-0.2739923	8.952255	9.433691	0.0057460	0.2911715	ENSG00000135835	KIAA1614	KIAA1614	1	180912897	180951614	protein_coding	HGNC:29327	6.5969273	6.7144483	5.2193033	6.3706510	5.9843482	6.6246488	6.6246488	5.9331855	6.6568842
ENSG00000125730	1.8369782	0.6747547	8.454262	9.419329	0.0057734	0.2911715	ENSG00000125730	C3	complement C3	19	6677704	6730562	protein_coding	HGNC:1318	6.4468885	6.0564216	6.8090023	7.4962931	7.7407966	6.6314155	6.6314156	7.3996934	6.2648250
ENSG00000236881	-10.0429572	-10.0429572	5.568992	11.286069	0.0057871	0.2911715	ENSG00000236881			HSCHR6_MHC_SSTO_CTG1	1029240	1030230	unprocessed_pseudogene		1.7180889	8.5043045	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	7.5173166
ENSG00000026025	1.1274195	0.3943130	8.821839	9.396190	0.0058177	0.2911715	ENSG00000026025	VIM	vimentin	10	17228241	17237593	protein_coding	HGNC:12692	7.5306969	7.2353373	8.2181658	9.0129395	8.7377944	7.9634218	7.9634221	8.6926940	7.3905628
ENSG00000273873	0.0000000	7.7396701	2.674795	12.931281	0.0058191	0.2911715	ENSG00000273873	BDP1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	HSCHR5_2_CTG1_1	1454100	1566305	protein_coding	HGNC:13652	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	1.2187217	1.2187217	-13.2877124	-13.2877124
ENSG00000189051	-2.5905373	-2.5158061	3.438608	8.752428	0.0058552	0.2911715	ENSG00000189051	RNF222	ring finger protein 222	17	8390702	8397827	protein_coding	HGNC:34517	2.6362940	2.9088517	0.6327624	-1.3363293	0.8282367	0.2672505	0.2672505	0.3111439	2.7789997
ENSG00000274305	-1.2704818	-1.4322470	5.404873	9.381856	0.0058772	0.2911715	ENSG00000274305	LENG8	leukocyte receptor cluster member 8	HSCHR19LRC_PGF1_CTG3_1	353405	366704	protein_coding	HGNC:15500	3.6330207	4.2559114	3.0241257	2.4436016	2.8585060	2.5761329	2.5761329	2.7954571	3.9778252
ENSG00000122877	1.5928260	1.2872950	5.365371	9.375204	0.0058846	0.2911715	ENSG00000122877	EGR2	early growth response 2	10	62811996	62819167	protein_coding	HGNC:3239	2.7898133	3.5734454	4.2532142	4.1708131	4.3453876	3.8970000	3.8970000	4.2582353	3.2341938
ENSG00000150337	-2.5384139	-0.9048985	3.530401	8.724087	0.0059021	0.2911715	ENSG00000150337	FCGR1A	Fc gamma receptor Ia	1	149782671	149791675	protein_coding	HGNC:3613	3.0353887	3.1826905	0.0337352	2.2265427	0.6436872	4.4175403	4.4175403	1.2762161	3.1109188
ENSG00000105372	1.0543832	0.5560870	8.289872	9.350753	0.0059064	0.2911715	ENSG00000105372	RPS19	ribosomal protein S19	19	41860255	41872925	protein_coding	HGNC:10402	9.0479756	9.2990457	10.2605948	10.1399068	10.4972507	9.7519786	9.7519786	10.3069728	9.1789656
ENSG00000166428	-0.8690380	-1.2158256	7.121262	9.350903	0.0059074	0.2911715	ENSG00000166428	PLD4	phospholipase D family member 4	14	104924713	104937761	protein_coding	HGNC:23792	6.0093093	6.0842844	5.1074203	4.9221171	4.8355349	4.8773248	4.8773246	4.9595263	6.0472838
ENSG00000064270	-1.6391371	-0.4563799	4.884922	9.383281	0.0059138	0.2911715	ENSG00000064270	ATP2C2	ATPase secretory pathway Ca2+ transporting 2	16	84368527	84464187	protein_coding	HGNC:29103	4.7444694	5.5783051	2.6926269	3.4967131	3.9636836	4.4532550	4.4532548	3.4748734	5.2208086
ENSG00000109790	1.6920350	-0.2936910	4.398770	9.371263	0.0059323	0.2911715	ENSG00000109790	KLHL5	kelch like family member 5	4	39045039	39126857	protein_coding	HGNC:6356	2.1788851	2.0528356	3.4226439	3.1468616	4.5369231	1.5459639	1.5459639	3.8343849	2.1172366
ENSG00000243742	-1.4050330	0.4053536	5.384324	9.312679	0.0060353	0.2949198	ENSG00000243742	RPLP0P2		11	61636680	61637640	transcribed_processed_pseudogene	HGNC:17960	6.2776059	5.6782799	4.5257445	5.2387442	4.4351461	6.7502591	6.7502591	4.7800733	6.0088432
ENSG00000168542	2.5378410	1.5437305	12.821132	9.275814	0.0060557	0.2949198	ENSG00000168542	COL3A1	collagen type III alpha 1 chain	2	188974373	189012746	protein_coding	HGNC:2201	9.1601471	7.1359891	10.9735484	10.9789479	11.5904598	10.1716370	10.1716371	11.2112501	8.4772758
ENSG00000206376	6.4116319	8.6549656	3.938155	9.978848	0.0062123	0.3013792	ENSG00000206376	EHMT2	euchromatic histone lysine methyltransferase 2	HSCHR6_MHC_QBL_CTG1	3135732	3153671	protein_coding	HGNC:14129	-13.2877124	-13.2877124	0.0941077	2.7639803	-13.2877124	3.6820648	3.6820648	1.3896004	-13.2877124
ENSG00000183054	1.9218175	-0.2896590	4.463314	9.199945	0.0062762	0.3018090	ENSG00000183054	RGPD6	RANBP2 like and GRIP domain containing 6	2	110513802	110610840	protein_coding	HGNC:32419	4.1325601	4.0514663	4.8745600	3.2129143	3.7344957	2.1814292	2.1814292	4.1131983	4.0925829
ENSG00000105640	1.0210544	-0.0807569	6.860648	9.164324	0.0062885	0.3018090	ENSG00000105640	RPL18A	ribosomal protein L18a	19	17859910	17864153	protein_coding	HGNC:10311	7.2756582	7.9604583	8.8004211	8.7155494	9.2386992	7.5655814	7.5655812	8.9369862	7.6583143
ENSG00000089157	1.2616479	0.5131805	8.617190	9.161382	0.0062932	0.3018090	ENSG00000089157	RPLP0	ribosomal protein lateral stalk subunit P0	12	120196699	120201235	protein_coding	HGNC:10371	8.0525124	7.8014259	9.0468062	9.1607665	9.6946134	8.5184230	8.5184230	9.3293369	7.9324244
ENSG00000038427	2.8411118	1.4412898	8.698859	9.083243	0.0064621	0.3087332	ENSG00000038427	VCAN	versican	5	83471618	83582303	protein_coding	HGNC:2464	4.7095984	2.4604047	6.5941875	6.7369823	7.0556049	6.0771500	6.0771500	6.8087001	3.9850131
ENSG00000204967	-0.3337650	1.6168295	4.910004	9.093268	0.0065151	0.3100827	ENSG00000204967	PCDHA4	protocadherin alpha 4	5	140807037	141012347	protein_coding	HGNC:8670	2.1498495	2.3376843	1.9172457	0.4329680	3.0005606	4.1570367	4.1570364	2.1298468	2.2468215
ENSG00000112210	1.4214326	0.7247883	7.501275	9.047754	0.0065409	0.3101359	ENSG00000112210	RAB23	RAB23, member RAS oncogene family	6	57186992	57222307	protein_coding	HGNC:14263	4.4819156	3.7302072	5.4842747	5.7732801	5.8651029	4.9710144	4.9710142	5.7164798	4.1544763
ENSG00000153071	1.6245573	0.7776533	6.322927	9.029384	0.0065869	0.3106885	ENSG00000153071	DAB2	DAB adaptor protein 2	5	39371675	39462300	protein_coding	HGNC:2662	4.9533564	2.5544184	5.1588672	4.9677232	4.5344704	5.3642087	5.3642086	4.9099607	4.2038378
ENSG00000068305	-1.0850677	-1.5231686	5.667997	9.001657	0.0066637	0.3106885	ENSG00000068305	MEF2A	myocyte enhancer factor 2A	15	99565417	99716488	protein_coding	HGNC:6993	4.9617242	3.9741766	3.9363521	2.6483532	4.0770967	3.3789359	3.3789360	3.6802219	4.5508496
ENSG00000240661	1.3130801	-1.2649210	5.605540	8.996306	0.0066675	0.3106885	ENSG00000240661	BTNL12P		3	120357754	120367874	transcribed_unitary_pseudogene	HGNC:52935	5.5343702	3.9763997	6.3885041	6.6940881	6.0826224	4.0417551	4.0417546	6.4099206	4.9562031
ENSG00000126709	-2.2107786	-2.7680819	6.847280	8.991995	0.0066744	0.3106885	ENSG00000126709	IFI6	interferon alpha inducible protein 6	1	27666064	27672212	protein_coding	HGNC:4054	6.6129959	9.5964569	6.9512028	6.4606735	6.2408461	5.9654819	5.9654819	6.5821878	8.7682289
ENSG00000231852	1.8247205	4.1374550	3.711932	8.656910	0.0066762	0.3106885	ENSG00000231852	CYP21A2	cytochrome P450 family 21 subfamily A member 2	6	32038327	32041644	protein_coding	HGNC:2600	1.1824438	-13.2877124	1.4577246	2.8665694	1.9769061	4.5091127	4.5091127	2.2199705	0.1825080
ENSG00000274779	-1.4350193	0.6046036	6.051681	8.973732	0.0067351	0.3122761	ENSG00000274779	NOMO1	NODAL modulator 1	HSCHR16_1_CTG1	890754	953160	protein_coding	HGNC:30060	4.4458145	6.3260953	5.7780008	5.6316141	5.5691843	6.5913941	6.5913941	5.6622767	5.6727752
ENSG00000269343	-2.1530323	-0.3922967	4.443605	8.919230	0.0067709	0.3127823	ENSG00000269343	ZNF587B	zinc finger protein 587B	19	57819721	57846238	protein_coding	HGNC:37142	2.4230115	4.0686460	1.9536843	1.5208004	0.9989363	3.0387175	3.0387175	1.5429434	3.4687531
ENSG00000069424	-1.7575585	-1.4702178	4.327557	8.947184	0.0068098	0.3134271	ENSG00000069424	KCNAB2	potassium voltage-gated channel subfamily A regulatory beta subunit 2	1	5990927	6101193	protein_coding	HGNC:6229	3.8031706	3.5343986	1.8199620	4.2473973	2.1227608	3.3472949	3.3472949	3.1634453	3.6750345
ENSG00000267645	-6.4098180	0.8783934	3.182076	10.621695	0.0068981	0.3142581	ENSG00000267645		POLR2J2-UPK3BL1 readthrough	7	102637049	102671641	protein_coding		3.7711223	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.7999683	3.7999683	-13.2877124	2.7711330
ENSG00000152661	1.4525217	0.6511305	6.264219	8.891837	0.0069042	0.3142581	ENSG00000152661	GJA1	gap junction protein alpha 1	6	121435595	121449727	protein_coding	HGNC:4274	3.6370637	3.5885662	4.7743594	5.0406278	5.6048357	4.3278449	4.3278447	5.1825151	3.6130188
ENSG00000115271	-2.3842192	-2.1730207	3.799471	8.642279	0.0069191	0.3142581	ENSG00000115271	GCA	grancalcin	2	162318840	162371595	protein_coding	HGNC:15990	2.9821275	5.4576733	3.4383433	2.5433533	1.1365806	3.8003805	3.8003805	2.6529373	4.6962140
ENSG00000187955	2.9438775	1.6645057	7.947268	8.880325	0.0069279	0.3142581	ENSG00000187955	COL14A1	collagen type XIV alpha 1 chain	8	120059780	120373573	protein_coding	HGNC:2191	3.6205839	0.7084248	5.4391153	6.4113648	6.0628345	4.5820899	4.5820899	6.0249558	2.8005374
ENSG00000206505	-4.6865491	-6.7568771	7.742670	8.886620	0.0069580	0.3144858	ENSG00000206505	HLA-A	major histocompatibility complex, class I, A	HSCHR6_MHC_QBL_CTG1	1196218	1264879	protein_coding	HGNC:4931	2.0688654	9.8636792	-2.4096691	1.4288386	4.4985148	-0.0382019	-0.0382019	3.0865932	8.8701614
ENSG00000127124	0.2310142	-2.6928390	4.853986	8.867762	0.0069870	0.3146658	ENSG00000127124	HIVEP3	HIVEP zinc finger 3	1	41506365	42035925	protein_coding	HGNC:13561	1.6944599	2.4480327	0.9143403	1.5388565	1.7437515	-0.1096342	-0.1096342	1.4399592	2.1198993
ENSG00000233948	3.4909216	7.4419138	2.620577	7.859173	0.0070382	0.3150361	ENSG00000233948	TRIM27	tripartite motif containing 27	HSCHR6_MHC_MCF_CTG1	168757	189744	protein_coding	HGNC:9975	-13.2877124	-13.2877124	-13.2877124	-0.4926204	-13.2877124	4.6350946	4.6350946	-2.0771768	-13.2877124
ENSG00000145113	3.1354496	5.6144008	2.804079	8.244339	0.0070837	0.3150361	ENSG00000145113	MUC4	mucin 4, cell surface associated	3	195746765	195811973	protein_coding	HGNC:7514	-1.4992918	-13.2877124	0.4786188	1.3087808	0.6727919	2.4232062	2.4232062	0.8652286	-2.4988840
ENSG00000176788	0.8442757	-0.8542313	7.211782	8.801667	0.0071174	0.3150361	ENSG00000176788	BASP1	brain abundant membrane attached signal protein 1	5	17065598	17276843	protein_coding	HGNC:957	6.0517650	6.1244867	6.6644343	6.7642978	7.4919873	5.2884494	5.2884494	7.0229599	6.0885841
ENSG00000162068	-3.7619565	-1.1150322	2.908693	7.631549	0.0071223	0.3150361	ENSG00000162068	NTN3	netrin 3	16	2471297	2474145	protein_coding	HGNC:8030	2.2577626	2.9660995	-0.8100477	-0.7805322	-13.2877124	1.5593592	1.5593592	-1.3800518	2.6549737
ENSG00000157227	1.4976029	1.1306270	9.008907	8.793395	0.0071370	0.3150361	ENSG00000157227	MMP14	matrix metallopeptidase 14	14	22836560	22849041	protein_coding	HGNC:7160	8.0086166	7.5620529	8.8410617	9.5892213	9.7481994	9.0448361	9.0448362	9.4435408	7.8025448
ENSG00000011465	2.3917382	1.9241638	9.049624	8.783495	0.0071617	0.3150361	ENSG00000011465	DCN	decorin	12	91140484	91183217	protein_coding	HGNC:2705	7.2471987	5.1797891	8.7405021	8.8721524	9.4110514	8.6884179	8.6884179	9.0380751	6.5558945
ENSG00000168497	-4.7928719	2.6965445	2.790227	10.221245	0.0071849	0.3150361	ENSG00000168497	CAVIN2	caveolae associated protein 2	2	191834310	191847088	protein_coding	HGNC:10690	-0.3173997	0.4993229	-13.2877124	-13.2877124	-13.2877124	2.9278320	2.9278320	-13.2877124	0.1479995
ENSG00000198053	1.2029250	-0.6060259	5.159176	8.779691	0.0071958	0.3150361	ENSG00000198053	SIRPA	signal regulatory protein alpha	20	1894167	1940592	protein_coding	HGNC:9662	1.8143367	2.8643583	3.5732702	3.6791247	3.8947781	1.8649710	1.8649710	3.7219950	2.4328389
ENSG00000127241	2.6386687	1.9710233	8.270414	8.754858	0.0072340	0.3156105	ENSG00000127241	MASP1	MBL associated serine protease 1	3	187217282	187291980	protein_coding	HGNC:6901	5.9903845	3.8662873	7.5566542	7.7265656	7.8909737	7.3788332	7.3788332	7.7311765	5.2883324
ENSG00000028277	-0.4536936	-2.8384879	4.632106	8.757658	0.0072808	0.3165492	ENSG00000028277	POU2F2	POU class 2 homeobox 2	19	42086110	42196585	protein_coding	HGNC:9213	2.4169319	3.5445655	4.6460360	1.8400523	1.6469557	-0.7198466	-0.7198466	3.4037110	3.0882256
ENSG00000145734	-0.5959134	-7.5172364	4.125774	8.759797	0.0073103	0.3167356	ENSG00000145734	BDP1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	5	71455651	71567820	protein_coding	HGNC:13652	1.8917547	2.1823993	0.7751719	0.1641684	0.7239875	-13.2877124	-13.2877124	0.5797131	2.0443840
ENSG00000090054	1.7696176	0.9256671	5.011911	8.703867	0.0074114	0.3178411	ENSG00000090054	SPTLC1	serine palmitoyltransferase long chain base subunit 1	9	92000087	92115413	protein_coding	HGNC:11277	2.7302737	3.9640928	5.1391956	4.3994215	4.6489444	3.7729060	3.7729055	4.7625843	3.4752470
ENSG00000105379	2.3316142	1.4359784	4.117241	8.644349	0.0074956	0.3178411	ENSG00000105379	ETFB	electron transfer flavoprotein subunit beta	19	51345169	51366388	protein_coding	HGNC:3482	0.5815479	1.6996431	5.5321106	4.2384646	5.3877518	4.6732668	4.6732670	5.1567263	1.2463047
ENSG00000143341	1.7597773	0.9560991	6.553141	8.654642	0.0074957	0.3178411	ENSG00000143341	HMCN1	hemicentin 1	1	185734391	186190949	protein_coding	HGNC:19194	1.3239482	0.3793348	3.0275469	3.4951952	2.9888117	3.0499149	3.0499149	3.1894825	0.9276105
ENSG00000155463	1.1497424	1.6644536	5.260553	8.650169	0.0075376	0.3178411	ENSG00000155463	OXA1L	OXA1L mitochondrial inner membrane protein	14	22766522	22773042	protein_coding	HGNC:8526	3.3869610	3.7032128	4.8673630	4.6431075	5.3151750	5.2177917	5.2177918	4.9694641	3.5537353
ENSG00000183840	-1.7146648	-2.7429832	5.760923	8.644740	0.0075463	0.3178411	ENSG00000183840	GPR39	G protein-coupled receptor 39	2	132416805	132646582	protein_coding	HGNC:4496	4.8841966	6.3153986	2.7519189	4.6990095	4.2361668	3.0220789	3.0220789	4.1031089	5.7704396
ENSG00000164692	2.5120841	1.3544465	12.339077	8.631842	0.0075505	0.3178411	ENSG00000164692	COL1A2	collagen type I alpha 2 chain	7	94394895	94431227	protein_coding	HGNC:2198	9.0557982	7.1719427	10.4058781	10.8336342	11.2958216	9.6853324	9.6853324	10.8907014	8.4017154
ENSG00000070495	0.9478971	-1.5484153	4.787353	8.644911	0.0075548	0.3178411	ENSG00000070495	JMJD6	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	17	76712832	76726799	protein_coding	HGNC:19355	3.2507054	3.1844565	4.0948029	3.5037699	3.5808431	1.7227965	1.7227965	3.7511711	3.2179612
ENSG00000136235	1.8209778	1.1722562	7.159510	8.626946	0.0075658	0.3178411	ENSG00000136235	GPNMB	glycoprotein nmb	7	23235967	23275108	protein_coding	HGNC:4462	5.0291233	3.9570420	6.0489696	6.7623986	6.2424117	5.8024183	5.8024184	6.3836086	4.5904565
ENSG00000103196	2.5196750	1.4107902	6.051489	8.630481	0.0075777	0.3178411	ENSG00000103196	CRISPLD2	cysteine rich secretory protein LCCL domain containing 2	16	84819985	84920768	protein_coding	HGNC:25248	3.1456453	2.8679431	3.7294147	5.4701741	5.0010722	3.3612619	3.3612616	4.9007277	3.0134658
ENSG00000231925	5.2799945	6.2131618	6.078774	8.270593	0.0075887	0.3178411	ENSG00000231925	TAPBP	TAP binding protein	6	33299694	33314284	protein_coding	HGNC:11566	1.0637735	-13.2877124	5.9444599	0.9459373	4.5972238	5.4238913	5.4238913	4.8697772	0.0638425
ENSG00000155760	2.3354955	0.3965506	4.750898	8.602519	0.0076906	0.3190376	ENSG00000155760	FZD7	frizzled class receptor 7	2	202033855	202038441	protein_coding	HGNC:4045	1.4305460	0.3947852	2.7020398	3.1928177	4.2199304	1.4896940	1.4896940	3.5145854	1.0036864
ENSG00000184232	3.9540534	2.9413573	4.222890	8.141627	0.0077744	0.3190376	ENSG00000184232	OAF	out at first homolog	11	120211032	120230334	protein_coding	HGNC:28752	0.5822419	-13.2877124	2.7797493	4.2563222	5.3627546	3.6963860	3.6963860	4.4838443	-0.4176617
ENSG00000120885	-0.0757908	2.6162443	9.314702	8.544943	0.0077853	0.3190376	ENSG00000120885	CLU	clusterin	8	27596917	27614700	protein_coding	HGNC:2095	8.7217550	8.3809251	9.7077418	8.4009937	5.2899658	11.6660223	11.6660223	8.6598439	8.5613815
ENSG00000121440	1.1676343	-0.3027284	6.068769	8.537602	0.0078117	0.3190376	ENSG00000121440	PDZRN3	PDZ domain containing ring finger 3	3	73382431	73624941	protein_coding	HGNC:17704	3.8284742	3.2499892	4.4358884	5.2008153	4.8843534	3.4740414	3.4740414	4.8737807	3.5680345
ENSG00000184047	1.3237223	-2.5197452	4.079643	8.566909	0.0078219	0.3190376	ENSG00000184047	DIABLO	diablo IAP-binding mitochondrial protein	12	122207668	122226062	protein_coding	HGNC:21528	2.1106779	1.5023403	4.3350617	3.7725823	3.6011257	-0.9814969	-0.9814969	3.9381195	1.8383387
ENSG00000158714	-1.6702919	-0.2937571	4.834561	8.553140	0.0078484	0.3190376	ENSG00000158714	SLAMF8	SLAM family member 8	1	159826811	159837492	protein_coding	HGNC:21391	3.5250310	3.9527684	2.4536638	2.4708981	1.0644207	3.5035998	3.5035998	2.1279934	3.7546942
ENSG00000282367	3.7434263	3.7266551	3.668321	7.845984	0.0078779	0.3190376	ENSG00000282367	PTDSS2	phosphatidylserine synthase 2	HSCHR11_1_CTG8	3536	21040	protein_coding	HGNC:15463	-13.2877124	0.7052959	3.2182545	2.7034139	5.2992502	3.8174993	3.8174993	4.2015337	-0.2946157
ENSG00000120868	-0.0065341	-2.7535680	6.755042	8.508427	0.0078881	0.3190376	ENSG00000120868	APAF1	apoptotic peptidase activating factor 1	12	98645149	98735433	protein_coding	HGNC:576	4.7080411	5.9260650	4.8815621	5.1718719	6.4897166	1.9005059	1.9005059	5.6948184	5.4419501
ENSG00000137801	1.2490877	-1.7281518	10.692451	8.505790	0.0078935	0.3190376	ENSG00000137801	THBS1	thrombospondin 1	15	39581079	39599466	protein_coding	HGNC:11785	7.7937426	5.9782940	8.5761599	8.6797334	8.5179261	6.0191308	6.0191308	8.5928325	7.1545180
ENSG00000097007	1.2115588	0.6893666	7.163707	8.503001	0.0079029	0.3190376	ENSG00000097007	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase	9	130713043	130887675	protein_coding	HGNC:76	5.0732506	3.7919137	4.9223429	5.0300211	5.8506567	4.5942027	4.5942028	5.3303458	4.5703919
ENSG00000234507	5.9480928	9.2793374	4.257380	9.096056	0.0079605	0.3190376	ENSG00000234507	BRD2	bromodomain containing 2	HSCHR6_MHC_COX_CTG1	4380869	4393720	protein_coding	HGNC:1103	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.1298905	5.2354273	5.2354273	1.5449611	-13.2877124
ENSG00000153132	1.3171710	-1.3153845	4.300604	8.498753	0.0079967	0.3190376	ENSG00000153132	CLGN	calmegin	4	140388453	140427661	protein_coding	HGNC:2060	1.2795420	2.5293710	3.5752442	3.2838981	3.4487628	0.7178315	0.7178315	3.4408738	2.0357678
ENSG00000112531	1.2990685	0.6102112	5.650951	8.468893	0.0080130	0.3190376	ENSG00000112531	QKI	QKI, KH domain containing RNA binding	6	163414000	163578592	protein_coding	HGNC:21100	4.1798207	4.3264283	6.0437524	5.6967415	5.9158122	5.2837215	5.2837214	5.8924697	4.2549863
ENSG00000163814	1.0150892	2.8902595	3.562296	8.367851	0.0080458	0.3190376	ENSG00000163814	CDCP1	CUB domain containing protein 1	3	45082277	45146422	protein_coding	HGNC:24357	1.5812760	0.6957240	0.6187301	0.6506975	-0.3547041	3.0279177	3.0279177	0.3738731	1.2054057
ENSG00000185008	-1.3988802	-1.6499001	4.785187	8.470601	0.0080734	0.3190376	ENSG00000185008	ROBO2	roundabout guidance receptor 2	3	75906695	77649964	protein_coding	HGNC:10250	2.9529329	4.0608567	1.9931439	3.0732384	4.4897613	2.5897654	2.5897654	3.5387469	3.6107341
ENSG00000173258	-2.1850287	-2.6539820	3.600994	8.208037	0.0080741	0.3190376	ENSG00000173258	ZNF483	zinc finger protein 483	9	111525159	111577844	protein_coding	HGNC:23384	2.3448151	3.1355168	0.2515325	1.0406049	0.1742300	0.3007868	0.3007868	0.5446249	2.7936714
ENSG00000175920	-1.4428158	-0.5217291	5.066629	8.461356	0.0080932	0.3190376	ENSG00000175920	DOK7	docking protein 7	4	3463306	3501473	protein_coding	HGNC:26594	4.4193989	5.2302877	3.3374325	3.8949588	3.0868040	5.2527051	5.2527052	3.4802923	4.8810802
ENSG00000196411	1.8001597	1.5432105	5.073963	8.453672	0.0080951	0.3190376	ENSG00000196411	EPHB4	EPH receptor B4	7	100802565	100827523	protein_coding	HGNC:3395	3.3608550	3.0747984	4.3794211	4.7120284	3.9550488	4.6937291	4.6937291	4.3815596	3.2249050
ENSG00000229006	0.0000000	7.6035818	2.581606	11.328969	0.0081085	0.3190376	ENSG00000229006	TRIM27	tripartite motif containing 27	HSCHR6_MHC_SSTO_CTG1	212404	233381	protein_coding	HGNC:9975	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.1245088	3.1245088	-13.2877124	-13.2877124
ENSG00000072657	0.2271392	1.5628873	6.673650	8.426065	0.0081251	0.3190376	ENSG00000072657	TRHDE	thyrotropin releasing hormone degrading enzyme	12	72087266	72670758	protein_coding	HGNC:30748	2.8135553	2.3295628	3.1832774	3.1401736	2.3897989	4.2357068	4.2357068	2.9474060	2.5917605
ENSG00000214562	-0.9008437	0.8575698	5.355617	8.426646	0.0081744	0.3191768	ENSG00000214562	NUTM2D	NUT family member 2D	10	87357720	87370695	protein_coding	HGNC:23447	5.1836880	4.6169141	3.6438047	3.6239690	4.2796883	5.6041278	5.6041280	3.8826871	4.9279566
ENSG00000137727	3.0254943	1.2968623	3.621382	8.138688	0.0081814	0.3191768	ENSG00000137727	ARHGAP20	Rho GTPase activating protein 20	11	110577042	110713189	protein_coding	HGNC:18357	-1.9150486	-1.3283081	3.0896241	0.5020240	1.9368663	-0.1563071	-0.1563071	2.1972021	-1.5920534
ENSG00000232653	-2.2653301	-0.6718703	4.108386	8.274100	0.0082049	0.3191768	ENSG00000232653	GOLGA8N	golgin A8 family member N	15	32593456	32607310	protein_coding	HGNC:44405	4.1079493	3.3303064	1.3561528	1.8656603	3.1601407	3.0269164	3.0269164	2.3356673	3.7709012
ENSG00000276657	6.8220327	6.7777340	3.462158	9.053968	0.0082516	0.3198113	ENSG00000276657	PYCR3	pyrroline-5-carboxylate reductase 3	HSCHR8_3_CTG7	93953	99813	protein_coding	HGNC:25846	-13.2877124	-13.2877124	3.3815370	1.0967200	2.9584932	2.6462200	2.6462200	2.7608332	-13.2877124
ENSG00000204950	-1.6582192	-0.0652654	5.477647	8.395776	0.0082721	0.3198113	ENSG00000204950	LRRC10B	leucine rich repeat containing 10B	11	61508749	61511018	protein_coding	HGNC:37215	5.2201983	4.3289092	3.7214358	3.3888889	2.5766605	4.8730183	4.8730183	3.3040839	4.8423154
ENSG00000274334	9.2216031	0.0000000	5.279139	8.975021	0.0083594	0.3219020	ENSG00000274334	VASN	vasorin	HSCHR16_3_CTG1	74171	85851	protein_coding	HGNC:18517	-13.2877124	-13.2877124	-13.2877124	5.0947682	5.7235556	-13.2877124	-13.2877124	4.8581899	-13.2877124
ENSG00000102109	-1.2147808	-1.4493868	6.169402	8.338541	0.0083904	0.3219020	ENSG00000102109	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	X	48831096	48835610	protein_coding	HGNC:17301	7.1618302	7.0396252	6.5641057	5.6670823	5.5857720	5.7198901	5.7198901	6.0109329	7.1020212
ENSG00000129167	-1.8569796	-7.2735530	3.516488	8.185533	0.0084030	0.3219020	ENSG00000129167	TPH1	tryptophan hydroxylase 1	11	18017555	18046269	protein_coding	HGNC:12008	3.0864732	1.0149358	0.6208716	-0.7621793	-0.1827484	-13.2877124	-13.2877124	0.0040497	2.3943747
ENSG00000146674	2.0598383	1.4042692	9.000774	8.302295	0.0084884	0.3220955	ENSG00000146674	IGFBP3	insulin like growth factor binding protein 3	7	45912245	45921874	protein_coding	HGNC:5472	6.7138242	5.3119325	7.7151404	8.8608191	8.4699451	7.7203526	7.7203526	8.4229317	6.1768529
ENSG00000175497	-2.4955429	-0.0362775	4.352532	8.160525	0.0084969	0.3220955	ENSG00000175497	DPP10	dipeptidyl peptidase like 10	2	114442299	115845780	protein_coding	HGNC:20823	4.1465260	2.3058045	1.2339580	0.2646289	1.5814158	3.9887087	3.9887087	1.1256676	3.5017478
ENSG00000156113	-1.7094327	-2.0008258	4.999288	8.313311	0.0085351	0.3220955	ENSG00000156113	KCNMA1	potassium calcium-activated channel subfamily M alpha 1	10	76869601	77638369	protein_coding	HGNC:6284	2.9899345	4.5051795	3.1285052	2.4459176	1.9748417	2.5054512	2.5054512	2.5949352	3.9379647
ENSG00000132386	1.3343565	1.9861405	8.109443	8.277704	0.0085644	0.3220955	ENSG00000132386	SERPINF1	serpin family F member 1	17	1762029	1777565	protein_coding	HGNC:8824	8.0459464	7.1931549	8.9585823	8.7498725	8.7672408	9.2687472	9.2687471	8.8283758	7.6816657
ENSG00000115738	1.0679820	-0.5596402	5.547913	8.281619	0.0085661	0.3220955	ENSG00000115738	ID2	inhibitor of DNA binding 2	2	8678845	8684461	protein_coding	HGNC:5361	5.2774461	5.9939216	6.7307626	5.4948930	7.4567360	4.9934876	4.9934873	6.7680758	5.6797115
ENSG00000148082	1.8236804	0.5809730	5.213023	8.287534	0.0085743	0.3220955	ENSG00000148082	SHC3	SHC adaptor protein 3	9	89005771	89178818	protein_coding	HGNC:18181	0.9012040	-0.1449575	2.8092142	2.5404412	1.7718716	1.1454010	1.1454010	2.4366650	0.4709429
ENSG00000161558	-3.5954725	-6.4096991	2.650444	7.208860	0.0085875	0.3220955	ENSG00000161558	TMEM143	transmembrane protein 143	19	48332356	48364059	protein_coding	HGNC:25603	3.5891461	3.9796707	-13.2877124	1.9384653	2.3693118	-13.2877124	-13.2877124	1.5849663	3.7975823
ENSG00000112773	-1.1850244	-0.1724907	6.495634	8.264664	0.0086136	0.3221119	ENSG00000112773	TENT5A	terminal nucleotidyltransferase 5A	6	81491439	81752774	protein_coding	HGNC:18345	4.4274467	4.5708165	3.7461020	3.2813282	2.8165528	4.3009655	4.3009657	3.3308122	4.5009117
ENSG00000187498	1.3903107	2.0673741	8.220106	8.239059	0.0086845	0.3228828	ENSG00000187498	COL4A1	collagen type IV alpha 1 chain	13	110148963	110307202	protein_coding	HGNC:2202	4.6516425	3.7481263	5.7809915	6.0945119	5.3467788	6.3278673	6.3278673	5.7727126	4.2694888
ENSG00000178568	-6.8014600	-6.8014600	2.828783	9.739971	0.0086856	0.3228828	ENSG00000178568	ERBB4	erb-b2 receptor tyrosine kinase 4	2	211375717	212538841	protein_coding	HGNC:3432	-0.3673428	1.0881552	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	0.5366637
ENSG00000074276	-0.8978472	-1.3497908	6.124753	8.225750	0.0087360	0.3237999	ENSG00000074276	CDHR2	cadherin related family member 2	5	176542511	176595974	protein_coding	HGNC:18231	6.7140662	7.1555155	6.7000648	6.6265694	6.3077437	6.0870694	6.0870694	6.5545847	6.9516102
ENSG00000008513	0.7890515	-1.0454159	6.068149	8.209422	0.0087835	0.3239888	ENSG00000008513	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	8	133454848	133571926	protein_coding	HGNC:10862	3.2564958	2.6352664	3.6090382	4.9639046	3.7113458	1.8446383	1.8446383	4.2354691	2.9790637
ENSG00000100077	-2.6285201	-4.1567636	3.499673	7.776197	0.0087927	0.3239888	ENSG00000100077	GRK3	G protein-coupled receptor kinase 3	22	25564675	25729294	protein_coding	HGNC:290	0.4006538	1.6091748	-1.6294518	-0.5973258	-13.2877124	-1.3667269	-1.3667269	-1.6078088	1.1279234
ENSG00000106624	1.8591048	0.9989620	6.608480	8.195312	0.0088284	0.3243547	ENSG00000106624	AEBP1	AE binding protein 1	7	44104345	44114562	protein_coding	HGNC:303	3.9146648	4.0825068	5.1704669	4.9004437	6.6771004	4.2447228	4.2447227	5.8091644	4.0010249
ENSG00000070214	1.7168984	1.4999214	5.671570	8.171495	0.0089243	0.3255904	ENSG00000070214	SLC44A1	solute carrier family 44 member 1	9	105244622	105439171	protein_coding	HGNC:18798	2.0895076	3.2220029	2.7539149	3.0629423	5.2632637	3.2081898	3.2081898	4.1567285	2.7641383
ENSG00000228960	3.2999762	1.6719793	5.930101	8.162357	0.0089823	0.3255904	ENSG00000228960	OR2A9P		7	144299373	144300305	transcribed_unprocessed_pseudogene	HGNC:8236	3.8781614	-13.2877124	6.8994339	6.6081954	5.6560169	4.5093999	4.5093999	6.4776940	2.8781711
ENSG00000142871	2.3617214	-0.0521812	7.536972	8.141172	0.0090001	0.3255904	ENSG00000142871	CCN1	cellular communication network factor 1	1	85580761	85584589	protein_coding	HGNC:2654	5.5012952	2.4580699	7.3050217	7.5212970	7.0220443	4.7641323	4.7641322	7.2971246	4.6664805
ENSG00000213694	1.4819396	0.0000072	5.602657	8.144309	0.0090057	0.3255904	ENSG00000213694	S1PR3	sphingosine-1-phosphate receptor 3	9	88990863	89005155	protein_coding	HGNC:3167	2.5161675	2.6601437	4.2807533	3.2598079	4.0926772	1.9260457	1.9260457	3.9410241	2.5899509
ENSG00000155252	1.0912842	0.6666540	6.500187	8.139407	0.0090080	0.3255904	ENSG00000155252	PI4K2A	phosphatidylinositol 4-kinase type 2 alpha	10	97640671	97676434	protein_coding	HGNC:30031	3.5570715	3.6824840	4.7310000	4.7624931	4.9581953	4.3442031	4.3442029	4.8207814	3.6211399
ENSG00000148841	1.1129203	-0.9624185	6.085731	8.137156	0.0090175	0.3255904	ENSG00000148841	ITPRIP	inositol 1,4,5-trisphosphate receptor interacting protein	10	104309698	104338465	protein_coding	HGNC:29370	3.1460708	2.7207292	3.9293271	3.9093185	5.0745749	2.2109137	2.2109137	4.4140901	2.9490186
ENSG00000232632	-3.1224349	-8.3985884	4.290040	7.919610	0.0090922	0.3271474	ENSG00000232632	GABBR1	gamma-aminobutyric acid type B receptor subunit 1	HSCHR6_MHC_COX_CTG1	1042093	1119641	protein_coding	HGNC:4070	3.1430479	3.5259625	-13.2877124	-13.2877124	2.1808296	-13.2877124	-13.2877124	0.5959304	3.3471720
ENSG00000171298	-0.7170919	0.5377297	7.820378	8.099094	0.0091383	0.3271474	ENSG00000171298	GAA	alpha glucosidase	17	80101533	80119881	protein_coding	HGNC:4065	6.6549946	6.6072208	6.5432613	6.2373712	5.7740603	7.2845047	7.2845047	6.2187372	6.6313054
ENSG00000142197	-0.8539536	-1.4974633	5.727260	8.104171	0.0091388	0.3271474	ENSG00000142197	DOP1B	DOP1 leucine zipper like protein B	21	36156782	36294274	protein_coding	HGNC:1291	3.4026345	4.5444722	2.5357623	4.1995926	2.2629692	1.7623271	1.7623271	3.2716547	4.0836875
ENSG00000110900	-1.0575616	0.4237915	6.768321	8.091716	0.0091690	0.3272972	ENSG00000110900	TSPAN11	tetraspanin 11	12	30926428	30996602	protein_coding	HGNC:30795	4.0936006	5.3567977	4.0479572	4.5957492	3.3300498	5.3669852	5.3669852	4.0811513	4.8592500
ENSG00000104936	-0.9765887	-0.1895446	7.195304	8.060884	0.0092687	0.3299200	ENSG00000104936	DMPK	DM1 protein kinase	19	45769709	45782552	protein_coding	HGNC:2933	6.1931104	6.4788247	5.7517284	5.3115344	5.3189654	6.1650997	6.1650997	5.4758706	6.3430290
ENSG00000148143	0.7269259	-0.5883770	6.355541	8.029504	0.0093772	0.3321646	ENSG00000148143	ZNF462	zinc finger protein 462	9	106863166	107013634	protein_coding	HGNC:21684	4.1168643	2.7774671	3.4617204	3.6264283	3.4048557	3.0009048	3.0009048	3.5007606	3.5973215
ENSG00000242511	-6.7704463	-6.7704463	2.807107	9.454260	0.0093993	0.3321646	ENSG00000242511	RPL23AP1		HSCHR6_MHC_SSTO_CTG1	1032898	1033368	transcribed_processed_pseudogene	HGNC:10318	-13.2877124	7.0585888	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	6.0585899
ENSG00000185624	1.0099956	1.3008021	8.851348	8.017157	0.0094161	0.3321646	ENSG00000185624	P4HB	prolyl 4-hydroxylase subunit beta	17	81843159	81860856	protein_coding	HGNC:8548	7.2975634	6.9117810	8.2136506	8.1177841	8.1898927	8.5283039	8.5283041	8.1743485	7.1175288
ENSG00000273686	-2.1186070	-1.6016561	8.423470	8.005088	0.0094588	0.3321646	ENSG00000273686	B2M	beta-2-microglobulin	HSCHR15_3_CTG8	34826	42225	protein_coding	HGNC:914	9.0142582	11.3939102	9.3099702	8.4917397	8.3565842	9.1161840	9.1161841	8.7840557	10.6474829
ENSG00000078687	-1.7831153	-1.0031677	4.433800	8.020536	0.0094640	0.3321646	ENSG00000078687	TNRC6C	trinucleotide repeat containing adaptor 6C	17	77958703	78108822	protein_coding	HGNC:29318	2.7356002	2.3130900	0.6626576	2.1062599	3.2395817	1.1691939	1.1691939	2.3536934	2.5397574
ENSG00000139352	-0.7771320	0.1265148	10.252700	7.960614	0.0096142	0.3356249	ENSG00000139352	ASCL1	achaete-scute family bHLH transcription factor 1	12	102957674	102960513	protein_coding	HGNC:738	9.2544235	9.2809293	8.6832022	8.5855829	8.5419974	9.4552502	9.4552502	8.6048089	9.2677373
ENSG00000269955	-6.7602478	-6.7602478	2.799974	9.359545	0.0096523	0.3356249	ENSG00000269955	FMC1-LUC7L2	FMC1-LUC7L2 readthrough	7	139341360	139422599	protein_coding	HGNC:44671	-13.2877124	4.2350405	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	-13.2877124	3.2350481
ENSG00000232439	-1.5476975	-0.1185244	4.421783	7.951555	0.0097080	0.3356249	ENSG00000232439	RPL18AP7		3	38526802	38527325	processed_pseudogene	HGNC:35607	6.5845319	6.8820318	5.1945903	5.3543659	5.4273159	6.6855828	6.6855828	5.3286649	6.7409367
ENSG00000170801	2.8616262	2.1326436	4.923599	7.928393	0.0097592	0.3356249	ENSG00000170801	HTRA3	HtrA serine peptidase 3	4	8269754	8307098	protein_coding	HGNC:30406	1.9785563	-0.5262256	3.1752317	4.8742770	4.3874272	3.4946586	3.4946586	4.3047917	1.2126795
ENSG00000072195	-1.3718970	-1.5935148	4.746188	7.943936	0.0097666	0.3356249	ENSG00000072195	SPEG	striated muscle enriched protein kinase	2	219434843	219493629	protein_coding	HGNC:16901	2.1759138	3.7493855	3.7907817	3.9196031	2.5112077	0.7453793	0.7453793	3.5308125	3.1673043
ENSG00000196562	2.2624293	2.4109172	7.798095	7.918125	0.0097687	0.3356249	ENSG00000196562	SULF2	sulfatase 2	20	47656197	47786616	protein_coding	HGNC:20392	4.9355765	3.3663151	5.6392349	7.3069101	6.9941930	7.0507912	7.0507913	6.8059330	4.3545551
ENSG00000130940	-1.6139825	-0.1835508	5.474095	7.929285	0.0097930	0.3356249	ENSG00000130940	CASZ1	castor zinc finger 1	1	10636604	10796650	protein_coding	HGNC:26002	4.1616572	5.3470356	2.5788103	2.5098443	0.8418773	2.9506819	2.9506819	2.1659049	4.8728131
ENSG00000218475	-1.2466235	-0.3458774	5.847177	7.917251	0.0097983	0.3356249	ENSG00000218475	ACTG1P18		6	101430411	101431553	processed_pseudogene	HGNC:51498	5.9501242	6.8159376	5.3892835	5.0132667	5.4310758	6.1288211	6.1288211	5.2897242	6.4470297
ENSG00000213222	1.4327415	0.2999752	6.814995	7.902044	0.0098280	0.3356249	ENSG00000213222	TOMM40P4		2	131723253	131724279	processed_pseudogene	HGNC:54633	6.5417759	5.4559897	7.4973892	7.8067829	7.7645718	6.5050878	6.5050878	7.6959430	6.0987059
ENSG00000169122	1.7285734	0.3191359	5.237063	7.906492	0.0098485	0.3356249	ENSG00000169122	FAM110B	family with sequence similarity 110 member B	8	57994523	58204279	protein_coding	HGNC:28587	2.6109776	2.9508672	4.6142961	4.3541932	4.3683504	2.5962995	2.5962995	4.4506464	2.7909088
ENSG00000128641	1.5962314	0.4494822	5.834767	7.891755	0.0098779	0.3356249	ENSG00000128641	MYO1B	myosin IB	2	191245185	191425389	protein_coding	HGNC:7596	3.2404780	1.7245372	3.7453523	4.4336761	4.1705278	3.1374929	3.1374929	4.1437559	2.6730831
ENSG00000137693	1.9157391	1.3870228	4.683162	7.909298	0.0098831	0.3356249	ENSG00000137693	YAP1	Yes1 associated transcriptional regulator	11	102110447	102233424	protein_coding	HGNC:16262	2.4513454	2.0604943	3.5679193	2.8411264	3.9158419	3.0323691	3.0323691	3.5075081	2.2691158
ENSG00000184545	6.2713213	0.0000000	2.707484	8.441158	0.0099832	0.3381090	ENSG00000184545	DUSP8	dual specificity phosphatase 8	11	1554051	1572271	protein_coding	HGNC:3074	-13.2877124	-13.2877124	1.4001018	0.9260207	0.9960611	-13.2877124	-13.2877124	1.1229549	-13.2877124

outPath = "output/day28/DEG"
Test = "day28.SCN2A.vs.WT"
qlf = glmQLFTest(fit, coef=2)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     1    86   190
## NotSig  12565 12565 12560 12294 12056
## Up          0     0     4   185   319

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("SCN2A", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

SCN2AUp = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
SCN2ADown = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "day28.CHD2.vs.WT"
qlf = glmQLFTest(fit, coef=3)
sig.gene.summary(qlf)

##        q0.005 q0.01 q0.05  q0.2 p0.01
## Down        0     0     0     2    78
## NotSig  12565 12565 12565 12558 12386
## Up          0     0     0     5   101

deg = attach_annotations_by_p(qlf, 0.01)
maxAveTPM = data.frame(maxAveTPM = apply(deg[,c("CHD2", "WT")], 1, max))
deg = cbind(deg, maxAveTPM)
# deg %>%
#   kbl() %>%
#   kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
#   scroll_box(width = "100%", height = "300px")

write.table(deg, file=paste(outPath,ExperimentName,Test,"txt", sep="."), quote=FALSE, row.names=TRUE, col.names=TRUE, sep="\t")

#MvsA plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logCPM, y=logFC)) +
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

#Volcano plot
ggplot(data = as.data.frame(topTags(qlf, n=NULL)) %>% arrange(desc(PValue)), aes(x=logFC, y=-log10(PValue))) + 
  geom_point(aes(color=PValue<0.01)) +
  scale_color_manual(values = xgfs_normal12[c(13,2)]) +
  theme_minimal()

CHD2Up = row.names(deg[deg[,"logFC"] > 0 & deg[,"maxAveTPM"] > log2(0.1),])
CHD2Down = row.names(deg[deg[,"logFC"] < 0 & deg[,"maxAveTPM"] > log2(0.1),])

Test = "day28"
venn.diagram(list(CHD2 = CHD2Up, SCN2A = SCN2AUp), filename = paste(outPath,ExperimentName,Test,"up.png", sep="."), imagetype = "png", main = paste(Test, "up regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

venn.diagram(list(CHD2 = CHD2Down, SCN2A = SCN2ADown), filename = paste(outPath,ExperimentName,Test,"down.png", sep="."), imagetype = "png", main = paste(Test, "down regulated", sep = " "), col = xgfs_normal12[1:2])

## [1] 1

SCN2AUp.d28 = SCN2AUp
SCN2ADown.d28 = SCN2ADown
CHD2Up.d28 = CHD2Up
CHD2Down.d28 = CHD2Down

Venn diagram up regulated

Venn diagram down regulated

Note:

Compare between time points

Take the DEGs from each timepoint and examine the overlaps

outPath = "output/misc/DEG"
Test = "SCN2A"
venn.diagram(list( 
  FB = c(SCN2AUp.FB, SCN2ADown.FB), 
  day_10 = c(SCN2AUp.d10, SCN2ADown.d10), 
  day_22 = c(SCN2AUp.d22, SCN2ADown.d22), 
  day_28 = c(SCN2AUp.d28, SCN2ADown.d28)), 
  filename = paste(outPath,ExperimentName,Test,"png", sep="."), 
  imagetype = "png", main = paste(Test, "DEGs per differentiation stage", sep = " "), 
  col = xgfs_normal12[c(4,6,7,9)])

## [1] 1

Test = "CHD2"
venn.diagram(list( 
  FB = c(CHD2Up.FB, CHD2Down.FB), 
  day_10 = c(CHD2Up.d10, CHD2Down.d10), 
  day_22 = c(CHD2Up.d22, CHD2Down.d22), 
  day_28 = c(CHD2Up.d28, CHD2Down.d28)), 
  filename = paste(outPath,ExperimentName,Test,"png", sep="."), 
  imagetype = "png", main = paste(Test, "DEGs per differentiation stage", sep = " "), 
  col = xgfs_normal12[c(4,6,7,9)])

## [1] 1

# Stats
hypergeometric.tests = rbind(
  SCN2A.FBvd10 = hypergeometric_test_of_lists(union(FB.genes.expressed,d10.genes.expressed),c(SCN2AUp.FB, SCN2ADown.FB),c(SCN2AUp.d10, SCN2ADown.d10)),
  SCN2A.FBvd22 = hypergeometric_test_of_lists(union(FB.genes.expressed,d22.genes.expressed),c(SCN2AUp.FB, SCN2ADown.FB),c(SCN2AUp.d22, SCN2ADown.d22)),
  SCN2A.FBvd28 = hypergeometric_test_of_lists(union(FB.genes.expressed,d28.genes.expressed),c(SCN2AUp.d28, SCN2ADown.d28),c(SCN2AUp.FB, SCN2ADown.FB)),
  SCN2A.d10vd22 = hypergeometric_test_of_lists(union(d22.genes.expressed,d10.genes.expressed),c(SCN2AUp.d22, SCN2ADown.d22),c(SCN2AUp.d10, SCN2ADown.d10)),
  SCN2A.d10vd28 = hypergeometric_test_of_lists(union(d28.genes.expressed,d10.genes.expressed),c(SCN2AUp.d28, SCN2ADown.d28),c(SCN2AUp.d10, SCN2ADown.d10)),
  SCN2A.d22vd28 = hypergeometric_test_of_lists(union(d28.genes.expressed,d22.genes.expressed),c(SCN2AUp.d28, SCN2ADown.d28),c(SCN2AUp.d22, SCN2ADown.d22)), 
  CHD2.FBvd10 = hypergeometric_test_of_lists(union(FB.genes.expressed,d10.genes.expressed),c(CHD2Up.FB, CHD2Down.FB),c(CHD2Up.d10, CHD2Down.d10)),
  CHD2.FBvd22 = hypergeometric_test_of_lists(union(FB.genes.expressed,d22.genes.expressed),c(CHD2Up.FB, CHD2Down.FB),c(CHD2Up.d22, CHD2Down.d22)),
  CHD2.FBvd28 = hypergeometric_test_of_lists(union(FB.genes.expressed,d28.genes.expressed),c(CHD2Up.d28, CHD2Down.d28),c(CHD2Up.FB, CHD2Down.FB)),
  CHD2.d10vd22 = hypergeometric_test_of_lists(union(d22.genes.expressed,d10.genes.expressed),c(CHD2Up.d22, CHD2Down.d22),c(CHD2Up.d10, CHD2Down.d10)),
  CHD2.d10vd28 = hypergeometric_test_of_lists(union(d28.genes.expressed,d10.genes.expressed),c(CHD2Up.d28, CHD2Down.d28),c(CHD2Up.d10, CHD2Down.d10)),
  CHD2.d22vd28 = hypergeometric_test_of_lists(union(d28.genes.expressed,d22.genes.expressed),c(CHD2Up.d28, CHD2Down.d28),c(CHD2Up.d22, CHD2Down.d22)))

hypergeometric.tests %>%
  kbl() %>%
  kable_styling(bootstrap_options = c("striped", "hover", "condensed")) %>%
  scroll_box(width = "100%", height = "300px")

	total.genes	list.1	list.2	intersection	PValue
SCN2A.FBvd10	14404	402	144	12	0.0007132
SCN2A.FBvd22	13458	402	200	13	0.0071271
SCN2A.FBvd28	14169	509	402	33	0.0000088
SCN2A.d10vd22	13543	200	144	12	0.0000015
SCN2A.d10vd28	14088	509	144	16	0.0000644
SCN2A.d22vd28	12792	509	200	53	0.0000000
CHD2.FBvd10	14404	195	271	5	0.3056768
CHD2.FBvd22	13458	195	182	8	0.0050461
CHD2.FBvd28	14169	179	195	7	0.0119882
CHD2.d10vd22	13543	182	271	43	0.0000000
CHD2.d10vd28	14088	179	271	21	0.0000000
CHD2.d22vd28	12792	179	182	23	0.0000000

Note: The low numbers of genes showing consistent differential expression between iNeuron time points is of potential concern. In the day

Heatmaps for genesets

DEE genes

Generate heat map for wild-type genotype cell lines based on the Genes4Epilepsy list

DEEMatrix = gene.TPM[ match(DEE_List,row.names(gene.TPM)) , colnames(gene.TPM) %in% WTsamples]
#ensembl = useMart("ensembl",dataset="hsapiens_gene_ensembl")
Annotations = getBM(attributes = c('hgnc_symbol','ensembl_gene_id'),
                     filters = 'ensembl_gene_id',
                     values = DEE_List,
                     mart = ensembl)
Annotations = left_join(data.frame(ensembl_gene_id = DEE_List), Annotations, by="ensembl_gene_id")
row.names(DEEMatrix) <- Annotations$hgnc_symbol

pheatmap(log2(DEEMatrix + 0.0001), color = colorRampPalette(rev(brewer.pal(n = 7, name ="RdBu"))) (100), 
                   angle_col = 90, cluster_cols = TRUE, cluster_rows = FALSE,
                   main = "Expression (log2 TPM)")

png(filename=paste("output/misc/DEE",ExperimentName,"heatmap","png", sep="."), height=9130, width=980, bg="white")
    pheatmap(log2(DEEMatrix + 0.0001), color = colorRampPalette(rev(brewer.pal(n = 7, name ="RdBu"))) (100), 
                   angle_col = 90, cluster_cols = TRUE, cluster_rows = FALSE,
                   main = "Expression (log2 TPM)")

dev.off()

## png 
##   3

DEEMatrix = gene.TPM[ match(DEE_biobank_list$ensembl_gene_id,row.names(gene.TPM)), colnames(gene.TPM) %in% WTsamples]
ensembl = useMart("ensembl",dataset="hsapiens_gene_ensembl")
Annotations = getBM(attributes = c('hgnc_symbol','ensembl_gene_id'),
                     filters = 'ensembl_gene_id',
                     values = DEE_biobank_list$ensembl_gene_id,
                     mart = ensembl)
Annotations = left_join(DEE_biobank_list, Annotations, by="ensembl_gene_id")
row.names(DEEMatrix) <- Annotations$hgnc_symbol

pheatmap(log2(DEEMatrix + 0.0001), color = colorRampPalette(rev(brewer.pal(n = 7, name ="RdBu"))) (100), 
                   angle_col = 90, cluster_cols = TRUE, cluster_rows = FALSE,
                   main = "Expression (log2 TPM)")

png(filename=paste("output/misc/DEE_biobank",ExperimentName,"heatmap","png", sep="."), height=1500, width=980, bg="white")
    pheatmap(log2(DEEMatrix + 0.0001), color = colorRampPalette(rev(brewer.pal(n = 7, name ="RdBu"))) (100), 
                   angle_col = 90, cluster_cols = TRUE, cluster_rows = TRUE,
                   main = "Expression (log2 TPM)", fontsize = 16)

dev.off()

## png 
##   3

References

Mapping and counts data

Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C. Salmon: fast and bias-aware quantification of transcript expression using dual-phase inference. Nat Methods. 2017 Apr;14(4):417–9.

Love MI, Soneson C, Hickey PF, Johnson LK, Pierce NT, Shepherd L, Morgan M, Patro R. Tximeta: Reference sequence checksums for provenance identification in RNA-seq PLOS Computational Biology 16(2): e1007664

Differential gene expression

McCarthy DJ, Chen Y, Smyth GK. Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Nucleic Acids Res. 2012 May;40(10):4288–97.

Gene annotations

Durinck S, Spellman PT, Birney E, Huber W. Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt. , Nature Protocols 4, 1184-1191 (2009).

Durinck S, Moreau Y, Kasprzyk A, Davis S, De Moor , Brazma A, Huber W. BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Bioinformatics 21, 3439-3440 (2005).

Gene Ontology

Raudvere, U., CHD2lberg, L., Kuzmin, I., Arak, T., Adler, P., Peterson, H. and Vilo, J., 2019. g: Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Research, 47(W1), pp.W191-W198

Supek F, Bošnjak M, Škunca N, Šmuc T. REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms. PLOS ONE. 2011 Jul 18;6(7):e21800.

Differential transcript and exon usage

Love MI, Soneson C and Patro R. Swimming downstream: statistical analysis of differential transcript usage following Salmon quantification [version 3; peer review: 3 approved]. F1000Research 2018, 7:952

Anders S, Reyes A, Huber W. Detecting differential usage of exons from RNA-seq data. Genome Res. 2012 Oct 1;22(10):2008–17.

Session Information

This information documents the computing environment used to do this analysis to enable others to replicate these findings.

sessionInfo()

## R version 4.4.1 (2024-06-14 ucrt)
## Platform: x86_64-w64-mingw32/x64
## Running under: Windows 10 x64 (build 19045)
## 
## Matrix products: default
## 
## 
## locale:
## [1] LC_COLLATE=English_Australia.utf8  LC_CTYPE=English_Australia.utf8    LC_MONETARY=English_Australia.utf8 LC_NUMERIC=C                      
## [5] LC_TIME=English_Australia.utf8    
## 
## time zone: Australia/Adelaide
## tzcode source: internal
## 
## attached base packages:
## [1] grid      stats4    stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] biomaRt_2.60.1              rtracklayer_1.64.0          VennDiagram_1.7.3           futile.logger_1.4.3         pheatmap_1.0.12            
##  [6] ggplot2_3.5.1               RColorBrewer_1.1-3          edgeR_4.2.1                 limma_3.60.4                SummarizedExperiment_1.34.0
## [11] Biobase_2.64.0              GenomicRanges_1.56.1        GenomeInfoDb_1.40.1         IRanges_2.38.1              S4Vectors_0.42.1           
## [16] BiocGenerics_0.50.0         MatrixGenerics_1.16.0       matrixStats_1.4.1           tximeta_1.22.1              reshape2_1.4.4             
## [21] dplyr_1.1.4                 kableExtra_1.4.0            rgl_1.3.1                  
## 
## loaded via a namespace (and not attached):
##   [1] rstudioapi_0.16.0        jsonlite_1.8.8           tximport_1.32.0          magrittr_2.0.3           GenomicFeatures_1.56.0  
##   [6] farver_2.1.2             rmarkdown_2.28           BiocIO_1.14.0            zlibbioc_1.50.0          vctrs_0.6.5             
##  [11] memoise_2.0.1            Rsamtools_2.20.0         RCurl_1.98-1.16          base64enc_0.1-3          htmltools_0.5.8.1       
##  [16] S4Arrays_1.4.1           progress_1.2.3           AnnotationHub_3.12.0     lambda.r_1.2.4           curl_5.2.2              
##  [21] SparseArray_1.4.8        sass_0.4.9               bslib_0.8.0              htmlwidgets_1.6.4        plyr_1.8.9              
##  [26] httr2_1.0.4              futile.options_1.0.1     cachem_1.1.0             GenomicAlignments_1.40.0 lifecycle_1.0.4         
##  [31] pkgconfig_2.0.3          Matrix_1.7-0             R6_2.5.1                 fastmap_1.2.0            GenomeInfoDbData_1.2.12 
##  [36] digest_0.6.37            colorspace_2.1-1         AnnotationDbi_1.66.0     RSQLite_2.3.7            labeling_0.4.3          
##  [41] filelock_1.0.3           fansi_1.0.6              httr_1.4.7               abind_1.4-8              compiler_4.4.1          
##  [46] bit64_4.0.5              withr_3.0.1              BiocParallel_1.38.0      DBI_1.2.3                highr_0.11              
##  [51] Rttf2pt1_1.3.12          rappdirs_0.3.3           DelayedArray_0.30.1      rjson_0.2.23             tools_4.4.1             
##  [56] extrafontdb_1.0          glue_1.7.0               restfulr_0.0.15          generics_0.1.3           gtable_0.3.5            
##  [61] tzdb_0.4.0               ensembldb_2.28.1         hms_1.1.3                xml2_1.3.6               utf8_1.2.4              
##  [66] XVector_0.44.0           BiocVersion_3.19.1       pillar_1.9.0             stringr_1.5.1            vroom_1.6.5             
##  [71] splines_4.4.1            BiocFileCache_2.12.0     lattice_0.22-6           bit_4.0.5                tidyselect_1.2.1        
##  [76] locfit_1.5-9.10          Biostrings_2.72.1        knitr_1.48               ProtGenerics_1.36.0      svglite_2.1.3           
##  [81] xfun_0.47                statmod_1.5.0            stringi_1.8.4            UCSC.utils_1.0.0         lazyeval_0.2.2          
##  [86] yaml_2.3.10              evaluate_1.0.0           codetools_0.2-20         extrafont_0.19           tibble_3.2.1            
##  [91] BiocManager_1.30.25      cli_3.6.3                systemfonts_1.1.0        jquerylib_0.1.4          munsell_0.5.1           
##  [96] Rcpp_1.0.13              dbplyr_2.5.0             png_0.1-8                XML_3.99-0.17            parallel_4.4.1          
## [101] readr_2.1.5              blob_1.2.4               prettyunits_1.2.0        AnnotationFilter_1.28.0  bitops_1.0-8            
## [106] txdbmaker_1.0.1          viridisLite_0.4.2        scales_1.3.0             purrr_1.0.2              crayon_1.5.3            
## [111] rlang_1.1.4              formatR_1.14             KEGGREST_1.44.1